ACY-1215
|
- $28 - $2395.3
- Product name: ACY-1215
- CAS: 1316214-52-4
- MF: C24H27N5O3
- MW: 433.5
- EINECS:
- MDL Number:MFCD22666356
- Synonyms:Rocilinostat (ACY-1215);2-(Diphenylamino)-N-[7-(hydroxyamino)-7-oxoheptyl]-5-pyrimidinecarboxamide;ACY 63;2-(DiphenylaMino)-N-(7-(hydroxyaMino)-7-oxoheptyl)pyriMidine-5-carboxaMide;Rocilinostat, >=99%;5-Pyrimidinecarboxamide, 2-(diphenylamino)-N-[7-(hydroxyamino)-7-oxoheptyl]-;2-(Diphenylamino)-N-[7-(hydroxyamino)-7-oxoheptyl]-5-pyrimidinecarboxamide ACY 1215;Ricolinostat
27 prices
Selected condition：
Brand
- AK Scientific
- American Custom Chemicals Corporation
- ApexBio Technology
- Arctom
- Biorbyt Ltd
- Biosynth Carbosynth
- Cayman Chemical
- Chemenu
- ChemScene
- Crysdot
- DC Chemicals
- TRC
Package
- 1unit
- 5MG
- 10mg
- 20mg
- 25mg
- 50mg
- 100mg
- 200mg
- 250mg
- 1000mg
- 10mM(in 1mL DMSO)
- ManufacturerAK Scientific
- Product numberX5832
- Product descriptionACY-1215
- Packaging100mg
- Price$232
- Updated2021-12-16
- Buy
- ManufacturerAmerican Custom Chemicals Corporation
- Product numberINB0001873
- Product descriptionACY-1215 95.00%
- Packaging5MG
- Price$251.9
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA4083
- Product descriptionRocilinostat(ACY-1215)
- Packaging1unit
- Price$28
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA4083
- Product descriptionRocilinostat(ACY-1215)
- Packaging5mg
- Price$70
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA4083
- Product descriptionRocilinostat(ACY-1215)
- Packaging10mM(in 1mL DMSO)
- Price$75
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA4083
- Product descriptionRocilinostat(ACY-1215)
- Packaging10mg
- Price$100
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA4083
- Product descriptionRocilinostat(ACY-1215)
- Packaging50mg
- Price$280
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA4083
- Product descriptionRocilinostat(ACY-1215)
- Packaging200mg
- Price$850
- Updated2021-12-16
- Buy
- ManufacturerArctom
- Product numberCFN60110
- Product descriptionRicolinostat(ACY-1215) ≥98%
- Packaging20mg
- Price$138
- Updated2021-12-16
- Buy
- ManufacturerBiorbyt Ltd
- Product numberorb180914
- Product descriptionRocilinostat (ACY-1215) >98%
- Packaging100mg
- Price$690.2
- Updated2021-12-16
- Buy
- ManufacturerBiorbyt Ltd
- Product numberorb180914
- Product descriptionRocilinostat (ACY-1215) >98%
- Packaging250mg
- Price$1283.5
- Updated2021-12-16
- Buy
- ManufacturerBiorbyt Ltd
- Product numberorb180914
- Product descriptionRocilinostat (ACY-1215) >98%
- Packaging1000mg
- Price$2395.3
- Updated2021-12-16
- Buy
- ManufacturerBiosynth Carbosynth
- Product numberBA164806
- Product descriptionACY 1215
- Packaging10mg
- Price$85
- Updated2021-12-16
- Buy
- ManufacturerBiosynth Carbosynth
- Product numberBA164806
- Product descriptionACY 1215
- Packaging50mg
- Price$297.5
- Updated2021-12-16
- Buy
- ManufacturerCayman Chemical
- Product number21531
- Product descriptionACY-1215 ≥98%
- Packaging25mg
- Price$72
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number21531
