Cabazitaxel
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- $29 - $3980
- Product name: Cabazitaxel
- CAS: 183133-96-2
- MF: C45H57NO14
- MW: 835.93
- EINECS:680-632-7
- MDL Number:MFCD18827611
- Synonyms:(2AR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-12b-acetoxy-9-(((2R,3S)-3-((tert-butoxycarbonyl)amino)-2-;TXD-258;(αR,βS)-β-[[(1,1-DiMethylethoxy)carbonyl]aMino]-α-hydroxybenzenepropanoic Acid (2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-12b-(Acetyloxy)-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-11-hydroxy-4,6-diMethoxy-4a,8,13,13-tetraMethyl-5-oxo-7,11-Methano-1H-cyclodeca[3,4]benz[1,2-b]oxet-9-yl Ester;XRP 6258;Cabazitaxel;β-[[(1,1-DiMethylethoxy)carbonyl]aMino]-α-hydroxybenzenepropanoic Acid [2aR-[2aα,4β,4aβ,6β,9α(αR*,βS*),11α,12α,12aα,12bα]]-12b-(Acetyloxy)-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-11-hydroxy-4,6-diMethoxy-4a,8,13,13-tetraMethyl;7β, 10β-DiMethoxydocetaxel;Cabazitaxel(XRP-6258)
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- aablocks
- AccelPharmtech
- ACHEMBLOCK
- AK Scientific
- American Custom Chemicals Corporation
- ApexBio Technology
- Arctom
- AvaChem
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- Biosynth
- BroadPharm
- Cayman Chemical
- Chemenu
- Chem-Impex
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- Frontier Specialty Chemicals
- JR MediChem
- Medical Isotopes, Inc.
- Sigma-Aldrich
- TCI Chemical
- TRC
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Package
- 5MG
- 10mg
- 10mM(in1mLDMSO)
- 1mg
- 10mM(1mLinDMSO)
- 20mg
- 25mg
- 50mg
- 100mg
- 200mg
- 250mg
- 0.5g
- 500mg
- 1g
- 2g
- 5g
- 10g
- 20g
- 25g
- Manufactureraablocks
- Product numberAA0024C0
- Product descriptionBenzenepropanoic acid, β-[[(1,1-dimethylethoxy)carbonyl]amino]-α-hydroxy-, (2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-12b-(acetyloxy)-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-11-hydroxy-4,6-dimethoxy-4a,8,13,13-tetramethyl-5-oxo-7,11-methano-1H-cyclodeca[3,4]benz[1,2-b]oxet-9-yl ester, (αR,βS)- ≥99%
- Packaging10mg
- Price$31
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA0024C0
- Product descriptionBenzenepropanoic acid, β-[[(1,1-dimethylethoxy)carbonyl]amino]-α-hydroxy-, (2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-12b-(acetyloxy)-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-11-hydroxy-4,6-dimethoxy-4a,8,13,13-tetramethyl-5-oxo-7,11-methano-1H-cyclodeca[3,4]benz[1,2-b]oxet-9-yl ester, (αR,βS)-
- Packaging20mg
- Price$61
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA0024C0
- Product descriptionBenzenepropanoic acid, β-[[(1,1-dimethylethoxy)carbonyl]amino]-α-hydroxy-, (2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-12b-(acetyloxy)-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-11-hydroxy-4,6-dimethoxy-4a,8,13,13-tetramethyl-5-oxo-7,11-methano-1H-cyclodeca[3,4]benz[1,2-b]oxet-9-yl ester, (αR,βS)- >98.0%(HPLC)
- Packaging25mg
- Price$64
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA0024C0
- Product descriptionBenzenepropanoic acid, β-[[(1,1-dimethylethoxy)carbonyl]amino]-α-hydroxy-, (2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-12b-(acetyloxy)-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-11-hydroxy-4,6-dimethoxy-4a,8,13,13-tetramethyl-5-oxo-7,11-methano-1H-cyclodeca[3,4]benz[1,2-b]oxet-9-yl ester, (αR,βS)- ≥99%
