ASP-9521
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- $41 - $2340
- Product name: ASP-9521
- CAS: 1126084-37-4
- MF: C19H26N2O3
- MW: 330.42
- EINECS:
- MDL Number:MFCD30532740
- Synonyms:ASP-9521;1-[1-[(5-Methoxy-1H-indol-2-yl)carbonyl]piperidin-4-yl]-2-methylpropan-2-ol;AKR1C3 inhibitor;ASP-9521; ASP 9521; AKR1C3 INHIBITOR; 17??HSD5 INHIBITOR;[4-(2-Hydroxy-2-methylpropyl)-1-piperidinyl](5-methoxy-1H-indol-2-yl)methanone;17HSD5 inhibitor;ASP 9521. AKR1C3 inhibitor;ASP9521; ASP-9521; ASP 9521. AKR1C3 INHIBITOR ; 17HSD5 INHIBITOR
18 prices
Selected condition：
Brand
- AK Scientific
- American Custom Chemicals Corporation
- Axon Medchem
- Cayman Chemical
- Crysdot
- DC Chemicals
- Tocris
- TRC
Package
- 50
- 5mg
- 10
- 10mg
- 25mg
- 50mg
- 100mg
- 250mg
- 1g
- ManufacturerAK Scientific
- Product number3183DC
- Product description[4-(2-Hydroxy-2-methylpropyl)piperidin-1-yl]-(5-methoxy-1H-indol-2-yl)methanone
- Packaging10mg
- Price$199
- Updated2021-12-16
- Buy
- ManufacturerAK Scientific
- Product number3183DC
- Product description[4-(2-Hydroxy-2-methylpropyl)piperidin-1-yl]-(5-methoxy-1H-indol-2-yl)methanone
- Packaging5mg
- Price$166
- Updated2021-12-16
- Buy
- ManufacturerAmerican Custom Chemicals Corporation
- Product numberINB0005733
- Product descriptionASP-9521 95.00%
- Packaging5MG
- Price$451.52
- Updated2021-12-16
- Buy
- ManufacturerAxon Medchem
- Product numberAxon2787
- Product descriptionASP9521 99%
- Packaging10mg
- Price$82.5
- Updated2021-12-16
- Buy
- ManufacturerAxon Medchem
- Product numberAxon2787
- Product descriptionASP9521 99%
- Packaging50mg
- Price$291.5
- Updated2021-12-16
- Buy
- ManufacturerCayman Chemical
- Product number27308
- Product descriptionASP9521
- Packaging5mg
- Price$62
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number27308
- Product descriptionASP9521
- Packaging10mg
- Price$92
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number27308
- Product descriptionASP9521
- Packaging25mg
- Price$166
- Updated2024-03-01
- Buy
- ManufacturerCrysdot
- Product numberCD31004987
- Product descriptionASP9521 98%
- Packaging250mg
- Price$553
- Updated2021-12-16
- Buy
- ManufacturerCrysdot
- Product numberCD31004987
- Product descriptionASP9521 98%
- Packaging100mg
- Price$333
- Updated2021-12-16
- Buy
- ManufacturerCrysdot
- Product numberCD31004987
- Product descriptionASP9521 98%
- Packaging25mg
- Price$123
- Updated2021-12-16
- Buy
- ManufacturerCrysdot
- Product numberCD31004987
- Product descriptionASP9521 98%
- Packaging10mg
- Price$57
- Updated2021-12-16
- Buy
- ManufacturerCrysdot
- Product numberCD31004987
- Product descriptionASP9521 98%
- Packaging5mg
- Price$41
- Updated2021-12-16
- Buy
- ManufacturerDC Chemicals
- Product numberDC10588
- Product descriptionASP-9521 >98%
- Packaging250mg
- Price$1170
- Updated2021-12-16
- Buy
- ManufacturerDC Chemicals
- Product numberDC10588
- Product descriptionASP-9521 >98%
- Packaging1g
- Price$2340
- Updated2021-12-16
- Buy
- ManufacturerTocris
- Product number6084
- Product descriptionASP9521 ≥98%(HPLC)
- Packaging10
