GDC-0152
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- $18 - $2841
- Product name: GDC-0152
- CAS: 873652-48-3
- MF: C25H34N6O3S
- MW: 498.64
- EINECS:
- MDL Number:MFCD26142660
- Synonyms:GDC-0152;(S)-1-((S)-2-Cyclohexyl-2-((S)-2-(methylamino)propanamido)acetyl)-N-(4-phenyl-1,2,3-thiadiazol-5-yl)pyrrolidine-2-carboxamide;L-Prolinamide, N-methyl-L-alanyl-(2S)-2-cyclohexylglycyl-N-(4-phenyl-1,2,3-thiadiazol-5-yl)-;GDC0152;GDC 0152.;CS-2247;GDC-0152; GDC0152; GDC 0152.;GDC-0152 USP/EP/BP;GDC-0152,IAP,Inhibitor,inhibit,GDC 0152
45 prices
Selected condition：
Brand
- aablocks
- ACHEMBLOCK
- AK Scientific
- American Custom Chemicals Corporation
- ApexBio Technology
- Arctom
- Cayman Chemical
- ChemScene
- Crysdot
- DC Chemicals
- TRC
- Usbiological
Package
- 10mM*1mLinDMSO(Solid+Solvent)
- 1g
- 10mM(in1mLDMSO)
- 250mg
- 10mM(1mLinDMSO)
- 10mM*1mLinDMSO(Solution)
- 10mM(in 1mL DMSO)
- 1mg
- 5mg
- 10mg
- 25mg
- 50MG
- 100mg
- Manufactureraablocks
- Product numberAA00GU5Q
- Product descriptionGDC-0152 98+%
- Packaging10mg
- Price$54
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA00GU5Q
- Product descriptionGDC-0152 98+%
- Packaging1mg
- Price$18
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA00GU5Q
- Product descriptionGDC-0152 98+%
- Packaging5mg
- Price$37
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA00GU5Q
- Product descriptionGDC-0152 98
- Packaging100mg
- Price$460
- Updated2026-05-28
- Buy
- ManufacturerACHEMBLOCK
- Product numberX212225
- Product descriptionGDC-0152 97%
- Packaging50MG
- Price$440
- Updated2026-05-27
- Buy
- ManufacturerACHEMBLOCK
- Product numberX212225
- Product descriptionGDC-0152 97%
- Packaging100MG
- Price$655
- Updated2026-05-27
- Buy
- ManufacturerAK Scientific
- Product number2426AH
- Product descriptionGDC-0152
- Packaging10mg
- Price$290
- Updated2021-12-16
- Buy
- ManufacturerAK Scientific
- Product number2426AH
- Product descriptionGDC-0152
- Packaging25mg
- Price$528
- Updated2021-12-16
- Buy
- ManufacturerAmerican Custom Chemicals Corporation
- Product numberINB0004770
- Product descriptionN-METHYL-L-ALANYL-(2S)-2-CYCLOHEXYLGLYCYL-N-(4-PHENYL-1,2,3-THIADIAZOL-5-YL)-L-PROLINAMIDE 95.00%
- Packaging5MG
- Price$497.29
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA4224
- Product descriptionGDC-0152
- Packaging50mg
- Price$584
- Updated2026-05-06
- Buy
- ManufacturerApexBio Technology
- Product numberA4224
- Product descriptionGDC-0152
- Packaging10mM(in 1mL DMSO)
- Price$140
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA4224
- Product descriptionGDC-0152
- Packaging10mM(in1mLDMSO)
- Price$193
- Updated2026-05-06
- Buy
- ManufacturerApexBio Technology
- Product numberA4224
- Product descriptionGDC-0152
- Packaging10mg
- Price$194
- Updated2026-05-06
- Buy
- ManufacturerApexBio Technology
- Product numberA4224
- Product descriptionGDC-0152
- Packaging100mg
- Price$974
- Updated2026-05-06
- Buy
- ManufacturerArctom
- Product numberSLK-S7010
- Product descriptionGDC-0152 99.73%
- Packaging100mg
- Price$922
- Updated2026-05-26
- Buy
- ManufacturerArctom
- Product numberSLK-S7010
- Product descriptionGDC-0152 99.73%
- Packaging1g
- Price$2841
- Updated2026-05-26
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| aablocks | AA00GU5Q | GDC-0152 98+% | 10mg | $54 | 2026-05-28 | Buy |
| aablocks | AA00GU5Q | GDC-0152 98+% | 1mg | $18 | 2026-05-28 | Buy |
| aablocks | AA00GU5Q | GDC-0152 98+% | 5mg | $37 | 2026-05-28 | Buy |
| aablocks | AA00GU5Q | GDC-0152 98 | 100mg | $460 | 2026-05-28 | Buy |
| ACHEMBLOCK | X212225 | GDC-0152 97% | 50MG | $440 | 2026-05-27 | Buy |
| ACHEMBLOCK | X212225 | GDC-0152 97% | 100MG | $655 | 2026-05-27 | Buy |
| AK Scientific | 2426AH | GDC-0152 | 10mg | $290 | 2021-12-16 | Buy |
| AK Scientific | 2426AH | GDC-0152 | 25mg | $528 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | INB0004770 | N-METHYL-L-ALANYL-(2S)-2-CYCLOHEXYLGLYCYL-N-(4-PHENYL-1,2,3-THIADIAZOL-5-YL)-L-PROLINAMIDE 95.00% | 5MG | $497.29 | 2021-12-16 | Buy |
| ApexBio Technology | A4224 | GDC-0152 | 50mg | $584 | 2026-05-06 | Buy |
| ApexBio Technology | A4224 | GDC-0152 | 10mM(in 1mL DMSO) | $140 | 2021-12-16 | Buy |
| ApexBio Technology | A4224 | GDC-0152 | 10mM(in1mLDMSO) | $193 | 2026-05-06 | Buy |
| ApexBio Technology | A4224 | GDC-0152 | 10mg | $194 | 2026-05-06 | Buy |
| ApexBio Technology | A4224 | GDC-0152 | 100mg | $974 | 2026-05-06 | Buy |
| Arctom | SLK-S7010 | GDC-0152 99.73% | 100mg | $922 | 2026-05-26 | Buy |
| Arctom | SLK-S7010 | GDC-0152 99.73% | 1g | $2841 | 2026-05-26 | Buy |
Properties
Melting point :175-177oC
storage temp. :-20°C Freezer
solubility :DMSO (Slightly)
form :Solid
color :White
storage temp. :-20°C Freezer
solubility :DMSO (Slightly)
form :Solid
color :White
Safety Information
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Description
Inhibitor of apoptosis proteins (IAPs), which block various signaling pathways leading to apoptotic cell death, are commonly over-expressed in cancer cells. GDC-0152 is a potent inhibitor of specific IAPs that binds baculoviral IAP repeat (BIR) domains (Kis = 28, 14, 17, and 43 nM for XIAP BIR3, NL-IAP BIR, BIRC2 (c-IAP1) BIR3, and BIRC3 (c-IAP2) BIR3, respectively). GDC-0152 induces activation of caspases, decreasing the viability of cancer cells without affecting normal cells. It is orally bioavailable and suppresses tumor growth in breast cancer xenografts in mice. GDC-0152 also induces NF-κB transcriptional activity, resulting in the expression of several cytokines, including TNF-α. In dogs and rats, but not humans, this leads to a pronounced inflammatory response.More related product prices
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