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ChemicalBook >> CAS DataBase List >> BI-847325

BI-847325

$12 - $1899
Product name: BI-847325
CAS: 1207293-36-4
MF: C29H28N4O2
MW: 464.56
EINECS:-0
MDL Number:MFCD28978743
Synonyms:BI-847325;3-[3-[[[4-[(Dimethylamino)methyl]phenyl]amino]phenylmethylene]-2,3-dihydro-2-oxo-1H-indol-6-yl]-N-ethyl-2-propynamide;BI-847325, 98%, an ATP competitive dual inhibitor of MEK and aurora kinases (AK);3-[3-[[4-(dimethylaminomethyl)anilino]-phenylmethylidene]-2-oxo-1H-indol-6-yl]-N-ethylprop-2-ynamide;BI 847325;BI847325;BI-847325;BI 847325;BI847325;(Z)-3-(3-(((4-((Dimethylamino)methyl)phenyl)amino)(phenyl)methylene)-2-oxoindolin-6-yl)-N-ethylpropiolamide;2-Propynamide, 3-[3-[[[4-[(dimethylamino)methyl]phenyl]amino]phenylmethylene]-2,3-dihydro-2-oxo-1H-indol-6-yl]-N-ethyl-

Price67 Properties Safety Information Description

67 prices

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Brand

aablocks
ACHEMBLOCK
Activate Scientific
AK Scientific
American Custom Chemicals Corporation
ApexBio Technology
Arctom
Biosynth
Cayman Chemical
ChemScene
Crysdot
DC Chemicals
TRC
Usbiological

Package

10mM*1mLinDMSO(Solid+Solvent)
25mg
10mM*1mLinDMSO(Solution)
50mg
1mg
5mg
10mg
10mM*1mLinDMSO
100MG
250mg
1G

Manufactureraablocks
Product numberAA008ZRI
Product description3-(3-(((4-((Dimethylamino)Methyl)Phenyl)Amino)(Phenyl)Methylene)-2-Oxoindolin-6-Yl)-N-Ethylpropiolamide 99+%
Packaging1mg
Price$12
Updated2026-05-28
Buy

Manufactureraablocks
Product numberAA008ZRI
Product description3-(3-(((4-((Dimethylamino)Methyl)Phenyl)Amino)(Phenyl)Methylene)-2-Oxoindolin-6-Yl)-N-Ethylpropiolamide 99+%
Packaging5mg
Price$23
Updated2026-05-28
Buy

Manufactureraablocks
Product numberAA008ZRI
Product description3-(3-(((4-((Dimethylamino)Methyl)Phenyl)Amino)(Phenyl)Methylene)-2-Oxoindolin-6-Yl)-N-Ethylpropiolamide 99+%
Packaging10mg
Price$32
Updated2026-05-28
Buy

Manufactureraablocks
Product numberAA008ZRI
Product description3-(3-(((4-((Dimethylamino)Methyl)Phenyl)Amino)(Phenyl)Methylene)-2-Oxoindolin-6-Yl)-N-Ethylpropiolamide 95%
Packaging250mg
Price$580
Updated2026-05-28
Buy

ManufacturerACHEMBLOCK
Product numberQ65426
Product description(Z)-3-(3-(((4-((dimethylamino)methyl)phenyl)amino)(phenyl)methylene)-2-oxoindolin-6-yl)-N-ethylpropiolamide 98%
Packaging1G
Price$1005
Updated2026-05-25
Buy

ManufacturerACHEMBLOCK
Product numberQ65426
Product description(Z)-3-(3-(((4-((dimethylamino)methyl)phenyl)amino)(phenyl)methylene)-2-oxoindolin-6-yl)-N-ethylpropiolamide 98%
Packaging1G
Price$1005
Updated2026-05-27
Buy

ManufacturerACHEMBLOCK
Product numberQ65426
Product description(Z)-3-(3-(((4-((dimethylamino)methyl)phenyl)amino)(phenyl)methylene)-2-oxoindolin-6-yl)-N-ethylpropiolamide 98%
Packaging100MG
Price$450
Updated2026-05-27
Buy

ManufacturerACHEMBLOCK
Product numberQ65426
Product description(Z)-3-(3-(((4-((dimethylamino)methyl)phenyl)amino)(phenyl)methylene)-2-oxoindolin-6-yl)-N-ethylpropiolamide 98%
Packaging100MG
Price$450
Updated2026-05-25
Buy

ManufacturerActivate Scientific
Product numberAS116436
Product descriptionBI-847325 99+%
Packaging100mg
Price$1203
Updated2021-12-16
Buy

ManufacturerActivate Scientific
Product numberAS116436
Product descriptionBI-847325 99+%
Packaging25mg
Price$575
Updated2021-12-16
Buy

ManufacturerActivate Scientific
Product numberAS116436
Product descriptionBI-847325 99+%
Packaging5mg
Price$198
Updated2021-12-16
Buy

ManufacturerActivate Scientific
Product numberAS116436
Product descriptionBI-847325 99+%
Packaging1mg
Price$113
Updated2021-12-16
Buy

ManufacturerAK Scientific
Product number3237EM
Product description3-[3-[N-[4-[(Dimethylamino)methyl]phenyl]-C-phenylcarbonimidoyl]-2-hydroxy-1H-indol-6-yl]-N-ethylprop-2-ynamide
Packaging1mg
Price$179
Updated2021-12-16
Buy

