Chlortalidone
|
- $29 - $1260
- Product name: Chlortalidone
- CAS: 77-36-1
- MF: C14H11ClN2O4S
- MW: 338.77
- EINECS:201-022-5
- MDL Number:MFCD00036257
- Synonyms:thalitone;2-chloro-5-(2,3-dihydro-1-hydroxy-3-oxo-1h-isoindol-1-yl)benzenesulfonamide;hygroton;CHLORTHALIDONE;CHLORTALIDONE;1-keto-3-(3’-sulfamyl-4’-chlorophenyl)-3-hydroxyisoindoline ;1-oxo-3-(3-sulfamyl-4-chlorophenyl)-3-hydroxyisoindoline ;2-chloro-5-(1-hydroxy-3-oxo-1-isoindolinyl)-benzenesulfonamid
52 prices
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Brand
- AHH
- AK Scientific
- American Custom Chemicals Corporation
- AvaChem
- Biorbyt Ltd
- Biosynth
- Cayman Chemical
- Crysdot
- DC Chemicals
- Matrix Scientific
- Sigma-Aldrich
- TCI Chemical
- TRC
Package
- Y0002129
- 5mg
- 10mg
- 25mg
- 50mg
- 100mg
- 200mg
- 250mg
- 1g
- c1950000
- 5G
- 10g
- 25g
- 50g
- 100g
- 250g
- 1.017 mg
- 1.02 mg
- 150 mg
- 400 mg
- ManufacturerAHH
- Product numberAPI-1560
- Product descriptionChlorthalidone 98%
- Packaging1g
- Price$400
- Updated2021-12-16
- Buy
- ManufacturerAHH
- Product numberAPI-1560
- Product descriptionChlorthalidone 97%
- Packaging1g
- Price$400
- Updated2026-05-26
- Buy
- ManufacturerAK Scientific
- Product numberH530
- Product descriptionChlorthalidone
- Packaging5mg
- Price$29
- Updated2021-12-16
- Buy
- ManufacturerAK Scientific
- Product numberH530
- Product descriptionChlorthalidone
- Packaging25mg
- Price$95
- Updated2021-12-16
- Buy
- ManufacturerAK Scientific
- Product numberH530
- Product descriptionChlorthalidone
- Packaging100mg
- Price$267
- Updated2021-12-16
- Buy
- ManufacturerAmerican Custom Chemicals Corporation
- Product numberAPI0001976
- Product descriptionCHLORTHALIDONE 95.00%
- Packaging25MG
- Price$449.65
- Updated2021-12-16
- Buy
- ManufacturerAmerican Custom Chemicals Corporation
- Product numberAPI0001976
- Product descriptionCHLORTHALIDONE 95.00%
- Packaging100MG
- Price$598.6
- Updated2021-12-16
- Buy
- ManufacturerAvaChem
- Product number3756
- Product descriptionChlortalidone
- Packaging1g
- Price$449
- Updated2021-12-16
- Buy
- ManufacturerAvaChem
- Product number3756
- Product descriptionChlortalidone 99%
- Packaging1g
- Price$449
- Updated2026-05-22
- Buy
- ManufacturerAvaChem
- Product number3756
- Product descriptionChlortalidone 99%
- Packaging25mg
- Price$79
- Updated2026-05-22
- Buy
- ManufacturerAvaChem
- Product number3756
- Product descriptionChlortalidone
- Packaging100mg
- Price$149
- Updated2021-12-16
- Buy
- ManufacturerAvaChem
- Product number3756
- Product descriptionChlortalidone 99%
- Packaging100mg
- Price$149
- Updated2026-05-22
- Buy
- ManufacturerAvaChem
- Product number3756
- Product descriptionChlortalidone
- Packaging25mg
- Price$79
- Updated2021-12-16
- Buy
- ManufacturerBiorbyt Ltd
- Product numberorb134644
- Product descriptionChlorthalidone (Chlortalidone) >99%
- Packaging100mg
- Price$330
- Updated2026-05-06
- Buy
- ManufacturerBiorbyt Ltd
- Product numberorb134644
- Product descriptionChlorthalidone (Chlortalidone) >99%
- Packaging250mg
- Price$640
- Updated2026-05-06
- Buy
- ManufacturerBiorbyt Ltd
- Product numberorb134644
- Product descriptionChlorthalidone (Chlortalidone) >99%
- Packaging1g
- Price$1260
- Updated2026-05-06
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| AHH | API-1560 | Chlorthalidone 98% | 1g | $400 | 2021-12-16 | Buy |
| AHH | API-1560 | Chlorthalidone 97% | 1g | $400 | 2026-05-26 | Buy |
