Aprepitant
- $5 - $3204
- Product name: Aprepitant
- CAS: 170729-80-3
- MF: C23H21F7N4O3
- MW: 534.43
- EINECS:677-636-6
- MDL Number:MFCD08277635
- Synonyms:MK-0869;5-[[(2R,3S)-2-[(1R)-1-[3,5-Bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)-4-morpholinyl]methyl]-1,2-dihydro-3H-1,;5-[[(2R,3S)-2-[(1R)-1-[3,5-Bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)-4-morpholinyl]methyl]-1,2-dihydro-3H-1,2,4-triazol-3-one, Emend;Aprepitant(MK-0869);ONO 7436;5-(((2R,3S)-2-((R)-1-(3,5-bis(trifluoroMethyl)phenyl)ethoxy)-3-(4-fluorophenyl)Morpholino)Methyl)-1H-1,2,4-triazol-3(2H)-one;Aprepirant;aprepitant
65 prices
Selected condition:
Brand
- AccelPharmtech
- AK Scientific
- Ambeed
- American Custom Chemicals Corporation
- ApexBio Technology
- Arctom
- Ark Pharm
- AvaChem
- Biorbyt Ltd
- Biosynth Carbosynth
- Cayman Chemical
- Chemenu
- ChemScene
- Chemtos
- Crysdot
- CSNpharm
- DC Chemicals
- Labseeker
- Matrix Scientific
- Medical Isotopes, Inc.
- Sigma-Aldrich
- TCI Chemical
- Tocris
- TRC
Package
- 1mg
- 20mg
- 25mg
- 50
- 150MG
- 200mg
- 500mg
- 2g
- 100g
- 10mM(in 1mL DMSO)
- 5mg
- 10mg
- 50mg
- 100mg
- 250mg
- 1g
- 5g
- 10G
- 25g
- ManufacturerAccelPharmtech
- Product numberLY1035
- Product descriptionAprepitant 99.90%
- Packaging10G
- Price$320
- Updated2021-12-16
- Buy
- ManufacturerAK Scientific
- Product numberJ51364
- Product descriptionAprepitant
- Packaging1g
- Price$121
- Updated2021-12-16
- Buy
- ManufacturerAK Scientific
- Product numberL982
- Product descriptionAprepitant
- Packaging1g
- Price$250
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA103179
- Product description5-(((2R,3S)-2-((R)-1-(3,5-Bis(trifluoromethyl)phenyl)ethoxy)-3-(4-fluorophenyl)morpholino)methyl)-1H-1,2,4-triazol-3(2H)-one 98+%
- Packaging5mg
- Price$5
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA103179
- Product description5-(((2R,3S)-2-((R)-1-(3,5-Bis(trifluoromethyl)phenyl)ethoxy)-3-(4-fluorophenyl)morpholino)methyl)-1H-1,2,4-triazol-3(2H)-one 98+%
- Packaging10mg
- Price$7
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA103179
- Product description5-(((2R,3S)-2-((R)-1-(3,5-Bis(trifluoromethyl)phenyl)ethoxy)-3-(4-fluorophenyl)morpholino)methyl)-1H-1,2,4-triazol-3(2H)-one 98+%
- Packaging50mg
- Price$9
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA103179
- Product description5-(((2R,3S)-2-((R)-1-(3,5-Bis(trifluoromethyl)phenyl)ethoxy)-3-(4-fluorophenyl)morpholino)methyl)-1H-1,2,4-triazol-3(2H)-one 98+%
- Packaging100mg
- Price$11
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA103179
- Product description5-(((2R,3S)-2-((R)-1-(3,5-Bis(trifluoromethyl)phenyl)ethoxy)-3-(4-fluorophenyl)morpholino)methyl)-1H-1,2,4-triazol-3(2H)-one 98+%
- Packaging250mg
- Price$14
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA103179
- Product description5-(((2R,3S)-2-((R)-1-(3,5-Bis(trifluoromethyl)phenyl)ethoxy)-3-(4-fluorophenyl)morpholino)methyl)-1H-1,2,4-triazol-3(2H)-one 98+%