- Packaging50mg
- Price$87
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA0024C0
- Product descriptionBenzenepropanoic acid, β-[[(1,1-dimethylethoxy)carbonyl]amino]-α-hydroxy-, (2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-12b-(acetyloxy)-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-11-hydroxy-4,6-dimethoxy-4a,8,13,13-tetramethyl-5-oxo-7,11-methano-1H-cyclodeca[3,4]benz[1,2-b]oxet-9-yl ester, (αR,βS)- 98%
- Packaging100mg
- Price$90
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA0024C0
- Product descriptionBenzenepropanoic acid, β-[[(1,1-dimethylethoxy)carbonyl]amino]-α-hydroxy-, (2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-12b-(acetyloxy)-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-11-hydroxy-4,6-dimethoxy-4a,8,13,13-tetramethyl-5-oxo-7,11-methano-1H-cyclodeca[3,4]benz[1,2-b]oxet-9-yl ester, (αR,βS)- 98%
- Packaging250mg
- Price$129
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA0024C0
- Product descriptionBenzenepropanoic acid, β-[[(1,1-dimethylethoxy)carbonyl]amino]-α-hydroxy-, (2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-12b-(acetyloxy)-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-11-hydroxy-4,6-dimethoxy-4a,8,13,13-tetramethyl-5-oxo-7,11-methano-1H-cyclodeca[3,4]benz[1,2-b]oxet-9-yl ester, (αR,βS)- 98%
- Packaging1g
- Price$318
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA0024C0
- Product descriptionBenzenepropanoic acid, β-[[(1,1-dimethylethoxy)carbonyl]amino]-α-hydroxy-, (2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-12b-(acetyloxy)-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-11-hydroxy-4,6-dimethoxy-4a,8,13,13-tetramethyl-5-oxo-7,11-methano-1H-cyclodeca[3,4]benz[1,2-b]oxet-9-yl ester, (αR,βS)- 98%
- Packaging5g
- Price$940
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA0024C0
- Product descriptionBenzenepropanoic acid, β-[[(1,1-dimethylethoxy)carbonyl]amino]-α-hydroxy-, (2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-12b-(acetyloxy)-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-11-hydroxy-4,6-dimethoxy-4a,8,13,13-tetramethyl-5-oxo-7,11-methano-1H-cyclodeca[3,4]benz[1,2-b]oxet-9-yl ester, (αR,βS)- 98%
- Packaging25g
- Price$2987
- Updated2026-05-28
- Buy
- ManufacturerAccelPharmtech
- Product numberSY1649
- Product descriptionCabazitaxel 99.00%
- Packaging1G
- Price$370
- Updated2026-05-21
- Buy
- ManufacturerACHEMBLOCK
- Product number10299
- Product descriptionCabazitaxel 98%
- Packaging1G
- Price$250
- Updated2026-05-27
- Buy
- ManufacturerACHEMBLOCK
- Product number10299
- Product descriptionCabazitaxel 98%
- Packaging5G
- Price$820
- Updated2026-05-27
- Buy
- ManufacturerACHEMBLOCK
- Product number10299
- Product descriptionCabazitaxel 98%
- Packaging100MG
- Price$70
- Updated2026-05-27
- Buy
- ManufacturerACHEMBLOCK
- Product number10299
- Product descriptionCabazitaxel 98%
- Packaging25MG
- Price$45
- Updated2026-05-27
- Buy
- ManufacturerAK Scientific
- Product numberX7252
- Product descriptionCabazitaxel
- Packaging1mg
- Price$29
- Updated2021-12-16
- Buy
- ManufacturerAK Scientific
- Product numberX7252
- Product descriptionCabazitaxel
- Packaging500mg
- Price$879
- Updated2021-12-16
