BI-847325
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- $12 - $1899
- Product name: BI-847325
- CAS: 1207293-36-4
- MF: C29H28N4O2
- MW: 464.56
- EINECS:-0
- MDL Number:MFCD28978743
- Synonyms:BI-847325;3-[3-[[[4-[(Dimethylamino)methyl]phenyl]amino]phenylmethylene]-2,3-dihydro-2-oxo-1H-indol-6-yl]-N-ethyl-2-propynamide;BI-847325, 98%, an ATP competitive dual inhibitor of MEK and aurora kinases (AK);3-[3-[[4-(dimethylaminomethyl)anilino]-phenylmethylidene]-2-oxo-1H-indol-6-yl]-N-ethylprop-2-ynamide;BI 847325;BI847325;BI-847325;BI 847325;BI847325;(Z)-3-(3-(((4-((Dimethylamino)methyl)phenyl)amino)(phenyl)methylene)-2-oxoindolin-6-yl)-N-ethylpropiolamide;2-Propynamide, 3-[3-[[[4-[(dimethylamino)methyl]phenyl]amino]phenylmethylene]-2,3-dihydro-2-oxo-1H-indol-6-yl]-N-ethyl-
49 prices
Selected condition：
Brand
- aablocks
- ACHEMBLOCK
- Activate Scientific
- AK Scientific
- American Custom Chemicals Corporation
- ApexBio Technology
- Arctom
- Biosynth
- Cayman Chemical
- ChemScene
- Crysdot
- DC Chemicals
- TRC
- Usbiological
Package
- 10mM*1mLinDMSO(Solid+Solvent)
- 1mg
- 5mg
- 10mg
- 25mg
- 50mg
- 100MG
- 250mg
- 10mM*1mLinDMSO
- 1G
- 10mM*1mLinDMSO(Solution)
- Manufactureraablocks
- Product numberAA008ZRI
- Product description3-(3-(((4-((Dimethylamino)Methyl)Phenyl)Amino)(Phenyl)Methylene)-2-Oxoindolin-6-Yl)-N-Ethylpropiolamide 99+%
- Packaging1mg
- Price$12
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA008ZRI
- Product description3-(3-(((4-((Dimethylamino)Methyl)Phenyl)Amino)(Phenyl)Methylene)-2-Oxoindolin-6-Yl)-N-Ethylpropiolamide 99+%
- Packaging5mg
- Price$23
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA008ZRI
- Product description3-(3-(((4-((Dimethylamino)Methyl)Phenyl)Amino)(Phenyl)Methylene)-2-Oxoindolin-6-Yl)-N-Ethylpropiolamide 99+%
- Packaging10mg
- Price$32
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA008ZRI
- Product description3-(3-(((4-((Dimethylamino)Methyl)Phenyl)Amino)(Phenyl)Methylene)-2-Oxoindolin-6-Yl)-N-Ethylpropiolamide 95%
- Packaging250mg
- Price$580
- Updated2026-05-28
- Buy
- ManufacturerACHEMBLOCK
- Product numberQ65426
- Product description(Z)-3-(3-(((4-((dimethylamino)methyl)phenyl)amino)(phenyl)methylene)-2-oxoindolin-6-yl)-N-ethylpropiolamide 98%
- Packaging100MG
- Price$450
- Updated2026-05-27
- Buy
- ManufacturerACHEMBLOCK
- Product numberQ65426
- Product description(Z)-3-(3-(((4-((dimethylamino)methyl)phenyl)amino)(phenyl)methylene)-2-oxoindolin-6-yl)-N-ethylpropiolamide 98%
- Packaging1G
- Price$1005
- Updated2026-05-27
- Buy
- ManufacturerActivate Scientific
- Product numberAS116436
- Product descriptionBI-847325 99+%
- Packaging100mg
- Price$1203
- Updated2021-12-16
- Buy
- ManufacturerActivate Scientific
- Product numberAS116436
- Product descriptionBI-847325 99+%
- Packaging25mg
- Price$575
- Updated2021-12-16
- Buy
- ManufacturerActivate Scientific
- Product numberAS116436
- Product descriptionBI-847325 99+%
- Packaging1mg
- Price$113
- Updated2021-12-16
- Buy
- ManufacturerActivate Scientific
- Product numberAS116436
- Product descriptionBI-847325 99+%
- Packaging5mg
- Price$198
- Updated2021-12-16
- Buy
- ManufacturerAK Scientific
- Product number3237EM
- Product description3-[3-[N-[4-[(Dimethylamino)methyl]phenyl]-C-phenylcarbonimidoyl]-2-hydroxy-1H-indol-6-yl]-N-ethylprop-2-ynamide
- Packaging1mg
- Price$179
- Updated2021-12-16
- Buy
- ManufacturerAmerican Custom Chemicals Corporation
- Product numberINB0005692
- Product descriptionBI-847325 95.00%
- Packaging5MG
- Price$497.76
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberB6014
- Product descriptionBI-847325
- Packaging50mg
- Price$633
- Updated2026-05-06
- Buy
- ManufacturerApexBio Technology
- Product numberB6014
