GSK583
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- $35 - $11260
- Product name: GSK583
- CAS: 1346547-00-9
- MF: C20H19FN4O2S
- MW: 398.45
- EINECS:-0
- MDL Number:MFCD30343846
- Synonyms:GSK583;SK583;6-[(1,1-Dimethylethyl)sulfonyl]-N-(5-fluoro-1H-indazol-3-yl)-4-quinolinamine;RIP2 kinase inhibitor 583;CS-2216;GSK583, >98%;GSK-583;GSK 583;4-Quinolinamine, 6-[(1,1-dimethylethyl)sulfonyl]-N-(5-fluoro-1H-indazol-3-yl)-
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Brand
- aablocks
- ACHEMBLOCK
- Ambeed
- Arctom
- AvaChem
- Biosynth
- Cayman Chemical
- ChemScene
- Crysdot
- DC Chemicals
- Sigma-Aldrich
- Tocris
- TRC
Package
- 10mM*1mLinDMSO(Solid+Solvent)
- 10mM*1mLinDMSO
- 5MG
- 10mM*1mLinDMSO(Solution)
- 1mg
- 2mg
- 5
- 25
- 10mg
- 25mg
- 50mg
- 100mg
- 250mg
- 1000mg
- 1g
- 2000mg
- 5 mg
- 25 mg
- Manufactureraablocks
- Product numberAA009CK9
- Product description6-[(1,1-Dimethylethyl)sulfonyl]-N-(5-fluoro-1H-indazol-3-yl)-4-quinolinamine 98%
- Packaging1mg
- Price$36
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA009CK9
- Product description6-[(1,1-Dimethylethyl)sulfonyl]-N-(5-fluoro-1H-indazol-3-yl)-4-quinolinamine 98%
- Packaging2mg
- Price$47
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA009CK9
- Product description6-[(1,1-Dimethylethyl)sulfonyl]-N-(5-fluoro-1H-indazol-3-yl)-4-quinolinamine ≥98%
- Packaging10mg
- Price$49
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA009CK9
- Product description6-[(1,1-Dimethylethyl)sulfonyl]-N-(5-fluoro-1H-indazol-3-yl)-4-quinolinamine ≥98%
- Packaging25mg
- Price$115
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA009CK9
- Product description6-[(1,1-Dimethylethyl)sulfonyl]-N-(5-fluoro-1H-indazol-3-yl)-4-quinolinamine 98%
- Packaging50mg
- Price$194
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA009CK9
- Product description6-[(1,1-Dimethylethyl)sulfonyl]-N-(5-fluoro-1H-indazol-3-yl)-4-quinolinamine ≥98%
- Packaging100mg
- Price$376
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA009CK9
- Product description6-[(1,1-Dimethylethyl)sulfonyl]-N-(5-fluoro-1H-indazol-3-yl)-4-quinolinamine 98%
- Packaging250mg
- Price$913
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA009CK9
- Product description6-[(1,1-Dimethylethyl)sulfonyl]-N-(5-fluoro-1H-indazol-3-yl)-4-quinolinamine 98%
- Packaging1g
- Price$2192
- Updated2026-05-28
- Buy
- ManufacturerACHEMBLOCK
- Product numberO33801
- Product descriptionGSK583 98%
- Packaging1G
- Price$1105
- Updated2026-05-27
- Buy
- ManufacturerACHEMBLOCK
- Product numberO33801
- Product descriptionGSK583 98%
- Packaging5MG
- Price$35
- Updated2026-05-27
- Buy
- ManufacturerACHEMBLOCK
- Product numberO33801
- Product descriptionGSK583 98%
- Packaging100MG
- Price$275
- Updated2026-05-27
- Buy
- ManufacturerACHEMBLOCK
- Product numberO33801
- Product descriptionGSK583 98%
- Packaging25MG
- Price$95
- Updated2026-05-27
- Buy
- ManufacturerAmbeed
- Product numberA341470
- Product description6-(tert-Butylsulfonyl)-N-(5-fluoro-1H-indazol-3-yl)quinolin-4-amine 98+%
- Packaging10mg
- Price$119
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA341470
- Product description6-(tert-Butylsulfonyl)-N-(5-fluoro-1H-indazol-3-yl)quinolin-4-amine 98+%
- Packaging50mg
- Price$202
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA341470
- Product description6-(tert-Butylsulfonyl)-N-(5-fluoro-1H-indazol-3-yl)quinolin-4-amine 98+%
- Packaging5mg
- Price$91
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA341470
- Product description6-(tert-Butylsulfonyl)-N-(5-fluoro-1H-indazol-3-yl)quinolin-4-amine 98+%
- Packaging25mg
- Price$155
- Updated2021-12-16
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| aablocks | AA009CK9 | 6-[(1,1-Dimethylethyl)sulfonyl]-N-(5-fluoro-1H-indazol-3-yl)-4-quinolinamine 98% | 1mg | $36 | 2026-05-28 | Buy |