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| aablocks | AA0024C0 | Benzenepropanoic acid, β-[[(1,1-dimethylethoxy)carbonyl]amino]-α-hydroxy-, (2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-12b-(acetyloxy)-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-11-hydroxy-4,6-dimethoxy-4a,8,13,13-tetramethyl-5-oxo-7,11-methano-1H-cyclodeca[3,4]benz[1,2-b]oxet-9-yl ester, (αR,βS)- ≥99% | 10mg | $31 | 2026-05-28 | Buy |
| aablocks | AA0024C0 | Benzenepropanoic acid, β-[[(1,1-dimethylethoxy)carbonyl]amino]-α-hydroxy-, (2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-12b-(acetyloxy)-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-11-hydroxy-4,6-dimethoxy-4a,8,13,13-tetramethyl-5-oxo-7,11-methano-1H-cyclodeca[3,4]benz[1,2-b]oxet-9-yl ester, (αR,βS)- | 20mg | $61 | 2026-05-28 | Buy |
| aablocks | AA0024C0 | Benzenepropanoic acid, β-[[(1,1-dimethylethoxy)carbonyl]amino]-α-hydroxy-, (2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-12b-(acetyloxy)-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-11-hydroxy-4,6-dimethoxy-4a,8,13,13-tetramethyl-5-oxo-7,11-methano-1H-cyclodeca[3,4]benz[1,2-b]oxet-9-yl ester, (αR,βS)- >98.0%(HPLC) | 25mg | $64 | 2026-05-28 | Buy |
| aablocks | AA0024C0 | Benzenepropanoic acid, β-[[(1,1-dimethylethoxy)carbonyl]amino]-α-hydroxy-, (2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-12b-(acetyloxy)-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-11-hydroxy-4,6-dimethoxy-4a,8,13,13-tetramethyl-5-oxo-7,11-methano-1H-cyclodeca[3,4]benz[1,2-b]oxet-9-yl ester, (αR,βS)- ≥99% | 50mg | $87 | 2026-05-28 | Buy |
| aablocks | AA0024C0 | Benzenepropanoic acid, β-[[(1,1-dimethylethoxy)carbonyl]amino]-α-hydroxy-, (2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-12b-(acetyloxy)-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-11-hydroxy-4,6-dimethoxy-4a,8,13,13-tetramethyl-5-oxo-7,11-methano-1H-cyclodeca[3,4]benz[1,2-b]oxet-9-yl ester, (αR,βS)- 98% | 100mg | $90 | 2026-05-28 | Buy |
| aablocks | AA0024C0 | Benzenepropanoic acid, β-[[(1,1-dimethylethoxy)carbonyl]amino]-α-hydroxy-, (2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-12b-(acetyloxy)-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-11-hydroxy-4,6-dimethoxy-4a,8,13,13-tetramethyl-5-oxo-7,11-methano-1H-cyclodeca[3,4]benz[1,2-b]oxet-9-yl ester, (αR,βS)- 98% | 250mg | $129 | 2026-05-28 | Buy |
| aablocks | AA0024C0 | Benzenepropanoic acid, β-[[(1,1-dimethylethoxy)carbonyl]amino]-α-hydroxy-, (2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-12b-(acetyloxy)-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-11-hydroxy-4,6-dimethoxy-4a,8,13,13-tetramethyl-5-oxo-7,11-methano-1H-cyclodeca[3,4]benz[1,2-b]oxet-9-yl ester, (αR,βS)- 98% | 1g | $318 | 2026-05-28 | Buy |
| aablocks | AA0024C0 | Benzenepropanoic acid, β-[[(1,1-dimethylethoxy)carbonyl]amino]-α-hydroxy-, (2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-12b-(acetyloxy)-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-11-hydroxy-4,6-dimethoxy-4a,8,13,13-tetramethyl-5-oxo-7,11-methano-1H-cyclodeca[3,4]benz[1,2-b]oxet-9-yl ester, (αR,βS)- 98% | 5g | $940 | 2026-05-28 | Buy |
