GDC-0032
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- $37 - $17576
- Product name: GDC-0032
- CAS: 1282512-48-4
- MF: C24H28N8O2
- MW: 460.53
- EINECS:
- MDL Number:MFCD26142641
- Synonyms:GDC-0032;RG7604/GDC-0032;4-[5,6-Dihydro-2-[3-methyl-1-(1-methylethyl)-1H-1,2,4-triazol-5-yl]imidazo[1,2-d][1,4]benzoxazepin-9-yl]-α,α-dimethyl-1H-pyrazole-1-acetamide;GDC-0032/(RG-7604);2-Methyl-2-[4-[2-(5-Methyl-2-propan-2-yl-1,2,4-triazol-3-yl)-5,6-dihydroiMidazo[1,2-d][1,4]benzoxazepin-9-yl]pyrazol-1-yl]propanaMide;Taselisib;4-[5,6-Dihydro-2-[3-methyl-1-(1-methylethyl)-1H-1,2,4-triazol-5-yl]imidazo[1,2-d][1,4]benzoxazepin-9-yl]-alpha,alpha-dimethyl-1H-pyrazole-1-acetamide;GDC-0032 4-[5,6-Dihydro-2-[3-methyl-1-(1-methylethyl)-1H-1,2,4-triazol-5-yl]imidazo[1,2-d][1,4]benzoxazepin-9-yl]-alpha,alpha-dimethyl-1H-pyrazole-1-acetamide
40 prices
Selected condition:
Brand
- Adipogen Life Sciences
- AK Scientific
- ApexBio Technology
- Axon Medchem
- Biorbyt Ltd
- Cayman Chemical
- ChemScene
- Crysdot
- DC Chemicals
- Matrix Scientific
- TRC
Package
- 2x5mg
- 200mg
- 250mg
- 10mM(in1mLDMSO)
- 1g
- 1000mg
- 10mM(in 1mL DMSO)
- 1mg
- 5mg
- 10mg
- 25mg
- 50mg
- 100mg
- ManufacturerAdipogen Life Sciences
- Product numberSYN-1202-M001
- Product descriptionGDC-0032 ≥95%
- Packaging1mg
- Price$86
- Updated2021-12-16
- Buy
- ManufacturerAdipogen Life Sciences
- Product numberSYN-1202-M001
- Product descriptionGDC-0032 ≥95%
- Packaging1mg
- Price$86
- Updated2026-05-06
- Buy
- ManufacturerAdipogen Life Sciences
- Product numberSYN-1202-M005
- Product descriptionGDC-0032 ≥95%
- Packaging5mg
- Price$130
- Updated2021-12-16
- Buy
- ManufacturerAdipogen Life Sciences
- Product numberSYN-1202-M005
- Product descriptionGDC-0032 ≥95%
- Packaging5mg
- Price$130
- Updated2026-05-06
- Buy
- ManufacturerAdipogen Life Sciences
- Product numberSYN-1202-M010
- Product descriptionGDC-0032 ≥95%
- Packaging10mg
- Price$216
- Updated2026-05-06
- Buy
- ManufacturerAdipogen Life Sciences
- Product numberSYN-1202-M050
- Product descriptionGDC-0032 ≥95%
- Packaging50mg
- Price$702
- Updated2026-05-06
- Buy
- ManufacturerAK Scientific
- Product number9344AF
- Product descriptionGDC-0032
- Packaging25mg
- Price$226
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberB1047
- Product descriptionGDC-0032
- Packaging25mg
- Price$233
- Updated2026-05-06
- Buy
- ManufacturerApexBio Technology
- Product numberB1047
- Product descriptionGDC-0032
- Packaging25mg
- Price$265
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberB1047
- Product descriptionGDC-0032
- Packaging100mg
- Price$584
- Updated2026-05-06
- Buy
- ManufacturerApexBio Technology
- Product numberB1047
- Product descriptionGDC-0032
- Packaging100mg
- Price$615
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberB1047
- Product descriptionGDC-0032
- Packaging10mg
- Price$142
- Updated2026-05-06
- Buy
- ManufacturerApexBio Technology
- Product numberB1047
- Product descriptionGDC-0032
- Packaging10mM(in 1mL DMSO)
- Price$109
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberB1047
