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ChemicalBook >> CAS DataBase List >> GDC-0994

GDC-0994

GDC-0994 price.
  • $32 - $3500
  • Product name: GDC-0994
  • CAS: 1453848-26-4
  • MF: C21H18ClFN6O2
  • MW: 440.86
  • EINECS:
  • MDL Number:MFCD28143918
  • Synonyms:GDC-0994;(S)-1-(1-(4-chloro-3-fluorophenyl)-2-hydroxyethyl)-4-(2-((1-methyl-1H-pyrazol-5-yl)amino)pyrimidin-4-yl)pyridin-2(1H)-one GDC-0994;(S)-1-(1-(4-chloro-3-fluorophenyl)-2-hydroxyethyl)-4-(2-((1-methyl-1H-pyrazol-5-yl)amino)pyrimidin-4-yl)pyridin-2(1H)-one;1-[(1S)-1-(4-Chloro-3-fluorophenyl)-2-hydroxyethyl]-4-[2-[(1-methyl-1H-pyrazol-5-yl)amino]-4-pyrimidinyl]-2(1H)-pyridinone;Ravoxertinib;GDC 0994;GDC-0994;GDC0994;CS-1841;GDC-0994;RAVOXERTINIB
Price17 Properties Safety Information Description
17 prices
Selected condition：
Brand
  • AK Scientific
  • ApexBio Technology
  • Arctom
  • Cayman Chemical
  • Chemenu
  • ChemScene
  • Crysdot
  • DC Chemicals
  • TRC
Package
  • 500μg
  • 1mg
  • 2.5mg
  • 5mg
  • 10mg
  • 50mg
  • 100mg
  • 1g
  • ManufacturerAK Scientific
  • Product number2428AH
  • Product description(S)-1-(1-(4-Chloro-3-fluorophenyl)-2-hydroxyethyl)-4-(2-((1-methyl-1H-pyrazol-5-yl)amino)pyrimidin-4-yl)pyridin-2(1H)-one
  • Packaging1mg
  • Price$160
  • Updated2021-12-16
  • Buy
  • ManufacturerAK Scientific
  • Product number2428AH
  • Product description(S)-1-(1-(4-Chloro-3-fluorophenyl)-2-hydroxyethyl)-4-(2-((1-methyl-1H-pyrazol-5-yl)amino)pyrimidin-4-yl)pyridin-2(1H)-one
  • Packaging5mg
  • Price$353
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberB5817
  • Product descriptionGDC-0994
  • Packaging50mg
  • Price$500
  • Updated2021-12-16
  • Buy
  • ManufacturerArctom
  • Product numberCFN60296
  • Product descriptionRavoxertinib(GDC-0994)
  • Packaging10mg
  • Price$238
  • Updated2021-12-16
  • Buy
  • ManufacturerCayman Chemical
  • Product number21107
  • Product descriptionGDC-0994 ≥98%
  • Packaging500μg
  • Price$32
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number21107
  • Product descriptionGDC-0994 ≥98%
  • Packaging1mg
  • Price$57
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number21107
  • Product descriptionGDC-0994 ≥98%
  • Packaging5mg
  • Price$230
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number21107
  • Product descriptionGDC-0994 ≥98%
  • Packaging10mg
  • Price$426
  • Updated2024-03-01
  • Buy
  • ManufacturerChemenu
  • Product numberCM116161
  • Product description(S)-1-[1-(4-Chloro-3-fluorophenyl)-2-hydroxyethyl]-4-[2-[(1-methyl-5-pyrazolyl)amino]-4-pyrimidyl]-2(1H)-pyridone 98%
  • Packaging50mg
  • Price$491
  • Updated2021-12-16
  • Buy
  • ManufacturerChemScene
  • Product numberCS-3704
  • Product descriptionRavoxertinib 99.75%
  • Packaging5mg
  • Price$96
  • Updated2021-12-16
  • Buy
  • ManufacturerChemScene
  • Product numberCS-3704
  • Product descriptionRavoxertinib 99.75%
  • Packaging10mg
  • Price$120
  • Updated2021-12-16
  • Buy
  • ManufacturerChemScene
  • Product numberCS-3704
  • Product descriptionRavoxertinib 99.75%
  • Packaging50mg
  • Price$360
  • Updated2021-12-16
  • Buy
  • ManufacturerCrysdot
  • Product numberCD31003430
  • Product descriptionGDC-0994 98+%
  • Packaging10mg
  • Price$293
  • Updated2021-12-16
  • Buy
  • ManufacturerCrysdot
  • Product numberCD31003430
  • Product descriptionGDC-0994 98+%
  • Packaging50mg
  • Price$851
  • Updated2021-12-16
  • Buy
  • ManufacturerDC Chemicals
  • Product numberDC7766
  • Product descriptionRavoxertinib(GDC0994) >98%,eepurity:94%
  • Packaging100mg
  • Price$1000
  • Updated2021-12-16
  • Buy
  • ManufacturerDC Chemicals
  • Product numberDC7766
  • Product descriptionRavoxertinib(GDC0994) >98%,eepurity:94%
  • Packaging1g
  • Price$3500
  • Updated2021-12-16
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
AK Scientific 2428AH (S)-1-(1-(4-Chloro-3-fluorophenyl)-2-hydroxyethyl)-4-(2-((1-methyl-1H-pyrazol-5-yl)amino)pyrimidin-4-yl)pyridin-2(1H)-one 1mg $160 2021-12-16 Buy
AK Scientific 2428AH (S)-1-(1-(4-Chloro-3-fluorophenyl)-2-hydroxyethyl)-4-(2-((1-methyl-1H-pyrazol-5-yl)amino)pyrimidin-4-yl)pyridin-2(1H)-one 5mg $353 2021-12-16 Buy
ApexBio Technology B5817 GDC-0994 50mg $500 2021-12-16 Buy
Arctom CFN60296 Ravoxertinib(GDC-0994) 10mg $238 2021-12-16 Buy
Cayman Chemical 21107 GDC-0994 ≥98% 500μg $32 2024-03-01 Buy
Cayman Chemical 21107 GDC-0994 ≥98% 1mg $57 2024-03-01 Buy
Cayman Chemical 21107 GDC-0994 ≥98% 5mg $230 2024-03-01 Buy
Cayman Chemical 21107 GDC-0994 ≥98% 10mg $426 2024-03-01 Buy
Chemenu CM116161 (S)-1-[1-(4-Chloro-3-fluorophenyl)-2-hydroxyethyl]-4-[2-[(1-methyl-5-pyrazolyl)amino]-4-pyrimidyl]-2(1H)-pyridone 98% 50mg $491 2021-12-16 Buy
ChemScene CS-3704 Ravoxertinib 99.75% 5mg $96 2021-12-16 Buy
ChemScene CS-3704 Ravoxertinib 99.75% 10mg $120 2021-12-16 Buy
ChemScene CS-3704 Ravoxertinib 99.75% 50mg $360 2021-12-16 Buy
Crysdot CD31003430 GDC-0994 98+% 10mg $293 2021-12-16 Buy
Crysdot CD31003430 GDC-0994 98+% 50mg $851 2021-12-16 Buy
DC Chemicals DC7766 Ravoxertinib(GDC0994) >98%,eepurity:94% 100mg $1000 2021-12-16 Buy
DC Chemicals DC7766 Ravoxertinib(GDC0994) >98%,eepurity:94% 1g $3500 2021-12-16 Buy
Next Last

