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ChemicalBook >> CAS DataBase List >> HG-9-91-01

HG-9-91-01

HG-9-91-01 price.
  • $65 - $1800
  • Product name: HG-9-91-01
  • CAS: 1456858-58-4
  • MF: C32H37N7O3
  • MW: 567.68
  • EINECS:-0
  • MDL Number:MFCD28167714
  • Synonyms:HG-9-91-01;N-(2,4-Dimethoxyphenyl)-N'-(2,6-dimethylphenyl)-N-[6-[[4-(4-methyl-1-piperazinyl)phenyl]amino]-4-pyrimidinyl]urea;1-(2,4-dimethoxyphenyl)-3-(2,6-dimethylphenyl)-1-(6-((4-(4-methylpiperazin-1-yl)phenyl)amino)pyrimidin-4-yl)urea;SIK INHIBITOR 1;1-(2,4-dimethoxyphenyl)-3-(2,6-dimethylphenyl)-1-[6-[4-(4-methylpiperazin-1-yl)anilino]pyrimidin-4-yl]urea;Urea, N-(2,4-dimethoxyphenyl)-N'-(2,6-dimethylphenyl)-N-[6-[[4-(4-methyl-1-piperazinyl)phenyl]amino]-4-pyrimidinyl]-;Salt-inducible Kinase (SIK),HG99101,SIK inhibitor-1,SIK inhibitor1,inhibit,HG 9 91 01,Inhibitor
Price22 Properties Safety Information Description
22 prices
Selected condition：
Brand
  • AK Scientific
  • ApexBio Technology
  • Axon Medchem
  • Cayman Chemical
  • Chemenu
  • ChemScene
  • Crysdot
  • DC Chemicals
Package
  • 500μg
  • 1mg
  • 2mg
  • 5mg
  • 2x5mg
  • 10mg
  • 25mg
  • 50mg
  • 100mg
  • 250mg
  • 1g
  • ManufacturerAK Scientific
  • Product number1537DY
  • Product descriptionCID78357808
  • Packaging1mg
  • Price$233
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberB1052
  • Product descriptionHG-9-91-01
  • Packaging2mg
  • Price$148
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberB1052
  • Product descriptionHG-9-91-01
  • Packaging5mg
  • Price$195
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberB1052
  • Product descriptionHG-9-91-01
  • Packaging10mg
  • Price$315
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberB1052
  • Product descriptionHG-9-91-01
  • Packaging50mg
  • Price$795
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberB1052
  • Product descriptionHG-9-91-01
  • Packaging100mg
  • Price$1237
  • Updated2021-12-16
  • Buy
  • ManufacturerAxon Medchem
  • Product numberAxon2311
  • Product descriptionHG-9-91-01 98%
  • Packaging2x5mg
  • Price$308
  • Updated2021-12-16
  • Buy
  • ManufacturerCayman Chemical
  • Product number19179
  • Product descriptionHG-9-91-01 ≥95%
  • Packaging500μg
  • Price$65
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number19179
  • Product descriptionHG-9-91-01 ≥95%
  • Packaging1mg
  • Price$121
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number19179
  • Product descriptionHG-9-91-01 ≥95%
  • Packaging5mg
  • Price$505
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number19179
  • Product descriptionHG-9-91-01 ≥95%
  • Packaging10mg
  • Price$884
  • Updated2024-03-01
  • Buy
  • ManufacturerChemenu
  • Product numberCM167729
  • Product description1-(2,4-dimethoxyphenyl)-3-(2,6-dimethylphenyl)-1-(6-((4-(4-methylpiperazin-1-yl)phenyl)amino)pyrimidin-4-yl)urea 98%
  • Packaging100mg
  • Price$810
  • Updated2021-12-16
  • Buy
  • ManufacturerChemScene
  • Product numberCS-1749
  • Product descriptionHG-9-91-01 98.02%
  • Packaging5mg
  • Price$286
  • Updated2021-12-16
  • Buy
  • ManufacturerChemScene
  • Product numberCS-1749
  • Product descriptionHG-9-91-01 98.02%
  • Packaging10mg
  • Price$433
  • Updated2021-12-16
  • Buy
  • ManufacturerChemScene
  • Product numberCS-1749
  • Product descriptionHG-9-91-01 98.02%
  • Packaging50mg
  • Price$880
  • Updated2021-12-16
  • Buy
  • ManufacturerChemScene
  • Product numberCS-1749
  • Product descriptionHG-9-91-01 98.02%
  • Packaging100mg
  • Price$1360
  • Updated2021-12-16
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
AK Scientific 1537DY CID78357808 1mg $233 2021-12-16 Buy
ApexBio Technology B1052 HG-9-91-01 2mg $148 2021-12-16 Buy
ApexBio Technology B1052 HG-9-91-01 5mg $195 2021-12-16 Buy
ApexBio Technology B1052 HG-9-91-01 10mg $315 2021-12-16 Buy
ApexBio Technology B1052 HG-9-91-01 50mg $795 2021-12-16 Buy
ApexBio Technology B1052 HG-9-91-01 100mg $1237 2021-12-16 Buy
Axon Medchem Axon2311 HG-9-91-01 98% 2x5mg $308 2021-12-16 Buy
Cayman Chemical 19179 HG-9-91-01 ≥95% 500μg $65 2024-03-01 Buy
Cayman Chemical 19179 HG-9-91-01 ≥95% 1mg $121 2024-03-01 Buy
Cayman Chemical 19179 HG-9-91-01 ≥95% 5mg $505 2024-03-01 Buy
Cayman Chemical 19179 HG-9-91-01 ≥95% 10mg $884 2024-03-01 Buy
Chemenu CM167729 1-(2,4-dimethoxyphenyl)-3-(2,6-dimethylphenyl)-1-(6-((4-(4-methylpiperazin-1-yl)phenyl)amino)pyrimidin-4-yl)urea 98% 100mg $810 2021-12-16 Buy
ChemScene CS-1749 HG-9-91-01 98.02% 5mg $286 2021-12-16 Buy
ChemScene CS-1749 HG-9-91-01 98.02% 10mg $433 2021-12-16 Buy
ChemScene CS-1749 HG-9-91-01 98.02% 50mg $880 2021-12-16 Buy
ChemScene CS-1749 HG-9-91-01 98.02% 100mg $1360 2021-12-16 Buy
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Properties

