AEM1
|
- $35 - $6554.9
- Product name: AEM1
- CAS: 1030123-90-0
- MF: C20H14FN3O2S
- MW: 379.41
- EINECS:
- MDL Number:MFCD15017488
- Synonyms:N-(benzo[d][1,3]dioxol-5-ylmethyl)-5-(4-fluorophenyl)thieno[2,3-d]pyrimidin-4-amine;N-(1,3-Benzodioxol-5-ylmethyl)-5-(4-fluorophenyl)thieno[2,3-d]pyrimidin-4-amine;AEM1 (NRF2 inhibitor AEM1);Thieno[2,3-d]pyrimidin-4-amine, N-(1,3-benzodioxol-5-ylmethyl)-5-(4-fluorophenyl)-;AEM1 >=98% (HPLC);AEM-1,AEM1,inhibit,AEM 1,Inhibitor,Keap1-Nrf2;1-(2H-1,3-benzodioxol-5-yl)-N-[5-(4-fluorophenyl)-1H,4H-thieno[2,3-d]pyrimidin-4-ylidene]methanamine;N-[(2H-1,3-benzodioxol-5-yl)methyl]-5-(4-fluorophenyl)thieno[2,3-d]pyrimidin-4-amine
28 prices
Selected condition：
Brand
- aablocks
- ACHEMBLOCK
- AK Scientific
- Biosynth
- Cayman Chemical
- ChemScene
- DC Chemicals
- Sigma-Aldrich
- TRC
Package
- 1mg
- 10mM*1mLinDMSO
- 500μg
- 2mg
- 5mg
- 10mg
- 25mg
- 50mg
- 100mg
- 250mg
- 0.5g
- 1G
- 500g
- Manufactureraablocks
- Product numberAA01C13I
- Product descriptionAEM1 ≥98%
- Packaging1mg
- Price$36
- Updated2026-05-29
- Buy
- Manufactureraablocks
- Product numberAA01C13I
- Product descriptionAEM1
- Packaging2mg
- Price$44
- Updated2026-05-29
- Buy
- Manufactureraablocks
- Product numberAA01C13I
- Product descriptionAEM1
- Packaging5mg
- Price$58
- Updated2026-05-29
- Buy
- Manufactureraablocks
- Product numberAA01C13I
- Product descriptionAEM1
- Packaging10mg
- Price$88
- Updated2026-05-29
- Buy
- Manufactureraablocks
- Product numberAA01C13I
- Product descriptionAEM1
- Packaging25mg
- Price$163
- Updated2026-05-29
- Buy
- Manufactureraablocks
- Product numberAA01C13I
- Product descriptionAEM1
- Packaging50mg
- Price$243
- Updated2026-05-29
- Buy
- Manufactureraablocks
- Product numberAA01C13I
- Product descriptionAEM1
- Packaging100mg
- Price$377
- Updated2026-05-29
- Buy
- ManufacturerACHEMBLOCK
- Product numberU127630
- Product descriptionAEM1 98%
- Packaging100MG
- Price$535
- Updated2026-05-27
- Buy
- ManufacturerACHEMBLOCK
- Product numberU127630
- Product descriptionAEM1 98%
- Packaging1G
- Price$3210
- Updated2026-05-27
- Buy
- ManufacturerAK Scientific
- Product number9477CQ
- Product descriptionN-(Benzo[d][1,3]dioxol-5-ylmethyl)-5-(4-fluorophenyl)thieno[2,3-d]pyrimidin-4-amine
- Packaging1mg
- Price$190
- Updated2021-12-16
- Buy
- ManufacturerBiosynth
- Product numberFRB12390
- Product descriptionAEM1
- Packaging0.5g
- Price$6554.9
- Updated2026-06-04
- Buy
- ManufacturerBiosynth
- Product numberFRB12390
- Product descriptionAEM1
- Packaging50mg
- Price$2405
- Updated2026-06-04
- Buy
- ManufacturerCayman Chemical
- Product number18321
- Product descriptionAEM1 ≥98%
- Packaging10mg
- Price$203
- Updated2026-04-30
- Buy
- ManufacturerCayman Chemical
- Product number18321
- Product descriptionAEM1 ≥98%
- Packaging5mg
- Price$110
- Updated2026-04-30
- Buy
- ManufacturerCayman Chemical
- Product number18321
- Product descriptionAEM1 ≥98%
- Packaging500μg
- Price$35
- Updated2021-12-16
- Buy
- ManufacturerCayman Chemical
- Product number18321
- Product descriptionAEM1 ≥98%
