JZL 195
|
- $10 - $1200
- Product name: JZL 195
- CAS: 1210004-12-8
- MF: C24H23N3O5
- MW: 433.46
- EINECS:
- MDL Number:MFCD18382122
- Synonyms:JZL 195;4-nitrophenyl 4-(3-phenoxybenzyl)piperazine-1-carboxylate;4-[(3-Phenoxyphenyl)methyl]-1-piperazinecarboxylic acid 4-nitrophenyl ester;CS-1586;JZL-195;JZL 195;JZL195;1-Piperazinecarboxylic acid, 4-[(3-phenoxyphenyl)methyl]-, 4-nitrophenyl ester;4-Nitrophenyl 4-[(3-phenoxyphenyl)methyl]-1-piperazinecarboxylate;Autophagy,Monoacylglycerol lipase,inhibit,MAGL,Fatty acid amide hydrolase,JZL-195,JZL195,Inhibitor,FAAH,JZL 195
48 prices
Selected condition：
Brand
- aablocks
- ACHEMBLOCK
- AK Scientific
- ApexBio Technology
- Arctom
- Biorbyt Ltd
- Cayman Chemical
- Chemenu
- ChemScene
- Crysdot
- DC Chemicals
- Sigma-Aldrich
- Tocris
- Usbiological
Package
- 50
- 5mg
- 10mg
- 10
- 25mg
- 50mg
- 100mg
- 250MG
- 10mM*1mLinDMSO(Solution)
- 1G
- 10mM*1mLinDMSO(Solid+Solvent)
- Manufactureraablocks
- Product numberAA008SP9
- Product descriptionJZL 195 ≥98%
- Packaging5mg
- Price$10
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA008SP9
- Product descriptionJZL 195 ≥98%
- Packaging10mg
- Price$16
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA008SP9
- Product descriptionJZL 195 ≥98%
- Packaging25mg
- Price$35
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA008SP9
- Product descriptionJZL 195 ≥98%
- Packaging50mg
- Price$62
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA008SP9
- Product descriptionJZL 195 98%
- Packaging100mg
- Price$97
- Updated2026-05-28
- Buy
- ManufacturerACHEMBLOCK
- Product numberY232565
- Product descriptionJZL195 98%
- Packaging1G
- Price$540
- Updated2026-05-27
- Buy
- ManufacturerACHEMBLOCK
- Product numberY232565
- Product descriptionJZL195 98%
- Packaging250MG
- Price$180
- Updated2026-05-27
- Buy
- ManufacturerACHEMBLOCK
- Product numberY232565
- Product descriptionJZL195 98%
- Packaging100MG
- Price$110
- Updated2026-05-27
- Buy
- ManufacturerAK Scientific
- Product number3756AH
- Product description4-Nitrophenyl4-(3-phenoxybenzyl)piperazine-1-carboxylate
- Packaging10mg
- Price$222
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberB7701
- Product descriptionJZL 195
- Packaging50mg
- Price$411
- Updated2026-05-06
- Buy
- ManufacturerApexBio Technology
- Product numberB7701
- Product descriptionJZL 195
- Packaging10mg
- Price$111
- Updated2026-05-06
- Buy
- ManufacturerApexBio Technology
- Product numberB7701
- Product descriptionJZL 195
- Packaging5mg
- Price$71
- Updated2026-05-06
- Buy
- ManufacturerApexBio Technology
- Product numberB7701
- Product descriptionJZL 195
- Packaging100mg
- Price$658
- Updated2026-05-06
- Buy
- ManufacturerArctom
- Product numberHY-15250
- Product descriptionJZL195 99.75%
- Packaging10mg
- Price$78
- Updated2026-05-26
- Buy
- ManufacturerArctom
- Product numberHY-15250
- Product descriptionJZL195 99.75%
- Packaging5mg
- Price$48
- Updated2026-05-26
- Buy
- ManufacturerArctom
- Product numberHY-15250
- Product descriptionJZL195 99.75%
- Packaging10mM*1mLinDMSO(Solid+Solvent)
- Price$50
- Updated2026-05-26
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| aablocks | AA008SP9 | JZL 195 ≥98% | 5mg | $10 | 2026-05-28 | Buy |
| aablocks | AA008SP9 | JZL 195 ≥98% | 10mg | $16 | 2026-05-28 | Buy |
