ICILIN
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- $13 - $1200
- Product name: ICILIN
- CAS: 36945-98-9
- MF: C16H13N3O4
- MW: 311.29
- EINECS:
- MDL Number:MFCD01689072
- Synonyms:ICILIN;3,6-DIHYDRO-1-(2-HYDROXYPHENYL)-4-(3-NITROPHENYL)-2(1H)-PYRIMIDINONE;3,4-DIHYDRO-3-(2-HYDROXYPHENYL)-6-(3-NITROPHENYL)-(1H)-PYRIMIDIN-2-ONE;1-(2-HYDROXYPHENYL)-4-(3-NITROPHENYL)-1,2,3,6-TETRAHYDROPYRIMIDIN-2-ONE;1-(2-hydroxyphenyl)-4-(3-nitrophenyl)-1,2,3,6-tetrahydropyrimidine-2-one ;3,6-dihydro-1-(2-hydroxyphenyl)-4-(3-nitrophenyl)-2(1h)-pyrimidinon ;Iciline;AG-3-5, 1-(2-Hydroxyphenyl)-4-(3-nitrophenyl)-1,2,3,6-tetrahydropyrimidin-2-one
66 prices
Selected condition：
Brand
- aablocks
- ACHEMBLOCK
- AK Scientific
- Ambeed
- ApexBio Technology
- Arctom
- AvaChem
- Biorbyt Ltd
- Biosynth
- Cayman Chemical
- Chemenu
- ChemScene
- Crysdot
- CSNpharm
- DC Chemicals
- Sigma-Aldrich
- Thermo Scientific Chemicals
- Tocris
- TRC
- Usbiological
Package
- 10mM(in 1mL DMSO)
- 1mg
- 50
- 5mg
- 10mg
- 25mg
- 10
- 50mg
- 100mg
- 250mg
- 500mg
- 1g
- 10mM(in1mLDMSO)
- Manufactureraablocks
- Product numberAA00BZ7J
- Product descriptionIcilin 99%
- Packaging1mg
- Price$13
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA00BZ7J
- Product descriptionIcilin 99%
- Packaging5mg
- Price$22
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA00BZ7J
- Product descriptionIcilin 99%
- Packaging10mg
- Price$36
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA00BZ7J
- Product descriptionIcilin 99%
- Packaging25mg
- Price$49
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA00BZ7J
- Product descriptionIcilin 99%
- Packaging50mg
- Price$63
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA00BZ7J
- Product descriptionIcilin 99%
- Packaging100mg
- Price$107
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA00BZ7J
- Product descriptionIcilin 97%
- Packaging250mg
- Price$229
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA00BZ7J
- Product descriptionIcilin 97%
- Packaging1g
- Price$507
- Updated2026-05-28
- Buy
- ManufacturerACHEMBLOCK
- Product numberO33963
- Product descriptionICILIN 98%
- Packaging250MG
- Price$260
- Updated2026-05-27
- Buy
- ManufacturerACHEMBLOCK
- Product numberO33963
- Product descriptionICILIN 98%
- Packaging100MG
- Price$130
- Updated2026-05-27
- Buy
- ManufacturerAK Scientific
- Product number1796AH
- Product descriptionICILIN
- Packaging1g
- Price$651
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA881912
- Product descriptionIcilin 97%
- Packaging10mg
- Price$42
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA881912
- Product descriptionIcilin 97%
- Packaging50mg
- Price$72
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberB1055
- Product descriptionIcilin
- Packaging10mM(in1mLDMSO)
- Price$72
- Updated2026-05-06
- Buy
- ManufacturerApexBio Technology
- Product numberB1055
- Product descriptionIcilin
- Packaging10mg
- Price$62
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberB1055
- Product descriptionIcilin
- Packaging10mM(in 1mL DMSO)
- Price$50
- Updated2021-12-16
