MAZ51
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- $10 - $2980
- Product name: MAZ51
- CAS: 163655-37-6
- MF: C21H18N2O
- MW: 314.38
- EINECS:
- MDL Number:MFCD04036983
- Synonyms:MAZ51;3-(4-DIMETHYLAMINO-NAPHTHALEN-1-YLMETHYLENE)-1,3-DIHYDRO-INDOL-2-ONE;(3E)-3-{[4-(Dimethylamino)-1-naphthyl]methylene}-1,3-dihydro-2H-indol-2-one;(3E)-3-[[4-(dimethylamino)naphthalen-1-yl]methylidene]-1H-indol-2-one;CS-2885;MAZ51;MAZ-51;MAZ 51;2H-Indol-2-one, 3-[[4-(dimethylamino)-1-naphthalenyl]methylene]-1,3-dihydro-;VEGFR3 Kinase Inhibitor, MAZ
31 prices
Selected condition：
Brand
- aablocks
- ACHEMBLOCK
- Ambeed
- ApexBio Technology
- Cayman Chemical
- ChemScene
- DC Chemicals
- Medical Isotopes, Inc.
- Sigma-Aldrich
- TRC
Package
- 1mg
- 2mg
- 5mg
- 10mg
- 25mg
- 50mg
- 100mg
- 250MG
- 1G
- 5G
- Manufactureraablocks
- Product numberAA001U7O
- Product description3-((4-(Dimethylamino)naphthalen-1-yl)methylene)indolin-2-one ≥98%
- Packaging2mg
- Price$10
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA001U7O
- Product description3-((4-(Dimethylamino)naphthalen-1-yl)methylene)indolin-2-one ≥98%
- Packaging5mg
- Price$21
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA001U7O
- Product description3-((4-(Dimethylamino)naphthalen-1-yl)methylene)indolin-2-one 98%
- Packaging25mg
- Price$67
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA001U7O
- Product description3-((4-(Dimethylamino)naphthalen-1-yl)methylene)indolin-2-one 98%
- Packaging50mg
- Price$97
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA001U7O
- Product description3-((4-(Dimethylamino)naphthalen-1-yl)methylene)indolin-2-one ≥98%
- Packaging100mg
- Price$167
- Updated2026-05-28
- Buy
- ManufacturerACHEMBLOCK
- Product numberX185974
- Product description3-[[4-(Dimethylamino)-naphthalen-1-yl]methylene]-1,3-dihydro-2H-indol-2-one 95%
- Packaging250MG
- Price$355
- Updated2026-05-27
- Buy
- ManufacturerACHEMBLOCK
- Product numberX185974
- Product description3-[[4-(Dimethylamino)-naphthalen-1-yl]methylene]-1,3-dihydro-2H-indol-2-one 95%
- Packaging1G
- Price$745
- Updated2026-05-27
- Buy
- ManufacturerACHEMBLOCK
- Product numberX185974
- Product description3-[[4-(Dimethylamino)-naphthalen-1-yl]methylene]-1,3-dihydro-2H-indol-2-one 95%
- Packaging5G
- Price$2980
- Updated2026-05-27
- Buy
- ManufacturerAmbeed
- Product numberA1361928
- Product description3-((4-(Dimethylamino)naphthalen-1-yl)methylene)indolin-2-one 98%
- Packaging50mg
- Price$124
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA1361928
- Product description3-((4-(Dimethylamino)naphthalen-1-yl)methylene)indolin-2-one 98%
- Packaging100mg
- Price$186
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA1361928
- Product description3-((4-(Dimethylamino)naphthalen-1-yl)methylene)indolin-2-one 98%
- Packaging25mg
- Price$83
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberC3342
- Product descriptionMAZ51
- Packaging5mg
- Price$87
- Updated2026-05-06
- Buy
- ManufacturerApexBio Technology
- Product numberC3342
- Product descriptionMAZ51
- Packaging1mg
- Price$50
- Updated2026-05-06
- Buy
- ManufacturerApexBio Technology
- Product numberC3342
- Product descriptionMAZ51
- Packaging25mg
- Price$301
- Updated2026-05-06
- Buy
- ManufacturerApexBio Technology
- Product numberC3342
- Product descriptionMAZ51
- Packaging10mg
- Price$150
- Updated2026-05-06
- Buy
- ManufacturerCayman Chemical
- Product number16168
- Product descriptionMAZ51 ≥95%
- Packaging25mg
- Price$458
- Updated2026-04-30
