KML-29
|
- $48 - $2400
- Product name: KML-29
- CAS: 1380424-42-9
- MF: C24H21F6NO7
- MW: 549.42
- EINECS:
- MDL Number:MFCD22987957
- Synonyms:KML-29;KML29;KML-29;KML 29;4-[Bis(1,3-benzodioxol-5-yl)hydroxymethyl]-1-piperidinecarboxylic acid 2,2,2-trifluoro-1-(trifluoromethyl)ethyl ester;CS-2396;KML29 (KML-29);1-Piperidinecarboxylic acid, 4-[bis(1,3-benzodioxol-5-yl)hydroxymethyl]-, 2,2,2-trifluoro-1-(trifluoromethyl)ethyl ester;1,1,1,3,3,3-hexafluoropropan-2-yl 4-(bis(benzo[d][1,3]dioxol-5-yl)(hydroxy)methyl)piperidine-1-carboxylate;LPS,allodynia,Monoacylglycerol lipase,KML29,MAGL,inhibit,2-AG,Inhibitor,HFIP,KML 29,KML-29
46 prices
Selected condition：
Brand
- aablocks
- ACHEMBLOCK
- AK Scientific
- ApexBio Technology
- Arctom
- Cayman Chemical
- Chemenu
- ChemScene
- Crysdot
- DC Chemicals
- Medical Isotopes, Inc.
- Sigma-Aldrich
- Tocris
- TRC
- Usbiological
Package
- 10mM*1mLinDMSO
- 10
- 5mg
- 10mg
- 25mg
- 50mg
- 100mg
- 250mg
- 1g
- 50
- 5g
- 10mM*1mLinDMSO(Solid+Solvent)
- 10mM*1mLinDMSO(Solution)
- Manufactureraablocks
- Product numberAA009CFY
- Product descriptionKML-29 96
- Packaging10mg
- Price$52
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA009CFY
- Product descriptionKML-29 96
- Packaging25mg
- Price$88
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA009CFY
- Product descriptionKML-29 96%
- Packaging100mg
- Price$152
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA009CFY
- Product descriptionKML-29 96
- Packaging50mg
- Price$123
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA009CFY
- Product descriptionKML-29 96%
- Packaging250mg
- Price$252
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA009CFY
- Product descriptionKML-29 96%
- Packaging1g
- Price$618
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA009CFY
- Product descriptionKML-29 96%
- Packaging5g
- Price$1886
- Updated2026-05-28
- Buy
- ManufacturerACHEMBLOCK
- Product numberQ70017
- Product description1,1,1,3,3,3-hexafluoropropan-2-yl 4-(bis(benzo[d][1,3]dioxol-5-yl)(hydroxy)methyl)piperidine-1-carboxylate 98%
- Packaging25MG
- Price$110
- Updated2026-05-27
- Buy
- ManufacturerACHEMBLOCK
- Product numberQ70017
- Product description1,1,1,3,3,3-hexafluoropropan-2-yl 4-(bis(benzo[d][1,3]dioxol-5-yl)(hydroxy)methyl)piperidine-1-carboxylate 98%
- Packaging100MG
- Price$230
- Updated2026-05-27
- Buy
- ManufacturerAK Scientific
- Product number0860DV
- Product descriptionCID71656212
- Packaging10mg
- Price$222
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberB5745
- Product descriptionKML 29
- Packaging50mg
- Price$378
- Updated2026-05-06
- Buy
- ManufacturerApexBio Technology
- Product numberB5745
- Product descriptionKML 29
- Packaging10mg
- Price$107
- Updated2026-05-06
- Buy
- ManufacturerApexBio Technology
- Product numberB5745
- Product descriptionKML 29
- Packaging5mg
- Price$64
- Updated2026-05-06
- Buy
- ManufacturerApexBio Technology
- Product numberB5745
- Product descriptionKML 29
- Packaging100mg
- Price$605
- Updated2026-05-06
- Buy
- ManufacturerArctom
- Product numberHY-18977
- Product descriptionKML29 99.64%
- Packaging100mg
- Price$371
- Updated2026-05-26
- Buy
- ManufacturerArctom
- Product numberHY-18977
- Product descriptionKML29 99.64%
- Packaging10mM*1mLinDMSO(Solid+Solvent)
- Price$55
- Updated2026-05-26
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| aablocks | AA009CFY | KML-29 96 | 10mg | $52 | 2026-05-28 | Buy |
| aablocks | AA009CFY | KML-29 96 | 25mg | $88 | 2026-05-28 | Buy |
| aablocks | AA009CFY | KML-29 96% | 100mg | $152 | 2026-05-28 | Buy |
