E-4031
|
- $19 - $3550
- Product name: E-4031
- CAS: 113559-13-0
- MF: C21H33Cl2N3O5S
- MW: 510.47
- EINECS:
- MDL Number:MFCD00889193
- Synonyms:1-(2-(6-methyl-2-pyridyl)ethyl)-4-(4-methylsulfonylaminobenzoyl)piperidined ;methanesulfonamide,n-(4-((1-(2-(6-methyl-2-pyridinyl)ethyl)-4-piperidinyl)carb ;E-4031;N-[4-[[1-[2-(6-Methyl-2-pyridinyl)ethyl]-4-piperidinyl]carbonyl]phenyl]methanesulfonamide dihydrochloride;N-[4-[1-[2-(6-Methyl-2-pyridinyl)ethyl]-4-piperidinylcarbonyl]phenyl]methanesulfonamide·2hydrochloric acid;E-4031 (hydrochloride);N-(4-(1-(2-(6-METHYLPYRIDIN-2-YL)ETHYL)PIPERIDINE-4-CARBONYL)PHENYL)METHANESULFONAMIDE 2HCL;N-[4-[1-[2-(6-methylpyridin-2-yl)ethyl]piperidine-4-carbonyl]phenyl]methanesulfonamide dihydrochloride
67 prices
Selected condition：
Brand
- aablocks
- ACHEMBLOCK
- Ambeed
- American Custom Chemicals Corporation
- ApexBio Technology
- Arctom
- AvaChem
- Axon Medchem
- Cayman Chemical
- Chemenu
- ChemScene
- Crysdot
- DC Chemicals
- Sigma-Aldrich
- Synthonix
Package
- 0.1mg
- 0.5mg
- 1mg
- 5mg
- 10mg
- 25mg
- 50MG
- 100mg
- 250mg
- 1g
- Manufactureraablocks
- Product numberAA0008W4
- Product descriptionE-4031 99%
- Packaging1mg
- Price$19
- Updated2026-05-25
- Buy
- Manufactureraablocks
- Product numberAA0008W4
- Product descriptionE-4031 99%
- Packaging5mg
- Price$45
- Updated2026-05-25
- Buy
- Manufactureraablocks
- Product numberAA0008W4
- Product descriptionE-4031 99%
- Packaging10mg
- Price$76
- Updated2026-05-25
- Buy
- Manufactureraablocks
- Product numberAA0008W4
- Product descriptionE-4031 98%
- Packaging100mg
- Price$580
- Updated2026-05-25
- Buy
- Manufactureraablocks
- Product numberAA0008W4
- Product descriptionE-4031 98%
- Packaging250mg
- Price$1022
- Updated2026-05-25
- Buy
- ManufacturerACHEMBLOCK
- Product numberY229144
- Product descriptionE-4031 97.00%
- Packaging100MG
- Price$755
- Updated2026-05-27
- Buy
- ManufacturerACHEMBLOCK
- Product numberY229144
- Product descriptionE-4031 97.00%
- Packaging50MG
- Price$420
- Updated2026-05-27
- Buy
- ManufacturerAmbeed
- Product numberA115118
- Product descriptionE-4031 98+%
- Packaging250mg
- Price$546
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA115118
- Product descriptionE-4031 98+%
- Packaging1g
- Price$546
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA115118
- Product descriptionE-4031 98+%
- Packaging10mg
- Price$51
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA115118
- Product descriptionE-4031 98+%
- Packaging1mg
- Price$26
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA115118
- Product descriptionE-4031 98+%
- Packaging5mg
- Price$26
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA115118
- Product descriptionE-4031 98+%
- Packaging25mg
- Price$157
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA115118
- Product descriptionE-4031 98+%
- Packaging50mg
- Price$204
- Updated2021-12-16
- Buy
- ManufacturerAmerican Custom Chemicals Corporation
- Product numberINB0003930
- Product descriptionE-4031 DIHYDROCHLORIDE 95.00%
- Packaging5MG
- Price$184.8
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberB6862
- Product descriptionE-4031 dihydrochloride
- Packaging10mg
