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ChemicalBook >> CAS DataBase List >> KIRA6

KIRA6

KIRA6 price.
  • $37 - $12766
  • Product name: KIRA6
  • CAS: 1589527-65-0
  • MF: C28H25F3N6O
  • MW: 518.53
  • EINECS:
  • MDL Number:MFCD29477497
  • Synonyms:1-(4-(8-amino-3-(tert-butyl)imidazo[1,5-a]pyrazin-1-yl)naphthalen-1-yl)-3-(3-(trifluoromethyl)phenyl)urea;1-(4-(8-Amino-3-(tert-butyl)imidazo[1,5-a]pyrazin-1-yl)naphthalen-1-yl)-3-(3-(trifluoromethyl);CS-2625;IRE1 Inhibitor IV;IRE1α Kinase Inhibiting RNase Attenuator 6;KIRA6;IRE1 INHIBITOR IV;IRE1Α KINASE INHIBITING RNASE ATTENUATOR 6;133808;3-(4-{8-amino-3-tert-butyl-1H,7H-imidazo[1,5-a]pyrazin-1-ylidene}-1,4-dihydronaphthalen-1-ylidene)-1-[3-(trifluoromethyl)phenyl]urea
Price11 Properties Safety Information Description
11 prices
Selected condition：
Brand
  • ACHEMBLOCK
  • AK Scientific
  • Cayman Chemical
  • ChemScene
  • Matrix Scientific
Package
  • 1mg
  • 5MG
  • 10mg
  • 25MG
  • 100MG
  • 1g
  • ManufacturerACHEMBLOCK
  • Product numberO32749
  • Product description1-(4-(8-Amino-3-(tert-butyl)imidazo[1,5-a]pyrazin-1-yl)naphthalen-1-yl)-3-(3-(trifluoromethyl)phenyl)urea 98%
  • Packaging5MG
  • Price$125
  • Updated2021-12-16
  • Buy
  • ManufacturerACHEMBLOCK
  • Product numberO32749
  • Product description1-(4-(8-Amino-3-(tert-butyl)imidazo[1,5-a]pyrazin-1-yl)naphthalen-1-yl)-3-(3-(trifluoromethyl)phenyl)urea 98%
  • Packaging25MG
  • Price$350
  • Updated2021-12-16
  • Buy
  • ManufacturerACHEMBLOCK
  • Product numberO32749
  • Product description1-(4-(8-Amino-3-(tert-butyl)imidazo[1,5-a]pyrazin-1-yl)naphthalen-1-yl)-3-(3-(trifluoromethyl)phenyl)urea 98%
  • Packaging100MG
  • Price$985
  • Updated2021-12-16
  • Buy
  • ManufacturerAK Scientific
  • Product number6687DW
  • Product description1-[4-(8-Amino-3-tert-butylimidazo[1,5-a]pyrazin-1-yl)naphthalen-1-yl]-3-[3-(trifluoromethyl)phenyl]urea
  • Packaging10mg
  • Price$334
  • Updated2021-12-16
  • Buy
  • ManufacturerCayman Chemical
  • Product number19151
  • Product descriptionKIRA6 ≥98%
  • Packaging1mg
  • Price$37
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number19151
  • Product descriptionKIRA6 ≥98%
  • Packaging5mg
  • Price$142
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number19151
  • Product descriptionKIRA6 ≥98%
  • Packaging10mg
  • Price$213
  • Updated2024-03-01
  • Buy
  • ManufacturerChemScene
  • Product numberCS-6901
  • Product descriptionKIRA6 99.86%
  • Packaging1mg
  • Price$50
  • Updated2021-12-16
  • Buy
  • ManufacturerChemScene
  • Product numberCS-6901
  • Product descriptionKIRA6 99.86%
  • Packaging5mg
  • Price$110
  • Updated2021-12-16
  • Buy
  • ManufacturerChemScene
  • Product numberCS-6901
  • Product descriptionKIRA6 99.86%
  • Packaging10mg
  • Price$170
  • Updated2021-12-16
  • Buy
  • ManufacturerMatrix Scientific
  • Product number153578
  • Product description1-(4-(8-Amino-3-(tert-butyl)imidazo[1,5-a]pyrazin-1-yl)naphthalen-1-yl)-3-(3-(trifluoromethyl)phenyl)urea 95%
  • Packaging1g
  • Price$12766
  • Updated2021-12-16
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
ACHEMBLOCK O32749 1-(4-(8-Amino-3-(tert-butyl)imidazo[1,5-a]pyrazin-1-yl)naphthalen-1-yl)-3-(3-(trifluoromethyl)phenyl)urea 98% 5MG $125 2021-12-16 Buy
ACHEMBLOCK O32749 1-(4-(8-Amino-3-(tert-butyl)imidazo[1,5-a]pyrazin-1-yl)naphthalen-1-yl)-3-(3-(trifluoromethyl)phenyl)urea 98% 25MG $350 2021-12-16 Buy
ACHEMBLOCK O32749 1-(4-(8-Amino-3-(tert-butyl)imidazo[1,5-a]pyrazin-1-yl)naphthalen-1-yl)-3-(3-(trifluoromethyl)phenyl)urea 98% 100MG $985 2021-12-16 Buy
AK Scientific 6687DW 1-[4-(8-Amino-3-tert-butylimidazo[1,5-a]pyrazin-1-yl)naphthalen-1-yl]-3-[3-(trifluoromethyl)phenyl]urea 10mg $334 2021-12-16 Buy
Cayman Chemical 19151 KIRA6 ≥98% 1mg $37 2024-03-01 Buy
Cayman Chemical 19151 KIRA6 ≥98% 5mg $142 2024-03-01 Buy
Cayman Chemical 19151 KIRA6 ≥98% 10mg $213 2024-03-01 Buy
ChemScene CS-6901 KIRA6 99.86% 1mg $50 2021-12-16 Buy
ChemScene CS-6901 KIRA6 99.86% 5mg $110 2021-12-16 Buy
ChemScene CS-6901 KIRA6 99.86% 10mg $170 2021-12-16 Buy
Matrix Scientific 153578 1-(4-(8-Amino-3-(tert-butyl)imidazo[1,5-a]pyrazin-1-yl)naphthalen-1-yl)-3-(3-(trifluoromethyl)phenyl)urea 95% 1g $12766 2021-12-16 Buy

