GSK583
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- $35 - $1800
- Product name: GSK583
- CAS: 1346547-00-9
- MF: C20H19FN4O2S
- MW: 398.45
- EINECS:-0
- MDL Number:MFCD30343846
- Synonyms:GSK583;SK583;6-[(1,1-Dimethylethyl)sulfonyl]-N-(5-fluoro-1H-indazol-3-yl)-4-quinolinamine;RIP2 kinase inhibitor 583;CS-2216;GSK583, >98%;GSK-583;GSK 583;4-Quinolinamine, 6-[(1,1-dimethylethyl)sulfonyl]-N-(5-fluoro-1H-indazol-3-yl)-
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Brand
- ACHEMBLOCK
- Ambeed
- Arctom
- AvaChem
- Biosynth
- Cayman Chemical
- Crysdot
- DC Chemicals
- Sigma-Aldrich
- Tocris
- TRC
Package
- 10mM*1mLinDMSO
- 10mM*1mLinDMSO(Solid+Solvent)
- 5MG
- 2mg
- 25
- 5
- 10mM*1mLinDMSO(Solution)
- 10mg
- 25MG
- 50mg
- 100MG
- 250mg
- 1G
- 5 mg
- 25 mg
- ManufacturerACHEMBLOCK
- Product numberO33801
- Product descriptionGSK583 98%
- Packaging5MG
- Price$35
- Updated2026-05-25
- Buy
- ManufacturerACHEMBLOCK
- Product numberO33801
- Product descriptionGSK583 98%
- Packaging5MG
- Price$35
- Updated2026-05-27
- Buy
- ManufacturerACHEMBLOCK
- Product numberO33801
- Product descriptionGSK583 98%
- Packaging25MG
- Price$95
- Updated2026-05-25
- Buy
- ManufacturerACHEMBLOCK
- Product numberO33801
- Product descriptionGSK583 98%
- Packaging25MG
- Price$95
- Updated2026-05-27
- Buy
- ManufacturerACHEMBLOCK
- Product numberO33801
- Product descriptionGSK583 98%
- Packaging100MG
- Price$275
- Updated2026-05-25
- Buy
- ManufacturerACHEMBLOCK
- Product numberO33801
- Product descriptionGSK583 98%
- Packaging100MG
- Price$275
- Updated2026-05-27
- Buy
- ManufacturerACHEMBLOCK
- Product numberO33801
- Product descriptionGSK583 98%
- Packaging1G
- Price$1105
- Updated2026-05-25
- Buy
- ManufacturerACHEMBLOCK
- Product numberO33801
- Product descriptionGSK583 98%
- Packaging1G
- Price$1105
- Updated2026-05-27
- Buy
- ManufacturerAmbeed
- Product numberA341470
- Product description6-(tert-Butylsulfonyl)-N-(5-fluoro-1H-indazol-3-yl)quinolin-4-amine 98+%
- Packaging25mg
- Price$155
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA341470
- Product description6-(tert-Butylsulfonyl)-N-(5-fluoro-1H-indazol-3-yl)quinolin-4-amine 98+%
- Packaging50mg
- Price$202
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA341470
- Product description6-(tert-Butylsulfonyl)-N-(5-fluoro-1H-indazol-3-yl)quinolin-4-amine 98+%
- Packaging5mg
- Price$91
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA341470
- Product description6-(tert-Butylsulfonyl)-N-(5-fluoro-1H-indazol-3-yl)quinolin-4-amine 98+%
- Packaging10mg
- Price$119
- Updated2021-12-16
- Buy
- ManufacturerArctom
- Product numberHY-100339
- Product descriptionGSK583 99.93%
- Packaging10mM*1mLinDMSO(Solution)
- Price$120
- Updated2026-05-26
- Buy
- ManufacturerArctom
- Product numberSLK-S8261
- Product descriptionGSK583 99.75%
- Packaging2mg
- Price$140
- Updated2026-05-26
- Buy
- ManufacturerArctom
- Product numberHY-100339
- Product descriptionGSK583 99.93%
- Packaging5mg
- Price$110
- Updated2026-05-26
- Buy
- ManufacturerArctom
- Product numberHY-100339
- Product descriptionGSK583 99.93%
- Packaging10mM*1mLinDMSO(Solid+Solvent)
- Price$114
- Updated2026-05-26
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| ACHEMBLOCK | O33801 | GSK583 98% | 5MG | $35 | 2026-05-25 | Buy |
| ACHEMBLOCK | O33801 | GSK583 98% | 5MG | $35 | 2026-05-27 | Buy |
