ABC294640
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- $26 - $3728.1
- Product name: ABC294640
- CAS: 915385-81-8
- MF: C23H25ClN2O
- MW: 380.91
- EINECS:
- MDL Number:MFCD22666355
- Synonyms:ABC294640;3-(4-Chlorophenyl)-N-(4-pyridinylmethyl)tricyclo[3.3.1.1(3,7)]decane-1-carboxamide;Tricyclo[3.3.1.13,7]decane-1-carboxamide, 3-(4-chlorophenyl)-N-(4-pyridinylmethyl);ABC294640(Opaganib);3-(4-chlorophenyl)-adamantane-1-carboxylic acid (pyridin-4-ylmethyl)amide;ABC294640; ABC-294640; ABC 294640; 3-(4-CHLOROPHENYL)-ADAMANTANE-1-CARBOXYLIC ACID (PYRIDIN-4-YLMETHYL)AMIDE;OPAGANIB;CS-802;ABC294640;ABC-294640;ABC 294640;3-(4-CHLOROPHENYL)-ADAMANTANE-1-CARBOXYLIC ACID (PYRIDIN-4-YLMETHYL)AMIDE.
78 prices
Selected condition：
Brand
- aablocks
- ACHEMBLOCK
- Adipogen Life Sciences
- Ambeed
- American Custom Chemicals Corporation
- ApexBio Technology
- Arctom
- Axon Medchem
- Biorbyt Ltd
- Biosynth
- Cayman Chemical
- Chemenu
- ChemScene
- Crysdot
- CSNpharm
- DC Chemicals
- Matrix Scientific
Package
- 10mM*1mLinDMSO(Solution)
- 10mM*1mLinDMSO(Solid+Solvent)
- 5.00mg
- 1mg
- 10mM*1mLinDMSO
- 10mM(1mLinDMSO)
- 5mg
- 10mg
- 10.00mg
- 25.00mg
- 25mg
- 50mg
- 100MG
- 250mg
- 500mg
- 1G
- Manufactureraablocks
- Product numberAA00H0QJ
- Product description3-(4-Chlorophenyl)-N-(4-pyridinylmethyl)tricyclo[3.3.1.13,7]decane-1-carboxamide 98%
- Packaging1mg
- Price$26
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA00H0QJ
- Product description3-(4-Chlorophenyl)-N-(4-pyridinylmethyl)tricyclo[3.3.1.13,7]decane-1-carboxamide 98%
- Packaging5mg
- Price$56
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA00H0QJ
- Product description3-(4-Chlorophenyl)-N-(4-pyridinylmethyl)tricyclo[3.3.1.13,7]decane-1-carboxamide 98%
- Packaging10mg
- Price$98
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA00H0QJ
- Product description3-(4-Chlorophenyl)-N-(4-pyridinylmethyl)tricyclo[3.3.1.13,7]decane-1-carboxamide ≥98%
- Packaging50mg
- Price$229
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA00H0QJ
- Product description3-(4-Chlorophenyl)-N-(4-pyridinylmethyl)tricyclo[3.3.1.13,7]decane-1-carboxamide ≥98%
- Packaging25mg
- Price$174
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA00H0QJ
- Product description3-(4-Chlorophenyl)-N-(4-pyridinylmethyl)tricyclo[3.3.1.13,7]decane-1-carboxamide 98%
- Packaging250mg
- Price$690
- Updated2026-05-28
- Buy
- ManufacturerACHEMBLOCK
- Product numberM15413
- Product descriptionABC294640 98%
- Packaging100MG
- Price$290
- Updated2026-05-27
- Buy
- ManufacturerACHEMBLOCK
- Product numberM15413
- Product descriptionABC294640 98%
- Packaging1G
- Price$1200
- Updated2026-05-27
- Buy
- ManufacturerACHEMBLOCK
- Product numberM15413
- Product descriptionABC294640 98%
- Packaging5MG
- Price$40
- Updated2026-05-27
- Buy
- ManufacturerACHEMBLOCK
- Product numberM15413
- Product descriptionABC294640 98%
- Packaging25MG
- Price$120
- Updated2026-05-27
- Buy
- ManufacturerAdipogen Life Sciences
- Product numberAG-CR1-3749-M005
- Product descriptionOpaganib ≥98%(HPLC)
- Packaging5mg
- Price$90
- Updated2026-05-06
- Buy
- ManufacturerAdipogen Life Sciences
- Product numberAG-CR1-3749-M025
- Product descriptionOpaganib ≥98%(HPLC)
- Packaging25mg
- Price$280
- Updated2026-05-06
- Buy
- ManufacturerAdipogen Life Sciences
- Product numberAG-CR1-3749-M100
- Product descriptionOpaganib ≥98%(HPLC)
- Packaging100mg
- Price$790
- Updated2026-05-06
- Buy
- ManufacturerAmbeed
- Product numberA110039
- Product descriptionABC294640 98+%
- Packaging10mg
- Price$108
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA110039
- Product descriptionABC294640 98+%
- Packaging1g
- Price$1203
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA110039
- Product descriptionABC294640 98+%
- Packaging5mg
- Price$74
- Updated2021-12-16
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| aablocks | AA00H0QJ | 3-(4-Chlorophenyl)-N-(4-pyridinylmethyl)tricyclo[3.3.1.13,7]decane-1-carboxamide 98% | 1mg | $26 | 2026-05-28 | Buy |
