Ko 143
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- $52 - $2500
- Product name: Ko 143
- CAS: 461054-93-3
- MF: C26H35N3O5
- MW: 469.57
- EINECS:
- MDL Number:MFCD11042273
- Synonyms:Pyrazino[1',2':1,6]pyrido[3,4-b]indole-3-propanoic acid, 1,2,3,4,6,7,12,12a-octahydro-9-methoxy-6-(2-methylpropyl)-1,4-dioxo-, 1,1-dimethylethyl ester, (3S,6S,12aS)-(Ko143);Ko 143;12a-octahydro-9-Methoxy-6-(2-Methylpropyl)-1;12aS)-;4-b]indole-3-propanoicacid;4-dioxo-;6]pyrido[3;Pyrazino[1'
46 prices
Selected condition：
Brand
- aablocks
- ACHEMBLOCK
- American Custom Chemicals Corporation
- ApexBio Technology
- Arctom
- AvaChem
- Axon Medchem
- Biosynth
- Cayman Chemical
- ChemScene
- DC Chemicals
- Sigma-Aldrich
- Tocris
- TRC
- Usbiological
Package
- 10mM*1mLinDMSO(Solid+Solvent)
- 1
- 1MG
- 2mg
- 5mg
- 10mg
- 25mg
- 10
- 50mg
- 100MG
- 1g
- 10mM*1mLinDMSO(Solution)
- 250mg
- Manufactureraablocks
- Product numberAA006XD1
- Product descriptiontert-Butyl 3-((3S,6S,12aS)-6-isobutyl-9-methoxy-1,4-dioxo-1,2,3,4,6,7,12,12a-octahydropyrazino[1',2':1,6]pyrido[3,4-b]indol-3-yl)propanoate
- Packaging2mg
- Price$52
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA006XD1
- Product descriptiontert-Butyl 3-((3S,6S,12aS)-6-isobutyl-9-methoxy-1,4-dioxo-1,2,3,4,6,7,12,12a-octahydropyrazino[1',2':1,6]pyrido[3,4-b]indol-3-yl)propanoate
- Packaging5mg
- Price$72
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA006XD1
- Product descriptiontert-Butyl 3-((3S,6S,12aS)-6-isobutyl-9-methoxy-1,4-dioxo-1,2,3,4,6,7,12,12a-octahydropyrazino[1',2':1,6]pyrido[3,4-b]indol-3-yl)propanoate
- Packaging10mg
- Price$111
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA006XD1
- Product descriptiontert-Butyl 3-((3S,6S,12aS)-6-isobutyl-9-methoxy-1,4-dioxo-1,2,3,4,6,7,12,12a-octahydropyrazino[1',2':1,6]pyrido[3,4-b]indol-3-yl)propanoate
- Packaging25mg
- Price$203
- Updated2026-05-28
- Buy
- ManufacturerACHEMBLOCK
- Product numberY230270
- Product descriptionKo 143 97.00%
- Packaging25MG
- Price$270
- Updated2026-05-27
- Buy
- ManufacturerACHEMBLOCK
- Product numberY230270
- Product descriptionKo 143 97.00%
- Packaging100MG
- Price$890
- Updated2026-05-27
- Buy
- ManufacturerAmerican Custom Chemicals Corporation
- Product numberINB0000360
- Product descriptionKO 143 95.00%
- Packaging1MG
- Price$641.55
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA3533
- Product descriptionKo 143
- Packaging25mg
- Price$470
- Updated2026-05-06
- Buy
- ManufacturerApexBio Technology
- Product numberA3533
- Product descriptionKo 143
- Packaging10mg
- Price$199
- Updated2026-05-06
- Buy
- ManufacturerApexBio Technology
- Product numberA3533
- Product descriptionKo 143
- Packaging5mg
- Price$124
- Updated2026-05-06
- Buy
- ManufacturerApexBio Technology
- Product numberA3533
- Product descriptionKo 143
- Packaging50mg
- Price$716
- Updated2026-05-06
- Buy
- ManufacturerArctom
- Product numberHY-10010
- Product descriptionKo 143 99.97%
- Packaging100mg
- Price$855
- Updated2026-05-26
- Buy
- ManufacturerArctom
- Product numberHY-10010
- Product descriptionKo 143 99.97%
- Packaging10mg
- Price$133
- Updated2026-05-26
- Buy
- ManufacturerArctom
- Product numberHY-10010
- Product descriptionKo 143 99.97%
- Packaging10mM*1mLinDMSO(Solution)
- Price$79
- Updated2026-05-26
- Buy
- ManufacturerArctom
- Product numberHY-10010
- Product descriptionKo 143 99.97%
- Packaging10mM*1mLinDMSO(Solid+Solvent)
- Price$76
- Updated2026-05-26
- Buy
- ManufacturerArctom
- Product numberHY-10010
- Product descriptionKo 143 99.97%
- Packaging5mg
- Price$76
- Updated2026-05-26