Boiling point :790.8±60.0 °C(Predicted)
Density :1.257±0.06 g/cm3(Predicted)
storage temp. :Store at -20°C
solubility :≥56.8 mg/mL in DMSO; ≥27.3 mg/mL in EtOH; ≥6.35 mg/mL in H2O with ultrasonic
form :Powder
pka :13.11±0.70(Predicted)

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H302 Harmful if swallowed Acute toxicity,oral Category 4 Warning GHS hazard pictograms P264, P270, P301+P312, P330, P501
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning GHS hazard pictograms P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning GHS hazard pictograms P264, P280, P305+P351+P338,P337+P313P
H335 May cause respiratory irritation Specific target organ toxicity, single exposure;Respiratory tract irritation Category 3 Warning GHS hazard pictograms
Precautionary statements:
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Description

HG-9-91-01 is an inhibitor of salt-inducible kinases (SIKs; IC50s = 0.92, 6.6, and 9.6 nM for SIK1, SIK2, and SIK3, respectively). It also inhibits Src, Lck, Yes, and BTK, as well as FGF and Ephrin receptors. HG-9-91-01 increases LPS-stimulated IL-10 production and suppresses pro-inflammatory cytokine secretion in bone marrow-derived macrophages. SIK inhibitors, including HG-9-91-01, enhance CREB-dependent gene transcription and IL-10 production in bone marrow-derived dendritic cells, THP-1 cells, and human primary macrophages.

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