Lomeguatrib
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- $37 - $1802
- Product name: Lomeguatrib
- CAS: 192441-08-0
- MF: C10H8BrN5OS
- MW: 326.17
- EINECS:
- MDL Number:MFCD23703756
- Synonyms:Lomeguatrib;2-Amino-6-[(4-bromo-2-thienyl)methoxy]-9H-purine;6-[(4-bromothiophen-2-yl)methoxy]-7H-purin-2-amine;6-((4-Bromo-2-thienyl)methoxy)purin-2-amine;C521206;2-AMino-6-(4-broMothiophen-2-ylMethoxy)-9H-purine;6-[(4-BroMo-2-thienyl)Methoxy] -1H-purin-2-aMine;6-[(4-BroMo-2-thienyl)Methoxy]-9H-purin-2-aMine
44 prices
Selected condition：
Brand
- AK Scientific
- Ambeed
- ApexBio Technology
- Arctom
- Axon Medchem
- Biorbyt Ltd
- Biosynth Carbosynth
- Cayman Chemical
- Chemenu
- ChemScene
- Crysdot
- CSNpharm
- DC Chemicals
- Matrix Scientific
- Sigma-Aldrich
- Tocris
- TRC
- Usbiological
Package
- 10.00mg
- 25mg
- 50.00mg
- 100.00mg
- 10
- 5mg
- 10mg
- 50mg
- 50
- 10mM(in1mLDMSO)
- 100mg
- 250mg
- 1000mg
- 1g
- ManufacturerAK Scientific
- Product numberJ96194
- Product descriptionLomeguatrib
- Packaging50mg
- Price$270
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA129482
- Product description6-((4-Bromothiophen-2-yl)methoxy)-9H-purin-2-amine 98+%
- Packaging10mg
- Price$163
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA129482
- Product description6-((4-Bromothiophen-2-yl)methoxy)-9H-purin-2-amine 98+%
- Packaging5mg
- Price$96
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA129482
- Product description6-((4-Bromothiophen-2-yl)methoxy)-9H-purin-2-amine 98+%
- Packaging50mg
- Price$415
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA1912
- Product descriptionLomeguatrib
- Packaging10mg
- Price$50
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA1912
- Product descriptionLomeguatrib
- Packaging10mg
- Price$50
- Updated2026-05-06
- Buy
- ManufacturerApexBio Technology
- Product numberA1912
- Product descriptionLomeguatrib
- Packaging10mM(in1mLDMSO)
- Price$60
- Updated2026-05-06
- Buy
- ManufacturerApexBio Technology
- Product numberA1912
- Product descriptionLomeguatrib
- Packaging50mg
- Price$200
- Updated2026-05-06
- Buy
- ManufacturerArctom
- Product numberAS443876
- Product descriptionLomeguatrib ≥98%
- Packaging50mg
- Price$411
- Updated2021-12-16
- Buy
- ManufacturerAxon Medchem
- Product numberAxon2223
- Product descriptionLomeguatrib-PaTrin2 99%
- Packaging50mg
- Price$522.5
- Updated2021-12-16
- Buy
- ManufacturerAxon Medchem
- Product numberAxon2223
- Product descriptionLomeguatrib
- Packaging50mg
- Price$522.5
- Updated2026-05-19
- Buy
- ManufacturerAxon Medchem
- Product numberAxon2223
- Product descriptionLomeguatrib
- Packaging10mg
- Price$148.5
- Updated2026-05-19
- Buy
- ManufacturerBiorbyt Ltd
- Product numberorb181050
- Product descriptionLomeguatrib (PaTrin-2) >98%
- Packaging1000mg
- Price$1802
- Updated2021-12-16
- Buy
- ManufacturerBiorbyt Ltd
- Product numberorb181050
- Product descriptionLomeguatrib (PaTrin-2) >98%
- Packaging250mg
- Price$912.9
- Updated2021-12-16
- Buy
- ManufacturerBiorbyt Ltd
- Product numberorb181050
- Product descriptionLomeguatrib (PaTrin-2) >98%
- Packaging100mg
- Price$606.9
- Updated2021-12-16
- Buy
- ManufacturerBiosynth Carbosynth
- Product numberFL65065
- Product descriptionLomeguatrib
- Packaging10mg
- Price$59
- Updated2021-12-16