| aablocks | AA00H0QJ | 3-(4-Chlorophenyl)-N-(4-pyridinylmethyl)tricyclo[3.3.1.13,7]decane-1-carboxamide 98% | 5mg | $56 | 2026-05-28 | Buy |
| aablocks | AA00H0QJ | 3-(4-Chlorophenyl)-N-(4-pyridinylmethyl)tricyclo[3.3.1.13,7]decane-1-carboxamide 98% | 10mg | $98 | 2026-05-28 | Buy |
| aablocks | AA00H0QJ | 3-(4-Chlorophenyl)-N-(4-pyridinylmethyl)tricyclo[3.3.1.13,7]decane-1-carboxamide ≥98% | 50mg | $229 | 2026-05-28 | Buy |
| aablocks | AA00H0QJ | 3-(4-Chlorophenyl)-N-(4-pyridinylmethyl)tricyclo[3.3.1.13,7]decane-1-carboxamide ≥98% | 25mg | $174 | 2026-05-28 | Buy |
| aablocks | AA00H0QJ | 3-(4-Chlorophenyl)-N-(4-pyridinylmethyl)tricyclo[3.3.1.13,7]decane-1-carboxamide 98% | 250mg | $690 | 2026-05-28 | Buy |
| ACHEMBLOCK | M15413 | ABC294640 98% | 100MG | $290 | 2026-05-27 | Buy |
| ACHEMBLOCK | M15413 | ABC294640 98% | 1G | $1200 | 2026-05-27 | Buy |
| ACHEMBLOCK | M15413 | ABC294640 98% | 5MG | $40 | 2026-05-27 | Buy |
| ACHEMBLOCK | M15413 | ABC294640 98% | 25MG | $120 | 2026-05-27 | Buy |
| Adipogen Life Sciences | AG-CR1-3749-M005 | Opaganib ≥98%(HPLC) | 5mg | $90 | 2026-05-06 | Buy |
| Adipogen Life Sciences | AG-CR1-3749-M025 | Opaganib ≥98%(HPLC) | 25mg | $280 | 2026-05-06 | Buy |
| Adipogen Life Sciences | AG-CR1-3749-M100 | Opaganib ≥98%(HPLC) | 100mg | $790 | 2026-05-06 | Buy |
| Ambeed | A110039 | ABC294640 98+% | 10mg | $108 | 2021-12-16 | Buy |
| Ambeed | A110039 | ABC294640 98+% | 1g | $1203 | 2021-12-16 | Buy |
| Ambeed | A110039 | ABC294640 98+% | 5mg | $74 | 2021-12-16 | Buy |
Properties
Boiling point :589.5±50.0 °C(Predicted)
Density :1.273±0.06 g/cm3(Predicted)
storage temp. :Inert atmosphere,Store in freezer, under -20°C
solubility :≥38.1 mg/mL in DMSO; insoluble in H2O; ≥58.9 mg/mL in EtOH
form :solid
pka :14.57±0.40(Predicted)
color :White to off-white
InChI :InChI=1S/C23H25ClN2O/c24-20-3-1-19(2-4-20)22-10-17-9-18(11-22)13-23(12-17,15-22)21(27)26-14-16-5-7-25-8-6-16/h1-8,17-18H,9-15H2,(H,26,27)
InChIKey :CAOTVXGYTWCKQE-UHFFFAOYSA-N
SMILES :C12(C(NCC3C=CN=CC=3)=O)CC3CC(CC(C4=CC=C(Cl)C=C4)(C3)C1)C2
Density :1.273±0.06 g/cm3(Predicted)
storage temp. :Inert atmosphere,Store in freezer, under -20°C
solubility :≥38.1 mg/mL in DMSO; insoluble in H2O; ≥58.9 mg/mL in EtOH
form :solid
pka :14.57±0.40(Predicted)
color :White to off-white
InChI :InChI=1S/C23H25ClN2O/c24-20-3-1-19(2-4-20)22-10-17-9-18(11-22)13-23(12-17,15-22)21(27)26-14-16-5-7-25-8-6-16/h1-8,17-18H,9-15H2,(H,26,27)
InChIKey :CAOTVXGYTWCKQE-UHFFFAOYSA-N
SMILES :C12(C(NCC3C=CN=CC=3)=O)CC3CC(CC(C4=CC=C(Cl)C=C4)(C3)C1)C2
Safety Information
| Symbol(GHS): |
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| Signal word: | Warning | |||||||
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Description
ABC294640 is an inhibitor of sphingosine kinase 2 (SPHK2; Ki = 9.8 μM). It inhibits SPHK2 (IC50 = 60 μM) without affecting SPHK1 activity up to 100 μM but does reduce SPHK1 isoform a (SPHK1a) protein levels in androgen-independent LNCaP (LNCaP-AI) cells via an SPHK1-indirect, proteasomal-dependent mechanism when used at concentrations ranging from 5 to 25 μM. ABC294640 is inactive against a panel of 20 lipid-regulated kinases at 50 μM. It decreases sphingosine-1-phosphate (S1P) production in MDA-MB-231 cells in a concentration-dependent manner. ABC294640 inhibits proliferation of a variety of cancer cells, including HepG2 liver, A-498 kidney, PANC-1 pancreas, and HT-29 colon cells (IC50s = 6, 12.2, 32.8, and 48.1 μM, respectively). It reduces actin filament polymerization in, and cell migration of, A-498 cells in a scratch assay. Oral administration of ABC294640 (35 and 100 mg/kg every other day) reduces tumor growth in a mouse syngeneic model of mammary adenocarcinoma. It also reduces colonic inflammation in mouse and rat models of Crohn’s disease induced by trinitrobenzene sulfonic acid (TNBS).More related product prices
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