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ChemicalBook >> CAS DataBase List >> Harpagoside

Harpagoside

Harpagoside price.
  • $116 - $179
  • Product name: Harpagoside
  • CAS: 19210-12-9
  • MF: C24H30O11
  • MW: 494.49
  • EINECS:242-881-6
  • MDL Number:MFCD00017415
  • Synonyms:(1S-(1alpha,4Aalpha,5alpha,7alpha(E),7aalpha))-1,4A,5,6,7,7A-hexahydro-4A,5-dihydroxy-7-methyl-7-((allyl-1-oxo-3-phenyl)oxy)cyclopenta(C)pyran-1-yl-beta-D-glucopyranoside;Einecs 242-881-6;HARPAGOSIDE(P);Harpagoside ,98%;Devil s Claw,grapple plant,wood spider;Harpa;side;Harpagoside, 98%, from Harpagophytum procumbens D.C.
2 prices
Selected condition:

Brand

  • Sigma-Aldrich

Package

  • y0000673
  • 10mg
  • ManufacturerSigma-Aldrich
  • Product number68527
  • Product descriptionHarpagoside analytical standard
  • Packaging10mg
  • Price$116
  • Updated2018-11-20
  • Buy
  • ManufacturerSigma-Aldrich
  • Product numberY0000673
  • Product descriptionHarpagoside European Pharmacopoeia (EP) Reference Standard
  • Packagingy0000673
  • Price$179
  • Updated2018-11-23
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
Sigma-Aldrich 68527 Harpagoside analytical standard 10mg $116 2018-11-20 Buy
Sigma-Aldrich Y0000673 Harpagoside European Pharmacopoeia (EP) Reference Standard y0000673 $179 2018-11-23 Buy

Properties

Melting point: :120°C (dec.)
storage temp.  :2-8°C
form  :neat
CAS DataBase Reference :19210-12-9(CAS DataBase Reference)

Safety Information

Symbol(GHS):
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H302 Harmful if swallowed Acute toxicity,oral Category 4 Warning P264, P270, P301+P312, P330, P501
Precautionary statements:

Description

Harpagoside is an anti-inflammatory small molecule natural product originally isolated from the Harpagophytum procumbens (Devil’s Claw) root, but can be isolated from other plants such as Crophularia ningpoensis Hemsl (Figwort). Treatment of HepG2 cells with Harpagoside demonstrated suppression of NF-κB nuclear translocation and degradation of IκB-α, blocking NF-κB activation. Multiple anti-inflammatory cellular effects were correlated with this blockade, as Harpagoside was observed to inhibit the expression of inflammation-mediating enzymes cyclooxygenase-2 (COX-2) and inducible nitric oxide synthase (iNOS), and to reduce lipopolysaccharide-induced mRNA levels. The suppression of NF-κB activation is indicated as the mechanism beneath the anti-inflammatory effects of Harpagoside.

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