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| AK Scientific | J96194 | Lomeguatrib | 50mg | $270 | 2021-12-16 | Buy |
| Ambeed | A129482 | 6-((4-Bromothiophen-2-yl)methoxy)-9H-purin-2-amine 98+% | 10mg | $163 | 2021-12-16 | Buy |
| Ambeed | A129482 | 6-((4-Bromothiophen-2-yl)methoxy)-9H-purin-2-amine 98+% | 5mg | $96 | 2021-12-16 | Buy |
| Ambeed | A129482 | 6-((4-Bromothiophen-2-yl)methoxy)-9H-purin-2-amine 98+% | 50mg | $415 | 2021-12-16 | Buy |
| ApexBio Technology | A1912 | Lomeguatrib | 10mg | $50 | 2021-12-16 | Buy |
| ApexBio Technology | A1912 | Lomeguatrib | 10mg | $50 | 2026-05-06 | Buy |
| ApexBio Technology | A1912 | Lomeguatrib | 10mM(in1mLDMSO) | $60 | 2026-05-06 | Buy |
| ApexBio Technology | A1912 | Lomeguatrib | 50mg | $200 | 2026-05-06 | Buy |
| Arctom | AS443876 | Lomeguatrib ≥98% | 50mg | $411 | 2021-12-16 | Buy |
| Axon Medchem | Axon2223 | Lomeguatrib-PaTrin2 99% | 50mg | $522.5 | 2021-12-16 | Buy |
| Axon Medchem | Axon2223 | Lomeguatrib | 50mg | $522.5 | 2026-05-19 | Buy |
| Axon Medchem | Axon2223 | Lomeguatrib | 10mg | $148.5 | 2026-05-19 | Buy |
| Biorbyt Ltd | orb181050 | Lomeguatrib (PaTrin-2) >98% | 1000mg | $1802 | 2021-12-16 | Buy |
| Biorbyt Ltd | orb181050 | Lomeguatrib (PaTrin-2) >98% | 250mg | $912.9 | 2021-12-16 | Buy |
| Biorbyt Ltd | orb181050 | Lomeguatrib (PaTrin-2) >98% | 100mg | $606.9 | 2021-12-16 | Buy |
| Biosynth Carbosynth | FL65065 | Lomeguatrib | 10mg | $59 | 2021-12-16 | Buy |
Properties
Boiling point :683.8±65.0 °C(Predicted)
Density :2.07
storage temp. :Keep in dark place,Inert atmosphere,2-8°C
solubility :DMSO: soluble10mg/mL, clear
pka :9.42±0.10(Predicted)
form :powder
color :white to beige
Stability :Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months.
InChI :1S/C10H8BrN5OS/c11-5-1-6(18-3-5)2-17-9-7-8(14-4-13-7)15-10(12)16-9/h1,3-4H,2H2,(H3,12,13,14,15,16)
InChIKey :JUJPKFNFCWJBCX-UHFFFAOYSA-N
SMILES :Nc1nc(OCc2cc(Br)cs2)c3nc[nH]c3n1
Density :2.07
storage temp. :Keep in dark place,Inert atmosphere,2-8°C
solubility :DMSO: soluble10mg/mL, clear
pka :9.42±0.10(Predicted)
form :powder
color :white to beige
Stability :Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months.
InChI :1S/C10H8BrN5OS/c11-5-1-6(18-3-5)2-17-9-7-8(14-4-13-7)15-10(12)16-9/h1,3-4H,2H2,(H3,12,13,14,15,16)
InChIKey :JUJPKFNFCWJBCX-UHFFFAOYSA-N
SMILES :Nc1nc(OCc2cc(Br)cs2)c3nc[nH]c3n1
Safety Information
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| Signal word: | Warning | ||||||||||||||
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Description
O6-Methylguanine-DNA methyltransferase (MGMT) is a DNA repair protein which removes an alkyl group from the O6 position on guanine in an autoinactivating reaction. Although important in normal DNA repair, this reaction confers resistance to treatments that use O6-alkylating agents to produce cytotoxicity, e.g., in cancer. Lomeguatrib is a modified quanine base which acts as a pseudosubstrate inactivator of MGMT (IC50 = ~3 nM). A non-toxic compound, lomeguatrib completely inactivates MGMT in human prostate and colorectal tumors when given as a single 120 mg oral dose and in primary central nervous system cancers at 160 mg.More related product prices
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