| aablocks | AA0024C0 | Benzenepropanoic acid, β-[[(1,1-dimethylethoxy)carbonyl]amino]-α-hydroxy-, (2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-12b-(acetyloxy)-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-11-hydroxy-4,6-dimethoxy-4a,8,13,13-tetramethyl-5-oxo-7,11-methano-1H-cyclodeca[3,4]benz[1,2-b]oxet-9-yl ester, (αR,βS)- 98% | 25g | $2987 | 2026-05-28 | Buy |
| AccelPharmtech | SY1649 | Cabazitaxel 99.00% | 1G | $370 | 2026-05-21 | Buy |
| ACHEMBLOCK | 10299 | Cabazitaxel 98% | 1G | $250 | 2026-05-27 | Buy |
| ACHEMBLOCK | 10299 | Cabazitaxel 98% | 5G | $820 | 2026-05-27 | Buy |
| ACHEMBLOCK | 10299 | Cabazitaxel 98% | 100MG | $70 | 2026-05-27 | Buy |
| ACHEMBLOCK | 10299 | Cabazitaxel 98% | 25MG | $45 | 2026-05-27 | Buy |
| AK Scientific | X7252 | Cabazitaxel | 1mg | $29 | 2021-12-16 | Buy |
| AK Scientific | X7252 | Cabazitaxel | 500mg | $879 | 2021-12-16 | Buy |
Properties
Melting point :180 °C
Boiling point :870.7±65.0 °C(Predicted)
Density :1.31
storage temp. :Inert atmosphere,Store in freezer, under -20°C
solubility :Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly)
form :White solid.
pka :11.20±0.46(Predicted)
color :White to Off-White
optical activity :[α]/D -36 to -44°, c =0.5 in methanol
InChIKey :BMQGVNUXMIRLCK-JACFBOAKNA-N
Boiling point :870.7±65.0 °C(Predicted)
Density :1.31
storage temp. :Inert atmosphere,Store in freezer, under -20°C
solubility :Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly)
form :White solid.
pka :11.20±0.46(Predicted)
color :White to Off-White
optical activity :[α]/D -36 to -44°, c =0.5 in methanol
InChIKey :BMQGVNUXMIRLCK-JACFBOAKNA-N
Safety Information
| Symbol(GHS): |
 
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| Signal word: | Warning | |||||||||||||||||||||||||||||||||||
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| Precautionary statements: |
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Description
In June 2010, the U.S. FDA approved cabazitaxel (also referred to as XRP6258 and RPR 116258A) in combination with the steroid prednisone for the treatment of metastatic Castration-Resistant Prostate Cancer (mCRPC) for patients who were previously treated with a docetaxelcontaining regimen for late-stage disease.Cabazitaxel is a semisynthetic analog of the natural product taxol, which is isolated from the bark of the yew tree. Cabazitaxel is a microtubule inhibitor that binds to the taxol-binding site of tubulin. Similar to other tubulin inhibitors of the taxol class, cabazitaxel inhibits microtubule disassembly resulting in mitotic blockade and cell death. Docetaxel, also a semisynthetic taxol analog, was approved by the FDA for the treatment of mCRPC in 2004. However, docetaxel is a substrate for P-gp, which is thought to contribute to the constitutive and acquired resistance of cancer cells to taxanes. Cabazitaxel has poor affinity for P-gp and showed antitumor activity in preclinical in vitro studies and in vivo tumor models that overexpress this protein. Cabazitaxel is synthesized on a commercial scale from 10-deacetylbaccatin .
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Suppliers and manufacturers
Nanjing jingzhu bio-technology Co.,Ltd
Chembest Research Laboratories Limited
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Hubei Chenxin Pharmaceutical Co., Ltd.
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