CRT5
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- $32 - $800
- Product name: CRT5
- CAS: 1034297-58-9
- MF: C28H30N4O2
- MW: 454.56
- EINECS:
- MDL Number:MFCD29081160
- Synonyms:CRT5;Benzamide, 3-[6-amino-5-(6-ethoxy-2-naphthalenyl)-3-pyridinyl]-N-[2-(dimethylamino)ethyl]-;CRT5 (CRT0066051);3-[6-amino-5-(6-ethoxynaphthalen-2-yl)pyridin-3-yl]-N-[2-(dimethylamino)ethyl]benzamide;CRT5, protein kinase D inhibitor
12 prices
Selected condition:
Brand
- AK Scientific
- ApexBio Technology
- Cayman Chemical
- DC Chemicals
- TRC
Package
- 1mg
- 5mg
- 10mg
- 25mg
- 50mg
- 100mg
- 250mg
- ManufacturerAK Scientific
- Product numberSYN5168
- Product descriptionCRT5
- Packaging50mg
- Price$775
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberC4165
- Product descriptionCRT5
- Packaging5mg
- Price$158
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberC4165
- Product descriptionCRT5
- Packaging10mg
- Price$277
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberC4165
- Product descriptionCRT5
- Packaging25mg
- Price$608
- Updated2021-12-16
- Buy
- ManufacturerCayman Chemical
- Product number18532
- Product descriptionCRT5 ≥98%
- Packaging1mg
- Price$32
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number18532
- Product descriptionCRT5 ≥98%
- Packaging5mg
- Price$139
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number18532
- Product descriptionCRT5 ≥98%
- Packaging10mg
- Price$243
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number18532
- Product descriptionCRT5 ≥98%
- Packaging25mg
- Price$533
- Updated2024-03-01
- Buy
- ManufacturerDC Chemicals
- Product numberDC42667
- Product descriptionCRT5 >98%
- Packaging100mg
- Price$500
- Updated2021-12-16
- Buy
- ManufacturerDC Chemicals
- Product numberDC42667
- Product descriptionCRT5 >98%
- Packaging250mg
- Price$800
- Updated2021-12-16
- Buy
- ManufacturerTRC
- Product numberC782015
- Product descriptionCRT5
- Packaging5mg
- Price$120
- Updated2021-12-16
- Buy
- ManufacturerTRC
- Product numberC782015
- Product descriptionCRT5
- Packaging25mg
- Price$415
- Updated2021-12-16
- Buy
Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|
AK Scientific | SYN5168 | CRT5 | 50mg | $775 | 2021-12-16 | Buy |
ApexBio Technology | C4165 | CRT5 | 5mg | $158 | 2021-12-16 | Buy |
ApexBio Technology | C4165 | CRT5 | 10mg | $277 | 2021-12-16 | Buy |
ApexBio Technology | C4165 | CRT5 | 25mg | $608 | 2021-12-16 | Buy |
Cayman Chemical | 18532 | CRT5 ≥98% | 1mg | $32 | 2024-03-01 | Buy |
Cayman Chemical | 18532 | CRT5 ≥98% | 5mg | $139 | 2024-03-01 | Buy |
Cayman Chemical | 18532 | CRT5 ≥98% | 10mg | $243 | 2024-03-01 | Buy |
Cayman Chemical | 18532 | CRT5 ≥98% | 25mg | $533 | 2024-03-01 | Buy |
DC Chemicals | DC42667 | CRT5 >98% | 100mg | $500 | 2021-12-16 | Buy |
DC Chemicals | DC42667 | CRT5 >98% | 250mg | $800 | 2021-12-16 | Buy |
TRC | C782015 | CRT5 | 5mg | $120 | 2021-12-16 | Buy |
TRC | C782015 | CRT5 | 25mg | $415 | 2021-12-16 | Buy |
Properties
Boiling point :651.2±55.0 °C(Predicted)
Density :1.173±0.06 g/cm3(Predicted)
storage temp. :Store at -20°C
solubility :≤2.5mg/ml in DMSO;0.25mg/ml in dimethyl formamide
form :crystalline solid
pka :14.23±0.46(Predicted)
Density :1.173±0.06 g/cm3(Predicted)
storage temp. :Store at -20°C
solubility :≤2.5mg/ml in DMSO;0.25mg/ml in dimethyl formamide
form :crystalline solid
pka :14.23±0.46(Predicted)
Safety Information
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Description
Protein kinase D (PKD) is a serine/threonine protein kinase that is activated by diacylglycerol, commonly downstream of PKC signaling. The three human PKD isoforms target a variety of proteins to alter cell proliferation, survival, invasion, and protein transport. CRT5 is a pyrazine benzamide that prevents activation of all three isoforms of PKD in endothelial cells treated with VEGF (IC50s = 1, 2, and 1.5 nM for PKD1, PKD2, and PKD3, respectively). It has little effect on a panel of additional kinases when given at 1 μM. CRT5 blocks phosphorylation of PKD1 on Ser916 and PKD2 on Ser876, but does not affect PKC-dependent PKD phosphorylation or PKD autophosphorylation. It also decreases VEGF-induced endothelial migration, proliferation, and tubulogenesis.Suppliers and manufacturers
Career Henan Chemica Co
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Shenyang Zhongshen Zekang Biomedical Technology Research Co., Ltd
Aladdin Scientific
Wuhan Jingkang en Biomedical Technology Co., Ltd
Shanghai Lollane Biological Technology Co.,Ltd.
Pharmacodia (Beijing) Co.,Ltd
Shanghai EFE Biological Technology Co., Ltd.