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ChemicalBook >> CAS DataBase List >> Candesartan cilexetil

Candesartan cilexetil

Candesartan cilexetil  price.
  • $60 - $1140
  • Product name: Candesartan cilexetil
  • CAS: 145040-37-5
  • MF: C33H34N6O6
  • MW: 610.66
  • EINECS:627-030-2
  • MDL Number:MFCD00871371
  • Synonyms:1H-Benzimidazole-7-carboxylic acid, 2-ethoxy-1-[[2'-(2H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-, 1-[[(cyclohexyloxy)carbonyl]oxy]ethyl ester;Candesantan Cilexetil;1-(((cyclohexyloxy)carbonyl)oxy)ethyl 1-((2'-(1H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl)methyl)-2-ethoxy-1H-benzo[d]imidazole-7-carboxylate;1-(((Cyclohexyloxy)carbonyl)oxy)ethyl 1-((2'-(2H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl)methyl)-2;1-(Cyclohexyloxycarbonyloxy)ethyl 1-((2'-(1H-tetrazol-5-yl)biphenyl-4-yl)methyl)-2-ethoxy-1H-b;CANDESARTAN CILEXITIL;CANDESARTAN CILEXETIL;1-[[(cyclohexyloxy)carbonyl]oxy]ethyl 2-ethoxy-1-[[2'-(1h-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-1h-benzimidazole-7-carboxylate
13 prices
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  • Cayman Chemical
  • Sigma-Aldrich
  • TCI Chemical

Package

  • y0001387
  • 50mg
  • y0001388
  • 10mg
  • y0001389
  • 100mg
  • 200mg
  • 500mg
  • 1g
  • 5g
  • 10g
  • ManufacturerCayman Chemical
  • Product number10489
  • Product descriptionCandesartan cilexetil ≥98%
  • Packaging1g
  • Price$114
  • Updated2018-11-13
  • Buy
  • ManufacturerCayman Chemical
  • Product number10489
  • Product descriptionCandesartan cilexetil ≥98%
  • Packaging500mg
  • Price$60
  • Updated2018-11-13
  • Buy
  • ManufacturerCayman Chemical
  • Product number10489
  • Product descriptionCandesartan cilexetil ≥98%
  • Packaging5g
  • Price$480
  • Updated2018-11-13
  • Buy
  • ManufacturerCayman Chemical
  • Product number10489
  • Product descriptionCandesartan cilexetil ≥98%
  • Packaging10g
  • Price$840
  • Updated2018-11-13
  • Buy
  • ManufacturerSigma-Aldrich
  • Product number1087803
  • Product descriptionCandesartan cilexetil United States Pharmacopeia (USP) Reference Standard
  • Packaging100mg
  • Price$1140
  • Updated2018-11-13
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  • ManufacturerSigma-Aldrich
  • Product numberSML0245
  • Product descriptionCandesartan cilexetil ≥98% (HPLC)
  • Packaging10mg
  • Price$70.5
  • Updated2018-11-20
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  • ManufacturerSigma-Aldrich
  • Product numberPHR1854
  • Product descriptionCandesartan cilexetil Pharmaceutical Secondary Standard; Certified Reference Material
  • Packaging200mg
  • Price$164
  • Updated2018-11-13
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  • ManufacturerSigma-Aldrich
  • Product numberY0001387
  • Product descriptionCandesartan cilexetil for peak identification European Pharmacopoeia (EP) Reference Standard
  • Packagingy0001387
  • Price$179
  • Updated2018-11-23
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  • ManufacturerSigma-Aldrich
  • Product numberY0001388
  • Product descriptionCandesartan cilexetil European Pharmacopoeia (EP) Reference Standard
  • Packagingy0001388
  • Price$179
  • Updated2018-11-23
  • Buy
  • ManufacturerSigma-Aldrich
  • Product numberY0001389
  • Product descriptionCandesartan cilexetil for system suitability European Pharmacopoeia (EP) Reference Standard
  • Packagingy0001389
  • Price$179
  • Updated2018-11-23
  • Buy
  • ManufacturerSigma-Aldrich
  • Product numberSML0245
  • Product descriptionCandesartan cilexetil ≥98% (HPLC)
  • Packaging50mg
  • Price$287
  • Updated2018-11-20
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  • ManufacturerTCI Chemical
  • Product numberC2635
  • Product descriptionCandesartan Cilexetil >98.0%(HPLC)(T)
  • Packaging1g
  • Price$272
  • Updated2018-11-22
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  • ManufacturerTCI Chemical
  • Product numberC2635
  • Product descriptionCandesartan Cilexetil >98.0%(HPLC)(T)
  • Packaging200mg
  • Price$80
  • Updated2018-11-22
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
Cayman Chemical 10489 Candesartan cilexetil ≥98% 1g $114 2018-11-13 Buy
Cayman Chemical 10489 Candesartan cilexetil ≥98% 500mg $60 2018-11-13 Buy
Cayman Chemical 10489 Candesartan cilexetil ≥98% 5g $480 2018-11-13 Buy
Cayman Chemical 10489 Candesartan cilexetil ≥98% 10g $840 2018-11-13 Buy
Sigma-Aldrich 1087803 Candesartan cilexetil United States Pharmacopeia (USP) Reference Standard 100mg $1140 2018-11-13 Buy
Sigma-Aldrich SML0245 Candesartan cilexetil ≥98% (HPLC) 10mg $70.5 2018-11-20 Buy
Sigma-Aldrich PHR1854 Candesartan cilexetil Pharmaceutical Secondary Standard; Certified Reference Material 200mg $164 2018-11-13 Buy
Sigma-Aldrich Y0001387 Candesartan cilexetil for peak identification European Pharmacopoeia (EP) Reference Standard y0001387 $179 2018-11-23 Buy
Sigma-Aldrich Y0001388 Candesartan cilexetil European Pharmacopoeia (EP) Reference Standard y0001388 $179 2018-11-23 Buy
Sigma-Aldrich Y0001389 Candesartan cilexetil for system suitability European Pharmacopoeia (EP) Reference Standard y0001389 $179 2018-11-23 Buy
Sigma-Aldrich SML0245 Candesartan cilexetil ≥98% (HPLC) 50mg $287 2018-11-20 Buy
TCI Chemical C2635 Candesartan Cilexetil >98.0%(HPLC)(T) 1g $272 2018-11-22 Buy
TCI Chemical C2635 Candesartan Cilexetil >98.0%(HPLC)(T) 200mg $80 2018-11-22 Buy