- Product descriptionBI-847325
- Packaging10mg
- Price$175
- Updated2026-05-06
- Buy
- ManufacturerApexBio Technology
- Product numberB6014
- Product descriptionBI-847325
- Packaging25mg
- Price$369
- Updated2026-05-06
- Buy
- ManufacturerApexBio Technology
- Product numberB6014
- Product descriptionBI-847325
- Packaging5mg
- Price$119
- Updated2026-05-06
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| aablocks | AA008ZRI | 3-(3-(((4-((Dimethylamino)Methyl)Phenyl)Amino)(Phenyl)Methylene)-2-Oxoindolin-6-Yl)-N-Ethylpropiolamide 99+% | 1mg | $12 | 2026-05-28 | Buy |
| aablocks | AA008ZRI | 3-(3-(((4-((Dimethylamino)Methyl)Phenyl)Amino)(Phenyl)Methylene)-2-Oxoindolin-6-Yl)-N-Ethylpropiolamide 99+% | 5mg | $23 | 2026-05-28 | Buy |
| aablocks | AA008ZRI | 3-(3-(((4-((Dimethylamino)Methyl)Phenyl)Amino)(Phenyl)Methylene)-2-Oxoindolin-6-Yl)-N-Ethylpropiolamide 99+% | 10mg | $32 | 2026-05-28 | Buy |
| aablocks | AA008ZRI | 3-(3-(((4-((Dimethylamino)Methyl)Phenyl)Amino)(Phenyl)Methylene)-2-Oxoindolin-6-Yl)-N-Ethylpropiolamide 95% | 250mg | $580 | 2026-05-28 | Buy |
| ACHEMBLOCK | Q65426 | (Z)-3-(3-(((4-((dimethylamino)methyl)phenyl)amino)(phenyl)methylene)-2-oxoindolin-6-yl)-N-ethylpropiolamide 98% | 100MG | $450 | 2026-05-27 | Buy |
| ACHEMBLOCK | Q65426 | (Z)-3-(3-(((4-((dimethylamino)methyl)phenyl)amino)(phenyl)methylene)-2-oxoindolin-6-yl)-N-ethylpropiolamide 98% | 1G | $1005 | 2026-05-27 | Buy |
| Activate Scientific | AS116436 | BI-847325 99+% | 100mg | $1203 | 2021-12-16 | Buy |
| Activate Scientific | AS116436 | BI-847325 99+% | 25mg | $575 | 2021-12-16 | Buy |
| Activate Scientific | AS116436 | BI-847325 99+% | 1mg | $113 | 2021-12-16 | Buy |
| Activate Scientific | AS116436 | BI-847325 99+% | 5mg | $198 | 2021-12-16 | Buy |
| AK Scientific | 3237EM | 3-[3-[N-[4-[(Dimethylamino)methyl]phenyl]-C-phenylcarbonimidoyl]-2-hydroxy-1H-indol-6-yl]-N-ethylprop-2-ynamide | 1mg | $179 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | INB0005692 | BI-847325 95.00% | 5MG | $497.76 | 2021-12-16 | Buy |
| ApexBio Technology | B6014 | BI-847325 | 50mg | $633 | 2026-05-06 | Buy |
| ApexBio Technology | B6014 | BI-847325 | 10mg | $175 | 2026-05-06 | Buy |
| ApexBio Technology | B6014 | BI-847325 | 25mg | $369 | 2026-05-06 | Buy |
| ApexBio Technology | B6014 | BI-847325 | 5mg | $119 | 2026-05-06 | Buy |
Properties
Density :1.265±0.10 g/cm3(Temp: 25 °C; Press: 760 Torr)(predicted)
storage temp. :Store at -20°C
solubility :≥24.1 mg/mL in DMSO; insoluble in EtOH; insoluble in H2O
form :crystalline solid
pka :11.073±0.20(predicted)
color :Light yellow to yellow
storage temp. :Store at -20°C
solubility :≥24.1 mg/mL in DMSO; insoluble in EtOH; insoluble in H2O
form :crystalline solid
pka :11.073±0.20(predicted)
color :Light yellow to yellow
Safety Information
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Description
BI-847325 is a selective dual MEK/Aurora kinase inhibitor with IC50 values of 3, 25, 15, 25, and 4 nM for X. laevis Aurora B, human Aurora A and Aurora C, and human MEK1 and MEK2, respectively. It can inhibit the growth and survival of both treatment-naive and drug-resistant melanoma cell lines, decreasing the expression of MEK and Mcl-1 while increasing the expression of pro-apoptotic protein Bim. At 70 mg/kg, BI-847325 induces apoptosis in treatment-naive and drug-resistant xenografted melanoma in vivo.Suppliers and manufacturers
Shanghai Boyle Chemical Co., Ltd.
Chembest Research Laboratories Limited
MedChemexpress LLC
ShangHai Caerulum Pharma Discovery Co., Ltd.
Finetech Industry Limited
AdooQ Bioscience CHINA
Shanghai Lollane Biological Technology Co.,Ltd.
Pharmacodia (Beijing) Co.,Ltd
Shanghai YuanYe Biotechnology Co., Ltd.
Shanghai SuperLan Chemcial Technique Centre