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ChemicalBook >> CAS DataBase List >> CCT251545

CCT251545

CCT251545 price.
  • $48 - $2600
  • Product name: CCT251545
  • CAS: 1661839-45-7
  • MF: C23H24ClN5O
  • MW: 421.92
  • EINECS:
  • MDL Number:MFCD29472582
  • Synonyms:CCT251545;8-[3-Chloro-5-[4-(1-methyl-1H-pyrazol-4-yl)phenyl]-4-pyridinyl]-2,8-diazaspiro[4.5]decan-1-one;LM-3773,CCT251545;8-(3-chloro-5-(4-(1-methyl-1H-pyrazol-4-yl)phenyl)pyridin-4-yl)-2,8-diazaspiro[4.5]decan-1-one;2,8-Diazaspiro[4.5]decan-1-one, 8-[3-chloro-5-[4-(1-methyl-1H-pyrazol-4-yl)phenyl]-4-pyridinyl]-;CCT-251545;CCT 251545;CS-2537;inhibit,Wnt,CCT251545,Inhibitor,CCT-251545,CCT 251545
Price42 Properties Safety Information Description
42 prices
Selected condition：
Brand
  • aablocks
  • ACHEMBLOCK
  • AK Scientific
  • ApexBio Technology
  • Arctom
  • Biosynth
  • Cayman Chemical
  • ChemScene
  • Crysdot
  • DC Chemicals
  • TRC
Package
  • 10mM*1mLinDMSO(Solution)
  • 1mg
  • 5mg
  • 10mM*1mLinDMSO(Solid+Solvent)
  • 10mg
  • 20mg
  • 25mg
  • 50mg
  • 10mM(1mLinDMSO)
  • 100mg
  • 250MG
  • 1g
  • Manufactureraablocks
  • Product numberAA001WGC
  • Product descriptionCCT251545
  • Packaging1mg
  • Price$48
  • Updated2026-05-28
  • Buy
  • Manufactureraablocks
  • Product numberAA001WGC
  • Product descriptionCCT251545
  • Packaging5mg
  • Price$85
  • Updated2026-05-28
  • Buy
  • Manufactureraablocks
  • Product numberAA001WGC
  • Product descriptionCCT251545
  • Packaging10mg
  • Price$124
  • Updated2026-05-28
  • Buy
  • Manufactureraablocks
  • Product numberAA001WGC
  • Product descriptionCCT251545
  • Packaging25mg
  • Price$231
  • Updated2026-05-28
  • Buy
  • Manufactureraablocks
  • Product numberAA001WGC
  • Product descriptionCCT251545
  • Packaging50mg
  • Price$363
  • Updated2026-05-28
  • Buy
  • Manufactureraablocks
  • Product numberAA001WGC
  • Product descriptionCCT251545
  • Packaging100mg
  • Price$572
  • Updated2026-05-28
  • Buy
  • ManufacturerACHEMBLOCK
  • Product numberX203371
  • Product descriptionCCT251545 98.00%
  • Packaging100MG
  • Price$825
  • Updated2026-05-27
  • Buy
  • ManufacturerACHEMBLOCK
  • Product numberX203371
  • Product descriptionCCT251545 98.00%
  • Packaging250MG
  • Price$1650
  • Updated2026-05-27
  • Buy
  • ManufacturerAK Scientific
  • Product number0185DY
  • Product description8-[3-Chloro-5-[4-(1-methylpyrazol-4-yl)phenyl]pyridin-4-yl]-2,8-diazaspiro[4.5]decan-1-one
  • Packaging5mg
  • Price$310
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberB5979
  • Product descriptionCCT251545
  • Packaging5mg
  • Price$110
  • Updated2026-05-06
  • Buy
  • ManufacturerApexBio Technology
  • Product numberB5979
  • Product descriptionCCT251545
  • Packaging50mg
  • Price$572
  • Updated2026-05-06
  • Buy
  • ManufacturerApexBio Technology
  • Product numberB5979
  • Product descriptionCCT251545
  • Packaging20mg
  • Price$286
  • Updated2026-05-06
  • Buy
  • ManufacturerApexBio Technology
  • Product numberB5979
  • Product descriptionCCT251545
  • Packaging10mg
  • Price$176
  • Updated2026-05-06
  • Buy
  • ManufacturerArctom
  • Product numberSLK-S7981
  • Product descriptionCCT251545 99.87%
  • Packaging10mM(1mLinDMSO)
  • Price$188
  • Updated2026-05-26
  • Buy
  • ManufacturerArctom
  • Product numberHY-12681
  • Product descriptionCCT251545 99.39%
  • Packaging25mg
  • Price$304
  • Updated2026-05-26
  • Buy
  • ManufacturerArctom
  • Product numberSLK-S7981
  • Product descriptionCCT251545 99.87%
  • Packaging5mg
  • Price$140
  • Updated2026-05-26
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
aablocks AA001WGC CCT251545 1mg $48 2026-05-28 Buy
aablocks AA001WGC CCT251545 5mg $85 2026-05-28 Buy
aablocks AA001WGC CCT251545 10mg $124 2026-05-28 Buy
aablocks AA001WGC CCT251545 25mg $231 2026-05-28 Buy
aablocks AA001WGC CCT251545 50mg $363 2026-05-28 Buy
aablocks AA001WGC CCT251545 100mg $572 2026-05-28 Buy
ACHEMBLOCK X203371 CCT251545 98.00% 100MG $825 2026-05-27 Buy
ACHEMBLOCK X203371 CCT251545 98.00% 250MG $1650 2026-05-27 Buy
AK Scientific 0185DY 8-[3-Chloro-5-[4-(1-methylpyrazol-4-yl)phenyl]pyridin-4-yl]-2,8-diazaspiro[4.5]decan-1-one 5mg $310 2021-12-16 Buy
ApexBio Technology B5979 CCT251545 5mg $110 2026-05-06 Buy
ApexBio Technology B5979 CCT251545 50mg $572 2026-05-06 Buy
ApexBio Technology B5979 CCT251545 20mg $286 2026-05-06 Buy
ApexBio Technology B5979 CCT251545 10mg $176 2026-05-06 Buy
Arctom SLK-S7981 CCT251545 99.87% 10mM(1mLinDMSO) $188 2026-05-26 Buy
Arctom HY-12681 CCT251545 99.39% 25mg $304 2026-05-26 Buy
Arctom SLK-S7981 CCT251545 99.87% 5mg $140 2026-05-26 Buy
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Properties