- Product descriptionACY-1215 ≥98%
- Packaging50mg
- Price$129
- Updated2024-03-01
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| AK Scientific | X5832 | ACY-1215 | 100mg | $232 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | INB0001873 | ACY-1215 95.00% | 5MG | $251.9 | 2021-12-16 | Buy |
| ApexBio Technology | A4083 | Rocilinostat(ACY-1215) | 1unit | $28 | 2021-12-16 | Buy |
| ApexBio Technology | A4083 | Rocilinostat(ACY-1215) | 5mg | $70 | 2021-12-16 | Buy |
| ApexBio Technology | A4083 | Rocilinostat(ACY-1215) | 10mM(in 1mL DMSO) | $75 | 2021-12-16 | Buy |
| ApexBio Technology | A4083 | Rocilinostat(ACY-1215) | 10mg | $100 | 2021-12-16 | Buy |
| ApexBio Technology | A4083 | Rocilinostat(ACY-1215) | 50mg | $280 | 2021-12-16 | Buy |
| ApexBio Technology | A4083 | Rocilinostat(ACY-1215) | 200mg | $850 | 2021-12-16 | Buy |
| Arctom | CFN60110 | Ricolinostat(ACY-1215) ≥98% | 20mg | $138 | 2021-12-16 | Buy |
| Biorbyt Ltd | orb180914 | Rocilinostat (ACY-1215) >98% | 100mg | $690.2 | 2021-12-16 | Buy |
| Biorbyt Ltd | orb180914 | Rocilinostat (ACY-1215) >98% | 250mg | $1283.5 | 2021-12-16 | Buy |
| Biorbyt Ltd | orb180914 | Rocilinostat (ACY-1215) >98% | 1000mg | $2395.3 | 2021-12-16 | Buy |
| Biosynth Carbosynth | BA164806 | ACY 1215 | 10mg | $85 | 2021-12-16 | Buy |
| Biosynth Carbosynth | BA164806 | ACY 1215 | 50mg | $297.5 | 2021-12-16 | Buy |
| Cayman Chemical | 21531 | ACY-1215 ≥98% | 25mg | $72 | 2024-03-01 | Buy |
| Cayman Chemical | 21531 | ACY-1215 ≥98% | 50mg | $129 | 2024-03-01 | Buy |
Properties
Melting point :189 - 191°C
Density :1.239±0.06 g/cm3(Predicted)
storage temp. :-20°C Freezer
solubility :DMSO (Slightly), Methanol (Slightly)
pka :9.47±0.20(Predicted)
form :Solid
color :White to Off-White
Density :1.239±0.06 g/cm3(Predicted)
storage temp. :-20°C Freezer
solubility :DMSO (Slightly), Methanol (Slightly)
pka :9.47±0.20(Predicted)
form :Solid
color :White to Off-White
Safety Information
| Symbol(GHS): | ||||||||
|---|---|---|---|---|---|---|---|---|
| Signal word: | ||||||||
| Hazard statements: |
|
|||||||
| Precautionary statements: |
|
Description
ACY-1215 is an inhibitor of histone deacetylase 6 (HDAC6; IC50 = 5 nM). It is at least 10-fold less active against other HDACs in enzymatic assays. ACY-1215 shows synergistic activity with the proteasome inhibitor bortezomib against multiple myeloma (MM) cells, inducing protracted endoplasmic reticulum stress and apoptosis. ACY-1215 combined with proteasome inhibitors suppresses tumor growth and increases survival in mice with MM and mantle cell lymphoma xenografts. A multicenter phase I trial examining ACY-1215 combined with the E3 ligase inhibitor lenalidomide and dexamethasone in multiple myeloma found inhibition of HDAC6 in vivo. ACY-1215 also diminishes liver cyst development and fibrosis in a rat model of polycystic liver disease.Related product price
- Crizotinib
$5-1963.5 - Entinostat
$21-1963.5 - N-Hydroxy-4-[(1,2,3,4-tetrahydro-2-methyl-5H-pyrido[4,3-b]indol-5-yl)methyl]benzamide hydrochloride
$50-3994