| aablocks | AA009CFY | KML-29 96 | 50mg | $123 | 2026-05-28 | Buy |
| aablocks | AA009CFY | KML-29 96% | 250mg | $252 | 2026-05-28 | Buy |
| aablocks | AA009CFY | KML-29 96% | 1g | $618 | 2026-05-28 | Buy |
| aablocks | AA009CFY | KML-29 96% | 5g | $1886 | 2026-05-28 | Buy |
| ACHEMBLOCK | Q70017 | 1,1,1,3,3,3-hexafluoropropan-2-yl 4-(bis(benzo[d][1,3]dioxol-5-yl)(hydroxy)methyl)piperidine-1-carboxylate 98% | 25MG | $110 | 2026-05-27 | Buy |
| ACHEMBLOCK | Q70017 | 1,1,1,3,3,3-hexafluoropropan-2-yl 4-(bis(benzo[d][1,3]dioxol-5-yl)(hydroxy)methyl)piperidine-1-carboxylate 98% | 100MG | $230 | 2026-05-27 | Buy |
| AK Scientific | 0860DV | CID71656212 | 10mg | $222 | 2021-12-16 | Buy |
| ApexBio Technology | B5745 | KML 29 | 50mg | $378 | 2026-05-06 | Buy |
| ApexBio Technology | B5745 | KML 29 | 10mg | $107 | 2026-05-06 | Buy |
| ApexBio Technology | B5745 | KML 29 | 5mg | $64 | 2026-05-06 | Buy |
| ApexBio Technology | B5745 | KML 29 | 100mg | $605 | 2026-05-06 | Buy |
| Arctom | HY-18977 | KML29 99.64% | 100mg | $371 | 2026-05-26 | Buy |
| Arctom | HY-18977 | KML29 99.64% | 10mM*1mLinDMSO(Solid+Solvent) | $55 | 2026-05-26 | Buy |
Properties
Melting point :204-206°C
Boiling point :554.8±50.0 °C(Predicted)
Density :1.511±0.06 g/cm3(Predicted)
storage temp. :-20°C Freezer
solubility :Chloroform (Slightly, Heated, Sonicated), Methanol (Slightly, Heated)
pka :13.32±0.29(Predicted)
form :Solid
color :White to Off-White
InChIKey :SXHQLPHDBLTFPM-UHFFFAOYSA-N
SMILES :FC(F)(F)C(OC(=O)N1CCC(CC1)C(O)(c4cc5c(cc4)OCO5)c2cc3c(cc2)OCO3)C(F)(F)F
Boiling point :554.8±50.0 °C(Predicted)
Density :1.511±0.06 g/cm3(Predicted)
storage temp. :-20°C Freezer
solubility :Chloroform (Slightly, Heated, Sonicated), Methanol (Slightly, Heated)
pka :13.32±0.29(Predicted)
form :Solid
color :White to Off-White
InChIKey :SXHQLPHDBLTFPM-UHFFFAOYSA-N
SMILES :FC(F)(F)C(OC(=O)N1CCC(CC1)C(O)(c4cc5c(cc4)OCO5)c2cc3c(cc2)OCO3)C(F)(F)F
Safety Information
| Symbol(GHS): | ||||||||
|---|---|---|---|---|---|---|---|---|
| Signal word: | ||||||||
| Hazard statements: |
|
|||||||
| Precautionary statements: |
|
Description
Endocannabinoids such as 2-arachidonoyl glycerol (2-AG) and arachidonoyl ethanolamide are biologically active lipids that are involved in a number of synaptic processes including activation of cannabinoid receptors. Monoacylglycerol lipase (MAGL) is a serine hydrolase responsible for the hydrolysis of 2-AG to arachidonic acid and glycerol, thus terminating its biological function. KML29 is an O-hexafluoroisopropyl carbamate analog of JZL 184 that potently and selectively inhibits MAGL (IC50s = 15, 43, and 5.9 nM in mouse, rat, and human brain proteomes, respectively) over FAAH (IC50s >50 μM). At 5-20 mg/kg, KML29 dose-dependently blocks mouse brain MAGL activity in vivo, without any measurable effect on FAAH activity. As a second generation MAGL inhibitor, KML29 supersedes the low-level cross-reactivity that JZL 184 displays for FAAH yet still maintains comparable potency to its parent compound.Related product price
-
KML-29
$48-2400 -
GLYCEROPHOSPHO-N-ARACHIDONOYL ETHANOLAMINE
$93-938 -
N-OLEOYLGLYCINE
$15-1260
Suppliers and manufacturers
Shanghai Boyle Chemical Co., Ltd.
J & K SCIENTIFIC LTD.
BOC Sciences
Haoyuan Chemexpress Co., Ltd.
SHANGHAI FORTUNE CHEMICAL TECHNOLOGY CO., LTD
MedChemexpress LLC
Shanghai TaoSu Biochemical Technology Co., Ltd.
Shanghai Lollane Biological Technology Co.,Ltd.
Shanghaizehan biopharma technology co., Ltd.
Shanghai Beckham Medical Technology Co., Ltd