AZD 1080
|
- $15 - $2839
- Product name: AZD 1080
- CAS: 612487-72-6
- MF: C19H18N4O2
- MW: 334.37
- EINECS:
- MDL Number:MFCD12031593
- Synonyms:AZD 1080;AZD1080;AZD-1080;2-Hydroxy-3-(5-(morpholinomethyl)pyridin-2-yl)-1H-indole-5-carbonitrile;2-Hydroxy-3-[5-[(morpholin-4-yl)methyl]pyridin-2-yl]-1H-indole-5-carbonitrile;2-Hydroxy-3-[5-[(morpholin-4-yl)methyl]pyridin-2-yl]-1H-indole-5-carbonitrile AZD1080;CS-809;AZD 1080;AZD-1080
47 prices
Selected condition：
Brand
- aablocks
- ACHEMBLOCK
- AK Scientific
- American Custom Chemicals Corporation
- ApexBio Technology
- Axon Medchem
- Biorbyt Ltd
- Biosynth
- Cayman Chemical
- Chemenu
- ChemScene
- Crysdot
- DC Chemicals
- Sigma-Aldrich
- TRC
Package
- 10mg
- 10mM(in1mLDMSO)
- 10mM(in 1mL DMSO)
- 10mM*1mLinDMSO
- 1mg
- 2mg
- 5mg
- 25MG
- 50mg
- 100MG
- 250mg
- 1G
- Manufactureraablocks
- Product numberAA003EBQ
- Product descriptionAZD1080 98+%
- Packaging1mg
- Price$15
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA003EBQ
- Product descriptionAZD1080 98+%
- Packaging2mg
- Price$18
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA003EBQ
- Product descriptionAZD1080 98+%
- Packaging5mg
- Price$23
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA003EBQ
- Product descriptionAZD1080 98+%
- Packaging50mg
- Price$83
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA003EBQ
- Product descriptionAZD1080 98+%
- Packaging10mg
- Price$32
- Updated2026-05-28
- Buy
- ManufacturerACHEMBLOCK
- Product numberM15675
- Product descriptionAZD1080 98%
- Packaging25MG
- Price$75
- Updated2026-05-27
- Buy
- ManufacturerACHEMBLOCK
- Product numberM15675
- Product descriptionAZD1080 98%
- Packaging100MG
- Price$225
- Updated2026-05-27
- Buy
- ManufacturerACHEMBLOCK
- Product numberM15675
- Product descriptionAZD1080 98%
- Packaging1G
- Price$1300
- Updated2026-05-27
- Buy
- ManufacturerAK Scientific
- Product numberX6996
- Product descriptionAZD1080
- Packaging25mg
- Price$527
- Updated2021-12-16
- Buy
- ManufacturerAK Scientific
- Product numberX6996
- Product descriptionAZD1080
- Packaging1mg
- Price$124
- Updated2021-12-16
- Buy
- ManufacturerAmerican Custom Chemicals Corporation
- Product numberKIN0000375
- Product description2-HYDROXY-3-(5-(MORPHOLINOMETHYL)PYRIDIN-2-YL)-1H-INDOLE-5-CARBONITRILE 95.00%
- Packaging5MG
- Price$500.17
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberB1536
- Product descriptionAZD1080
- Packaging100mg
- Price$743
- Updated2026-05-06
- Buy
- ManufacturerApexBio Technology
- Product numberB1536
- Product descriptionAZD1080
- Packaging50mg
- Price$446
- Updated2026-05-06
- Buy
- ManufacturerApexBio Technology
- Product numberB1536
- Product descriptionAZD1080
- Packaging10mM(in 1mL DMSO)
- Price$242
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberB1536
- Product descriptionAZD1080
- Packaging25mg
- Price$286
- Updated2026-05-06
- Buy
- ManufacturerApexBio Technology
- Product numberB1536
- Product descriptionAZD1080
- Packaging10mg
- Price$149
- Updated2026-05-06
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| aablocks | AA003EBQ | AZD1080 98+% | 1mg | $15 | 2026-05-28 | Buy |
| aablocks | AA003EBQ | AZD1080 98+% | 2mg | $18 | 2026-05-28 | Buy |
| aablocks | AA003EBQ | AZD1080 98+% | 5mg | $23 | 2026-05-28 | Buy |
| aablocks | AA003EBQ | AZD1080 98+% | 50mg | $83 | 2026-05-28 | Buy |
