BAY 41-2272
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- $44 - $1700
- Product name: BAY 41-2272
- CAS: 256376-24-6
- MF: C20H17FN6
- MW: 360.39
- EINECS:
- MDL Number:MFCD06411391
- Synonyms:5-Cyclopropyl-2-[1-[(2-fluorophenyl)Methyl]-1H-pyrazolo[3,4-b]pyridin-3-yl]-4-pyriMidinaMine;5-Cyclopropyl-2-(1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl)pyrimidin-4-amine;BAY 41-2272; 256376-24-6; UNII-34A162J6WB; IN1523; BAY-41-2272; 3-(4-AMINO-5-CYCLOPROPYLPYRIMIDIN-2-YL)-1-(2-FLUOROBENZYL)-1H-PYRAZOLO[3;4-B]PYRIDINE;IN1523;UNII-34A162J6WB;3-(4-Amino-5-cyclopropylpyrimidin-2-yl)-1-(2-fluorobenzyl)-1H-pyrazolo[3;4-Pyrimidinamine, 5-cyclopropyl-2-[1-[(2-fluorophenyl)methyl]-1H-pyrazolo[3,4-b]pyridin-3-yl]-;Inhibitor,inhibit,Guanylate Cyclase,BAY 41 2272,BAY 412272,BAY 41-2272
57 prices
Selected condition：
Brand
- aablocks
- ACHEMBLOCK
- AK Scientific
- Ambeed
- American Custom Chemicals Corporation
- ApexBio Technology
- Arctom
- Cayman Chemical
- ChemScene
- Crysdot
- CSNpharm
- DC Chemicals
- Sigma-Aldrich
- TRC
Package
- 10mM*1mLinDMSO
- 1mg
- 2mg
- 5mg
- 10mg
- 25mg
- 50mg
- 100mg
- 250mg
- 1g
- 5 mg
- 25 mg
- Manufactureraablocks
- Product numberAA007MDX
- Product descriptionBAY 41-2272 99%
- Packaging1mg
- Price$44
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA007MDX
- Product descriptionBAY 41-2272 99
- Packaging2mg
- Price$44
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA007MDX
- Product descriptionBAY 41-2272 99%
- Packaging5mg
- Price$53
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA007MDX
- Product descriptionBAY 41-2272 99%
- Packaging10mg
- Price$81
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA007MDX
- Product descriptionBAY 41-2272 99
- Packaging25mg
- Price$158
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA007MDX
- Product descriptionBAY 41-2272 99
- Packaging50mg
- Price$240
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA007MDX
- Product descriptionBAY 41-2272 99
- Packaging100mg
- Price$336
- Updated2026-05-28
- Buy
- ManufacturerACHEMBLOCK
- Product numberG-7887
- Product descriptionBAY 41-2272 98%
- Packaging100MG
- Price$450
- Updated2026-05-27
- Buy
- ManufacturerACHEMBLOCK
- Product numberG-7887
- Product descriptionBAY 41-2272 98%
- Packaging25MG
- Price$205
- Updated2026-05-27
- Buy
- ManufacturerAK Scientific
- Product number3081CR
- Product descriptionBay41-2272
- Packaging1mg
- Price$109
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA749144
- Product descriptionBAY41-2272 98+%
- Packaging10mg
- Price$138
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA749144
- Product descriptionBAY41-2272 98+%
- Packaging5mg
- Price$82
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA749144
- Product descriptionBAY41-2272 98+%
- Packaging50mg
- Price$303
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA749144
- Product descriptionBAY41-2272 98+%
- Packaging25mg
- Price$233
- Updated2021-12-16
- Buy
- ManufacturerAmerican Custom Chemicals Corporation
- Product numberAPI0008609
- Product descriptionBAY 41-2272 95.00%
- Packaging25MG
- Price$1205.47
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberB7664
- Product descriptionBAY 41-2272
- Packaging100mg
- Price$1231
- Updated2026-05-06
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| aablocks | AA007MDX | BAY 41-2272 99% | 1mg | $44 | 2026-05-28 | Buy |
