KL001
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- $31 - $1950
- Product name: KL001
- CAS: 309928-48-1
- MF: C21H22N2O4S
- MW: 398.48
- EINECS:
- MDL Number:MFCD02086647
- Synonyms:N-[3-(9H-Carbazol-9-yl)-2-hydroxypropyl]-N-(2-furanylmethyl)-methanesulfonamide;N-(3-(9H-Carbazol-9-yl)-2-hydroxypropyl)-N-(furan-2-ylmethyl)methanesulfonamide;Methanesulfonamide, N-[3-(9H-carbazol-9-yl)-2-hydroxypropyl]-N-(2-furanylmethyl)-;KL001(KL-001;Inhibitor,inhibit,stabilizer,KL001,circadian,cryptochrome,ubiquitin,period,gluconeogenesis,CRY;KL001(KL-001,KL 001);KL001, 10 mM in DMSO
68 prices
Selected condition：
Brand
- aablocks
- ACHEMBLOCK
- AK Scientific
- Alichem
- American Custom Chemicals Corporation
- ApexBio Technology
- Arctom
- AvaChem
- Biosynth
- Cayman Chemical
- Chemenu
- Crysdot
- DC Chemicals
- Matrix Scientific
- Medical Isotopes, Inc.
- Sigma-Aldrich
- TRC
Package
- 1mg
- 2mg
- 5mg
- 10.00mg
- 10mg
- 25.00mg
- 25mg
- 50mg
- 50.00mg
- 100mg
- 250mg
- 500MG
- 1g
- 25 mg
- Manufactureraablocks
- Product numberAA00C26K
- Product descriptionN-(3-(9H-Carbazol-9-yl)-2-hydroxypropyl)-N-(furan-2-ylmethyl)methanesulfonamide 99%
- Packaging1mg
- Price$31
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA00C26K
- Product descriptionN-(3-(9H-Carbazol-9-yl)-2-hydroxypropyl)-N-(furan-2-ylmethyl)methanesulfonamide 99%
- Packaging5mg
- Price$38
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA00C26K
- Product descriptionN-(3-(9H-Carbazol-9-yl)-2-hydroxypropyl)-N-(furan-2-ylmethyl)methanesulfonamide 99%
- Packaging10mg
- Price$50
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA00C26K
- Product descriptionN-(3-(9H-Carbazol-9-yl)-2-hydroxypropyl)-N-(furan-2-ylmethyl)methanesulfonamide 99%
- Packaging25mg
- Price$64
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA00C26K
- Product descriptionN-(3-(9H-Carbazol-9-yl)-2-hydroxypropyl)-N-(furan-2-ylmethyl)methanesulfonamide 99%
- Packaging50mg
- Price$84
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA00C26K
- Product descriptionN-(3-(9H-Carbazol-9-yl)-2-hydroxypropyl)-N-(furan-2-ylmethyl)methanesulfonamide 99%
- Packaging100mg
- Price$108
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA00C26K
- Product descriptionN-(3-(9H-Carbazol-9-yl)-2-hydroxypropyl)-N-(furan-2-ylmethyl)methanesulfonamide 99%
- Packaging250mg
- Price$206
- Updated2026-05-28
- Buy
- ManufacturerACHEMBLOCK
- Product numberY227351
- Product descriptionKL001 97.00%
- Packaging100MG
- Price$525
- Updated2026-05-27
- Buy
- ManufacturerACHEMBLOCK
- Product numberY227351
- Product descriptionKL001 97.00%
- Packaging500MG
- Price$1180
- Updated2026-05-27
- Buy
- ManufacturerAK Scientific
- Product number4099CJ
- Product descriptionN-(3-(9H-Carbazol-9-yl)-2-hydroxypropyl)-N-(furan-2-ylmethyl)methanesulfonamide
- Packaging2mg
- Price$218
- Updated2021-12-16
- Buy
- ManufacturerAlichem
- Product number309928481
- Product descriptionN-(3-(9H-Carbazol-9-yl)-2-hydroxypropyl)-N-(furan-2-ylmethyl)methanesulfonamide
- Packaging50mg
- Price$1091.8
- Updated2021-12-16
- Buy
- ManufacturerAmerican Custom Chemicals Corporation
- Product numberCBL0015791
- Product descriptionN-[3-(9H-CARBAZOL-9-YL)-2-HYDROXYPROPYL]-N-(2-FURANYLMETHYL)-METHANESULFONAMIDE 95.00%
- Packaging5MG
- Price$453.9
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberB5684
- Product descriptionKL001
- Packaging50mg
- Price$1158
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberB5684
- Product descriptionKL 001
- Packaging50mg
- Price$1158
- Updated2026-05-06
- Buy
- ManufacturerApexBio Technology
- Product numberB5684
- Product descriptionKL001
- Packaging10mg
- Price$282
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberB5684
- Product descriptionKL 001
