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ChemicalBook >> CAS DataBase List >> DEMECOLCINE

DEMECOLCINE

DEMECOLCINE price.
  • $30 - $16040
  • Product name: DEMECOLCINE
  • CAS: 477-30-5
  • MF: C21H25NO5
  • MW: 371.43
  • EINECS:207-514-6
  • MDL Number:MFCD00075459
  • Synonyms:substancef ;DEMECOLCINE HYBRI-MAXR;Colcemid-D3=Demecolcine-D3;N-Deacetyl-N-methyl(deutero)colchicine;COLCEMIDE(R);COLCEMID(R);DEMECOLCIN;DEMECOLCINE
90 prices
Selected condition:
Brand
  • aablocks
  • ACHEMBLOCK
  • Adipogen Life Sciences
  • AHH
  • AK Scientific
  • Alichem
  • American Custom Chemicals Corporation
  • Arctom
  • Biosynth
  • Cayman Chemical
  • ChemScene
  • DC Chemicals
  • Labseeker
  • Medical Isotopes, Inc.
  • Sigma-Aldrich
  • Thermo Scientific Chemicals
  • TRC
  • Usbiological
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  • 1 unit
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  • 10mM*1mLinDMSO(Solid+Solvent)
  • 10mM*1mLinDMSO(Solution)
  • Manufactureraablocks
  • Product numberAA00DDVW
  • Product description(S)-1,2,3,10-Tetramethoxy-7-(methylamino)-6,7-dihydrobenzo[a]heptalen-9(5H)-one
  • Packaging5mg
  • Price$99
  • Updated2026-05-28
  • Buy
  • Manufactureraablocks
  • Product numberAA00DDVW
  • Product description(S)-1,2,3,10-Tetramethoxy-7-(methylamino)-6,7-dihydrobenzo[a]heptalen-9(5H)-one
  • Packaging10mg
  • Price$145
  • Updated2026-05-28
  • Buy
  • Manufactureraablocks
  • Product numberAA00DDVW
  • Product description(S)-1,2,3,10-Tetramethoxy-7-(methylamino)-6,7-dihydrobenzo[a]heptalen-9(5H)-one
  • Packaging25mg
  • Price$219
  • Updated2026-05-28
  • Buy
  • Manufactureraablocks
  • Product numberAA00DDVW
  • Product description(S)-1,2,3,10-Tetramethoxy-7-(methylamino)-6,7-dihydrobenzo[a]heptalen-9(5H)-one
  • Packaging1mg
  • Price$45
  • Updated2026-05-28
  • Buy
  • Manufactureraablocks
  • Product numberAA00DDVW
  • Product description(S)-1,2,3,10-Tetramethoxy-7-(methylamino)-6,7-dihydrobenzo[a]heptalen-9(5H)-one
  • Packaging50mg
  • Price$321
  • Updated2026-05-28
  • Buy
  • ManufacturerACHEMBLOCK
  • Product numberY226998
  • Product descriptionColcemid 97.00%
  • Packaging25MG
  • Price$400
  • Updated2026-05-27
  • Buy
  • ManufacturerACHEMBLOCK
  • Product numberY226998
  • Product descriptionColcemid 97.00%
  • Packaging100MG
  • Price$1040
  • Updated2026-05-27
  • Buy
  • ManufacturerAdipogen Life Sciences
  • Product numberCDX-C0022-M025
  • Product descriptionColcemid ≥98%(HPLC)
  • Packaging25mg
  • Price$290
  • Updated2026-05-06
  • Buy
  • ManufacturerAdipogen Life Sciences
  • Product numberAG-CR1-3567-M001
  • Product descriptionColcemid ≥98%(HPLC)
  • Packaging1mg
  • Price$30
  • Updated2021-12-16
  • Buy
  • ManufacturerAdipogen Life Sciences
  • Product numberAG-CR1-3567-M001
  • Product descriptionColcemid ≥98%(HPLC)
  • Packaging1mg
  • Price$30
  • Updated2026-05-06
  • Buy
  • ManufacturerAdipogen Life Sciences
  • Product numberAG-CR1-3567-M005
  • Product descriptionColcemid ≥98%(HPLC)
  • Packaging5mg
  • Price$75
  • Updated2026-05-06
  • Buy
  • ManufacturerAHH
  • Product numberMT-49841
  • Product descriptionDemecolcine 97%
  • Packaging0.05g
  • Price$290
  • Updated2026-05-25
  • Buy
  • ManufacturerAHH
  • Product numberMT-49841
  • Product descriptionDemecolcine 97%
  • Packaging0.05g
  • Price$290
  • Updated2026-05-26
  • Buy
  • ManufacturerAK Scientific
  • Product numberV0182
  • Product descriptionDemecolcine
  • Packaging10mg
  • Price$276
  • Updated2021-12-16
  • Buy
  • ManufacturerAK Scientific
  • Product numberV0182
  • Product descriptionDemecolcine
  • Packaging5mg
  • Price$198
  • Updated2021-12-16
  • Buy
  • ManufacturerAK Scientific
  • Product numberV0182
  • Product descriptionDemecolcine
  • Packaging1mg
  • Price$139
  • Updated2021-12-16
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
aablocks AA00DDVW (S)-1,2,3,10-Tetramethoxy-7-(methylamino)-6,7-dihydrobenzo[a]heptalen-9(5H)-one 5mg $99 2026-05-28 Buy
aablocks AA00DDVW (S)-1,2,3,10-Tetramethoxy-7-(methylamino)-6,7-dihydrobenzo[a]heptalen-9(5H)-one 10mg $145 2026-05-28 Buy
aablocks AA00DDVW (S)-1,2,3,10-Tetramethoxy-7-(methylamino)-6,7-dihydrobenzo[a]heptalen-9(5H)-one 25mg $219 2026-05-28 Buy
aablocks AA00DDVW (S)-1,2,3,10-Tetramethoxy-7-(methylamino)-6,7-dihydrobenzo[a]heptalen-9(5H)-one 1mg $45 2026-05-28 Buy
aablocks AA00DDVW (S)-1,2,3,10-Tetramethoxy-7-(methylamino)-6,7-dihydrobenzo[a]heptalen-9(5H)-one 50mg $321 2026-05-28 Buy
ACHEMBLOCK Y226998 Colcemid 97.00% 25MG $400 2026-05-27 Buy
ACHEMBLOCK Y226998 Colcemid 97.00% 100MG $1040 2026-05-27 Buy
Adipogen Life Sciences CDX-C0022-M025 Colcemid ≥98%(HPLC) 25mg $290 2026-05-06 Buy
Adipogen Life Sciences AG-CR1-3567-M001 Colcemid ≥98%(HPLC) 1mg $30 2021-12-16 Buy
Adipogen Life Sciences AG-CR1-3567-M001 Colcemid ≥98%(HPLC) 1mg $30 2026-05-06 Buy
Adipogen Life Sciences AG-CR1-3567-M005 Colcemid ≥98%(HPLC) 5mg $75 2026-05-06 Buy
AHH MT-49841 Demecolcine 97% 0.05g $290 2026-05-25 Buy
AHH MT-49841 Demecolcine 97% 0.05g $290 2026-05-26 Buy
AK Scientific V0182 Demecolcine 10mg $276 2021-12-16 Buy
AK Scientific V0182 Demecolcine 5mg $198 2021-12-16 Buy
AK Scientific V0182 Demecolcine 1mg $139 2021-12-16 Buy

