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ChemicalBook >> CAS DataBase List >> AEM1

AEM1

AEM1 price.
  • $32 - $435
  • Product name: AEM1
  • CAS: 1030123-90-0
  • MF: C20H14FN3O2S
  • MW: 379.41
  • EINECS:
  • MDL Number:MFCD15017488
  • Synonyms:N-(benzo[d][1,3]dioxol-5-ylmethyl)-5-(4-fluorophenyl)thieno[2,3-d]pyrimidin-4-amine;N-(1,3-Benzodioxol-5-ylmethyl)-5-(4-fluorophenyl)thieno[2,3-d]pyrimidin-4-amine;AEM1 (NRF2 inhibitor AEM1);Thieno[2,3-d]pyrimidin-4-amine, N-(1,3-benzodioxol-5-ylmethyl)-5-(4-fluorophenyl)-;AEM1 >=98% (HPLC);AEM-1,AEM1,inhibit,AEM 1,Inhibitor,Keap1-Nrf2;1-(2H-1,3-benzodioxol-5-yl)-N-[5-(4-fluorophenyl)-1H,4H-thieno[2,3-d]pyrimidin-4-ylidene]methanamine;N-[(2H-1,3-benzodioxol-5-yl)methyl]-5-(4-fluorophenyl)thieno[2,3-d]pyrimidin-4-amine
Price6 Properties Safety Information Description
6 prices
Selected condition：
Brand
  • AK Scientific
  • Cayman Chemical
  • TRC
Package
  • 500μg
  • 1mg
  • 5mg
  • 10mg
  • 500g
  • ManufacturerAK Scientific
  • Product number9477CQ
  • Product descriptionN-(Benzo[d][1,3]dioxol-5-ylmethyl)-5-(4-fluorophenyl)thieno[2,3-d]pyrimidin-4-amine
  • Packaging1mg
  • Price$190
  • Updated2021-12-16
  • Buy
  • ManufacturerCayman Chemical
  • Product number18321
  • Product descriptionAEM1 ≥98%
  • Packaging1mg
  • Price$32
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number18321
  • Product descriptionAEM1 ≥98%
  • Packaging500μg
  • Price$35
  • Updated2021-12-16
  • Buy
  • ManufacturerCayman Chemical
  • Product number18321
  • Product descriptionAEM1 ≥98%
  • Packaging5mg
  • Price$100
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number18321
  • Product descriptionAEM1 ≥98%
  • Packaging10mg
  • Price$184
  • Updated2024-03-01
  • Buy
  • ManufacturerTRC
  • Product numberB206920
  • Product descriptionN-(1,3-Benzodioxol-5-ylmethyl)-5-(4-fluorophenyl)thieno[2,3-d]pyrimidin-4-amine
  • Packaging500g
  • Price$50
  • Updated2021-12-16
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
AK Scientific 9477CQ N-(Benzo[d][1,3]dioxol-5-ylmethyl)-5-(4-fluorophenyl)thieno[2,3-d]pyrimidin-4-amine 1mg $190 2021-12-16 Buy
Cayman Chemical 18321 AEM1 ≥98% 1mg $32 2024-03-01 Buy
Cayman Chemical 18321 AEM1 ≥98% 500μg $35 2021-12-16 Buy
Cayman Chemical 18321 AEM1 ≥98% 5mg $100 2024-03-01 Buy
Cayman Chemical 18321 AEM1 ≥98% 10mg $184 2024-03-01 Buy
TRC B206920 N-(1,3-Benzodioxol-5-ylmethyl)-5-(4-fluorophenyl)thieno[2,3-d]pyrimidin-4-amine 500g $50 2021-12-16 Buy

Properties

Boiling point :582.1±50.0 °C(Predicted)
Density :1.457±0.06 g/cm3(Predicted)
storage temp. :Store at -20°C
solubility :DMF: 30 mg/mL; DMF:PBS (pH 7.2) (1:4): 0.2 mg/mL; DMSO: 20 mg/mL; Ethanol: 0.25 mg/mL
form :A crystalline solid
pka :5.04±0.40(Predicted)
color :White to off-white

Safety Information

Symbol(GHS):
Signal word:
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
Precautionary statements:

Description

Cancer cell survival appears partly dependent on antioxidative enzymes, whose expression is regulated by the Keap1-Nrf2 pathway, to quench potentially toxic reactive oxygen species generated by their metastatic transformation. AEM1 is an inhibitor of Nrf2-induced gene transcription at the antioxidant response element in cells at 1 to 10 μM. It sensitizes lung carcinoma A549 cells to chemotherapeutic agents and inhibits the growth of A549 cells in vitro and in vivo in animals. The effectiveness of AEM1 against cancer cells is restricted to those harboring mutations that render Nrf2 constitutively active.

Suppliers and manufacturers

Career Henan Chemica Co
TargetMol Chemicals Inc.
Wuhan Topule Biopharmaceutical Co., Ltd
Shenyang Zhongshen Zekang Biomedical Technology Research Co., Ltd
Aladdin Scientific
Wuhan Jingkang en Biomedical Technology Co., Ltd Shanghai Lollane Biological Technology Co.,Ltd. Shanghai EFE Biological Technology Co., Ltd. ShangHai Biochempartner Co.,Ltd Shanghai Rechem science Co., Ltd.