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| aablocks | AA001U7O | 3-((4-(Dimethylamino)naphthalen-1-yl)methylene)indolin-2-one ≥98% | 2mg | $10 | 2026-05-28 | Buy |
| aablocks | AA001U7O | 3-((4-(Dimethylamino)naphthalen-1-yl)methylene)indolin-2-one ≥98% | 5mg | $21 | 2026-05-28 | Buy |
| aablocks | AA001U7O | 3-((4-(Dimethylamino)naphthalen-1-yl)methylene)indolin-2-one 98% | 25mg | $67 | 2026-05-28 | Buy |
| aablocks | AA001U7O | 3-((4-(Dimethylamino)naphthalen-1-yl)methylene)indolin-2-one 98% | 50mg | $97 | 2026-05-28 | Buy |
| aablocks | AA001U7O | 3-((4-(Dimethylamino)naphthalen-1-yl)methylene)indolin-2-one ≥98% | 100mg | $167 | 2026-05-28 | Buy |
| ACHEMBLOCK | X185974 | 3-[[4-(Dimethylamino)-naphthalen-1-yl]methylene]-1,3-dihydro-2H-indol-2-one 95% | 250MG | $355 | 2026-05-27 | Buy |
| ACHEMBLOCK | X185974 | 3-[[4-(Dimethylamino)-naphthalen-1-yl]methylene]-1,3-dihydro-2H-indol-2-one 95% | 1G | $745 | 2026-05-27 | Buy |
| ACHEMBLOCK | X185974 | 3-[[4-(Dimethylamino)-naphthalen-1-yl]methylene]-1,3-dihydro-2H-indol-2-one 95% | 5G | $2980 | 2026-05-27 | Buy |
| Ambeed | A1361928 | 3-((4-(Dimethylamino)naphthalen-1-yl)methylene)indolin-2-one 98% | 50mg | $124 | 2021-12-16 | Buy |
| Ambeed | A1361928 | 3-((4-(Dimethylamino)naphthalen-1-yl)methylene)indolin-2-one 98% | 100mg | $186 | 2021-12-16 | Buy |
| Ambeed | A1361928 | 3-((4-(Dimethylamino)naphthalen-1-yl)methylene)indolin-2-one 98% | 25mg | $83 | 2021-12-16 | Buy |
| ApexBio Technology | C3342 | MAZ51 | 5mg | $87 | 2026-05-06 | Buy |
| ApexBio Technology | C3342 | MAZ51 | 1mg | $50 | 2026-05-06 | Buy |
| ApexBio Technology | C3342 | MAZ51 | 25mg | $301 | 2026-05-06 | Buy |
| ApexBio Technology | C3342 | MAZ51 | 10mg | $150 | 2026-05-06 | Buy |
| Cayman Chemical | 16168 | MAZ51 ≥95% | 25mg | $458 | 2026-04-30 | Buy |
Properties
Boiling point :553.917±50.00 °C(Press: 760.00 Torr)(predicted)
Density :1.253±0.06 g/cm3(Temp: 25 °C; Press: 760 Torr)(predicted)
storage temp. :2-8°C
solubility :DMSO: 11 mg/mL
form :solid
pka :12.137±0.20(predicted)
color :orange
InChI :1S/C21H18N2O/c1-23(2)20-12-11-14(15-7-3-4-9-17(15)20)13-18-16-8-5-6-10-19(16)22-21(18)24/h3-13H,1-2H3,(H,22,24)
InChIKey :VFCXONOPGCDDBQ-UHFFFAOYSA-N
SMILES :N1c2c(cccc2)C(=Cc3c4c(c(cc3)N(C)C)cccc4)C1=O
Density :1.253±0.06 g/cm3(Temp: 25 °C; Press: 760 Torr)(predicted)
storage temp. :2-8°C
solubility :DMSO: 11 mg/mL
form :solid
pka :12.137±0.20(predicted)
color :orange
InChI :1S/C21H18N2O/c1-23(2)20-12-11-14(15-7-3-4-9-17(15)20)13-18-16-8-5-6-10-19(16)22-21(18)24/h3-13H,1-2H3,(H,22,24)
InChIKey :VFCXONOPGCDDBQ-UHFFFAOYSA-N
SMILES :N1c2c(cccc2)C(=Cc3c4c(c(cc3)N(C)C)cccc4)C1=O
Safety Information
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Description
The VEGF receptors (VEGFRs) mediate signaling leading to angiogenesis, with VEGFR3 (FLT4), activated by VEGF isoforms VEGFC and VEGFD, primarily expressed on lymphatic endothelial cells and directing lymphangiogenesis. MAZ51 is an indolinone that selectively antagonizes the activation of VEGFR3 by VEGFC (IC50 = 1 μM) without blocking VEGFC-mediated stimulation of VEGFR2. It does not inhibit ligand-induced autophosphorylation of EGFR, IGF-1R, or PDGFRβ. By preventing VEGFR3 activation, MAZ51 interferes with an autocrine loop involving the induced expression of the ligand VEGFC as well as VEGFA. It reduces proliferation and induces apoptosis in a variety of cancer cells in vitro and suppresses tumor growth in vivo. MAZ51 is used to study the role of VEGFR3 in endothelial and cancer cell function and survival.More related product prices
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