- Packaging1mg
- Price$36
- Updated2026-04-30
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| aablocks | AA01C13I | AEM1 ≥98% | 1mg | $36 | 2026-05-29 | Buy |
| aablocks | AA01C13I | AEM1 | 2mg | $44 | 2026-05-29 | Buy |
| aablocks | AA01C13I | AEM1 | 5mg | $58 | 2026-05-29 | Buy |
| aablocks | AA01C13I | AEM1 | 10mg | $88 | 2026-05-29 | Buy |
| aablocks | AA01C13I | AEM1 | 25mg | $163 | 2026-05-29 | Buy |
| aablocks | AA01C13I | AEM1 | 50mg | $243 | 2026-05-29 | Buy |
| aablocks | AA01C13I | AEM1 | 100mg | $377 | 2026-05-29 | Buy |
| ACHEMBLOCK | U127630 | AEM1 98% | 100MG | $535 | 2026-05-27 | Buy |
| ACHEMBLOCK | U127630 | AEM1 98% | 1G | $3210 | 2026-05-27 | Buy |
| AK Scientific | 9477CQ | N-(Benzo[d][1,3]dioxol-5-ylmethyl)-5-(4-fluorophenyl)thieno[2,3-d]pyrimidin-4-amine | 1mg | $190 | 2021-12-16 | Buy |
| Biosynth | FRB12390 | AEM1 | 0.5g | $6554.9 | 2026-06-04 | Buy |
| Biosynth | FRB12390 | AEM1 | 50mg | $2405 | 2026-06-04 | Buy |
| Cayman Chemical | 18321 | AEM1 ≥98% | 10mg | $203 | 2026-04-30 | Buy |
| Cayman Chemical | 18321 | AEM1 ≥98% | 5mg | $110 | 2026-04-30 | Buy |
| Cayman Chemical | 18321 | AEM1 ≥98% | 500μg | $35 | 2021-12-16 | Buy |
| Cayman Chemical | 18321 | AEM1 ≥98% | 1mg | $36 | 2026-04-30 | Buy |
Properties
Boiling point :582.1±50.0 °C(Predicted)
Density :1.457±0.06 g/cm3(Predicted)
storage temp. :Store at -20°C
solubility :DMF: 30 mg/mL; DMF:PBS (pH 7.2) (1:4): 0.2 mg/mL; DMSO: 20 mg/mL; Ethanol: 0.25 mg/mL
form :A crystalline solid
pka :5.04±0.40(Predicted)
color :White to off-white
InChI :1S/C20H14FN3O2S/c21-14-4-2-13(3-5-14)15-9-27-20-18(15)19(23-10-24-20)22-8-12-1-6-16-17(7-12)26-11-25-16/h1-7,9-10H,8,11H2,(H,22,23,24)
InChIKey :QGYLTGSHWIGJJD-UHFFFAOYSA-N
SMILES :Fc1ccc(cc1)c2c3c([s]c2)[nH]cn[c]3=NCc4cc5c(cc4)OCO5
Density :1.457±0.06 g/cm3(Predicted)
storage temp. :Store at -20°C
solubility :DMF: 30 mg/mL; DMF:PBS (pH 7.2) (1:4): 0.2 mg/mL; DMSO: 20 mg/mL; Ethanol: 0.25 mg/mL
form :A crystalline solid
pka :5.04±0.40(Predicted)
color :White to off-white
InChI :1S/C20H14FN3O2S/c21-14-4-2-13(3-5-14)15-9-27-20-18(15)19(23-10-24-20)22-8-12-1-6-16-17(7-12)26-11-25-16/h1-7,9-10H,8,11H2,(H,22,23,24)
InChIKey :QGYLTGSHWIGJJD-UHFFFAOYSA-N
SMILES :Fc1ccc(cc1)c2c3c([s]c2)[nH]cn[c]3=NCc4cc5c(cc4)OCO5
Safety Information
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Description
Cancer cell survival appears partly dependent on antioxidative enzymes, whose expression is regulated by the Keap1-Nrf2 pathway, to quench potentially toxic reactive oxygen species generated by their metastatic transformation. AEM1 is an inhibitor of Nrf2-induced gene transcription at the antioxidant response element in cells at 1 to 10 μM. It sensitizes lung carcinoma A549 cells to chemotherapeutic agents and inhibits the growth of A549 cells in vitro and in vivo in animals. The effectiveness of AEM1 against cancer cells is restricted to those harboring mutations that render Nrf2 constitutively active.More related product prices
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