| aablocks | AA009CK9 | 6-[(1,1-Dimethylethyl)sulfonyl]-N-(5-fluoro-1H-indazol-3-yl)-4-quinolinamine 98% | 2mg | $47 | 2026-05-28 | Buy |
| aablocks | AA009CK9 | 6-[(1,1-Dimethylethyl)sulfonyl]-N-(5-fluoro-1H-indazol-3-yl)-4-quinolinamine ≥98% | 10mg | $49 | 2026-05-28 | Buy |
| aablocks | AA009CK9 | 6-[(1,1-Dimethylethyl)sulfonyl]-N-(5-fluoro-1H-indazol-3-yl)-4-quinolinamine ≥98% | 25mg | $115 | 2026-05-28 | Buy |
| aablocks | AA009CK9 | 6-[(1,1-Dimethylethyl)sulfonyl]-N-(5-fluoro-1H-indazol-3-yl)-4-quinolinamine 98% | 50mg | $194 | 2026-05-28 | Buy |
| aablocks | AA009CK9 | 6-[(1,1-Dimethylethyl)sulfonyl]-N-(5-fluoro-1H-indazol-3-yl)-4-quinolinamine ≥98% | 100mg | $376 | 2026-05-28 | Buy |
| aablocks | AA009CK9 | 6-[(1,1-Dimethylethyl)sulfonyl]-N-(5-fluoro-1H-indazol-3-yl)-4-quinolinamine 98% | 250mg | $913 | 2026-05-28 | Buy |
| aablocks | AA009CK9 | 6-[(1,1-Dimethylethyl)sulfonyl]-N-(5-fluoro-1H-indazol-3-yl)-4-quinolinamine 98% | 1g | $2192 | 2026-05-28 | Buy |
| ACHEMBLOCK | O33801 | GSK583 98% | 1G | $1105 | 2026-05-27 | Buy |
| ACHEMBLOCK | O33801 | GSK583 98% | 5MG | $35 | 2026-05-27 | Buy |
| ACHEMBLOCK | O33801 | GSK583 98% | 100MG | $275 | 2026-05-27 | Buy |
| ACHEMBLOCK | O33801 | GSK583 98% | 25MG | $95 | 2026-05-27 | Buy |
| Ambeed | A341470 | 6-(tert-Butylsulfonyl)-N-(5-fluoro-1H-indazol-3-yl)quinolin-4-amine 98+% | 10mg | $119 | 2021-12-16 | Buy |
| Ambeed | A341470 | 6-(tert-Butylsulfonyl)-N-(5-fluoro-1H-indazol-3-yl)quinolin-4-amine 98+% | 50mg | $202 | 2021-12-16 | Buy |
| Ambeed | A341470 | 6-(tert-Butylsulfonyl)-N-(5-fluoro-1H-indazol-3-yl)quinolin-4-amine 98+% | 5mg | $91 | 2021-12-16 | Buy |
| Ambeed | A341470 | 6-(tert-Butylsulfonyl)-N-(5-fluoro-1H-indazol-3-yl)quinolin-4-amine 98+% | 25mg | $155 | 2021-12-16 | Buy |
Properties
Boiling point :652.9±55.0 °C(Predicted)
Density :1.402±0.06 g/cm3(Predicted)
storage temp. :under inert gas (nitrogen or Argon) at 2–8 °C
solubility :Soluble in DMSO (up to at least 25 mg/ml).
form :solid
pka :12.59±0.40(Predicted)
color :Pale yellow
Stability :Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 1 month.
InChI :InChI=1S/C20H19FN4O2S/c1-20(2,3)28(26,27)13-5-7-16-14(11-13)17(8-9-22-16)23-19-15-10-12(21)4-6-18(15)24-25-19/h4-11H,1-3H3,(H2,22,23,24,25)
InChIKey :XLOGLWKOHPIJLV-UHFFFAOYSA-N
SMILES :N1C2C(=CC(S(C(C)(C)C)(=O)=O)=CC=2)C(NC2C3=C(NN=2)C=CC(F)=C3)=CC=1
Density :1.402±0.06 g/cm3(Predicted)
storage temp. :under inert gas (nitrogen or Argon) at 2–8 °C
solubility :Soluble in DMSO (up to at least 25 mg/ml).
form :solid
pka :12.59±0.40(Predicted)
color :Pale yellow
Stability :Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 1 month.
InChI :InChI=1S/C20H19FN4O2S/c1-20(2,3)28(26,27)13-5-7-16-14(11-13)17(8-9-22-16)23-19-15-10-12(21)4-6-18(15)24-25-19/h4-11H,1-3H3,(H2,22,23,24,25)
InChIKey :XLOGLWKOHPIJLV-UHFFFAOYSA-N
SMILES :N1C2C(=CC(S(C(C)(C)C)(=O)=O)=CC=2)C(NC2C3=C(NN=2)C=CC(F)=C3)=CC=1
Safety Information
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Description
GSK583 (1346547-00-9) is a highly selective and potent inhibitor of RIP2 kinase, IC50= 5 nM human and IC50= 2 nM rat.1It also potently inhibits isolated RIP3 kinase (IC50= 5 nM) but is inactive against RIP3 in cellular assays due to a very low KM,ATP. GSK583 blocks NOD2 signaling by interfering with XIAP-RIP2 binding resulting in decreased cytokine and chemokine production.1,2Related product price
Suppliers and manufacturers
Shanghai JiYi Biotechnology Co. Ltd.
Suzhou Ran enzyme Biotechnology Co., Ltd.
Jingmo (Xiamen) Biotechnology Co., Ltd
Shanghai Boyle Chemical Co., Ltd.
Dalian Meilun Biotech Co., Ltd.
Shanghai Topbiochem Technology Co., Ltd
Bide Pharmatech Ltd.
Hunan HuaTeng Pharmaceutical Co., Ltd.,
Shanghai Lollane Biological Technology Co.,Ltd.
Shanghai YuanYe Biotechnology Co., Ltd.