- Packaging25mg
- Price$325
- Updated2026-05-06
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| aablocks | AA00C26K | N-(3-(9H-Carbazol-9-yl)-2-hydroxypropyl)-N-(furan-2-ylmethyl)methanesulfonamide 99% | 1mg | $31 | 2026-05-28 | Buy |
| aablocks | AA00C26K | N-(3-(9H-Carbazol-9-yl)-2-hydroxypropyl)-N-(furan-2-ylmethyl)methanesulfonamide 99% | 5mg | $38 | 2026-05-28 | Buy |
| aablocks | AA00C26K | N-(3-(9H-Carbazol-9-yl)-2-hydroxypropyl)-N-(furan-2-ylmethyl)methanesulfonamide 99% | 10mg | $50 | 2026-05-28 | Buy |
| aablocks | AA00C26K | N-(3-(9H-Carbazol-9-yl)-2-hydroxypropyl)-N-(furan-2-ylmethyl)methanesulfonamide 99% | 25mg | $64 | 2026-05-28 | Buy |
| aablocks | AA00C26K | N-(3-(9H-Carbazol-9-yl)-2-hydroxypropyl)-N-(furan-2-ylmethyl)methanesulfonamide 99% | 50mg | $84 | 2026-05-28 | Buy |
| aablocks | AA00C26K | N-(3-(9H-Carbazol-9-yl)-2-hydroxypropyl)-N-(furan-2-ylmethyl)methanesulfonamide 99% | 100mg | $108 | 2026-05-28 | Buy |
| aablocks | AA00C26K | N-(3-(9H-Carbazol-9-yl)-2-hydroxypropyl)-N-(furan-2-ylmethyl)methanesulfonamide 99% | 250mg | $206 | 2026-05-28 | Buy |
| ACHEMBLOCK | Y227351 | KL001 97.00% | 100MG | $525 | 2026-05-27 | Buy |
| ACHEMBLOCK | Y227351 | KL001 97.00% | 500MG | $1180 | 2026-05-27 | Buy |
| AK Scientific | 4099CJ | N-(3-(9H-Carbazol-9-yl)-2-hydroxypropyl)-N-(furan-2-ylmethyl)methanesulfonamide | 2mg | $218 | 2021-12-16 | Buy |
| Alichem | 309928481 | N-(3-(9H-Carbazol-9-yl)-2-hydroxypropyl)-N-(furan-2-ylmethyl)methanesulfonamide | 50mg | $1091.8 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | CBL0015791 | N-[3-(9H-CARBAZOL-9-YL)-2-HYDROXYPROPYL]-N-(2-FURANYLMETHYL)-METHANESULFONAMIDE 95.00% | 5MG | $453.9 | 2021-12-16 | Buy |
| ApexBio Technology | B5684 | KL001 | 50mg | $1158 | 2021-12-16 | Buy |
| ApexBio Technology | B5684 | KL 001 | 50mg | $1158 | 2026-05-06 | Buy |
| ApexBio Technology | B5684 | KL001 | 10mg | $282 | 2021-12-16 | Buy |
| ApexBio Technology | B5684 | KL 001 | 25mg | $325 | 2026-05-06 | Buy |
Properties
storage temp. :2-8°C
solubility :DMSO: soluble20mg/mL, clear
form :powder
color :white to beige
Stability :Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months.
InChI :1S/C21H22N2O4S/c1-28(25,26)22(15-17-7-6-12-27-17)13-16(24)14-23-20-10-4-2-8-18(20)19-9-3-5-11-21(19)23/h2-12,16,24H,13-15H2,1H3
InChIKey :OQAFDLPAPSSOHY-UHFFFAOYSA-N
SMILES :[S](=O)(=O)(N(CC(O)C[n]2c3c(c4c2cccc4)cccc3)Cc1[o]ccc1)C
solubility :DMSO: soluble20mg/mL, clear
form :powder
color :white to beige
Stability :Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months.
InChI :1S/C21H22N2O4S/c1-28(25,26)22(15-17-7-6-12-27-17)13-16(24)14-23-20-10-4-2-8-18(20)19-9-3-5-11-21(19)23/h2-12,16,24H,13-15H2,1H3
InChIKey :OQAFDLPAPSSOHY-UHFFFAOYSA-N
SMILES :[S](=O)(=O)(N(CC(O)C[n]2c3c(c4c2cccc4)cccc3)Cc1[o]ccc1)C
Safety Information
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| Signal word: | Warning | ||||||||||||||
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Description
The cryptochrome proteins CRY1 and CRY2, which play central roles in maintaining the circadian clock, are expressed and then degraded in a rhythmic pattern. KL001 is a cell-permeable carbazolic compound which directly interacts with and stabilizes CRY1 and CRY2, preventing ubiquitin-dependent degradation while lengthening the circadian period (IC50 = 0.82-14 μM). As the expression of some gluconeogenic genes is both circadian and cryptochrome-dependent, KL001 effectively inhibits glucagon-induced gluconeogenesis in primary hepatocytes. This product can be used to study the regulation of cryptochrome-dependent physiology and aid in the development of clock-based therapeutics of diabetes.Related product price
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