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ChemicalBook >> CAS DataBase List >> CZ415

CZ415

CZ415 price.
  • $44 - $2100
  • Product name: CZ415
  • CAS: 1429639-50-8
  • MF: C22H29N5O4S
  • MW: 459.56
  • EINECS:604-604-1
  • MDL Number:MFCD30533321
  • Synonyms:CZ415;CZ415 (Free base);CZ 415;CZ-415;(S)-1-(4-(7,7-dimethyl-4-(3-methylmorpholino)-6,6-dioxido-5,7-dihydrothieno[3,4-d]pyrimidin-2-yl)phenyl)-3-ethylurea;CS-2392;Urea, N-[4-[5,7-dihydro-7,7-dimethyl-4-[(3S)-3-methyl-4-morpholinyl]-6,6-dioxidothieno[3,4-d]pyrimidin-2-yl]phenyl]-N'-ethyl-;inhibit,Inhibitor,mTOR,CZ415,CZ-415,CZ 415,Mammalian target of Rapamycin
Price14 Properties Safety Information Description
14 prices
Selected condition：
Brand
  • AK Scientific
  • Cayman Chemical
  • ChemScene
  • DC Chemicals
  • TRC
Package
  • 1mg
  • 2.5mg
  • 5mg
  • 10mg
  • 25mg
  • 50mg
  • 100mg
  • 250mg
  • 1g
  • ManufacturerAK Scientific
  • Product number9286DU
  • Product description1-[4-[7,7-Dimethyl-4-[(3S)-3-methylmorpholin-4-yl]-6,6-dioxo-5H-thieno[3,4-d]pyrimidin-2-yl]phenyl]-3-ethylurea
  • Packaging1mg
  • Price$147
  • Updated2021-12-16
  • Buy
  • ManufacturerCayman Chemical
  • Product number27668
  • Product descriptionCZ415
  • Packaging1mg
  • Price$44
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number27668
  • Product descriptionCZ415
  • Packaging5mg
  • Price$172
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number27668
  • Product descriptionCZ415
  • Packaging10mg
  • Price$321
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number27668
  • Product descriptionCZ415
  • Packaging25mg
  • Price$586
  • Updated2024-03-01
  • Buy
  • ManufacturerChemScene
  • Product numberCS-6131
  • Product descriptionCZ415 98.43%
  • Packaging1mg
  • Price$84
  • Updated2021-12-16
  • Buy
  • ManufacturerChemScene
  • Product numberCS-6131
  • Product descriptionCZ415 98.43%
  • Packaging5mg
  • Price$144
  • Updated2021-12-16
  • Buy
  • ManufacturerChemScene
  • Product numberCS-6131
  • Product descriptionCZ415 98.43%
  • Packaging10mg
  • Price$228
  • Updated2021-12-16
  • Buy
  • ManufacturerChemScene
  • Product numberCS-6131
  • Product descriptionCZ415 98.43%
  • Packaging50mg
  • Price$888
  • Updated2021-12-16
  • Buy
  • ManufacturerChemScene
  • Product numberCS-6131
  • Product descriptionCZ415 98.43%
  • Packaging100mg
  • Price$1440
  • Updated2021-12-16
  • Buy
  • ManufacturerDC Chemicals
  • Product numberDC10125
  • Product descriptionCZ415 >98%
  • Packaging250mg
  • Price$1000
  • Updated2021-12-16
  • Buy
  • ManufacturerDC Chemicals
  • Product numberDC10125
  • Product descriptionCZ415 >98%
  • Packaging1g
  • Price$2100
  • Updated2021-12-16
  • Buy
  • ManufacturerTRC
  • Product numberC998985
  • Product descriptionCZ415
  • Packaging1mg
  • Price$90
  • Updated2021-12-16
  • Buy
  • ManufacturerTRC
  • Product numberC998985
  • Product descriptionCZ415
  • Packaging2.5mg
  • Price$210
  • Updated2021-12-16
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
AK Scientific 9286DU 1-[4-[7,7-Dimethyl-4-[(3S)-3-methylmorpholin-4-yl]-6,6-dioxo-5H-thieno[3,4-d]pyrimidin-2-yl]phenyl]-3-ethylurea 1mg $147 2021-12-16 Buy
Cayman Chemical 27668 CZ415 1mg $44 2024-03-01 Buy
Cayman Chemical 27668 CZ415 5mg $172 2024-03-01 Buy
Cayman Chemical 27668 CZ415 10mg $321 2024-03-01 Buy
Cayman Chemical 27668 CZ415 25mg $586 2024-03-01 Buy
ChemScene CS-6131 CZ415 98.43% 1mg $84 2021-12-16 Buy
ChemScene CS-6131 CZ415 98.43% 5mg $144 2021-12-16 Buy
ChemScene CS-6131 CZ415 98.43% 10mg $228 2021-12-16 Buy
ChemScene CS-6131 CZ415 98.43% 50mg $888 2021-12-16 Buy
ChemScene CS-6131 CZ415 98.43% 100mg $1440 2021-12-16 Buy
DC Chemicals DC10125 CZ415 >98% 250mg $1000 2021-12-16 Buy
DC Chemicals DC10125 CZ415 >98% 1g $2100 2021-12-16 Buy
TRC C998985 CZ415 1mg $90 2021-12-16 Buy
TRC C998985 CZ415 2.5mg $210 2021-12-16 Buy