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| aablocks | AA00BZ7J | Icilin 99% | 1mg | $13 | 2026-05-28 | Buy |
| aablocks | AA00BZ7J | Icilin 99% | 5mg | $22 | 2026-05-28 | Buy |
| aablocks | AA00BZ7J | Icilin 99% | 10mg | $36 | 2026-05-28 | Buy |
| aablocks | AA00BZ7J | Icilin 99% | 25mg | $49 | 2026-05-28 | Buy |
| aablocks | AA00BZ7J | Icilin 99% | 50mg | $63 | 2026-05-28 | Buy |
| aablocks | AA00BZ7J | Icilin 99% | 100mg | $107 | 2026-05-28 | Buy |
| aablocks | AA00BZ7J | Icilin 97% | 250mg | $229 | 2026-05-28 | Buy |
| aablocks | AA00BZ7J | Icilin 97% | 1g | $507 | 2026-05-28 | Buy |
| ACHEMBLOCK | O33963 | ICILIN 98% | 250MG | $260 | 2026-05-27 | Buy |
| ACHEMBLOCK | O33963 | ICILIN 98% | 100MG | $130 | 2026-05-27 | Buy |
| AK Scientific | 1796AH | ICILIN | 1g | $651 | 2021-12-16 | Buy |
| Ambeed | A881912 | Icilin 97% | 10mg | $42 | 2021-12-16 | Buy |
| Ambeed | A881912 | Icilin 97% | 50mg | $72 | 2021-12-16 | Buy |
| ApexBio Technology | B1055 | Icilin | 10mM(in1mLDMSO) | $72 | 2026-05-06 | Buy |
| ApexBio Technology | B1055 | Icilin | 10mg | $62 | 2021-12-16 | Buy |
| ApexBio Technology | B1055 | Icilin | 10mM(in 1mL DMSO) | $50 | 2021-12-16 | Buy |
Properties
Boiling point :594.8±50.0 °C(Predicted)
Density :1.415±0.06 g/cm3(Predicted)
storage temp. :Inert atmosphere,Room Temperature
solubility :DMSO: 15 mg/mL, soluble
form :solid
pka :9.94±0.35(Predicted)
color :yellow
Stability :Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months.
InChI :InChI=1S/C16H13N3O4/c20-15-7-2-1-6-14(15)18-9-8-13(17-16(18)21)11-4-3-5-12(10-11)19(22)23/h1-8,10,20H,9H2,(H,17,21)
InChIKey :RCEFMOGVOYEGJN-UHFFFAOYSA-N
SMILES :C1(=O)N(C2=CC=CC=C2O)CC=C(C2=CC=CC([N+]([O-])=O)=C2)N1
Density :1.415±0.06 g/cm3(Predicted)
storage temp. :Inert atmosphere,Room Temperature
solubility :DMSO: 15 mg/mL, soluble
form :solid
pka :9.94±0.35(Predicted)
color :yellow
Stability :Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months.
InChI :InChI=1S/C16H13N3O4/c20-15-7-2-1-6-14(15)18-9-8-13(17-16(18)21)11-4-3-5-12(10-11)19(22)23/h1-8,10,20H,9H2,(H,17,21)
InChIKey :RCEFMOGVOYEGJN-UHFFFAOYSA-N
SMILES :C1(=O)N(C2=CC=CC=C2O)CC=C(C2=CC=CC([N+]([O-])=O)=C2)N1
Safety Information
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| Signal word: | Warning | ||||||||||||||||||||||||||||
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Description
Nociceptive sensory peripheral neurons often express both heat sensitive (VR1) and cold-sensitive (CMR1 (rat); TRPM8 (human)) receptors that are part of the transient receptor potential (TRP) superfamily. Icilin (AG 3-5) is a synthetic CMR1/TRPM8 super agonist that is 2.5-fold more efficacious and nearly 200-fold more potent than the reference cold thermosensory agonist, l-menthol. Icilin induces sensations of intense cold when applied orally in humans, and induces 'wet dog shakes', a behavioral marker of cold sensation, when given to rats. Icilin should serve as the reference cold nociceptive agonist for TRP-type ion channels in the future.Related product price
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