- Price$150
- Updated2026-05-06
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| aablocks | AA0008W4 | E-4031 99% | 1mg | $19 | 2026-05-25 | Buy |
| aablocks | AA0008W4 | E-4031 99% | 5mg | $45 | 2026-05-25 | Buy |
| aablocks | AA0008W4 | E-4031 99% | 10mg | $76 | 2026-05-25 | Buy |
| aablocks | AA0008W4 | E-4031 98% | 100mg | $580 | 2026-05-25 | Buy |
| aablocks | AA0008W4 | E-4031 98% | 250mg | $1022 | 2026-05-25 | Buy |
| ACHEMBLOCK | Y229144 | E-4031 97.00% | 100MG | $755 | 2026-05-27 | Buy |
| ACHEMBLOCK | Y229144 | E-4031 97.00% | 50MG | $420 | 2026-05-27 | Buy |
| Ambeed | A115118 | E-4031 98+% | 250mg | $546 | 2021-12-16 | Buy |
| Ambeed | A115118 | E-4031 98+% | 1g | $546 | 2021-12-16 | Buy |
| Ambeed | A115118 | E-4031 98+% | 10mg | $51 | 2021-12-16 | Buy |
| Ambeed | A115118 | E-4031 98+% | 1mg | $26 | 2021-12-16 | Buy |
| Ambeed | A115118 | E-4031 98+% | 5mg | $26 | 2021-12-16 | Buy |
| Ambeed | A115118 | E-4031 98+% | 25mg | $157 | 2021-12-16 | Buy |
| Ambeed | A115118 | E-4031 98+% | 50mg | $204 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | INB0003930 | E-4031 DIHYDROCHLORIDE 95.00% | 5MG | $184.8 | 2021-12-16 | Buy |
| ApexBio Technology | B6862 | E-4031 dihydrochloride | 10mg | $150 | 2026-05-06 | Buy |
Properties
storage temp. :-20°C
solubility :H2O: soluble
form :solid
color :off-white
Water Solubility :H2O: soluble
Stability :Hygroscopic
InChI :1S/C21H27N3O3S.2ClH/c1-16-4-3-5-19(22-16)12-15-24-13-10-18(11-14-24)21(25)17-6-8-20(9-7-17)23-28(2,26)27;;/h3-9,18,23H,10-15H2,1-2H3;2*1H
InChIKey :ZQBNWMFBOSOOLX-UHFFFAOYSA-N
SMILES :Cl.Cl.Cc1cccc(CCN2CCC(CC2)C(=O)c3ccc(NS(C)(=O)=O)cc3)n1
solubility :H2O: soluble
form :solid
color :off-white
Water Solubility :H2O: soluble
Stability :Hygroscopic
InChI :1S/C21H27N3O3S.2ClH/c1-16-4-3-5-19(22-16)12-15-24-13-10-18(11-14-24)21(25)17-6-8-20(9-7-17)23-28(2,26)27;;/h3-9,18,23H,10-15H2,1-2H3;2*1H
InChIKey :ZQBNWMFBOSOOLX-UHFFFAOYSA-N
SMILES :Cl.Cl.Cc1cccc(CCN2CCC(CC2)C(=O)c3ccc(NS(C)(=O)=O)cc3)n1
Safety Information
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| Signal word: | Warning | ||||||||||||||
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Description
Voltage-gated potassium ERG channels (Kv11.1), encoded by the ether-a-go-go related gene, mediate the inwardly rectifying potassium (K+) current that repolarizes myocardial cells, gut smooth muscle cells, and interstitial cells of Cajal. E-4031 is a methanesulfonanilide class III antiarrhythmic agent that prolongs cardiac action potential duration by blocking ERG K+ channels (IC50 = 29 nM). E-4031 inhibits the ERG1, ERG2, and ERG3 isoforms with KD values of 99, 116, and 193 nM, respectively. However, at higher μM concentrations E-4031 can demonstrate pro-arrhythmic activity, inducing early after depolarizations (prolonged repolarization) in cell models and torsade de pointes in animal models. E-4031 has been used to pharmacologically rescue misprocessed ERG in long QT syndrome type 2, an autosomal dominant cardiac disease associated with prolongation of the QT interval and torsade de pointes.Related product price
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