CPI-169
|
- $61 - $3772
- Product name: CPI-169
- CAS: 1450655-76-1
- MF: C27H36N4O5S
- MW: 528.66
- EINECS:
- MDL Number:MFCD28167777
- Synonyms:CPI-169;CPI-169 racemate;1-(1-(1-(Ethylsulfonyl)piperidin-4-yl)ethyl)-N-((4-methoxy-6-methyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-2-methyl-1H-indole-3-carboxamide;1H-Indole-3-carboxamide, N-[(1,2-dihydro-4-methoxy-6-methyl-2-oxo-3-pyridinyl)methyl]-1-[1-[1-(ethylsulfonyl)-4-piperidinyl]ethyl]-2-methyl-;CPI169;CPI 169;CPI-169;CPI 169;CPI169;CPI169 racemate,CPI 169 racemate;CPI-169, EZH2 inhibitor
38 prices
Selected condition：
Brand
- aablocks
- ACHEMBLOCK
- ApexBio Technology
- Arctom
- Biosynth
- Cayman Chemical
- Chemenu
- ChemScene
- Crysdot
- DC Chemicals
- TRC
Package
- 10mM*1mLinDMSO
- 1mg
- 10mM(1mLinDMSO)
- 2mg
- 5mg
- 10mg
- 25mg
- 10mM(in1mLDMSO)
- 50mg
- 100mg
- 250mg
- 1g
- Manufactureraablocks
- Product numberAA001KFU
- Product descriptionCPI-169
- Packaging1mg
- Price$61
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA001KFU
- Product descriptionCPI-169
- Packaging2mg
- Price$78
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA001KFU
- Product descriptionCPI-169
- Packaging10mg
- Price$164
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA001KFU
- Product descriptionCPI-169
- Packaging5mg
- Price$122
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA001KFU
- Product descriptionCPI-169
- Packaging25mg
- Price$337
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA001KFU
- Product descriptionCPI-169
- Packaging50mg
- Price$492
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA001KFU
- Product descriptionCPI-169
- Packaging100mg
- Price$692
- Updated2026-05-28
- Buy
- ManufacturerACHEMBLOCK
- Product numberM22560
- Product descriptionCPI-169 98%
- Packaging100MG
- Price$1005
- Updated2026-05-27
- Buy
- ManufacturerACHEMBLOCK
- Product numberM22560
- Product descriptionCPI-169 98%
- Packaging25MG
- Price$475
- Updated2026-05-27
- Buy
- ManufacturerApexBio Technology
- Product numberB4678
- Product descriptionCPI-169
- Packaging100mg
- Price$945
- Updated2026-05-06
- Buy
- ManufacturerApexBio Technology
- Product numberB4678
- Product descriptionCPI-169
- Packaging50mg
- Price$542
- Updated2026-05-06
- Buy
- ManufacturerApexBio Technology
- Product numberB4678
- Product descriptionCPI-169
- Packaging5mg
- Price$116
- Updated2026-05-06
- Buy
- ManufacturerApexBio Technology
- Product numberB4678
- Product descriptionCPI-169
- Packaging10mM(in1mLDMSO)
- Price$128
- Updated2026-05-06
- Buy
- ManufacturerApexBio Technology
- Product numberB4678
- Product descriptionCPI-169
- Packaging10mg
- Price$168
- Updated2026-05-06
- Buy
- ManufacturerArctom
- Product numberSLK-S7616
- Product descriptionCPI-169 99.00%
- Packaging5mg
- Price$188
- Updated2026-05-26
- Buy
- ManufacturerArctom
- Product numberSLK-S7616
- Product descriptionCPI-169 99.00%
- Packaging10mM(1mLinDMSO)
- Price$235
- Updated2026-05-26
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| aablocks | AA001KFU | CPI-169 | 1mg | $61 | 2026-05-28 | Buy |
| aablocks | AA001KFU | CPI-169 | 2mg | $78 | 2026-05-28 | Buy |
| aablocks | AA001KFU | CPI-169 | 10mg | $164 | 2026-05-28 | Buy |
| aablocks | AA001KFU | CPI-169 | 5mg | $122 | 2026-05-28 | Buy |
| aablocks | AA001KFU | CPI-169 | 25mg | $337 | 2026-05-28 | Buy |
| aablocks | AA001KFU | CPI-169 | 50mg | $492 | 2026-05-28 | Buy |
| aablocks | AA001KFU | CPI-169 | 100mg | $692 | 2026-05-28 | Buy |
| ACHEMBLOCK | M22560 | CPI-169 98% | 100MG | $1005 | 2026-05-27 | Buy |
| ACHEMBLOCK | M22560 | CPI-169 98% | 25MG | $475 | 2026-05-27 | Buy |
| ApexBio Technology | B4678 | CPI-169 | 100mg | $945 | 2026-05-06 | Buy |
| ApexBio Technology | B4678 | CPI-169 | 50mg | $542 | 2026-05-06 | Buy |
| ApexBio Technology | B4678 | CPI-169 | 5mg | $116 | 2026-05-06 | Buy |
| ApexBio Technology | B4678 | CPI-169 | 10mM(in1mLDMSO) | $128 | 2026-05-06 | Buy |
| ApexBio Technology | B4678 | CPI-169 | 10mg | $168 | 2026-05-06 | Buy |
| Arctom | SLK-S7616 | CPI-169 99.00% | 5mg | $188 | 2026-05-26 | Buy |
| Arctom | SLK-S7616 | CPI-169 99.00% | 10mM(1mLinDMSO) | $235 | 2026-05-26 | Buy |
Properties
Density :1.31±0.1 g/cm3(Predicted)
storage temp. :Store at -20°C
solubility :≥26.45 mg/mL in DMSO; insoluble in H2O; ≥2.18 mg/mL in EtOH with gentle warming and ultrasonic
form :solid
pka :11.01±0.10(Predicted)
storage temp. :Store at -20°C
solubility :≥26.45 mg/mL in DMSO; insoluble in H2O; ≥2.18 mg/mL in EtOH with gentle warming and ultrasonic
form :solid
pka :11.01±0.10(Predicted)
Safety Information
| Symbol(GHS): | |||||||||||||||
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| Signal word: | Warning | ||||||||||||||
| Hazard statements: |
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| Precautionary statements: |
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Description
The lysine methyltransferase EZH2 (KMT6), part of the polycomb repressive complex 2, catalyzes trimethylation of lysine 27 on histone H3 (H3K27me3) and is involved in proliferation and aggressive cell growth associated with neoplastic cells. CPI-169 is a selective EZH2 inhibitor with IC50 values of 0.24, 0.51, and 6.1 nM for wild-type EZH2, Y641N mutant EZH2, and wild-type EZH1, respectively. It decreases cellular levels of H3K27me3 (EC50 = 70 nM), triggering cell cycle arrest and ultimately resulting in apoptosis in a large panel of non-Hodgkin’s lymphoma (NHL) cell lines. With subcutaneous administration of 200 mg/kg/twice a day, CPI-169 was shown to inhibit tumor growth in a NHL xenograft model, reducing global H3K27me3. It has also been shown to synergize with the B-cell lymphoma 2 inhibitor, ABT-199 , to suppress the growth of NHL cell lines.Related product price
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