| aablocks | AA007MDX | BAY 41-2272 99 | 2mg | $44 | 2026-05-28 | Buy |
| aablocks | AA007MDX | BAY 41-2272 99% | 5mg | $53 | 2026-05-28 | Buy |
| aablocks | AA007MDX | BAY 41-2272 99% | 10mg | $81 | 2026-05-28 | Buy |
| aablocks | AA007MDX | BAY 41-2272 99 | 25mg | $158 | 2026-05-28 | Buy |
| aablocks | AA007MDX | BAY 41-2272 99 | 50mg | $240 | 2026-05-28 | Buy |
| aablocks | AA007MDX | BAY 41-2272 99 | 100mg | $336 | 2026-05-28 | Buy |
| ACHEMBLOCK | G-7887 | BAY 41-2272 98% | 100MG | $450 | 2026-05-27 | Buy |
| ACHEMBLOCK | G-7887 | BAY 41-2272 98% | 25MG | $205 | 2026-05-27 | Buy |
| AK Scientific | 3081CR | Bay41-2272 | 1mg | $109 | 2021-12-16 | Buy |
| Ambeed | A749144 | BAY41-2272 98+% | 10mg | $138 | 2021-12-16 | Buy |
| Ambeed | A749144 | BAY41-2272 98+% | 5mg | $82 | 2021-12-16 | Buy |
| Ambeed | A749144 | BAY41-2272 98+% | 50mg | $303 | 2021-12-16 | Buy |
| Ambeed | A749144 | BAY41-2272 98+% | 25mg | $233 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | API0008609 | BAY 41-2272 95.00% | 25MG | $1205.47 | 2021-12-16 | Buy |
| ApexBio Technology | B7664 | BAY 41-2272 | 100mg | $1231 | 2026-05-06 | Buy |
Properties
Melting point :210.5-211.4 °C
Boiling point :496.1±45.0 °C(Predicted)
Density :1.49±0.1 g/cm3(Predicted)
storage temp. :Keep in dark place,Inert atmosphere,2-8°C
solubility :DMSO: 26 mg/mL at 60 °C
form :solid
pka :2.71±0.10(Predicted)
color :white
InChI :1S/C20H17FN6/c21-16-6-2-1-4-13(16)11-27-20-14(5-3-9-23-20)17(26-27)19-24-10-15(12-7-8-12)18(22)25-19/h1-6,9-10,12H,7-8,11H2,(H2,22,24,25)
InChIKey :ATOAHNRJAXSBOR-UHFFFAOYSA-N
SMILES :Nc1nc(ncc1C2CC2)-c3nn(Cc4ccccc4F)c5ncccc35
Boiling point :496.1±45.0 °C(Predicted)
Density :1.49±0.1 g/cm3(Predicted)
storage temp. :Keep in dark place,Inert atmosphere,2-8°C
solubility :DMSO: 26 mg/mL at 60 °C
form :solid
pka :2.71±0.10(Predicted)
color :white
InChI :1S/C20H17FN6/c21-16-6-2-1-4-13(16)11-27-20-14(5-3-9-23-20)17(26-27)19-24-10-15(12-7-8-12)18(22)25-19/h1-6,9-10,12H,7-8,11H2,(H2,22,24,25)
InChIKey :ATOAHNRJAXSBOR-UHFFFAOYSA-N
SMILES :Nc1nc(ncc1C2CC2)-c3nn(Cc4ccccc4F)c5ncccc35
Safety Information
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| Signal word: | Warning | |||||||||||||||||||||||||||||||||||
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Description
Soluble guanylate cyclase (sGC), a receptor for nitric oxide (NO), is a heterodimer consisting of alpha and beta subunits, with the beta subunit featuring a heme-nitric oxide (H-NOX) binding domain. The binding of NO to H-NOX induces sGC to generate the second messenger cGMP. BAY 41-2272 is a pyrazolopyridine compound that acts as an activator of sGC, stimulating activity to a level that would be expected to cause biologically important increases in cGMP at concentrations as low as 10-100 nM. Through this effect, it inhibits platelet aggregation (IC50 = 36 nM), induces relaxation of phenylephrine-preconstricted rabbit aorta rings (IC50 = 304 nM), and reduces proliferation in smooth muscle. BAY 41-2272 is effective in vivo, as it decreases mean arterial blood pressure in hypertensive rats. Unlike another sGC activator, YC-1 , BAY 41-2772 does not inhibit phosphodiesterases.More related product prices
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