CCT 244747
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- $77 - $1430
- Product name: CCT 244747
- CAS: 1404095-34-6
- MF: C20H24N8O2
- MW: 408.46
- EINECS:
- MDL Number:MFCD25977017
- Synonyms:CCT 244747;3-[(1R)-2-(Dimethylamino)-1-methylethoxy]-5-[[4-methoxy-5-(1-methyl-1H-pyrazol-4-yl)-2-pyridinyl]amino]-2-pyrazinecarbonitrile;3-{[(2R)-1-(Dimethylamino)-2-propanyl]oxy}-5-{[4-methoxy-5-(1-methyl-1H-pyrazol-4-yl)-2-pyridinyl]amino}-2-pyrazinecarbonitrile;CCT244747; CCT-244747; CCT 244747;CS-1625;CCT-244747; CCT 244747;2-Pyrazinecarbonitrile, 3-[(1R)-2-(dimethylamino)-1-methylethoxy]-5-[[4-methoxy-5-(1-methyl-1H-pyrazol-4-yl)-2-pyridinyl]amino]-
30 prices
Selected condition：
Brand
- aablocks
- ACHEMBLOCK
- Adipogen Life Sciences
- AK Scientific
- ApexBio Technology
- Biosynth
- Cayman Chemical
- ChemScene
- DC Chemicals
Package
- 1mg
- 2mg
- 5mg
- 10mg
- 25MG
- 50mg
- 100mg
- Manufactureraablocks
- Product numberAA009CJF
- Product descriptionCCT244747 ≥98%
- Packaging1mg
- Price$77
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA009CJF
- Product descriptionCCT244747 ≥98%
- Packaging5mg
- Price$228
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA009CJF
- Product descriptionCCT244747 ≥98%
- Packaging10mg
- Price$376
- Updated2026-05-28
- Buy
- ManufacturerACHEMBLOCK
- Product numberAD279808
- Product descriptionCCT244747 98%
- Packaging5MG
- Price$235
- Updated2026-05-27
- Buy
- ManufacturerACHEMBLOCK
- Product numberAD279808
- Product descriptionCCT244747 98%
- Packaging25MG
- Price$715
- Updated2026-05-27
- Buy
- ManufacturerAdipogen Life Sciences
- Product numberSYN-1216-M010
- Product descriptionCCT244747 ≥95%
- Packaging10mg
- Price$313
- Updated2026-05-06
- Buy
- ManufacturerAdipogen Life Sciences
- Product numberSYN-1216-M005
- Product descriptionCCT244747 ≥95%
- Packaging5mg
- Price$205
- Updated2026-05-06
- Buy
- ManufacturerAdipogen Life Sciences
- Product numberSYN-1216-M001
- Product descriptionCCT244747 ≥95%
- Packaging1mg
- Price$97
- Updated2026-05-06
- Buy
- ManufacturerAK Scientific
- Product number2857DM
- Product descriptionCID54758482
- Packaging5mg
- Price$326
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberB5880
- Product descriptionCCT244747
- Packaging50mg
- Price$1046
- Updated2026-05-06
- Buy
- ManufacturerApexBio Technology
- Product numberB5880
- Product descriptionCCT244747
- Packaging10mg
- Price$290
- Updated2026-05-06
- Buy
- ManufacturerApexBio Technology
- Product numberB5880
- Product descriptionCCT244747
- Packaging2mg
- Price$80
- Updated2026-05-06
- Buy
- ManufacturerApexBio Technology
- Product numberB5880
- Product descriptionCCT244747
- Packaging25mg
- Price$610
- Updated2026-05-06
- Buy
- ManufacturerApexBio Technology
- Product numberB5880
- Product descriptionCCT244747
- Packaging5mg
- Price$203
- Updated2026-05-06
- Buy
- ManufacturerBiosynth
- Product numberFD145154
- Product description3-[(1R)-2-(Dimethylamino)-1-methylethoxy]-5-[[4-methoxy-5-(1-methyl-1H-pyrazol-4-yl)-2-pyridinyl]amino]-2-pyrazinecarbonitrile
- Packaging2mg
- Price$214
- Updated2021-12-16
- Buy
- ManufacturerBiosynth
- Product numberFD145154
