BMS453
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- $41 - $2188
- Product name: BMS453
- CAS: 166977-43-1
- MF: C27H24O2
- MW: 380.48
- EINECS:
- MDL Number:MFCD18086870
- Synonyms:BMS453;4-[(1E)-2-(5,6-Dihydro-5,5-dimethyl-8-phenyl-2-naphthalenyl)ethenyl]-benzoicacid;(E)-4-[2-(5,6-Dihydro-5,5-dimethyl-8-phenyl-2-naphthalenyl)ethenyl]-benzoic acid;Benzoic acid, 4-[(1E)-2-(5,6-dihydro-5,5-dimethyl-8-phenyl-2-naphthalenyl)ethenyl]-;(E)-4-[2-(5,5-Dimethyl-8-phenyl-5,6-dihydronaphthalen-2-yl)vinyl]benzoic acid;BMS-189453 (BMS189453;Inhibitor,BMS453,retinoid,RAR/RXR,inhibit,BMS-453,BMS 189453,TGFβ,breast,RARβ,RARγ,Retinoid X receptors,BMS189453,arrest,cell,RARα,Retinoic acid receptors;BMS453, 10 mM in DMSO
45 prices
Selected condition：
Brand
- aablocks
- ACHEMBLOCK
- AK Scientific
- ApexBio Technology
- Arctom
- Biorbyt Ltd
- Biosynth
- Cayman Chemical
- ChemScene
- DC Chemicals
- Sigma-Aldrich
- Tocris
- TRC
- Usbiological
Package
- 1mlx10mM(inDMSO)
- 10mM*1mLinDMSO(Solution)
- 250mg
- 10
- 10mM*1mLinDMSO
- 1g
- 10mM*1mLinDMSO(Solid+Solvent)
- 1mg
- 5mg
- 10mg
- 25mg
- 50mg
- 100MG
- Manufactureraablocks
- Product numberAA001WZL
- Product descriptionBMS 453 ≥98%
- Packaging1mg
- Price$41
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA001WZL
- Product descriptionBMS 453
- Packaging5mg
- Price$67
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA001WZL
- Product descriptionBMS 453
- Packaging10mg
- Price$98
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA001WZL
- Product descriptionBMS 453
- Packaging25mg
- Price$194
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA001WZL
- Product descriptionBMS 453
- Packaging50mg
- Price$280
- Updated2026-05-28
- Buy
- ManufacturerACHEMBLOCK
- Product numberY227172
- Product descriptionBMS453 97.00%
- Packaging25MG
- Price$260
- Updated2026-05-27
- Buy
- ManufacturerACHEMBLOCK
- Product numberY227172
- Product descriptionBMS453 97.00%
- Packaging100MG
- Price$560
- Updated2026-05-27
- Buy
- ManufacturerAK Scientific
- Product numberSYN5134
- Product descriptionBMS-453
- Packaging50mg
- Price$605
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberB7396
- Product descriptionBMS 453
- Packaging10mg
- Price$347
- Updated2026-05-06
- Buy
- ManufacturerArctom
- Product numberHY-100608
- Product descriptionBMS453 99.85%
- Packaging10mg
- Price$190
- Updated2026-05-26
- Buy
- ManufacturerArctom
- Product numberHY-100608
- Product descriptionBMS453 99.85%
- Packaging25mg
- Price$418
- Updated2026-05-26
- Buy
- ManufacturerArctom
- Product numberHY-100608
- Product descriptionBMS453 99.85%
- Packaging5mg
- Price$114
- Updated2026-05-26
- Buy
- ManufacturerArctom
- Product numberHY-100608
- Product descriptionBMS453 99.85%
- Packaging10mM*1mLinDMSO(Solid+Solvent)
- Price$119
- Updated2026-05-26
- Buy
- ManufacturerArctom
- Product numberHY-100608
- Product descriptionBMS453 99.85%
- Packaging10mM*1mLinDMSO(Solution)
- Price$126
- Updated2026-05-26
- Buy
- ManufacturerArctom
- Product numberHY-100608
- Product descriptionBMS453 99.85%
- Packaging50mg
- Price$713
- Updated2026-05-26
- Buy