Properties

Melting point: :168-170?C
storage temp.  :-20°C Freezer
solubility  :DMSO: ≥15mg/mL
pka :pKa 3.55 (H2O t=25.0 I=0.025) (Uncertain);5.91(H2O t=25.0 I=0.025) (Uncertain)
form  :powder
color  :white to beige
λmax :304nm(EtOH)(lit.)
Merck  :14,1739
InChIKey :GHOSNRCGJFBJIB-UHFFFAOYSA-N
CAS DataBase Reference :145040-37-5(CAS DataBase Reference)

Safety Information

Symbol(GHS):
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H360 May damage fertility or the unborn child Reproductive toxicity Category 1A, 1B Danger
H361 Suspected of damaging fertility or the unborn child Reproductive toxicity Category 2 Warning P201, P202, P281, P308+P313, P405,P501
H362 May cause harm to breast-fed children Reproductive toxicity, effects on or via lactation Additional category P201, P260, P263, P264, P270,P308+P313
H400 Very toxic to aquatic life Hazardous to the aquatic environment, acute hazard Category 1 Warning P273, P391, P501
Precautionary statements:
P201 Obtain special instructions before use.
P202 Do not handle until all safety precautions have been read and understood.
P260 Do not breathe dust/fume/gas/mist/vapours/spray.
P263 Avoid contact during pregnancy/while nursing.
P264 Wash hands thoroughly after handling.
P264 Wash skin thouroughly after handling.
P270 Do not eat, drink or smoke when using this product.
P273 Avoid release to the environment.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P281 Use personal protective equipment as required.
P308+P313 IF exposed or concerned: Get medical advice/attention.
P405 Store locked up.
P501 Dispose of contents/container to..…

Description

Candesartan cilexetil is a kind of prodrug being hydrolyzed to candesartan during absorption from the gastrointestinal tract. It appears as a white or off-white powder with a molecular weight of 610.67. It is soluble in methanol but insoluble in water. It is a kind of selective AT1 subtype angiotensin II receptor antagonist, mainly used for the treatment of hypertension and heart failure. Candesartan cilexetil takes effects through selectively blocking the binding of angiotensin II to the AT1 receptor in many tissues, such as vascular smooth muscle and the adrenal gland, further blocking the vasoconstrictor and aldosterone-secreting effects of angiotensin II. Therefore, its mode of action is not through interfering with the pathways for angiotensin II synthesis. Candesartan cilexetil may lead to various kinds of adverse reactions including headache, back pain, dizziness, upper respiratory tract infection, pharyngitis, rhinitis, bronchitis, coughing, sinusitis, nausea, abdominal pain, diarrhea, vomiting, arthralgia and albuminuria. It should be warned that candesartan cilexetil might have remarkable fetal toxicity. Therefore, upon pregnancy, candesartan cilexetil should be discontinued. It could also cause hypotension for heart-failure patients.

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