- Product descriptionGDC-0032
- Packaging10mg
- Price$120
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberB1047
- Product descriptionGDC-0032
- Packaging10mM(in1mLDMSO)
- Price$88
- Updated2026-05-06
- Buy
- ManufacturerApexBio Technology
- Product numberB1047
- Product descriptionGDC-0032
- Packaging5mg
- Price$90
- Updated2026-05-06
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| Adipogen Life Sciences | SYN-1202-M001 | GDC-0032 ≥95% | 1mg | $86 | 2021-12-16 | Buy |
| Adipogen Life Sciences | SYN-1202-M001 | GDC-0032 ≥95% | 1mg | $86 | 2026-05-06 | Buy |
| Adipogen Life Sciences | SYN-1202-M005 | GDC-0032 ≥95% | 5mg | $130 | 2021-12-16 | Buy |
| Adipogen Life Sciences | SYN-1202-M005 | GDC-0032 ≥95% | 5mg | $130 | 2026-05-06 | Buy |
| Adipogen Life Sciences | SYN-1202-M010 | GDC-0032 ≥95% | 10mg | $216 | 2026-05-06 | Buy |
| Adipogen Life Sciences | SYN-1202-M050 | GDC-0032 ≥95% | 50mg | $702 | 2026-05-06 | Buy |
| AK Scientific | 9344AF | GDC-0032 | 25mg | $226 | 2021-12-16 | Buy |
| ApexBio Technology | B1047 | GDC-0032 | 25mg | $233 | 2026-05-06 | Buy |
| ApexBio Technology | B1047 | GDC-0032 | 25mg | $265 | 2021-12-16 | Buy |
| ApexBio Technology | B1047 | GDC-0032 | 100mg | $584 | 2026-05-06 | Buy |
| ApexBio Technology | B1047 | GDC-0032 | 100mg | $615 | 2021-12-16 | Buy |
| ApexBio Technology | B1047 | GDC-0032 | 10mg | $142 | 2026-05-06 | Buy |
| ApexBio Technology | B1047 | GDC-0032 | 10mM(in 1mL DMSO) | $109 | 2021-12-16 | Buy |
| ApexBio Technology | B1047 | GDC-0032 | 10mg | $120 | 2021-12-16 | Buy |
| ApexBio Technology | B1047 | GDC-0032 | 10mM(in1mLDMSO) | $88 | 2026-05-06 | Buy |
| ApexBio Technology | B1047 | GDC-0032 | 5mg | $90 | 2026-05-06 | Buy |
Properties
Boiling point :783.3±70.0 °C(Predicted)
Density :1.40±0.1 g/cm3(Predicted)
storage temp. :Store at -20°C
solubility :≥23.05 mg/mL in DMSO; insoluble in H2O; ≥2.79 mg/mL in EtOH with gentle warming
form :solid
pka :15.54±0.50(Predicted)
color :White to off-white
Density :1.40±0.1 g/cm3(Predicted)
storage temp. :Store at -20°C
solubility :≥23.05 mg/mL in DMSO; insoluble in H2O; ≥2.79 mg/mL in EtOH with gentle warming
form :solid
pka :15.54±0.50(Predicted)
color :White to off-white
Safety Information
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| Signal word: | Warning | ||||||||||||||||||||||||||||||
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Description
GDC-0032 is a potent inhibitor of phosphatidylinositol 3-kinase (PI3K) isoforms α, δ, and γ (IC50s = 0.28, 0.12, and 0.97 nM, respectively) that is 31 times less potent at PI3Kβ. It is over 1,000-fold selective for p100α over other PI3K-like kinases, including DNA-dependent protein kinase catalytic subunits, ATM, and ATR. GDC-0032 has increased potency in cancer cell lines harboring PIK3CA-activating alterations, and is effective in vivo, suppressing the growth of tumors in a mouse xenograft model at low drug dose levels.Related product price
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