| ACHEMBLOCK | O33801 | GSK583 98% | 25MG | $95 | 2026-05-25 | Buy |
| ACHEMBLOCK | O33801 | GSK583 98% | 25MG | $95 | 2026-05-27 | Buy |
| ACHEMBLOCK | O33801 | GSK583 98% | 100MG | $275 | 2026-05-25 | Buy |
| ACHEMBLOCK | O33801 | GSK583 98% | 100MG | $275 | 2026-05-27 | Buy |
| ACHEMBLOCK | O33801 | GSK583 98% | 1G | $1105 | 2026-05-25 | Buy |
| ACHEMBLOCK | O33801 | GSK583 98% | 1G | $1105 | 2026-05-27 | Buy |
| Ambeed | A341470 | 6-(tert-Butylsulfonyl)-N-(5-fluoro-1H-indazol-3-yl)quinolin-4-amine 98+% | 25mg | $155 | 2021-12-16 | Buy |
| Ambeed | A341470 | 6-(tert-Butylsulfonyl)-N-(5-fluoro-1H-indazol-3-yl)quinolin-4-amine 98+% | 50mg | $202 | 2021-12-16 | Buy |
| Ambeed | A341470 | 6-(tert-Butylsulfonyl)-N-(5-fluoro-1H-indazol-3-yl)quinolin-4-amine 98+% | 5mg | $91 | 2021-12-16 | Buy |
| Ambeed | A341470 | 6-(tert-Butylsulfonyl)-N-(5-fluoro-1H-indazol-3-yl)quinolin-4-amine 98+% | 10mg | $119 | 2021-12-16 | Buy |
| Arctom | HY-100339 | GSK583 99.93% | 10mM*1mLinDMSO(Solution) | $120 | 2026-05-26 | Buy |
| Arctom | SLK-S8261 | GSK583 99.75% | 2mg | $140 | 2026-05-26 | Buy |
| Arctom | HY-100339 | GSK583 99.93% | 5mg | $110 | 2026-05-26 | Buy |
| Arctom | HY-100339 | GSK583 99.93% | 10mM*1mLinDMSO(Solid+Solvent) | $114 | 2026-05-26 | Buy |
Properties
Boiling point :652.9±55.0 °C(Predicted)
Density :1.402±0.06 g/cm3(Predicted)
storage temp. :under inert gas (nitrogen or Argon) at 2–8 °C
solubility :Soluble in DMSO (up to at least 25 mg/ml).
form :solid
pka :12.59±0.40(Predicted)
color :Pale yellow
Stability :Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 1 month.
InChI :InChI=1S/C20H19FN4O2S/c1-20(2,3)28(26,27)13-5-7-16-14(11-13)17(8-9-22-16)23-19-15-10-12(21)4-6-18(15)24-25-19/h4-11H,1-3H3,(H2,22,23,24,25)
InChIKey :XLOGLWKOHPIJLV-UHFFFAOYSA-N
SMILES :N1C2C(=CC(S(C(C)(C)C)(=O)=O)=CC=2)C(NC2C3=C(NN=2)C=CC(F)=C3)=CC=1
Density :1.402±0.06 g/cm3(Predicted)
storage temp. :under inert gas (nitrogen or Argon) at 2–8 °C
solubility :Soluble in DMSO (up to at least 25 mg/ml).
form :solid
pka :12.59±0.40(Predicted)
color :Pale yellow
Stability :Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 1 month.
InChI :InChI=1S/C20H19FN4O2S/c1-20(2,3)28(26,27)13-5-7-16-14(11-13)17(8-9-22-16)23-19-15-10-12(21)4-6-18(15)24-25-19/h4-11H,1-3H3,(H2,22,23,24,25)
InChIKey :XLOGLWKOHPIJLV-UHFFFAOYSA-N
SMILES :N1C2C(=CC(S(C(C)(C)C)(=O)=O)=CC=2)C(NC2C3=C(NN=2)C=CC(F)=C3)=CC=1
Safety Information
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| Signal word: | Warning | |||||||||||||||||||||||||||||||||||
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Description
GSK583 (1346547-00-9) is a highly selective and potent inhibitor of RIP2 kinase, IC50= 5 nM human and IC50= 2 nM rat.1It also potently inhibits isolated RIP3 kinase (IC50= 5 nM) but is inactive against RIP3 in cellular assays due to a very low KM,ATP. GSK583 blocks NOD2 signaling by interfering with XIAP-RIP2 binding resulting in decreased cytokine and chemokine production.1,2Related product price
Suppliers and manufacturers
ATK CHEMICAL COMPANY LIMITED
BOC Sciences
HANGZHOU CLAP TECHNOLOGY CO.,LTD
Zhejiang J&C Biological Technology Co.,Limited
InvivoChem
TargetMol Chemicals Inc.
ShenZhen Trendseen Biological Technology Co.,Ltd.
Zibo Hangyu Biotechnology Development Co., Ltd