- Product description3-[(1R)-2-(Dimethylamino)-1-methylethoxy]-5-[[4-methoxy-5-(1-methyl-1H-pyrazol-4-yl)-2-pyridinyl]amino]-2-pyrazinecarbonitrile
- Packaging10mg
- Price$620
- Updated2021-12-16
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| aablocks | AA009CJF | CCT244747 ≥98% | 1mg | $77 | 2026-05-28 | Buy |
| aablocks | AA009CJF | CCT244747 ≥98% | 5mg | $228 | 2026-05-28 | Buy |
| aablocks | AA009CJF | CCT244747 ≥98% | 10mg | $376 | 2026-05-28 | Buy |
| ACHEMBLOCK | AD279808 | CCT244747 98% | 5MG | $235 | 2026-05-27 | Buy |
| ACHEMBLOCK | AD279808 | CCT244747 98% | 25MG | $715 | 2026-05-27 | Buy |
| Adipogen Life Sciences | SYN-1216-M010 | CCT244747 ≥95% | 10mg | $313 | 2026-05-06 | Buy |
| Adipogen Life Sciences | SYN-1216-M005 | CCT244747 ≥95% | 5mg | $205 | 2026-05-06 | Buy |
| Adipogen Life Sciences | SYN-1216-M001 | CCT244747 ≥95% | 1mg | $97 | 2026-05-06 | Buy |
| AK Scientific | 2857DM | CID54758482 | 5mg | $326 | 2021-12-16 | Buy |
| ApexBio Technology | B5880 | CCT244747 | 50mg | $1046 | 2026-05-06 | Buy |
| ApexBio Technology | B5880 | CCT244747 | 10mg | $290 | 2026-05-06 | Buy |
| ApexBio Technology | B5880 | CCT244747 | 2mg | $80 | 2026-05-06 | Buy |
| ApexBio Technology | B5880 | CCT244747 | 25mg | $610 | 2026-05-06 | Buy |
| ApexBio Technology | B5880 | CCT244747 | 5mg | $203 | 2026-05-06 | Buy |
| Biosynth | FD145154 | 3-[(1R)-2-(Dimethylamino)-1-methylethoxy]-5-[[4-methoxy-5-(1-methyl-1H-pyrazol-4-yl)-2-pyridinyl]amino]-2-pyrazinecarbonitrile | 2mg | $214 | 2021-12-16 | Buy |
| Biosynth | FD145154 | 3-[(1R)-2-(Dimethylamino)-1-methylethoxy]-5-[[4-methoxy-5-(1-methyl-1H-pyrazol-4-yl)-2-pyridinyl]amino]-2-pyrazinecarbonitrile | 10mg | $620 | 2021-12-16 | Buy |
Properties
Boiling point :562.6±50.0 °C(Predicted)
Density :1.27±0.1 g/cm3(Predicted)
storage temp. :Store at -20°C
solubility :Soluble in DMSO
form :A solid
pka :8.15±0.28(Predicted)
color :Light yellow to yellow
Density :1.27±0.1 g/cm3(Predicted)
storage temp. :Store at -20°C
solubility :Soluble in DMSO
form :A solid
pka :8.15±0.28(Predicted)
color :Light yellow to yellow
Safety Information
| Symbol(GHS): |
 
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| Signal word: | Danger | |||||||||||||||||||||
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Description
CCT244747 is a potent inhibitor of checkpoint kinase 1 (Chk1; IC50 = 8 nM). It is selective for Chk1 over FLT3, Chk2, and CDK1 (IC50s = 600, >10,000, and >10,000 nM, respectively) as well as a panel of 121 additional kinases at a concentration of 10 μM. CCT244747 reverses cell cycle arrest at the G2/M phase induced by etoposide and SN-38 in HT-29 cells and gemcitabine (Item Nos. 11690 | 9003096) in SW620 cells, indicating cellular G2 checkpoint abrogation. It potentiates the genotoxicity of SN-38, gemcitabine, and etoposide in HT-29, SW620, MiaPaCa-2, and Calu-6 cells with potentiation index (PI) values ranging from 1.9-8.5, 2.6-12.2, 5-16, and 1.4-5.6, respectively. In vivo, CCT244747 (75 mg/kg), in combination with irinotecan or gemcitabine, increases the delay of tumor growth in SW620 and Calu-6 mouse xenograft models, respectively.Related product price
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CCT244747
CAS:1404095-34-6