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ChemicalBook >> CAS DataBase List >> K-252A

K-252A

K-252A price.
  • $50 - $3800
  • Product name: K-252A
  • CAS: 99533-80-9
  • MF: C27H21N3O5
  • MW: 467.47
  • EINECS:640-127-4
  • MDL Number:MFCD09878276
  • Synonyms:(9-alpha,10-beta,12-alpha)-este ;[9S,(+)]-2,3,9,10,11,12-Hexahydro-10α-hydroxy-9-methyl-1-oxo-9β,12β-epoxy-1H-diindolo[1,2,3-fg:3',2',1'-kl]pyrrolo[3,4-i][1,6]benzodiazocine-10-carboxylic acid methyl ester;9,12-Epoxy-1H-diindolo(1,2,3-fg:3',2',1'-kl)pyrrolo(3,4-I)(1,6)benzodiazocine-10-carboxylic acid, 2,3,9,10,11,12-hexahydro-10-hydroxy-9-methyl-1-oxo-, methyl ester, (9alpha,10beta,12alpha)-;9,1-Epoxy-1H-diindolo(1,2,3-fg:3',2',1'-kl)pyrrolo(3,4-I)(1,6)benzodiazocine-10-carboxylic acid, 2,3,9,10,11,12-hexahydro-10-hydroxy-9-methyl-1-oxo-, methyl ester, (9-alpha,10-beta,12-alpha)-;(9α,10β,12α)-2,3,9,10,11,12-hexahydro-10-hydroxy-9-Methyl-1-oxo-9,12-epoxy-1H-diindolo[1,2,3-fg:3',2',1'-kl]pyrrolo[3,4-i][1,6]benzodiazocine-10-carboxylic acid Methyl ester;K 252a(SF 2370);2,3,9,10,11,12-hexahydro-10-hydroxy-9-methyl-1-oxo-0-carboxylicacimethyl ;9,1-epoxy-1h-diindolo(1,2,3-fg:3’,2’,1’-kl)pyrrolo(3,4-i)(1,6)benzodiazocine-1
Price33 Properties Safety Information Description
33 prices
Selected condition：
Brand
  • Adipogen Life Sciences
  • ApexBio Technology
  • Arctom
  • AvaChem
  • Cayman Chemical
  • ChemScene
  • Sigma-Aldrich
  • Thermo Scientific Chemicals
  • TRC
Package
  • 10mM*1mLinDMSO(Solution)
  • 100UG-F
  • 0.5mg
  • 50mg
  • 200μL
  • 100μg
  • 1mg
  • 10mg
  • 5mg
  • 10mM*1mLinDMSO(Solid+Solvent)
  • ManufacturerAdipogen Life Sciences
  • Product numberAG-CN2-0019-C100
  • Product descriptionK-252a ≥98%(HPLC)
  • Packaging100μg
  • Price$60
  • Updated2021-12-16
  • Buy
  • ManufacturerAdipogen Life Sciences
  • Product numberAG-CN2-0019-C100
  • Product descriptionK-252a ≥98%(HPLC)
  • Packaging100μg
  • Price$60
  • Updated2026-05-06
  • Buy
  • ManufacturerAdipogen Life Sciences
  • Product numberAG-CN2-0019-M001
  • Product descriptionK-252a ≥98%(HPLC)
  • Packaging1mg
  • Price$120
  • Updated2026-05-06
  • Buy
  • ManufacturerApexBio Technology
  • Product numberB6828
  • Product descriptionK 252a
  • Packaging1mg
  • Price$220
  • Updated2026-05-06
  • Buy
  • ManufacturerApexBio Technology
  • Product numberB6828
  • Product descriptionK252a
  • Packaging1mg
  • Price$520
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberB6828
  • Product descriptionK 252a
  • Packaging5mg
  • Price$795
  • Updated2026-05-06
  • Buy
  • ManufacturerApexBio Technology
  • Product numberB6828
  • Product descriptionK252a
  • Packaging5mg
  • Price$1559
  • Updated2021-12-16
  • Buy
  • ManufacturerArctom
  • Product numberHY-N6732
  • Product descriptionK-252a 99.02%
  • Packaging10mg
  • Price$808
  • Updated2026-05-25
  • Buy
  • ManufacturerArctom
  • Product numberHY-N6732
  • Product descriptionK-252a 99.02%
  • Packaging10mg
  • Price$808
  • Updated2026-05-26
  • Buy
  • ManufacturerArctom
  • Product numberHY-N6732
  • Product descriptionK-252a 99.02%
  • Packaging10mM*1mLinDMSO(Solid+Solvent)
  • Price$464
  • Updated2026-05-25
  • Buy
  • ManufacturerArctom
  • Product numberHY-N6732
  • Product descriptionK-252a 99.02%
  • Packaging10mM*1mLinDMSO(Solid+Solvent)
  • Price$464
  • Updated2026-05-26
  • Buy
  • ManufacturerArctom
  • Product numberHY-N6732
  • Product descriptionK-252a 99.02%
  • Packaging5mg
  • Price$475
  • Updated2026-05-25
  • Buy
  • ManufacturerArctom
  • Product numberHY-N6732
  • Product descriptionK-252a 99.02%
  • Packaging5mg
  • Price$475
  • Updated2026-05-26
  • Buy
  • ManufacturerArctom
  • Product numberHY-N6732
  • Product descriptionK-252a 99.02%
  • Packaging10mM*1mLinDMSO(Solution)
  • Price$489
  • Updated2026-05-25
  • Buy
  • ManufacturerArctom
  • Product numberHY-N6732
  • Product descriptionK-252a 99.02%
  • Packaging10mM*1mLinDMSO(Solution)
  • Price$489
  • Updated2026-05-26
  • Buy
  • ManufacturerArctom
  • Product numberHY-N6732
  • Product descriptionK-252a 99.02%
  • Packaging1mg
  • Price$133
  • Updated2026-05-25
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
Adipogen Life Sciences AG-CN2-0019-C100 K-252a ≥98%(HPLC) 100μg $60 2021-12-16 Buy
Adipogen Life Sciences AG-CN2-0019-C100 K-252a ≥98%(HPLC) 100μg $60 2026-05-06 Buy
Adipogen Life Sciences AG-CN2-0019-M001 K-252a ≥98%(HPLC) 1mg $120 2026-05-06 Buy
ApexBio Technology B6828 K 252a 1mg $220 2026-05-06 Buy
ApexBio Technology B6828 K252a 1mg $520 2021-12-16 Buy
ApexBio Technology B6828 K 252a 5mg $795 2026-05-06 Buy
ApexBio Technology B6828 K252a 5mg $1559 2021-12-16 Buy
Arctom HY-N6732 K-252a 99.02% 10mg $808 2026-05-25 Buy
Arctom HY-N6732 K-252a 99.02% 10mg $808 2026-05-26 Buy
Arctom HY-N6732 K-252a 99.02% 10mM*1mLinDMSO(Solid+Solvent) $464 2026-05-25 Buy
Arctom HY-N6732 K-252a 99.02% 10mM*1mLinDMSO(Solid+Solvent) $464 2026-05-26 Buy
Arctom HY-N6732 K-252a 99.02% 5mg $475 2026-05-25 Buy
Arctom HY-N6732 K-252a 99.02% 5mg $475 2026-05-26 Buy
Arctom HY-N6732 K-252a 99.02% 10mM*1mLinDMSO(Solution) $489 2026-05-25 Buy
Arctom HY-N6732 K-252a 99.02% 10mM*1mLinDMSO(Solution) $489 2026-05-26 Buy
Arctom HY-N6732 K-252a 99.02% 1mg $133 2026-05-25 Buy
Next Last

