Hh-Ag 1.3
                                         
                                        
                                     | 
                                
- $117 - $1060
 - Product name: Hh-Ag 1.3
 - CAS: 364590-63-6
 - MF: C28H28ClN3OS
 - MW: 490.06
 - EINECS:-0
 - MDL Number:MFCD14636155
 - Synonyms:3-Chloro-N-[4-(methylamino)cyclohexyl]-N-[[3-(4-pyridinyl)phenyl]methyl]-benzo[b]thiophene-2-carboxamide;Smoothened Agonist, HCl;SAG . dihydrochloride (water soluble);Hh-Ag 1.3;3-chloro-N-[4-(methylamino)cyclohexyl]-N-[(3-pyridin-4-ylphenyl)methyl]-1-benzothiophene-2-carboxamide,hydrate,dihydrochloride;Benzo[b]thiophene-2-carboxamide, 3-chloro-N-[4-(methylamino)cyclohexyl]-N-[[3-(4-pyridinyl)phenyl]methyl]-;Frizzled6 agonist SAG1.3;(Rac)-SAG
 
2 prices
                Selected condition:
                            Brand
                                - Sigma-Aldrich
 
Package
                                    
                                - 1mg
 - 5mg
 
- ManufacturerSigma-Aldrich
 - Product number566660
 - Product descriptionSmoothened Agonist, SAG - CAS 364590-63-6 - Calbiochem
 - Packaging1mg
 - Price$371
 - Updated2025-07-31
 - Buy
 
- ManufacturerSigma-Aldrich
 - Product number566660
 - Product descriptionSmoothened Agonist, SAG - CAS 364590-63-6 - Calbiochem
 - Packaging5mg
 - Price$1060
 - Updated2025-07-31
 - Buy
 
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy | 
|---|---|---|---|---|---|---|
| Sigma-Aldrich | 566660 | Smoothened Agonist, SAG - CAS 364590-63-6 - Calbiochem | 1mg | $371 | 2025-07-31 | Buy | 
| Sigma-Aldrich | 566660 | Smoothened Agonist, SAG - CAS 364590-63-6 - Calbiochem | 5mg | $1060 | 2025-07-31 | Buy | 
Properties
                        
                        Boiling point :688.6±55.0 °C(Predicted)
Density :1.30±0.1 g/cm3(Predicted)
storage temp. :2-8°C
solubility :DMSO: 10mg/mL
water: 25mg/mL form :White to off-white solid.
pka :10?+-.0.40(Predicted)
color :light yellow
Water Solubility :Soluble in water.
Sensitive :Light Sensitive & Hygroscopic
                        
                    
                Density :1.30±0.1 g/cm3(Predicted)
storage temp. :2-8°C
solubility :DMSO: 10mg/mL
water: 25mg/mL form :White to off-white solid.
pka :10?+-.0.40(Predicted)
color :light yellow
Water Solubility :Soluble in water.
Sensitive :Light Sensitive & Hygroscopic
Safety Information
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Description
Smoothened Agonist, HCl (SAG), is a highly potent activator of Smo (smoothened). This chlorobenzothiophene compound is a hedgehog pathway agonist that interacts with the heptahelical domain of Smo. SAG is shown to act as an activator at low concentrations, but can inhibit Smo coupling at very high concentrations. The activating effects of SAG will counteract Cyclopamine or Cyclopamine-KAAD inhibition of Smo.Related product price
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