Properties

Density :1.36±0.1 g/cm3(Predicted)
storage temp. :Store at -20°C
solubility :DMSO:6.25(Max Conc. mg/mL);12.05(Max Conc. mM)
Ethanol:2.0(Max Conc. mg/mL);3.86(Max Conc. mM) form :A crystalline solid
pka :13.13±0.43(Predicted)

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning GHS hazard pictograms P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning GHS hazard pictograms P264, P280, P305+P351+P338,P337+P313P
H335 May cause respiratory irritation Specific target organ toxicity, single exposure;Respiratory tract irritation Category 3 Warning GHS hazard pictograms
Precautionary statements:
P264 Wash hands thoroughly after handling.
P264 Wash skin thouroughly after handling.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352 IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P321 Specific treatment (see … on this label).
P332+P313 IF SKIN irritation occurs: Get medical advice/attention.
P362 Take off contaminated clothing and wash before reuse.

Description

The IRE1 pathway is a component of the unfolded protein response that senses unfolded proteins via an ER luminal domain that becomes oligomerized during stress. It is associated with promoting cell survival through the activity of the IRE1α RNase, whose activity upregulates proteins that enhance ER protein folding and quality control. However, under high ER stress, the IRE1α RNase becomes hyperactive and is less discriminant in its substrate specificity, endonucleolytically cleaving many additional mRNAs that localize to the ER membrane, leading to cell proliferation blocks, inflammation, and apoptosis. KIRA6 is an ATP-competitive IRE1α kinase inhibiting RNase attenuator (KIRA) that allosterically inhibits IRE1α RNase kinase activity (IC50 = 0.6 μM) and prevents oligomerization. It has been shown to inhibit IRE1α in vivo and to promote cell survival under ER stress. At 20 μg/ml, KIRA6 is reported to preserve photoreceptor functional viability in rat models of ER stress-induced retinal degeneration. At 5 mg/kg, it has also been shown to preserve pancreatic β cells, increase insulin, and reduce hyperglycemia in Akita diabetic mice.

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