Kobe-0065
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- $37 - $2395.3
- Product name: Kobe-0065
- CAS: 436133-68-5
- MF: C15H11ClF3N5O4S
- MW: 449.79
- EINECS:
- MDL Number:MFCD04109603
- Synonyms:Kobe 0065;Kobe0065;Kobe-0065;N-(3-Chloro-4-Methylphenyl)-2-[2,6-dinitro-4-(trifluoroMethyl)phenyl]-hydrazinecarbothioaMide;Kobe0065, 436133-68-5;Kobe-0065 N-(3-Chloro-4-methylphenyl)-2-[2,6-dinitro-4-(trifluoromethyl)phenyl]hydrazinecarbothioamide;N-(3-Chloro-4-methylphenyl)-2-[2,6-dinitro-4-(trifluoromethyl)phenyl]hydrazinecarbothioamide KOBE0065;Kobe 0065, >=98%
25 prices
Selected condition：
Brand
- AK Scientific
- ApexBio Technology
- Axon Medchem
- Biorbyt Ltd
- Cayman Chemical
- ChemScene
- DC Chemicals
- Medical Isotopes, Inc.
- Sigma-Aldrich
- TRC
Package
- 1mg
- 5mg
- 10mg
- 25mg
- 50mg
- 100mg
- 200mg
- 250mg
- 500mg
- 1000mg
- 1g
- ManufacturerAK Scientific
- Product numberSYN5190
- Product descriptionKobe0065
- Packaging10mg
- Price$113
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberB3586
- Product descriptionKobe0065
- Packaging10mg
- Price$69
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberB3586
- Product descriptionKobe0065
- Packaging50mg
- Price$200
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberB3586
- Product descriptionKobe0065
- Packaging100mg
- Price$285
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberB3586
- Product descriptionKobe0065
- Packaging200mg
- Price$456
- Updated2021-12-16
- Buy
- ManufacturerAxon Medchem
- Product numberAxon2302
- Product descriptionKobe0065 99%
- Packaging50mg
- Price$231
- Updated2021-12-16
- Buy
- ManufacturerBiorbyt Ltd
- Product numberorb181269
- Product descriptionKobe0065 >98%
- Packaging100mg
- Price$615.4
- Updated2021-12-16
- Buy
- ManufacturerBiorbyt Ltd
- Product numberorb181269
- Product descriptionKobe0065 >98%
- Packaging250mg
- Price$1208.7
- Updated2021-12-16
- Buy
- ManufacturerBiorbyt Ltd
- Product numberorb181269
- Product descriptionKobe0065 >98%
- Packaging1000mg
- Price$2395.3
- Updated2021-12-16
- Buy
- ManufacturerCayman Chemical
- Product number16261
- Product descriptionKobe 0065 ≥98%
- Packaging1mg
- Price$37
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number16261
- Product descriptionKobe 0065 ≥98%
- Packaging5mg
- Price$90
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number16261
- Product descriptionKobe 0065 ≥98%
- Packaging10mg
- Price$161
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number16261
- Product descriptionKobe 0065 ≥98%
- Packaging25mg
- Price$353
- Updated2024-03-01
- Buy
- ManufacturerChemScene
- Product numberCS-3092
- Product descriptionKobe0065 99.94%
- Packaging10mg
- Price$72
- Updated2021-12-16
- Buy
- ManufacturerChemScene
- Product numberCS-3092
- Product descriptionKobe0065 99.94%
- Packaging50mg
- Price$162
- Updated2021-12-16
- Buy
- ManufacturerChemScene
- Product numberCS-3092
- Product descriptionKobe0065 99.94%
- Packaging100mg
- Price$264
- Updated2021-12-16
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| AK Scientific | SYN5190 | Kobe0065 | 10mg | $113 | 2021-12-16 | Buy |
| ApexBio Technology | B3586 | Kobe0065 | 10mg | $69 | 2021-12-16 | Buy |
