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ChemicalBook >> CAS DataBase List >> Crisaborole

Crisaborole

$45 - $3590
Product name: Crisaborole
CAS: 906673-24-3
MF: C14H10BNO3
MW: 251.05
EINECS:250-635-4
MDL Number:MFCD17169940
Synonyms:AN-2728, >=98%;AN2728, Crisaborole;Crisaborole (AN2728);AN 2728;AN2728/AN-2728;4-((1-Hydroxy-1,3-dihydrobenzo-[c][1,2]oxaborol-5-yl)oxy)benzonitrile;4-[(1,3-Dihydro-1-hydroxy-2,1-benzoxaborol-5-yl)oxy]benzonitrile;AN-2728;AN2728;AN 2728

Price32 Properties Safety Information Description

32 prices

Selected condition：

Brand

AK Scientific
American Custom Chemicals Corporation
ApexBio Technology
Axon Medchem
Biosynth Carbosynth
Cayman Chemical
Chemenu
ChemScene
Crysdot
DC Chemicals
Matrix Scientific
Sigma-Aldrich
TRC

Package

5MG
10mg
25mg
50mg
100mg
250MG
500mg
1g
25g
10mM(in 1mL DMSO)

ManufacturerAK Scientific
Product number5098AC
Product description4-((1-Hydroxy-1,3-dihydrobenzo[c][1,2]oxaborol-5-yl)oxy)benzonitrile
Packaging10mg
Price$115
Updated2021-12-16
Buy

ManufacturerAmerican Custom Chemicals Corporation
Product numberAPI0013781
Product descriptionAN-2728 95.00%
Packaging5MG
Price$479
Updated2021-12-16
Buy

ManufacturerAmerican Custom Chemicals Corporation
Product numberAPI0013781
Product descriptionAN-2728 95.00%
Packaging250MG
Price$3590
Updated2021-12-16
Buy

ManufacturerApexBio Technology
Product numberA3178
Product descriptionAN-2728
Packaging10mg
Price$45
Updated2021-12-16
Buy

ManufacturerApexBio Technology
Product numberA3178
Product descriptionAN-2728
Packaging10mM(in 1mL DMSO)
Price$61
Updated2021-12-16
Buy

ManufacturerApexBio Technology
Product numberA3178
Product descriptionAN-2728
Packaging50mg
Price$70
Updated2021-12-16
Buy

ManufacturerAxon Medchem
Product numberAxon3169
Product descriptionCrisaborole-AN2728 99%
Packaging10mg
Price$66
Updated2021-12-16
Buy

ManufacturerBiosynth Carbosynth
Product numberFC166718
Product descriptionCrisaborole
Packaging25mg
Price$50
Updated2021-12-16
Buy

ManufacturerBiosynth Carbosynth
Product numberFC166718
Product descriptionCrisaborole
Packaging50mg
Price$75
Updated2021-12-16
Buy

ManufacturerBiosynth Carbosynth
Product numberFC166718
Product descriptionCrisaborole
Packaging100mg
Price$120
Updated2021-12-16
Buy

ManufacturerBiosynth Carbosynth
Product numberFC166718
Product descriptionCrisaborole
Packaging250mg
Price$200
Updated2021-12-16
Buy

ManufacturerBiosynth Carbosynth
Product numberFC166718
Product descriptionCrisaborole
Packaging500mg
Price$350
Updated2021-12-16
Buy

ManufacturerCayman Chemical
Product number21455
Product descriptionAN2728 ≥98%
Packaging25mg
Price$62
Updated2024-03-01
Buy

ManufacturerCayman Chemical
Product number21455
Product descriptionAN2728 ≥98%
Packaging50mg
Price$115
Updated2024-03-01
Buy

ManufacturerCayman Chemical
Product number21455
Product descriptionAN2728 ≥98%
Packaging100mg
Price$216
Updated2024-03-01
Buy

ManufacturerCayman Chemical
Product number21455
Product descriptionAN2728 ≥98%
Packaging250mg
Price$448
Updated2024-03-01
Buy