Properties

Boiling point :734.6±70.0 °C(Predicted)
Density :1.45±0.1 g/cm3(Predicted)
storage temp. :Store at -20°C
solubility :≥44.1 mg/mL in DMSO; insoluble in H2O; ≥19.2 mg/mL in EtOH
form :solid
pka :14.03±0.10(Predicted)

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H302 Harmful if swallowed Acute toxicity,oral Category 4 Warning GHS hazard pictograms P264, P270, P301+P312, P330, P501
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning GHS hazard pictograms P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning GHS hazard pictograms P264, P280, P305+P351+P338,P337+P313P
H335 May cause respiratory irritation Specific target organ toxicity, single exposure;Respiratory tract irritation Category 3 Warning GHS hazard pictograms
Precautionary statements:
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Description

GDC-0994 is a potent and selective ERK1 and ERK2 inhibitor with IC50 values of 6.1 and 4.1 nM, respectively. It inhibits ERK-dependent p90RSK serine 380 phosphorylation in PMA-stimulated HepG2 cells with an IC50 value of 12 nM. GDC-0994 inhibited growth of HCT116 human colorectal cancer xenograft tumors by 49%, 57%, and 80% at 30, 60, and 100 mg/kg, respectively, when administered orally once daily for 21 days.

Suppliers and manufacturers

career henan chemical co
GDC-0994
$2.00 /1KG
GDC-0994 CAS: 1453848-26-4
Nanjing ChemLin Chemical Industry Co., Ltd.
ATK CHEMICAL COMPANY LIMITED
Biochempartner
HaBo Hong Kong Co., Limited.
BOC Sciences
Allfluoro pharmaceutical co. ltd.
HANGZHOU CLAP TECHNOLOGY CO.,LTD
InvivoChem
TargetMol Chemicals Inc.