| ApexBio Technology | B3586 | Kobe0065 | 50mg | $200 | 2021-12-16 | Buy |
| ApexBio Technology | B3586 | Kobe0065 | 100mg | $285 | 2021-12-16 | Buy |
| ApexBio Technology | B3586 | Kobe0065 | 200mg | $456 | 2021-12-16 | Buy |
| Axon Medchem | Axon2302 | Kobe0065 99% | 50mg | $231 | 2021-12-16 | Buy |
| Biorbyt Ltd | orb181269 | Kobe0065 >98% | 100mg | $615.4 | 2021-12-16 | Buy |
| Biorbyt Ltd | orb181269 | Kobe0065 >98% | 250mg | $1208.7 | 2021-12-16 | Buy |
| Biorbyt Ltd | orb181269 | Kobe0065 >98% | 1000mg | $2395.3 | 2021-12-16 | Buy |
| Cayman Chemical | 16261 | Kobe 0065 ≥98% | 1mg | $37 | 2024-03-01 | Buy |
| Cayman Chemical | 16261 | Kobe 0065 ≥98% | 5mg | $90 | 2024-03-01 | Buy |
| Cayman Chemical | 16261 | Kobe 0065 ≥98% | 10mg | $161 | 2024-03-01 | Buy |
| Cayman Chemical | 16261 | Kobe 0065 ≥98% | 25mg | $353 | 2024-03-01 | Buy |
| ChemScene | CS-3092 | Kobe0065 99.94% | 10mg | $72 | 2021-12-16 | Buy |
| ChemScene | CS-3092 | Kobe0065 99.94% | 50mg | $162 | 2021-12-16 | Buy |
| ChemScene | CS-3092 | Kobe0065 99.94% | 100mg | $264 | 2021-12-16 | Buy |
Properties
Melting point :>166°C (dec.)
Boiling point :485.1±55.0 °C(Predicted)
Density :1.653±0.06 g/cm3(Predicted)
storage temp. :Keep in dark place,Sealed in dry,2-8°C
solubility :DMSO: soluble15mg/mL, clear
form :powder
pka :9.25±0.70(Predicted)
color :white to beige
InChI :InChI=1S/C15H11ClF3N5O4S/c1-7-2-3-9(6-10(7)16)20-14(29)22-21-13-11(23(25)26)4-8(15(17,18)19)5-12(13)24(27)28/h2-6,21H,1H3,(H2,20,22,29)
InChIKey :KSJVAYBCXSURMQ-UHFFFAOYSA-N
SMILES :N(C(NC1=CC=C(C)C(Cl)=C1)=S)NC1=C([N+]([O-])=O)C=C(C(F)(F)F)C=C1[N+]([O-])=O
Boiling point :485.1±55.0 °C(Predicted)
Density :1.653±0.06 g/cm3(Predicted)
storage temp. :Keep in dark place,Sealed in dry,2-8°C
solubility :DMSO: soluble15mg/mL, clear
form :powder
pka :9.25±0.70(Predicted)
color :white to beige
InChI :InChI=1S/C15H11ClF3N5O4S/c1-7-2-3-9(6-10(7)16)20-14(29)22-21-13-11(23(25)26)4-8(15(17,18)19)5-12(13)24(27)28/h2-6,21H,1H3,(H2,20,22,29)
InChIKey :KSJVAYBCXSURMQ-UHFFFAOYSA-N
SMILES :N(C(NC1=CC=C(C)C(Cl)=C1)=S)NC1=C([N+]([O-])=O)C=C(C(F)(F)F)C=C1[N+]([O-])=O
Safety Information
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| Signal word: | Warning | |||||||||||||||||||||||||||||||||||
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Description
The Ras family of small GTPases (H-Ras, K-Ras, and N-Ras) function as molecular switches, cycling between a GTP-bound active state and a GDP-bound inactive state, to turn on downstream Raf protein kinases. This initiates complex signaling pathways involved in cell growth, differentiation, and apoptosis. Mutations leading to aberrant Ras activation are frequently associated with various human cancers. Kobe 0065 is an orally active Ras inhibitor with selectivity for H-Ras (Ki = 46 μM). It can inhibit both anchorage-dependent and -independent growth and induce apoptosis of H-RasG12V-transformed NIH 3T3 cells (IC50 = ~1.5 μM), which leads to a down-regulation of MEK/ERK, Akt, RalA, and Son of sevenless. At an oral dose of 80 mg/kg, Kobe 0065 also exhibits antitumor activity in mice bearing a xenograft of human colon cancer SW480 cells expressing K-RasG12V.Related product price
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