- Price$68
- Updated2021-12-16
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| AK Scientific | 3183DC | [4-(2-Hydroxy-2-methylpropyl)piperidin-1-yl]-(5-methoxy-1H-indol-2-yl)methanone | 10mg | $199 | 2021-12-16 | Buy |
| AK Scientific | 3183DC | [4-(2-Hydroxy-2-methylpropyl)piperidin-1-yl]-(5-methoxy-1H-indol-2-yl)methanone | 5mg | $166 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | INB0005733 | ASP-9521 95.00% | 5MG | $451.52 | 2021-12-16 | Buy |
| Axon Medchem | Axon2787 | ASP9521 99% | 10mg | $82.5 | 2021-12-16 | Buy |
| Axon Medchem | Axon2787 | ASP9521 99% | 50mg | $291.5 | 2021-12-16 | Buy |
| Cayman Chemical | 27308 | ASP9521 | 5mg | $62 | 2024-03-01 | Buy |
| Cayman Chemical | 27308 | ASP9521 | 10mg | $92 | 2024-03-01 | Buy |
| Cayman Chemical | 27308 | ASP9521 | 25mg | $166 | 2024-03-01 | Buy |
| Crysdot | CD31004987 | ASP9521 98% | 250mg | $553 | 2021-12-16 | Buy |
| Crysdot | CD31004987 | ASP9521 98% | 100mg | $333 | 2021-12-16 | Buy |
| Crysdot | CD31004987 | ASP9521 98% | 25mg | $123 | 2021-12-16 | Buy |
| Crysdot | CD31004987 | ASP9521 98% | 10mg | $57 | 2021-12-16 | Buy |
| Crysdot | CD31004987 | ASP9521 98% | 5mg | $41 | 2021-12-16 | Buy |
| DC Chemicals | DC10588 | ASP-9521 >98% | 250mg | $1170 | 2021-12-16 | Buy |
| DC Chemicals | DC10588 | ASP-9521 >98% | 1g | $2340 | 2021-12-16 | Buy |
| Tocris | 6084 | ASP9521 ≥98%(HPLC) | 10 | $68 | 2021-12-16 | Buy |
Properties
Boiling point :543.9±30.0 °C(Predicted)
Density :1.183±0.06 g/cm3(Predicted)
storage temp. :Sealed in dry,Store in freezer, under -20°C
solubility :DMSO:52.26(Max Conc. mg/mL);158.16(Max Conc. mM)
DMF:10.0(Max Conc. mg/mL);30.26(Max Conc. mM)
DMF:PBS (pH 7.2) (1:1):0.5(Max Conc. mg/mL);1.51(Max Conc. mM)
Ethanol:36.35(Max Conc. mg/mL);110.01(Max Conc. mM) form :A crystalline solid
pka :15.23±0.29(Predicted)
color :Light yellow to yellow
Density :1.183±0.06 g/cm3(Predicted)
storage temp. :Sealed in dry,Store in freezer, under -20°C
solubility :DMSO:52.26(Max Conc. mg/mL);158.16(Max Conc. mM)
DMF:10.0(Max Conc. mg/mL);30.26(Max Conc. mM)
DMF:PBS (pH 7.2) (1:1):0.5(Max Conc. mg/mL);1.51(Max Conc. mM)
Ethanol:36.35(Max Conc. mg/mL);110.01(Max Conc. mM) form :A crystalline solid
pka :15.23±0.29(Predicted)
color :Light yellow to yellow
Safety Information
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Description
ASP9521 is an inhibitor of 17β-hydroxysteroid dehydrogenase type 5/aldo-keto reductase 1C3 (17β-HSD5/AKR1C3; IC50 = 120 nM). It is selective for 17β-HSD5/AKR1C3 over AKR1C2 (IC50 = 20 μM). ASP9521 inhibits conversion of androstenedione into testosterone by 17β-HSD5/AKR1C3 (IC50s = 11 and 49 nM for human and cynomolgus monkey enzymes, respectively). It inhibits androstenedione-dependent production of prostate specific androgen (PSA) in and proliferation of LNCaP cells expressing 17β-HSD5/AKR1C3. ASP9521 (3 and 10 mg/kg) inhibits androstenedione-induced intratumor testosterone production in a CWR22R prostate cancer mouse xenograft model.Related product price
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