- Packaging1g
- Price$37
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA103179
- Product description5-(((2R,3S)-2-((R)-1-(3,5-Bis(trifluoromethyl)phenyl)ethoxy)-3-(4-fluorophenyl)morpholino)methyl)-1H-1,2,4-triazol-3(2H)-one 98+%
- Packaging5g
- Price$139
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA103179
- Product description5-(((2R,3S)-2-((R)-1-(3,5-Bis(trifluoromethyl)phenyl)ethoxy)-3-(4-fluorophenyl)morpholino)methyl)-1H-1,2,4-triazol-3(2H)-one 98+%
- Packaging25g
- Price$668
- Updated2021-12-16
- Buy
- ManufacturerAmerican Custom Chemicals Corporation
- Product numberAPI0000396
- Product descriptionAPREPITANT 95.00%
- Packaging5MG
- Price$220
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA1684
- Product descriptionAprepitant
- Packaging5mg
- Price$69
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA1684
- Product descriptionAprepitant
- Packaging10mM(in 1mL DMSO)
- Price$77
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA1684
- Product descriptionAprepitant
- Packaging25mg
- Price$190
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA1684
- Product descriptionAprepitant
- Packaging100mg
- Price$428
- Updated2021-12-16
- Buy
Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|
AccelPharmtech | LY1035 | Aprepitant 99.90% | 10G | $320 | 2021-12-16 | Buy |
AK Scientific | J51364 | Aprepitant | 1g | $121 | 2021-12-16 | Buy |
AK Scientific | L982 | Aprepitant | 1g | $250 | 2021-12-16 | Buy |
Ambeed | A103179 | 5-(((2R,3S)-2-((R)-1-(3,5-Bis(trifluoromethyl)phenyl)ethoxy)-3-(4-fluorophenyl)morpholino)methyl)-1H-1,2,4-triazol-3(2H)-one 98+% | 5mg | $5 | 2021-12-16 | Buy |
Ambeed | A103179 | 5-(((2R,3S)-2-((R)-1-(3,5-Bis(trifluoromethyl)phenyl)ethoxy)-3-(4-fluorophenyl)morpholino)methyl)-1H-1,2,4-triazol-3(2H)-one 98+% | 10mg | $7 | 2021-12-16 | Buy |
Ambeed | A103179 | 5-(((2R,3S)-2-((R)-1-(3,5-Bis(trifluoromethyl)phenyl)ethoxy)-3-(4-fluorophenyl)morpholino)methyl)-1H-1,2,4-triazol-3(2H)-one 98+% | 50mg | $9 | 2021-12-16 | Buy |
Ambeed | A103179 | 5-(((2R,3S)-2-((R)-1-(3,5-Bis(trifluoromethyl)phenyl)ethoxy)-3-(4-fluorophenyl)morpholino)methyl)-1H-1,2,4-triazol-3(2H)-one 98+% | 100mg | $11 | 2021-12-16 | Buy |
Ambeed | A103179 | 5-(((2R,3S)-2-((R)-1-(3,5-Bis(trifluoromethyl)phenyl)ethoxy)-3-(4-fluorophenyl)morpholino)methyl)-1H-1,2,4-triazol-3(2H)-one 98+% | 250mg | $14 | 2021-12-16 | Buy |
Ambeed | A103179 | 5-(((2R,3S)-2-((R)-1-(3,5-Bis(trifluoromethyl)phenyl)ethoxy)-3-(4-fluorophenyl)morpholino)methyl)-1H-1,2,4-triazol-3(2H)-one 98+% | 1g | $37 | 2021-12-16 | Buy |
Ambeed | A103179 | 5-(((2R,3S)-2-((R)-1-(3,5-Bis(trifluoromethyl)phenyl)ethoxy)-3-(4-fluorophenyl)morpholino)methyl)-1H-1,2,4-triazol-3(2H)-one 98+% | 5g | $139 | 2021-12-16 | Buy |
Ambeed | A103179 | 5-(((2R,3S)-2-((R)-1-(3,5-Bis(trifluoromethyl)phenyl)ethoxy)-3-(4-fluorophenyl)morpholino)methyl)-1H-1,2,4-triazol-3(2H)-one 98+% | 25g | $668 | 2021-12-16 | Buy |