Properties

Melting point :73-75°C
alpha :D20 -129.0° (c = 1 in chloroform)
Boiling point :501.11°C (rough estimate)
Density :1.2350 (rough estimate)
refractive index :1.5614 (estimate)
storage temp. :2-8°C
solubility :DMSO: 10 mg/mL
form :powder
pka :8.48±0.40(Predicted)
color :White to off-white
Sensitive :Air & Light Sensitive
BRN :2822892
Stability :Hygroscopic
InChI :1S/C21H25NO5/c1-22-15-8-6-12-10-18(25-3)20(26-4)21(27-5)19(12)13-7-9-17(24-2)16(23)11-14(13)15/h7,9-11,15,22H,6,8H2,1-5H3
InChIKey :NNJPGOLRFBJNIW-UHFFFAOYSA-N
SMILES :N(C1CCc2c(c(c(c(c2)OC)OC)OC)C3=CC=C(C(=O)C=C31)OC)C

Safety Information

Symbol(GHS): Skull and Crossbones (GHS06)
Signal word: Danger
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H300 Fatal if swallowed Acute toxicity,oral Category 1, 2 Danger P264, P270, P301+P310, P321, P330,P405, P501
Precautionary statements:
P264 Wash hands thoroughly after handling.
P264 Wash skin thouroughly after handling.
P301+P310 IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

Description

Colcemid is a colchicine derivative that inhibits tubulin polymerization as potently as colchicine (IC50 = 2.1 and 2.4 μM, respectively) but is less toxic. At very low (nanomolar) concentrations, colcemid suppresses microtubule dynamicity and inhibits cell migration, while at micromolar levels it blocks microtubule assembly, arresting cells in metaphase. Mitotic block by colcemid is used to synchronize cells and for karyotyping in cytogenetic studies. Prolonged exposure to colcemid can activate p53, leading to apoptosis.

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