| aablocks | AA008SP9 | JZL 195 ≥98% | 25mg | $35 | 2026-05-28 | Buy |
| aablocks | AA008SP9 | JZL 195 ≥98% | 50mg | $62 | 2026-05-28 | Buy |
| aablocks | AA008SP9 | JZL 195 98% | 100mg | $97 | 2026-05-28 | Buy |
| ACHEMBLOCK | Y232565 | JZL195 98% | 1G | $540 | 2026-05-27 | Buy |
| ACHEMBLOCK | Y232565 | JZL195 98% | 250MG | $180 | 2026-05-27 | Buy |
| ACHEMBLOCK | Y232565 | JZL195 98% | 100MG | $110 | 2026-05-27 | Buy |
| AK Scientific | 3756AH | 4-Nitrophenyl4-(3-phenoxybenzyl)piperazine-1-carboxylate | 10mg | $222 | 2021-12-16 | Buy |
| ApexBio Technology | B7701 | JZL 195 | 50mg | $411 | 2026-05-06 | Buy |
| ApexBio Technology | B7701 | JZL 195 | 10mg | $111 | 2026-05-06 | Buy |
| ApexBio Technology | B7701 | JZL 195 | 5mg | $71 | 2026-05-06 | Buy |
| ApexBio Technology | B7701 | JZL 195 | 100mg | $658 | 2026-05-06 | Buy |
| Arctom | HY-15250 | JZL195 99.75% | 10mg | $78 | 2026-05-26 | Buy |
| Arctom | HY-15250 | JZL195 99.75% | 5mg | $48 | 2026-05-26 | Buy |
| Arctom | HY-15250 | JZL195 99.75% | 10mM*1mLinDMSO(Solid+Solvent) | $50 | 2026-05-26 | Buy |
Properties
Boiling point :581.8±50.0 °C(Predicted)
Density :1.303±0.06 g/cm3(Predicted)
storage temp. :Sealed in dry,Store in freezer, under -20°C
solubility :DMSO: ≥5mg/mL at warmed
pka :6.13±0.10(Predicted)
form :powder
color :white to beige
InChI :1S/C24H23N3O5/c28-24(32-22-11-9-20(10-12-22)27(29)30)26-15-13-25(14-16-26)18-19-5-4-8-23(17-19)31-21-6-2-1-3-7-21/h1-12,17H,13-16,18H2
InChIKey :QNYRAEKLMNDRFY-UHFFFAOYSA-N
SMILES :[O-][N+](=O)c1ccc(OC(=O)N2CCN(CC2)Cc3cccc(Oc4ccccc4)c3)cc1
Density :1.303±0.06 g/cm3(Predicted)
storage temp. :Sealed in dry,Store in freezer, under -20°C
solubility :DMSO: ≥5mg/mL at warmed
pka :6.13±0.10(Predicted)
form :powder
color :white to beige
InChI :1S/C24H23N3O5/c28-24(32-22-11-9-20(10-12-22)27(29)30)26-15-13-25(14-16-26)18-19-5-4-8-23(17-19)31-21-6-2-1-3-7-21/h1-12,17H,13-16,18H2
InChIKey :QNYRAEKLMNDRFY-UHFFFAOYSA-N
SMILES :[O-][N+](=O)c1ccc(OC(=O)N2CCN(CC2)Cc3cccc(Oc4ccccc4)c3)cc1
Safety Information
| Symbol(GHS): |
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| Signal word: | Warning | ||||||||||||||
| Hazard statements: |
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| Precautionary statements: |
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Description
Fatty acid amide hydrolase (FAAH) and monoacylglycerol lipase (MAGL) mediate the hydrolysis of the endocannabinoids arachidonoyl ethanolamide (AEA) and 2-arachidonoylglycerol (2-AG), respectively. JZL 195 is a potent inhibitor of both FAAH and MAGL (IC50 = 2 and 4 nM, respectively). It poorly inhibits neuropathy target esterase and ABHD6 and does not inhibit other brain serine hydrolases. JZL 195 displays time-dependent inhibition of FAAH and MAGL in vivo, consistent with a covalent mechanism of activation. The in vivo inhibitory actions of JZL 195 against FAAH and MAGL are comparable to those of the selective inhibitors PF-3845 and JZL 184 , respectively. Through its inhibitory actions, JZL 195 simultaneously augments brain levels of AEA and 2-AG, producing antinociceptive, cataleptic, and hypomotility effects like those produced by direct CB1 agonists.Related product price
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