Boiling point :709.7±60.0 °C(Predicted)
Density :1.37±0.1 g/cm3(Predicted)
storage temp. :Inert atmosphere,Store in freezer, under -20°C
solubility :≥42.2 mg/mL in DMSO; insoluble in H2O; ≥2.33 mg/mL in EtOH with ultrasonic
form :solid
pka :15.81±0.20(Predicted)
color :White to off-white

Safety Information

Symbol(GHS): Exclamation Mark (GHS07)
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H302 Harmful if swallowed Acute toxicity,oral Category 4 Warning P264, P270, P301+P312, P330, P501
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning P264, P280, P305+P351+P338,P337+P313P
H335 May cause respiratory irritation Specific target organ toxicity, single exposure;Respiratory tract irritation Category 3 Warning
Precautionary statements:
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Description

CCT251545 is an orally bioavailable inhibitor of Wnt signaling (IC50 = 5 nM). It is a potent and selective inhibitor of the human mediator complex-associated protein kinases Cdk8 and Cdk19. Through its effects on Cdk8 and Cdk19, CCT251545 alters Wnt pathway-regulated gene expression. It reduces tumor growth in COLO 205 human colon cancer xenografts after oral dosing (70 mg/kg bid) and in Wnt-dependent tumors.

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Suppliers and manufacturers

Shanghai Boyle Chemical Co., Ltd. Spectrum Chemical Manufacturing Corp. Haoyuan Chemexpress Co., Ltd. SHANGHAI FORTUNE CHEMICAL TECHNOLOGY CO., LTD ShangHai Caerulum Pharma Discovery Co., Ltd. Bide Pharmatech Ltd. Shanghai KaiYuLin pharmaceutical technology co., LTD Shanghai Lollane Biological Technology Co.,Ltd. Shanghai EFE Biological Technology Co., Ltd. Shanghai YuanYe Biotechnology Co., Ltd.