KO-947
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- $32 - $1650
- Product name: KO-947
- CAS: 1695533-89-1
- MF: C21H17N5O
- MW: 355.39
- EINECS:
- MDL Number:MFCD31657422
- Synonyms:KO-947;6-benzyl-3-(pyridin-4-yl)-5,6-dihydro-1H-pyrazolo[4,3-g]quinazolin-7(8H)-one;KO947;KO-947;KO 947;7H-Pyrazolo[4,3-g]quinazolin-7-one, 1,5,6,8-tetrahydro-6-(phenylmethyl)-3-(4-pyridinyl)-;Inhibitor,ERK,KO-947,inhibit,KO 947,Extracellular signal regulated kinases,KO947;6-benzyl-3-(pyridin-4-yl)-1H,5H,6H,7H,8H-pyrazolo[4,3-g]quinazolin-7-one;KO-947 ，S8569
13 prices
Selected condition：
Brand
- AK Scientific
- Cayman Chemical
- ChemScene
- DC Chemicals
Package
- 1mg
- 5mg
- 10mg
- 25mg
- 50mg
- 100mg
- 250mg
- ManufacturerAK Scientific
- Product number8399EM
- Product description6-Benzyl-3-pyridin-4-yl-5,8-dihydro-1H-pyrazolo[4,3-g]quinazolin-7-one
- Packaging5mg
- Price$252
- Updated2021-12-16
- Buy
- ManufacturerAK Scientific
- Product number8399EM
- Product description6-Benzyl-3-pyridin-4-yl-5,8-dihydro-1H-pyrazolo[4,3-g]quinazolin-7-one
- Packaging10mg
- Price$370
- Updated2021-12-16
- Buy
- ManufacturerCayman Chemical
- Product number29213
- Product descriptionKO947
- Packaging1mg
- Price$32
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number29213
- Product descriptionKO947
- Packaging5mg
- Price$139
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number29213
- Product descriptionKO947
- Packaging10mg
- Price$243
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number29213
- Product descriptionKO947
- Packaging25mg
- Price$533
- Updated2024-03-01
- Buy
- ManufacturerChemScene
- Product numberCS-0043627
- Product descriptionKO-947 99.45%
- Packaging5mg
- Price$160
- Updated2021-12-16
- Buy
- ManufacturerChemScene
- Product numberCS-0043627
- Product descriptionKO-947 99.45%
- Packaging10mg
- Price$260
- Updated2021-12-16
- Buy
- ManufacturerChemScene
- Product numberCS-0043627
- Product descriptionKO-947 99.45%
- Packaging25mg
- Price$490
- Updated2021-12-16
- Buy
- ManufacturerChemScene
- Product numberCS-0043627
- Product descriptionKO-947 99.45%
- Packaging50mg
- Price$900
- Updated2021-12-16
- Buy
- ManufacturerChemScene
- Product numberCS-0043627
- Product descriptionKO-947 99.45%
- Packaging100mg
- Price$1650
- Updated2021-12-16
- Buy
- ManufacturerDC Chemicals
- Product numberDC10487
- Product descriptionKO947 >98%
- Packaging100mg
- Price$750
- Updated2021-12-16
- Buy
- ManufacturerDC Chemicals
- Product numberDC10487
- Product descriptionKO947 >98%
- Packaging250mg
- Price$1400
- Updated2021-12-16
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| AK Scientific | 8399EM | 6-Benzyl-3-pyridin-4-yl-5,8-dihydro-1H-pyrazolo[4,3-g]quinazolin-7-one | 5mg | $252 | 2021-12-16 | Buy |
| AK Scientific | 8399EM | 6-Benzyl-3-pyridin-4-yl-5,8-dihydro-1H-pyrazolo[4,3-g]quinazolin-7-one | 10mg | $370 | 2021-12-16 | Buy |
| Cayman Chemical | 29213 | KO947 | 1mg | $32 | 2024-03-01 | Buy |
| Cayman Chemical | 29213 | KO947 | 5mg | $139 | 2024-03-01 | Buy |
| Cayman Chemical | 29213 | KO947 | 10mg | $243 | 2024-03-01 | Buy |
| Cayman Chemical | 29213 | KO947 | 25mg | $533 | 2024-03-01 | Buy |
| ChemScene | CS-0043627 | KO-947 99.45% | 5mg | $160 | 2021-12-16 | Buy |
| ChemScene | CS-0043627 | KO-947 99.45% | 10mg | $260 | 2021-12-16 | Buy |
| ChemScene | CS-0043627 | KO-947 99.45% | 25mg | $490 | 2021-12-16 | Buy |
| ChemScene | CS-0043627 | KO-947 99.45% | 50mg | $900 | 2021-12-16 | Buy |
| ChemScene | CS-0043627 | KO-947 99.45% | 100mg | $1650 | 2021-12-16 | Buy |
| DC Chemicals | DC10487 | KO947 >98% | 100mg | $750 | 2021-12-16 | Buy |
| DC Chemicals | DC10487 | KO947 >98% | 250mg | $1400 | 2021-12-16 | Buy |
Properties
Boiling point :704.1±60.0 °C(Predicted)
Density :1.354±0.06 g/cm3(Predicted)
storage temp. :4°C, protect from light
solubility :DMSO:66.75(Max Conc. mg/mL);187.82(Max Conc. mM)
form :A crystalline solid
pka :13.32±0.20(Predicted)
color :White to off-white
Density :1.354±0.06 g/cm3(Predicted)
storage temp. :4°C, protect from light
solubility :DMSO:66.75(Max Conc. mg/mL);187.82(Max Conc. mM)
form :A crystalline solid
pka :13.32±0.20(Predicted)
color :White to off-white
Safety Information
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Description
KO947 is an ERK inhibitor (IC50 = <50 nM for ERK2). It is greater than 50-fold selective for ERK over a panel of 450 kinases. KO947 reduces phosphorylation of the ERK target p90 ribosomal S6 kinase (RSK) in A375 cancer cells containing constitutively active B-RAFV600E with an IC50 value of less than 250 nM. It inhibits proliferation of A375 cells, as well as mutant K-Ras-expressing HCT116 and H358 cancer cell lines (IC50s = 50-250 nM for all).Suppliers and manufacturers
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