Properties

Melting point :262-273℃ (decomposition) (methanol )
Boiling point :685.3±55.0 °C(Predicted)
Density :1.68
Flash point :87℃
storage temp. :-20°C
solubility :DMF: 1 mg/mL
pka :11.95±0.40(Predicted)
form :Lyophilized solid.
color :White or off-white
biological source :Nonomuraea longicatena
Stability :Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months.
InChIKey :KOZFSFOOLUUIGY-SOLYNIJKSA-N
SMILES :[H][C@]12C[C@](O)(C(=O)OC)[C@](C)(O1)n3c4ccccc4c5c6CNC(=O)c6c7c8ccccc8n2c7c35

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Danger
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H371 May cause damage to organs Specific target organ toxicity, single exposure Category 2 Warning P260, P264, P270, P309+P311, P405,P501
Precautionary statements:
P202 Do not handle until all safety precautions have been read and understood.
P260 Do not breathe dust/fume/gas/mist/vapours/spray.
P264 Wash hands thoroughly after handling.
P264 Wash skin thouroughly after handling.
P270 Do not eat, drink or smoke when using this product.
P280 Wear protective gloves/protective clothing/eye protection/face protection.

Description

K252a is a staurosporine analog isolated from Nocardiopsis sp. soil fungi that inhibits protein kinase (PK) C, PKA, Ca2+/calmodulin-dependent kinase type II, and phosphorylase kinase with IC50 values of 470, 140, 270, and 1.7 nM, respectively. Because it inhibits neurotrophin receptor tyrosine kinases, K252a at 100-500 nM has been used to suppress trophoblast proliferation and increase apoptosis associated with the disruption of mitochondrial functions in cultured choriocarcinoma cells. Recently, K252a has been shown to inhibit PRK1 (IC50 = 3.2 nM in vitro), a PKC-related kinase that phosphorylates histone H3 at threonine 11 and is involved in androgen-dependent gene expression.

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Suppliers and manufacturers

TargetMol Chemicals Inc.
K-252a
$99.00 /1mg
K-252a CAS:99533-80-9
BOC Sciences
TopScience Biochemical
Alfa Chemistry
Wuhan Topule Biopharmaceutical Co., Ltd
Jilin Chinese Academy of Sciences-yanshen Technology
Aladdin Scientific Guangzhou Yaoguang Technology Co., Ltd. 3B Pharmachem (Wuhan) International Co.,Ltd. Chemsky (shanghai) International Co.,Ltd