| AK Scientific | H530 | Chlorthalidone | 5mg | $29 | 2021-12-16 | Buy |
| AK Scientific | H530 | Chlorthalidone | 25mg | $95 | 2021-12-16 | Buy |
| AK Scientific | H530 | Chlorthalidone | 100mg | $267 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | API0001976 | CHLORTHALIDONE 95.00% | 25MG | $449.65 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | API0001976 | CHLORTHALIDONE 95.00% | 100MG | $598.6 | 2021-12-16 | Buy |
| AvaChem | 3756 | Chlortalidone | 1g | $449 | 2021-12-16 | Buy |
| AvaChem | 3756 | Chlortalidone 99% | 1g | $449 | 2026-05-22 | Buy |
| AvaChem | 3756 | Chlortalidone 99% | 25mg | $79 | 2026-05-22 | Buy |
| AvaChem | 3756 | Chlortalidone | 100mg | $149 | 2021-12-16 | Buy |
| AvaChem | 3756 | Chlortalidone 99% | 100mg | $149 | 2026-05-22 | Buy |
| AvaChem | 3756 | Chlortalidone | 25mg | $79 | 2021-12-16 | Buy |
| Biorbyt Ltd | orb134644 | Chlorthalidone (Chlortalidone) >99% | 100mg | $330 | 2026-05-06 | Buy |
| Biorbyt Ltd | orb134644 | Chlorthalidone (Chlortalidone) >99% | 250mg | $640 | 2026-05-06 | Buy |
| Biorbyt Ltd | orb134644 | Chlorthalidone (Chlortalidone) >99% | 1g | $1260 | 2026-05-06 | Buy |
Properties
Melting point :265-267°C (dec.)
Density :1.3356 (rough estimate)
refractive index :1.5630 (estimate)
storage temp. :2-8°C
solubility :DMSO: soluble5mg/mL, clear (warmed)
pka :pKa 9.4 (Uncertain)
form :powder
color :white to beige
Water Solubility :0.12g/L(25 ºC)
Stability :Hygroscopic
Major Application :pharmaceutical (small molecule)
InChI :1S/C14H11ClN2O4S/c15-11-6-5-8(7-12(11)22(16,20)21)14(19)10-4-2-1-3-9(10)13(18)17-14/h1-7,19H,(H,17,18)(H2,16,20,21)
InChIKey :JIVPVXMEBJLZRO-UHFFFAOYSA-N
SMILES :NS(=O)(=O)c1cc(ccc1Cl)C2(O)NC(=O)c3ccccc23
NIST Chemistry Reference :Chlorthalidone(77-36-1)
EPA Substance Registry System :Benzenesulfonamide, 2-chloro-5-(2,3-dihydro-1-hydroxy-3-oxo-1H-isoindol-1-yl)- (77-36-1)
Density :1.3356 (rough estimate)
refractive index :1.5630 (estimate)
storage temp. :2-8°C
solubility :DMSO: soluble5mg/mL, clear (warmed)
pka :pKa 9.4 (Uncertain)
form :powder
color :white to beige
Water Solubility :0.12g/L(25 ºC)
Stability :Hygroscopic
Major Application :pharmaceutical (small molecule)
InChI :1S/C14H11ClN2O4S/c15-11-6-5-8(7-12(11)22(16,20)21)14(19)10-4-2-1-3-9(10)13(18)17-14/h1-7,19H,(H,17,18)(H2,16,20,21)
InChIKey :JIVPVXMEBJLZRO-UHFFFAOYSA-N
SMILES :NS(=O)(=O)c1cc(ccc1Cl)C2(O)NC(=O)c3ccccc23
NIST Chemistry Reference :Chlorthalidone(77-36-1)
EPA Substance Registry System :Benzenesulfonamide, 2-chloro-5-(2,3-dihydro-1-hydroxy-3-oxo-1H-isoindol-1-yl)- (77-36-1)
Safety Information
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| Signal word: | Warning | ||||||||||||||||||||||||||||
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Description
Chlorthalidone is a nonthiazide diuretic that inhibits the sodium/chloride cotransporter in the distal convoluted tubule of the kidney, which prevents reabsorption of sodium and chloride leading to a reduction in plasma volume and cardiac output. It also effectively inhibits the activity of most platelet carbonic anhydrase isozymes (IC50s = 2.8 nM - 11 μM), which has been attributed to the sustained vasodilator capability of this compound. Chlorthalidone has been used independently or in combination with other antihypertensive agents to lower arterial blood pressure, and also as an adjuvant to address edema caused by cardiac or renal disorders.Related product price
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