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ChemicalBook >> CAS DataBase List >> EI1

EI1

EI1 price.
  • $16 - $1950
  • Product name: EI1
  • CAS: 1418308-27-6
  • MF: C23H26N4O2
  • MW: 390.48
  • EINECS:
  • MDL Number:MFCD25976740
  • Synonyms:EI1;Ezh2 inhibitor;6-Cyano-N-[(1,2-dihydro-4,6-dimethyl-2-oxo-3-pyridinyl)methyl]-1-(1-ethylpropyl)-1H-indole-4-carboxamide;EI1;EI-1;EI 1;6-cyano-N-((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-1-(pentan-3-yl)-1H-indole-4-carboxamide;CS-2378;EI1 (Ezh2 inhibitor;EI1;EI 1
Price40 Properties Safety Information Description
40 prices
Selected condition：
Brand
  • aablocks
  • ACHEMBLOCK
  • Ambeed
  • ApexBio Technology
  • Arctom
  • Cayman Chemical
  • Chemenu
  • ChemScene
  • Crysdot
  • DC Chemicals
  • Sigma-Aldrich
Package
  • 10mM*1mLinDMSO(Solid+Solvent)
  • 25mg
  • 10mM(in1mLDMSO)
  • 10mM*1mLinDMSO(Solution)
  • 1mg
  • 5mg
  • 10mg
  • 50mg
  • 100mg
  • 250mg
  • 1G
  • 10mM(in 1mL DMSO)
  • Manufactureraablocks
  • Product numberAA009C8H
  • Product descriptionEI1 96%
  • Packaging10mg
  • Price$46
  • Updated2026-05-28
  • Buy
  • Manufactureraablocks
  • Product numberAA009C8H
  • Product descriptionEI1 96%
  • Packaging1mg
  • Price$16
  • Updated2026-05-28
  • Buy
  • Manufactureraablocks
  • Product numberAA009C8H
  • Product descriptionEI1 96%
  • Packaging5mg
  • Price$33
  • Updated2026-05-28
  • Buy
  • Manufactureraablocks
  • Product numberAA009C8H
  • Product descriptionEI1 ≥96%
  • Packaging100mg
  • Price$421
  • Updated2026-05-28
  • Buy
  • ManufacturerACHEMBLOCK
  • Product numberS87310
  • Product descriptionEI1 98%
  • Packaging100MG
  • Price$320
  • Updated2026-05-27
  • Buy
  • ManufacturerACHEMBLOCK
  • Product numberS87310
  • Product descriptionEI1 98%
  • Packaging1G
  • Price$1595
  • Updated2026-05-27
  • Buy
  • ManufacturerAmbeed
  • Product numberA163218
  • Product descriptionEI1 98+%
  • Packaging100mg
  • Price$667
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA163218
  • Product descriptionEI1 98+%
  • Packaging50mg
  • Price$514
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA163218
  • Product descriptionEI1 98+%
  • Packaging5mg
  • Price$235
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA163218
  • Product descriptionEI1 98+%
  • Packaging10mg
  • Price$305
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberB1021
  • Product descriptionEI1
  • Packaging10mM(in 1mL DMSO)
  • Price$130
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberB1021
  • Product descriptionEI1
  • Packaging10mg
  • Price$172
  • Updated2026-05-06
  • Buy
  • ManufacturerApexBio Technology
  • Product numberB1021
  • Product descriptionEI1
  • Packaging5mg
  • Price$107
  • Updated2026-05-06
  • Buy
  • ManufacturerApexBio Technology
  • Product numberB1021
  • Product descriptionEI1
  • Packaging10mM(in1mLDMSO)
  • Price$110
  • Updated2026-05-06
  • Buy
  • ManufacturerApexBio Technology
  • Product numberB1021
  • Product descriptionEI1
  • Packaging25mg
  • Price$361
  • Updated2026-05-06
  • Buy
  • ManufacturerApexBio Technology
  • Product numberB1021
  • Product descriptionEI1
  • Packaging100mg
  • Price$831
  • Updated2026-05-06
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
aablocks AA009C8H EI1 96% 10mg $46 2026-05-28 Buy
aablocks AA009C8H EI1 96% 1mg $16 2026-05-28 Buy
aablocks AA009C8H EI1 96% 5mg $33 2026-05-28 Buy
aablocks AA009C8H EI1 ≥96% 100mg $421 2026-05-28 Buy
ACHEMBLOCK S87310 EI1 98% 100MG $320 2026-05-27 Buy
ACHEMBLOCK S87310 EI1 98% 1G $1595 2026-05-27 Buy
Ambeed A163218 EI1 98+% 100mg $667 2021-12-16 Buy
Ambeed A163218 EI1 98+% 50mg $514 2021-12-16 Buy
Ambeed A163218 EI1 98+% 5mg $235 2021-12-16 Buy
Ambeed A163218 EI1 98+% 10mg $305 2021-12-16 Buy
ApexBio Technology B1021 EI1 10mM(in 1mL DMSO) $130 2021-12-16 Buy
ApexBio Technology B1021 EI1 10mg $172 2026-05-06 Buy
ApexBio Technology B1021 EI1 5mg $107 2026-05-06 Buy
ApexBio Technology B1021 EI1 10mM(in1mLDMSO) $110 2026-05-06 Buy
ApexBio Technology B1021 EI1 25mg $361 2026-05-06 Buy
ApexBio Technology B1021 EI1 100mg $831 2026-05-06 Buy
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Properties