ManufacturerAmerican Custom Chemicals Corporation
Product numberINB0005692
Product descriptionBI-847325 95.00%
Packaging5MG
Price$497.76
Updated2021-12-16
Buy

ManufacturerApexBio Technology
Product numberB6014
Product descriptionBI-847325
Packaging5mg
Price$173
Updated2021-12-16
Buy

ManufacturerApexBio Technology
Product numberB6014
Product descriptionBI-847325
Packaging100mg
Price$1229
Updated2021-12-16
Buy

Manufacturer	Product number	Product description	Packaging	Price	Updated	Buy
aablocks	AA008ZRI	3-(3-(((4-((Dimethylamino)Methyl)Phenyl)Amino)(Phenyl)Methylene)-2-Oxoindolin-6-Yl)-N-Ethylpropiolamide 99+%	1mg	$12	2026-05-28	Buy
aablocks	AA008ZRI	3-(3-(((4-((Dimethylamino)Methyl)Phenyl)Amino)(Phenyl)Methylene)-2-Oxoindolin-6-Yl)-N-Ethylpropiolamide 99+%	5mg	$23	2026-05-28	Buy
aablocks	AA008ZRI	3-(3-(((4-((Dimethylamino)Methyl)Phenyl)Amino)(Phenyl)Methylene)-2-Oxoindolin-6-Yl)-N-Ethylpropiolamide 99+%	10mg	$32	2026-05-28	Buy
aablocks	AA008ZRI	3-(3-(((4-((Dimethylamino)Methyl)Phenyl)Amino)(Phenyl)Methylene)-2-Oxoindolin-6-Yl)-N-Ethylpropiolamide 95%	250mg	$580	2026-05-28	Buy
ACHEMBLOCK	Q65426	(Z)-3-(3-(((4-((dimethylamino)methyl)phenyl)amino)(phenyl)methylene)-2-oxoindolin-6-yl)-N-ethylpropiolamide 98%	1G	$1005	2026-05-25	Buy
ACHEMBLOCK	Q65426	(Z)-3-(3-(((4-((dimethylamino)methyl)phenyl)amino)(phenyl)methylene)-2-oxoindolin-6-yl)-N-ethylpropiolamide 98%	1G	$1005	2026-05-27	Buy
ACHEMBLOCK	Q65426	(Z)-3-(3-(((4-((dimethylamino)methyl)phenyl)amino)(phenyl)methylene)-2-oxoindolin-6-yl)-N-ethylpropiolamide 98%	100MG	$450	2026-05-27	Buy
ACHEMBLOCK	Q65426	(Z)-3-(3-(((4-((dimethylamino)methyl)phenyl)amino)(phenyl)methylene)-2-oxoindolin-6-yl)-N-ethylpropiolamide 98%	100MG	$450	2026-05-25	Buy
Activate Scientific	AS116436	BI-847325 99+%	100mg	$1203	2021-12-16	Buy
Activate Scientific	AS116436	BI-847325 99+%	25mg	$575	2021-12-16	Buy
Activate Scientific	AS116436	BI-847325 99+%	5mg	$198	2021-12-16	Buy
Activate Scientific	AS116436	BI-847325 99+%	1mg	$113	2021-12-16	Buy
AK Scientific	3237EM	3-[3-[N-[4-[(Dimethylamino)methyl]phenyl]-C-phenylcarbonimidoyl]-2-hydroxy-1H-indol-6-yl]-N-ethylprop-2-ynamide	1mg	$179	2021-12-16	Buy
American Custom Chemicals Corporation	INB0005692	BI-847325 95.00%	5MG	$497.76	2021-12-16	Buy
ApexBio Technology	B6014	BI-847325	5mg	$173	2021-12-16	Buy
ApexBio Technology	B6014	BI-847325	100mg	$1229	2021-12-16	Buy

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Properties

Density :1.265±0.10 g/cm3(Temp: 25 °C; Press: 760 Torr)(predicted)
storage temp. :Store at -20°C
solubility :≥24.1 mg/mL in DMSO; insoluble in EtOH; insoluble in H2O
form :crystalline solid
pka :11.073±0.20(predicted)
color :Light yellow to yellow

Safety Information

Symbol(GHS):

Signal word:

Warning

Hazard statements:

Code	Hazard statements	Hazard class	Category	Signal word	P-Codes
H302	Harmful if swallowed	Acute toxicity,oral	Category 4	Warning	P264, P270, P301+P312, P330, P501
H315	Causes skin irritation	Skin corrosion/irritation	Category 2	Warning	P264, P280, P302+P352, P321,P332+P313, P362
H319	Causes serious eye irritation	Serious eye damage/eye irritation	Category 2A	Warning	P264, P280, P305+P351+P338,P337+P313P
H335	May cause respiratory irritation	Specific target organ toxicity, single exposure;Respiratory tract irritation	Category 3	Warning

Precautionary statements:

P261	Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338	IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Description

BI-847325 is a selective dual MEK/Aurora kinase inhibitor with IC50 values of 3, 25, 15, 25, and 4 nM for X. laevis Aurora B, human Aurora A and Aurora C, and human MEK1 and MEK2, respectively. It can inhibit the growth and survival of both treatment-naive and drug-resistant melanoma cell lines, decreasing the expression of MEK and Mcl-1 while increasing the expression of pro-apoptotic protein Bim. At 70 mg/kg, BI-847325 induces apoptosis in treatment-naive and drug-resistant xenografted melanoma in vivo.

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Suppliers and manufacturers

TargetMol Chemicals Inc.

$93.00
BI-847325 CAS:1207293-36-4

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