American Custom Chemicals Corporation | API0000396 | APREPITANT 95.00% | 5MG | $220 | 2021-12-16 | Buy |
ApexBio Technology | A1684 | Aprepitant | 5mg | $69 | 2021-12-16 | Buy |
ApexBio Technology | A1684 | Aprepitant | 10mM(in 1mL DMSO) | $77 | 2021-12-16 | Buy |
ApexBio Technology | A1684 | Aprepitant | 25mg | $190 | 2021-12-16 | Buy |
ApexBio Technology | A1684 | Aprepitant | 100mg | $428 | 2021-12-16 | Buy |
Properties
Melting point :244-246°C
alpha :D25 +69° (c = 1.00 in methanol)
Density :1.51±0.1 g/cm3(Predicted)
storage temp. :Sealed in dry,2-8°C
solubility :Soluble in DMSO (>25 mg/ml)
pka :8.06±0.20(Predicted)
form :powder
color :white to beige
optical activity :[α]/D +61 to +71°, c = 1.0 in methanol
Stability :Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
CAS DataBase Reference :170729-80-3(CAS DataBase Reference)
alpha :D25 +69° (c = 1.00 in methanol)
Density :1.51±0.1 g/cm3(Predicted)
storage temp. :Sealed in dry,2-8°C
solubility :Soluble in DMSO (>25 mg/ml)
pka :8.06±0.20(Predicted)
form :powder
color :white to beige
optical activity :[α]/D +61 to +71°, c = 1.0 in methanol
Stability :Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
CAS DataBase Reference :170729-80-3(CAS DataBase Reference)
Safety Information
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Description
Substance P, a neurokinin peptide found in the brain and gastrointestinal tract, is thought to modulate stress responses, including the emetic reflex. Its actions are mediated through the neurokinin-1 (NK1) receptor, one of three GPCRs that couple neurokinin binding to the inositol phosphate signal transduction pathway. Aprepitant is an anti-emetic compound that selectively antagonizes the human NK1 receptor (Kis = 3 and 454.1 nM for hNK1 and hNK3, respectively; IC50 = 0.09 nM for hNK1). In in vivo assays to measure peripheral (guinea pig SYVAL assay) and central (gerbil foot-tapping stress response assay) inhibition of NK1 receptors, aprepitant demonstrates ED50 values of 0.008 and 0.36 mg/kg, respectively. Through antagonism of NK1 receptor activity, aprepitant has found clinical use to prevent chemotherapy-induced nausea and vomiting.More related product prices
Diphenyl oxide Moroxydine 123-06-8 149-74-6 Methyltriphenylphosphonium bromide Phenylacetic acid 127852-28-2 (2R)-2-[(1R)-1-[3,5-Bis(trifluoroMethyl)phenyl]ethoxy]-3-(4-fluorophenyl)-5,6-dihydro-2H-1,4-oxazine (R,R,R)-Aprepitant (2R,3S)-2-{(1R)-1-[3,5-BIS(TRIFLUOROMETHYL)PHENYL]ETHOXY}-3-(4-FLUOROPHENYL)MORPHOLINE HYDROCHLORIDE [[p-(2-methoxyethyl)phenoxy]methyl]oxirane Aprepitant-M3 Metabolite ent-AprepitantRelated product price
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Suppliers and manufacturers
Neostar United (Changzhou) Industrial Co., Ltd.
Capot Chemical Co.,Ltd.
Nanjing Gold Pharmaceutical Technology Co. Ltd.
Beijing Cooperate Pharmaceutical Co.,Ltd
Henan Tianfu Chemical Co.,Ltd.
Hangzhou FandaChem Co.,Ltd.
Nanjing ChemLin Chemical Industry Co., Ltd.