Boiling point :675.9±55.0 °C(Predicted)
Density :1.20±0.1 g/cm3(Predicted)
storage temp. :Sealed in dry,Store in freezer, under -20°C
solubility :insoluble in H2O; insoluble in EtOH; ≥19.5 mg/mL in DMSO
form :Powder
pka :11.88±0.10(Predicted)
color :White to off-white
InChI :1S/C23H26N4O2/c1-5-17(6-2)27-8-7-18-19(10-16(12-24)11-21(18)27)22(28)25-13-20-14(3)9-15(4)26-23(20)29/h7-11,17H,5-6,13H2,1-4H3,(H,25,28)(H,26,29)
InChIKey :PFHDWRIVDDIFRP-UHFFFAOYSA-N
SMILES :[nH]1[c](c(c(cc1C)C)CNC(=O)c2c3c([n](cc3)C(CC)CC)cc(c2)C#N)=O

Safety Information

Symbol(GHS): Exclamation Mark (GHS07)
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning P264, P280, P305+P351+P338,P337+P313P
Precautionary statements:
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P264 Wash hands thoroughly after handling.
P264 Wash skin thouroughly after handling.
P270 Do not eat, drink or smoke when using this product.
P271 Use only outdoors or in a well-ventilated area.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P332+P313 IF SKIN irritation occurs: Get medical advice/attention.
P337+P313 IF eye irritation persists: Get medical advice/attention.
P501 Dispose of contents/container to..…

Description

The lysine methyltransferase EZH2 (KMT6), part of polycomb repressive complex 2 (PRC2), catalyzes trimethylation of lysine 27 on histone H3 (H3K27) and is involved in proliferation and aggressive cell growth associated with neoplastic cells. EI1 is an EZH2 inhibitor that has activity against both wild-type and Y641F mutant EZH2 (IC50s = 15 and 13 nM, respectively). It displays 90-fold selectivity for EZH2 over EZH1 and >10,000-fold over other lysine methyltransferases. EI1 blocks cellular H3K27 methylation and activates PRC2-specific gene expression. Inhibition of EZH2 by EI1 in diffused large B cell lymphoma cells carrying Y641 mutations results in decreased proliferation, cell cycle arrest, and apoptosis.

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Suppliers and manufacturers

Shaanxi Dideu Medichem Co. Ltd
EI1
EI1 CAS:1418308-27-6
BOC Sciences
TargetMol Chemicals Inc.
Aladdin Scientific
Amadis Chemical Company Limited Jiangsu Aikon Biopharmaceutical R&D co.,Ltd. Shanghai Aladdin Bio-Chem Technology Co.,LTD Sichuan Wei Keqi Biological Technology Co., Ltd. Shanghai Lollane Biological Technology Co.,Ltd. Hangzhou ChangCun Biotechnology Co., Ltd.