| aablocks | AA003EBQ | AZD1080 98+% | 10mg | $32 | 2026-05-28 | Buy |
| ACHEMBLOCK | M15675 | AZD1080 98% | 25MG | $75 | 2026-05-27 | Buy |
| ACHEMBLOCK | M15675 | AZD1080 98% | 100MG | $225 | 2026-05-27 | Buy |
| ACHEMBLOCK | M15675 | AZD1080 98% | 1G | $1300 | 2026-05-27 | Buy |
| AK Scientific | X6996 | AZD1080 | 25mg | $527 | 2021-12-16 | Buy |
| AK Scientific | X6996 | AZD1080 | 1mg | $124 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | KIN0000375 | 2-HYDROXY-3-(5-(MORPHOLINOMETHYL)PYRIDIN-2-YL)-1H-INDOLE-5-CARBONITRILE 95.00% | 5MG | $500.17 | 2021-12-16 | Buy |
| ApexBio Technology | B1536 | AZD1080 | 100mg | $743 | 2026-05-06 | Buy |
| ApexBio Technology | B1536 | AZD1080 | 50mg | $446 | 2026-05-06 | Buy |
| ApexBio Technology | B1536 | AZD1080 | 10mM(in 1mL DMSO) | $242 | 2021-12-16 | Buy |
| ApexBio Technology | B1536 | AZD1080 | 25mg | $286 | 2026-05-06 | Buy |
| ApexBio Technology | B1536 | AZD1080 | 10mg | $149 | 2026-05-06 | Buy |
Properties
Boiling point :594.0±50.0 °C(Predicted)
Density :1.40±0.1 g/cm3(Predicted)
storage temp. :Store at -20°C
solubility :insoluble in H2O; insoluble in EtOH; ≥16.7 mg/mL in DMSO
form :solid
pka :8.32±0.50(Predicted)
color :Light yellow to orange
InChI :1S/C19H18N4O2/c20-10-13-1-3-16-15(9-13)18(19(24)22-16)17-4-2-14(11-21-17)12-23-5-7-25-8-6-23/h1-4,9,11,22,24H,5-8,12H2
InChIKey :BLTVBQXJFVRPFK-UHFFFAOYSA-N
SMILES :N4(CCOCC4)Cc1cnc(cc1)c2c3c([nH]c2O)ccc(c3)C#N
Density :1.40±0.1 g/cm3(Predicted)
storage temp. :Store at -20°C
solubility :insoluble in H2O; insoluble in EtOH; ≥16.7 mg/mL in DMSO
form :solid
pka :8.32±0.50(Predicted)
color :Light yellow to orange
InChI :1S/C19H18N4O2/c20-10-13-1-3-16-15(9-13)18(19(24)22-16)17-4-2-14(11-21-17)12-23-5-7-25-8-6-23/h1-4,9,11,22,24H,5-8,12H2
InChIKey :BLTVBQXJFVRPFK-UHFFFAOYSA-N
SMILES :N4(CCOCC4)Cc1cnc(cc1)c2c3c([nH]c2O)ccc(c3)C#N
Safety Information
| Symbol(GHS): |
|
|||||||||||||||||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Signal word: | Warning | |||||||||||||||||||||||||||||||||||
| Hazard statements: |
|
|||||||||||||||||||||||||||||||||||
| Precautionary statements: |
|
Description
The two isoforms of glycogen synthase kinase 3, GSK3α and GSK3β, constitutively phosphorylate and inactivate glycogen synthase, preventing glycogen synthesis. They also phosphorylate proteins that are relevant to Alzheimer’s disease and osteogenesis. AZD 1080 is a potent, brain permeable inhibitor of GSK3α and GSK3β (Kis = 6.9 and 31 nM, respectively). It shows >14-fold selectivity against several kinases, receptors, enzymes, and ion channels. AZD 1080 inhibits tau phosphorylation in cells. It shows good bioavailability after oral administration in vivo, inhibiting hippocampal tau phosphorylation and reversing cognitive deficits induced by the NMDA receptor antagonist MK-801. In humans, oral AZD 1080 inhibits GSK3 activity in peripheral blood lymphocytes following an initial delay in response.Related product price
-
Disulfiram
$18-1504.5 -
AZD-2858
$5-2395.3 -
Pictilisib (GDC-0941)
$16-3563.2
Suppliers and manufacturers
Shanghai Boyle Chemical Co., Ltd.
J & K SCIENTIFIC LTD.
Jinan Trio PharmaTech Co., Ltd.
Dalian Meilun Biotech Co., Ltd.
Jiangsu Aikon Biopharmaceutical R&D co.,Ltd.
Haoyuan Chemexpress Co., Ltd.
Shanghai Aladdin Bio-Chem Technology Co.,LTD
MedChemexpress LLC
AdooQ BioScience, LLC
CEG Chemical Science&Technology Co., Ltd.