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ChemicalBook >> CAS DataBase List >> EGFR inhibitor

EGFR inhibitor

EGFR inhibitor price.
  • $81 - $1163
  • Product name: EGFR inhibitor
  • CAS: 879127-07-8
  • MF: C21H18F3N5O
  • MW: 413.4
  • EINECS:-0
  • MDL Number:
  • Synonyms:EGFR inhibitor;CyclopropanecarboxaMide, N-[3-[[6-[[3-(trifluoroMethyl)phenyl]aMino]-4-pyriMidinyl]aMino]phenyl]-;EGFR Inhibitor [879127-07-8];EGFR-IN-12;EGFR inhibitor 324674;EGFR inhibitor(YUN27078);EGFR Inhibitor [879127-07-8] - EGFR Inhibitor 324674;N-(3-((6-((3-(Trifluoromethyl)phenyl)amino)pyrimidin-4-yl)amino)phenyl)cyclopropanecarboxamide
15 prices
Selected condition:
Brand
  • AK Scientific
  • American Custom Chemicals Corporation
  • ApexBio Technology
  • Cayman Chemical
  • ChemScene
  • DC Chemicals
  • Sigma-Aldrich
  • TRC
Package
  • 1mg
  • 5MG
  • 10mg
  • 25mg
  • 250mg
  • ManufacturerAK Scientific
  • Product number9766CQ
  • Product descriptionEGFRInhibitor
  • Packaging25mg
  • Price$1163
  • Updated2021-12-16
  • Buy
  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberAPI0010446
  • Product descriptionEGFR INHIBITOR-324674 99.00%
  • Packaging5MG
  • Price$275
  • Updated2021-12-16
  • Buy
  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberAPI0010446
  • Product descriptionEGFR INHIBITOR-324674 99.00%
  • Packaging25MG
  • Price$1062.6
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberC3327
  • Product descriptionEGFRInhibitor
  • Packaging1mg
  • Price$81
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberC3327
  • Product descriptionEGFRInhibitor
  • Packaging5mg
  • Price$244
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberC3327
  • Product descriptionEGFRInhibitor
  • Packaging25mg
  • Price$854
  • Updated2021-12-16
  • Buy
  • ManufacturerCayman Chemical
  • Product number15363
  • Product descriptionEGFR Inhibitor ≥98%
  • Packaging1mg
  • Price$93
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number15363
  • Product descriptionEGFR Inhibitor ≥98%
  • Packaging5mg
  • Price$275
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number15363
  • Product descriptionEGFR Inhibitor ≥98%
  • Packaging25mg
  • Price$957
  • Updated2024-03-01
  • Buy
  • ManufacturerChemScene
  • Product numberCS-0009241
  • Product descriptionEGFR-IN-12 99.49%
  • Packaging5mg
  • Price$180
  • Updated2021-12-16
  • Buy
  • ManufacturerChemScene
  • Product numberCS-0009241
  • Product descriptionEGFR-IN-12 99.49%
  • Packaging10mg
  • Price$300
  • Updated2021-12-16
  • Buy
  • ManufacturerChemScene
  • Product numberCS-0009241
  • Product descriptionEGFR-IN-12 99.49%
  • Packaging25mg
  • Price$600
  • Updated2021-12-16
  • Buy
  • ManufacturerDC Chemicals
  • Product numberDC34093
  • Product descriptionEGFRinhibitor(YUN27078)
  • Packaging250mg
  • Price$1100
  • Updated2021-12-16
  • Buy
  • ManufacturerSigma-Aldrich
  • Product number324674
  • Product descriptionEGFR Inhibitor - CAS 879127-07-8 - Calbiochem
  • Packaging1MG
  • Price$159
  • Updated2024-03-01
  • Buy
  • ManufacturerTRC
  • Product numberE440158
  • Product descriptionEGFRInhibitor
  • Packaging1mg
  • Price$115
  • Updated2021-12-16
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
AK Scientific 9766CQ EGFRInhibitor 25mg $1163 2021-12-16 Buy
American Custom Chemicals Corporation API0010446 EGFR INHIBITOR-324674 99.00% 5MG $275 2021-12-16 Buy
American Custom Chemicals Corporation API0010446 EGFR INHIBITOR-324674 99.00% 25MG $1062.6 2021-12-16 Buy
ApexBio Technology C3327 EGFRInhibitor 1mg $81 2021-12-16 Buy
ApexBio Technology C3327 EGFRInhibitor 5mg $244 2021-12-16 Buy
ApexBio Technology C3327 EGFRInhibitor 25mg $854 2021-12-16 Buy
Cayman Chemical 15363 EGFR Inhibitor ≥98% 1mg $93 2024-03-01 Buy
Cayman Chemical 15363 EGFR Inhibitor ≥98% 5mg $275 2024-03-01 Buy
Cayman Chemical 15363 EGFR Inhibitor ≥98% 25mg $957 2024-03-01 Buy
ChemScene CS-0009241 EGFR-IN-12 99.49% 5mg $180 2021-12-16 Buy
ChemScene CS-0009241 EGFR-IN-12 99.49% 10mg $300 2021-12-16 Buy
ChemScene CS-0009241 EGFR-IN-12 99.49% 25mg $600 2021-12-16 Buy
DC Chemicals DC34093 EGFRinhibitor(YUN27078) 250mg $1100 2021-12-16 Buy
Sigma-Aldrich 324674 EGFR Inhibitor - CAS 879127-07-8 - Calbiochem 1MG $159 2024-03-01 Buy
TRC E440158 EGFRInhibitor 1mg $115 2021-12-16 Buy

Properties

Boiling point :605.9±55.0 °C(Predicted)
Density :1.456±0.06 g/cm3(Predicted)
storage temp. :Store at -20°C
solubility :insoluble in H2O; insoluble in EtOH; ≥60.7 mg/mL in DMSO
form :crystalline solid
pka :14.50±0.70(Predicted)

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning GHS hazard pictograms P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning GHS hazard pictograms P264, P280, P305+P351+P338,P337+P313P
Precautionary statements:
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352 IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P332+P313 IF SKIN irritation occurs: Get medical advice/attention.
P337+P313 IF eye irritation persists: Get medical advice/attention.

Description

EGFR inhibitor is a cell permeable, 4,6-disubstituted pyrimidine compound that selectively inhibits the EGFR kinase with an IC50 value of 21 nM in vitro and blocks receptor autophosphorylation in cells. It can also inhibit the L858R and L861Q EGFR mutants (IC50s = 63 and 4 nM, respectively) yet displays strong selectivity for EGFR against a panel of 55 recombinant kinases (IC50s > 10 μM). Whereas overactivity of EGFR tyrosine kinases has been associated with a number of cancers, inhibition of EGFR has been shown to induce apoptosis by downregulating antiapoptotic proteins such as survivin and upregulating proapoptotic proteins such as Bim.