- ManufacturerArctom
- Product numberHY-100608
- Product descriptionBMS453 99.85%
- Packaging100mg
- Price$1235
- Updated2026-05-26
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| aablocks | AA001WZL | BMS 453 ≥98% | 1mg | $41 | 2026-05-28 | Buy |
| aablocks | AA001WZL | BMS 453 | 5mg | $67 | 2026-05-28 | Buy |
| aablocks | AA001WZL | BMS 453 | 10mg | $98 | 2026-05-28 | Buy |
| aablocks | AA001WZL | BMS 453 | 25mg | $194 | 2026-05-28 | Buy |
| aablocks | AA001WZL | BMS 453 | 50mg | $280 | 2026-05-28 | Buy |
| ACHEMBLOCK | Y227172 | BMS453 97.00% | 25MG | $260 | 2026-05-27 | Buy |
| ACHEMBLOCK | Y227172 | BMS453 97.00% | 100MG | $560 | 2026-05-27 | Buy |
| AK Scientific | SYN5134 | BMS-453 | 50mg | $605 | 2021-12-16 | Buy |
| ApexBio Technology | B7396 | BMS 453 | 10mg | $347 | 2026-05-06 | Buy |
| Arctom | HY-100608 | BMS453 99.85% | 10mg | $190 | 2026-05-26 | Buy |
| Arctom | HY-100608 | BMS453 99.85% | 25mg | $418 | 2026-05-26 | Buy |
| Arctom | HY-100608 | BMS453 99.85% | 5mg | $114 | 2026-05-26 | Buy |
| Arctom | HY-100608 | BMS453 99.85% | 10mM*1mLinDMSO(Solid+Solvent) | $119 | 2026-05-26 | Buy |
| Arctom | HY-100608 | BMS453 99.85% | 10mM*1mLinDMSO(Solution) | $126 | 2026-05-26 | Buy |
| Arctom | HY-100608 | BMS453 99.85% | 50mg | $713 | 2026-05-26 | Buy |
| Arctom | HY-100608 | BMS453 99.85% | 100mg | $1235 | 2026-05-26 | Buy |
Properties
Boiling point :560.9±50.0 °C(Predicted)
Density :1.167±0.06 g/cm3(Predicted)
storage temp. :Store at -20°C
solubility :DMSO: soluble10mg/mL, clear
form :powder
pka :4.27±0.10(Predicted)
color :white to beige
InChI :1S/C27H24O2/c1-27(2)17-16-23(21-6-4-3-5-7-21)24-18-20(12-15-25(24)27)9-8-19-10-13-22(14-11-19)26(28)29/h3-16,18H,17H2,1-2H3,(H,28,29)/b9-8+
InChIKey :VUODRPPTYLBGFM-CMDGGOBGSA-N
SMILES :OC(C(C=C1)=CC=C1/C=C/C(C=C2)=CC3=C2C(C)(C)CC=C3C4=CC=CC=C4)=O
Density :1.167±0.06 g/cm3(Predicted)
storage temp. :Store at -20°C
solubility :DMSO: soluble10mg/mL, clear
form :powder
pka :4.27±0.10(Predicted)
color :white to beige
InChI :1S/C27H24O2/c1-27(2)17-16-23(21-6-4-3-5-7-21)24-18-20(12-15-25(24)27)9-8-19-10-13-22(14-11-19)26(28)29/h3-16,18H,17H2,1-2H3,(H,28,29)/b9-8+
InChIKey :VUODRPPTYLBGFM-CMDGGOBGSA-N
SMILES :OC(C(C=C1)=CC=C1/C=C/C(C=C2)=CC3=C2C(C)(C)CC=C3C4=CC=CC=C4)=O
Safety Information
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Description
Nuclear retinoic acid receptors (RARs) are transcriptional regulators with roles in cell proliferation and differentiation. BMS 453 is a synthetic retinoid that acts as an agonist of RARβ and an antagonist of RARα and RARγ. It has been shown to inhibit the proliferation of normal breast cells via the induction of TGF-β activity, causing G1 arrest. BMS 453 binding to RARα and RARγ can induce a transrepression of phorbol ester-induced AP-1 activity (IC50s = ~0.1 nM in HeLa and MCSF-7 cells), which also correlates with reduced cell proliferation. BM 453 has been used to trigger the differentiation of mouse embryonic stem cells (mES) in a study of RARβ-induced mES cell adipogenesis.More related product prices
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