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| aablocks | AA006XD1 | tert-Butyl 3-((3S,6S,12aS)-6-isobutyl-9-methoxy-1,4-dioxo-1,2,3,4,6,7,12,12a-octahydropyrazino[1',2':1,6]pyrido[3,4-b]indol-3-yl)propanoate | 2mg | $52 | 2026-05-28 | Buy |
| aablocks | AA006XD1 | tert-Butyl 3-((3S,6S,12aS)-6-isobutyl-9-methoxy-1,4-dioxo-1,2,3,4,6,7,12,12a-octahydropyrazino[1',2':1,6]pyrido[3,4-b]indol-3-yl)propanoate | 5mg | $72 | 2026-05-28 | Buy |
| aablocks | AA006XD1 | tert-Butyl 3-((3S,6S,12aS)-6-isobutyl-9-methoxy-1,4-dioxo-1,2,3,4,6,7,12,12a-octahydropyrazino[1',2':1,6]pyrido[3,4-b]indol-3-yl)propanoate | 10mg | $111 | 2026-05-28 | Buy |
| aablocks | AA006XD1 | tert-Butyl 3-((3S,6S,12aS)-6-isobutyl-9-methoxy-1,4-dioxo-1,2,3,4,6,7,12,12a-octahydropyrazino[1',2':1,6]pyrido[3,4-b]indol-3-yl)propanoate | 25mg | $203 | 2026-05-28 | Buy |
| ACHEMBLOCK | Y230270 | Ko 143 97.00% | 25MG | $270 | 2026-05-27 | Buy |
| ACHEMBLOCK | Y230270 | Ko 143 97.00% | 100MG | $890 | 2026-05-27 | Buy |
| American Custom Chemicals Corporation | INB0000360 | KO 143 95.00% | 1MG | $641.55 | 2021-12-16 | Buy |
| ApexBio Technology | A3533 | Ko 143 | 25mg | $470 | 2026-05-06 | Buy |
| ApexBio Technology | A3533 | Ko 143 | 10mg | $199 | 2026-05-06 | Buy |
| ApexBio Technology | A3533 | Ko 143 | 5mg | $124 | 2026-05-06 | Buy |
| ApexBio Technology | A3533 | Ko 143 | 50mg | $716 | 2026-05-06 | Buy |
| Arctom | HY-10010 | Ko 143 99.97% | 100mg | $855 | 2026-05-26 | Buy |
| Arctom | HY-10010 | Ko 143 99.97% | 10mg | $133 | 2026-05-26 | Buy |
| Arctom | HY-10010 | Ko 143 99.97% | 10mM*1mLinDMSO(Solution) | $79 | 2026-05-26 | Buy |
| Arctom | HY-10010 | Ko 143 99.97% | 10mM*1mLinDMSO(Solid+Solvent) | $76 | 2026-05-26 | Buy |
| Arctom | HY-10010 | Ko 143 99.97% | 5mg | $76 | 2026-05-26 | Buy |
Properties
Melting point :147 ºC
Boiling point :689.8±55.0 °C(Predicted)
Density :1.24
storage temp. :Desiccate at -20°C
solubility :DMSO: >10mg/mL
pka :13.31±0.60(Predicted)
form :powder
color :white to off-white
Stability :Stable for 2 years from date of purchase as supplied. Protect from exposure to moisture. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.
InChIKey :ZXXZDXPNJJZRDC-PSLBYKFTSA-N
SMILES :O.COc1ccc2c3C[C@@H]4N([C@@H](CC(C)C)c3[nH]c2c1)C(=O)[C@H](CCC(=O)OC(C)(C)C)NC4=O
Boiling point :689.8±55.0 °C(Predicted)
Density :1.24
storage temp. :Desiccate at -20°C
solubility :DMSO: >10mg/mL
pka :13.31±0.60(Predicted)
form :powder
color :white to off-white
Stability :Stable for 2 years from date of purchase as supplied. Protect from exposure to moisture. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.
InChIKey :ZXXZDXPNJJZRDC-PSLBYKFTSA-N
SMILES :O.COc1ccc2c3C[C@@H]4N([C@@H](CC(C)C)c3[nH]c2c1)C(=O)[C@H](CCC(=O)OC(C)(C)C)NC4=O
Safety Information
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| Signal word: | Warning | ||||||||||||||||||||||||||||
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Description
Breast cancer resistance protein (BCRP) is an ATP-binding cassette protein known also as ABCG2. While it normally functions as a high-capacity urate exporter in the renal system, it also acts as a xenobiotic transporter and contributes to multidrug resistance (e.g., to mitoxantrone) in certain types of cancer. BCRP is abundant at the intestinal epithelium and blood-brain barrier, potentially restricting the distribution of certain drugs. Ko 143 is a potent and selective inhibitor of BCRP, preventing the export of mitoxantrone and topotecan in breast cancer cell lines (EC50s = 23 and 26 nM, respectively). It is much less effective at the transporters P-glycoprotein and multidrug resistance-associated protein 1, MRP1. Ko 143 is effective in vivo in mice.Related product price
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