Manufacturer	Product number	Product description	Packaging	Price	Updated	Buy
AK Scientific	5098AC	4-((1-Hydroxy-1,3-dihydrobenzo[c][1,2]oxaborol-5-yl)oxy)benzonitrile	10mg	$115	2021-12-16	Buy
American Custom Chemicals Corporation	API0013781	AN-2728 95.00%	5MG	$479	2021-12-16	Buy
American Custom Chemicals Corporation	API0013781	AN-2728 95.00%	250MG	$3590	2021-12-16	Buy
ApexBio Technology	A3178	AN-2728	10mg	$45	2021-12-16	Buy
ApexBio Technology	A3178	AN-2728	10mM(in 1mL DMSO)	$61	2021-12-16	Buy
ApexBio Technology	A3178	AN-2728	50mg	$70	2021-12-16	Buy
Axon Medchem	Axon3169	Crisaborole-AN2728 99%	10mg	$66	2021-12-16	Buy
Biosynth Carbosynth	FC166718	Crisaborole	25mg	$50	2021-12-16	Buy
Biosynth Carbosynth	FC166718	Crisaborole	50mg	$75	2021-12-16	Buy
Biosynth Carbosynth	FC166718	Crisaborole	100mg	$120	2021-12-16	Buy
Biosynth Carbosynth	FC166718	Crisaborole	250mg	$200	2021-12-16	Buy
Biosynth Carbosynth	FC166718	Crisaborole	500mg	$350	2021-12-16	Buy
Cayman Chemical	21455	AN2728 ≥98%	25mg	$62	2024-03-01	Buy
Cayman Chemical	21455	AN2728 ≥98%	50mg	$115	2024-03-01	Buy
Cayman Chemical	21455	AN2728 ≥98%	100mg	$216	2024-03-01	Buy
Cayman Chemical	21455	AN2728 ≥98%	250mg	$448	2024-03-01	Buy

Next Last

Properties

Melting point :>130°C (softened)
Boiling point :425.9±55.0 °C(Predicted)
Density :1.33±0.1 g/cm3(Predicted)
storage temp. :room temp
solubility :DMSO (Slightly), Methanol (Slightly)
pka :7.00±0.20(Predicted)
form :powder
color :white to beige
Stability :Hygroscopic
InChI :InChI=1S/C14H10BNO3/c16-8-10-1-3-12(4-2-10)19-13-5-6-14-11(7-13)9-18-15(14)17/h1-7,17H,9H2
InChIKey :USZAGAREISWJDP-UHFFFAOYSA-N
SMILES :C(#N)C1=CC=C(OC2=CC=C3B(O)OCC3=C2)C=C1

Safety Information

Symbol(GHS):

Signal word:

Danger

Hazard statements:

Code	Hazard statements	Hazard class	Category	Signal word	P-Codes
H315	Causes skin irritation	Skin corrosion/irritation	Category 2	Warning	P264, P280, P302+P352, P321,P332+P313, P362
H319	Causes serious eye irritation	Serious eye damage/eye irritation	Category 2A	Warning	P264, P280, P305+P351+P338,P337+P313P
H335	May cause respiratory irritation	Specific target organ toxicity, single exposure;Respiratory tract irritation	Category 3	Warning

Precautionary statements:

P261	Avoid breathing dust/fume/gas/mist/vapours/spray.
P301+P310	IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P305+P351+P338	IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P311	Call a POISON CENTER or doctor/physician.

Description

Crisaborole is a phosphodiesterase- 4 (PDE4) inhibitor that was approved by FDA on December 14, 2016 as Eucrisa, a topical treatment of for mild to moderate atopic dermatitis (AD) in patients aged two years and older. The drug, which was developed by Anacor Pharmaceuticals and later acquired and marketed by Pfizer, is delivered as a 2% ointment, which is applied topically. Its structure contains a boron atom, which facilitates skin penetration and binding to the bimetal center of the phosphodiesterase 4 enzyme. The unique employment of boron within the chemical structure of the drug is designed to enable selective engagement of PDE4 (an enzyme involved in the conversion of cAMP into AMP, which signals for downstream inflammatory events), effective penetration of the drug through human skin, and rapid clearance to limit systemic circulation.

Suppliers and manufacturers

S&Y Biochem Co.,Ltd

$2500.00 /1kg
Crisaborole CAS:906673-24-3

Guangzhou Tosun Pharmaceutical Ltd

$0.00 /5kg
Crisaborole CAS:906673-24-3

Wuhan Biocar Pharmacy CO.,Ltd.

$0.00 /1kg
Crisaborole CAS:906673-24-3

Hebei Yanxi Chemical Co., Ltd.

$0.00 /1kg
4-((1-Hydroxy-1,3-dihydrobenzo[c][1,2]oxaborol-5-yl)oxy)benzonitrile CAS:906673-24-3

Shanghai UCHEM Inc.

$63.00 /1g
AN 2728 CAS:906673-24-3

shandong perfect biotechnology co.ltd

$0.00 /1g
AN-2728 CAS:906673-24-3

Hangzhou ICH Biofarm Co., Ltd

$0.00 /1KG
Crisaborole CAS:906673-24-3

Zibo Hangyu Biotechnology Development Co., Ltd

$150.00 /1KG
Crisaborole CAS:906673-24-3

Hebei Xinsheng New Material Technology Co., LTD.

$0.00 /1kg
Crisaborole CAS:906673-24-3

Anhui Ruihan Technology Co., Ltd

$30.00 /1kg
Crisaborole CAS:906673-24-3

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