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ChemicalBook >> CAS DataBase List >> Cl-Amidine

Cl-Amidine

Cl-Amidine price.
  • $35 - $600
  • Product name: Cl-Amidine
  • CAS: 1043444-18-3
  • MF: C14H19ClN4O2 ? CF3CO2H
  • MW: 424.81
  • EINECS:
  • MDL Number:MFCD31536783
  • Synonyms:Cl-Amidine (trifluoroacetate salt);Cl-amidine TFA;(2S)-5-(2-Chloroethanimidamido)-2-(phenylformamido)pentanamide trifluoroacetic acid salt
Price6 Properties Safety Information Description
6 prices
Selected condition：
Brand
  • ApexBio Technology
  • Cayman Chemical
  • DC Chemicals
Package
  • 1mg
  • 5mg
  • 10mg
  • 100mg
  • ManufacturerApexBio Technology
  • Product numberC3829
  • Product descriptionCl-Amidine(trifluoroacetatesalt)
  • Packaging5mg
  • Price$139
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberC3829
  • Product descriptionCl-Amidine(trifluoroacetatesalt)
  • Packaging10mg
  • Price$221
  • Updated2021-12-16
  • Buy
  • ManufacturerCayman Chemical
  • Product number10599
  • Product descriptionCl-Amidine (trifluoroacetate salt) ≥95%
  • Packaging1mg
  • Price$35
  • Updated2021-12-16
  • Buy
  • ManufacturerCayman Chemical
  • Product number10599
  • Product descriptionCl-Amidine (trifluoroacetate salt) ≥95%
  • Packaging5mg
  • Price$140
  • Updated2021-12-16
  • Buy
  • ManufacturerCayman Chemical
  • Product number10599
  • Product descriptionCl-Amidine (trifluoroacetate salt) ≥95%
  • Packaging10mg
  • Price$193
  • Updated2021-12-16
  • Buy
  • ManufacturerDC Chemicals
  • Product numberDC9725
  • Product descriptionCl-amidine >98%
  • Packaging100mg
  • Price$600
  • Updated2021-12-16
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
ApexBio Technology C3829 Cl-Amidine(trifluoroacetatesalt) 5mg $139 2021-12-16 Buy
ApexBio Technology C3829 Cl-Amidine(trifluoroacetatesalt) 10mg $221 2021-12-16 Buy
Cayman Chemical 10599 Cl-Amidine (trifluoroacetate salt) ≥95% 1mg $35 2021-12-16 Buy
Cayman Chemical 10599 Cl-Amidine (trifluoroacetate salt) ≥95% 5mg $140 2021-12-16 Buy
Cayman Chemical 10599 Cl-Amidine (trifluoroacetate salt) ≥95% 10mg $193 2021-12-16 Buy
DC Chemicals DC9725 Cl-amidine >98% 100mg $600 2021-12-16 Buy

Properties

storage temp. :under inert gas (nitrogen or Argon) at 2–8 °C
solubility :≤20mg/ml in ethanol;50mg/ml in DMSO;14mg/ml in dimethyl formamide
form :crystalline solid

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H302 Harmful if swallowed Acute toxicity,oral Category 4 Warning GHS hazard pictograms P264, P270, P301+P312, P330, P501
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning GHS hazard pictograms P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning GHS hazard pictograms P264, P280, P305+P351+P338,P337+P313P
H335 May cause respiratory irritation Specific target organ toxicity, single exposure;Respiratory tract irritation Category 3 Warning GHS hazard pictograms
Precautionary statements:
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312 IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352 IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Description

Protein arginine deiminase 4 (PAD4) catalyzes the post-translational modification of arginine residues on histones to form citrulline, which plays a large role in regulating gene expression. Dysregulated PAD4 activity has been implicated in cancer and rheumatoid arthritis. Cl-amidine is an inhibitor of PAD4 deimination activity with an IC50 value of 5.9 μM in an in vitro activity assay. It irreversibly inactivates (kinact/KI = 13,000 M-1min-1) PAD4 by covalently modifying an active site cysteine that is important for its catalytic activity. Cl-amidine also inhibits PAD1 and PAD3 with IC50 values of 0.8 and 6.2 μM, respectively. Cl-amidine is cytotoxic to HL-60, MCF7, and HT-29 cancer cell lines (IC50s = 0.25, 0.05 and 1 μM, respectively). In a CIA mouse model of inflammatory arthritis, Cl-amidine dose dependently decreases the citrulline content in serum and joints and reduces the development of IgG autoantibodies.

Suppliers and manufacturers

TargetMol Chemicals Inc.
Cl-amidine TFA
$0.00 /100mg
Cl-amidine TFA CAS:1043444-18-3
ATK CHEMICAL COMPANY LIMITED
TargetMol Chemicals Inc.
Nantong HI-FUTURE Biology Co., Ltd.
Chemtour Biotech Co., Ltd
ShenZhen Trendseen Biological Technology Co.,Ltd.
Aladdin Scientific BOC Sciences ShangHai Caerulum Pharma Discovery Co., Ltd. LETOPHARM LIMITED