Properties

Boiling point :611.4±55.0 °C(Predicted)
Density :1.287±0.06 g/cm3(Predicted)
storage temp. :Store at -20°C
solubility :DMSO:73.67(Max Conc. mg/mL);160.3(Max Conc. mM)
DMSO:PBS (pH 7.2) (1:6):0.1(Max Conc. mg/mL);0.22(Max Conc. mM)
DMF:30.0(Max Conc. mg/mL);65.28(Max Conc. mM)
Ethanol:10.0(Max Conc. mg/mL);21.76(Max Conc. mM) form :A crystalline solid
pka :13.79±0.46(Predicted)

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning GHS hazard pictograms P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning GHS hazard pictograms P264, P280, P305+P351+P338,P337+P313P
H335 May cause respiratory irritation Specific target organ toxicity, single exposure;Respiratory tract irritation Category 3 Warning GHS hazard pictograms
Precautionary statements:
P264 Wash hands thoroughly after handling.
P264 Wash skin thouroughly after handling.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352 IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P321 Specific treatment (see … on this label).
P332+P313 IF SKIN irritation occurs: Get medical advice/attention.
P362 Take off contaminated clothing and wash before reuse.

Description

CZ415 is an inhibitor of mammalian target of rapamycin (mTOR; Kd = 6.3 nM). It is 1,000-fold selective for mTOR over a panel of 285 kinases. CZ415 inhibits phosphorylation of S6 ribosomal protein (S6RP) and Akt in HEK293T cells (IC50s = 14.5 and 14.8 nM, respectively). It inhibits IFN-γ secretion in IL-2, anti-CD3, and anti-CD28 antibody-stimulated human whole blood (IC50 = 226 nM). CZ415 (10 mg/kg) reduces fore paw joint erythema and swelling in a mouse model of collagen-induced arthritis. It also inhibits intratumor mTOR activity and reduces tumor growth in an OCC-1 oral cavity carcinoma mouse xenograft model when administered at a dose of 20 mg/kg.

Suppliers and manufacturers

ATK CHEMICAL COMPANY LIMITED
BOC Sciences
Career Henan Chemica Co
HANGZHOU CLAP TECHNOLOGY CO.,LTD
Zhejiang J&C Biological Technology Co.,Limited
InvivoChem
TargetMol Chemicals Inc.
ShenZhen Trendseen Biological Technology Co.,Ltd.
Aladdin Scientific
Wuhan Jingkang en Biomedical Technology Co., Ltd