METHYSERGIDE MALEATE
|
- $32 - $1385
- Product name: METHYSERGIDE MALEATE
- CAS: 129-49-7
- MF: C25H31N3O6
- MW: 469.54
- EINECS:204-950-9
- MDL Number:MFCD00083185
- Synonyms:1-(hydroxymethyl)propylamideof1-methyl-(+)-lysergicacidhydrogenmaleate ;deseril-retard ;ergoline-8-beta-carboxamide,9,10-didehydro-n-(1-(hydroxymethyl)propyl)-1,6-dim ;maleate(1:1)(salt) ;Methysergide Maleate, USP;Methysergide Maleate (350 mg);methysergidebimaleate ;methysergidedimaleate
30 prices
Selected condition：
Brand
- AK Scientific
- American Custom Chemicals Corporation
- ApexBio Technology
- Cayman Chemical
- Sigma-Aldrich
- Tocris
- TRC
- Usbiological
Package
- 5mg
- 10
- 1mg
- 2mg
- 10MG
- 50
- 25mg
- 50MG
- 350mg
- ManufacturerAK Scientific
- Product numberG831
- Product descriptionMethysergide maleate
- Packaging25mg
- Price$522
- Updated2021-12-16
- Buy
- ManufacturerAmerican Custom Chemicals Corporation
- Product numberAPI0002261
- Product descriptionDESERIL 95.00%
- Packaging10MG
- Price$726.44
- Updated2021-12-16
- Buy
- ManufacturerAmerican Custom Chemicals Corporation
- Product numberAPI0002261
- Product descriptionDESERIL 95.00%
- Packaging50MG
- Price$1352.22
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberB5046
- Product descriptionMethysergide maleate
- Packaging50mg
- Price$1385
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberB5046
- Product descriptionMethysergide maleate
- Packaging50mg
- Price$1385
- Updated2026-05-06
- Buy
- ManufacturerApexBio Technology
- Product numberB5046
- Product descriptionMethysergide maleate
- Packaging25mg
- Price$525
- Updated2026-05-06
- Buy
- ManufacturerApexBio Technology
- Product numberB5046
- Product descriptionMethysergide maleate
- Packaging10mg
- Price$329
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberB5046
- Product descriptionMethysergide maleate
- Packaging1mg
- Price$50
- Updated2026-05-06
- Buy
- ManufacturerApexBio Technology
- Product numberB5046
- Product descriptionMethysergide maleate
- Packaging5mg
- Price$150
- Updated2026-05-06
- Buy
- ManufacturerApexBio Technology
- Product numberB5046
- Product descriptionMethysergide maleate
- Packaging10mg
- Price$235
- Updated2026-05-06
- Buy
- ManufacturerCayman Chemical
- Product number27658
- Product descriptionMethysergide (maleate)
- Packaging10mg
- Price$169
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number27658
- Product descriptionMethysergide (maleate) ≥95%
- Packaging10mg
- Price$186
- Updated2026-04-30
- Buy
- ManufacturerCayman Chemical
- Product number27658
- Product descriptionMethysergide (maleate)
- Packaging5mg
- Price$109
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number27658
- Product descriptionMethysergide (maleate) ≥95%
- Packaging5mg
- Price$120
- Updated2026-04-30
- Buy
- ManufacturerCayman Chemical
- Product number27658
- Product descriptionMethysergide (maleate)
- Packaging1mg
- Price$32
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number27658
- Product descriptionMethysergide (maleate) ≥95%
- Packaging1mg
- Price$36
- Updated2026-04-30
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| AK Scientific | G831 | Methysergide maleate | 25mg | $522 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | API0002261 | DESERIL 95.00% | 10MG | $726.44 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | API0002261 | DESERIL 95.00% | 50MG | $1352.22 | 2021-12-16 | Buy |
| ApexBio Technology | B5046 | Methysergide maleate | 50mg | $1385 | 2021-12-16 | Buy |
| ApexBio Technology | B5046 | Methysergide maleate | 50mg | $1385 | 2026-05-06 | Buy |
| ApexBio Technology | B5046 | Methysergide maleate | 25mg | $525 | 2026-05-06 | Buy |
| ApexBio Technology | B5046 | Methysergide maleate | 10mg | $329 | 2021-12-16 | Buy |
| ApexBio Technology | B5046 | Methysergide maleate | 1mg | $50 | 2026-05-06 | Buy |
| ApexBio Technology | B5046 | Methysergide maleate | 5mg | $150 | 2026-05-06 | Buy |
| ApexBio Technology | B5046 | Methysergide maleate | 10mg | $235 | 2026-05-06 | Buy |
| Cayman Chemical | 27658 | Methysergide (maleate) | 10mg | $169 | 2024-03-01 | Buy |
| Cayman Chemical | 27658 | Methysergide (maleate) ≥95% | 10mg | $186 | 2026-04-30 | Buy |
| Cayman Chemical | 27658 | Methysergide (maleate) | 5mg | $109 | 2024-03-01 | Buy |
| Cayman Chemical | 27658 | Methysergide (maleate) ≥95% | 5mg | $120 | 2026-04-30 | Buy |
| Cayman Chemical | 27658 | Methysergide (maleate) | 1mg | $32 | 2024-03-01 | Buy |
| Cayman Chemical | 27658 | Methysergide (maleate) ≥95% | 1mg | $36 | 2026-04-30 | Buy |
Properties
storage temp. :Store at RT
solubility :DMSO: >10 mg/mL
form :solid
color :white to off-white
Water Solubility :Soluble to 10 mM in water with gentle warming
Stability :Hygroscopic
InChIKey :LWYXFDXUMVEZKS-ZVFOLQIPSA-N
SMILES :[n]1(c2c3c(c1)C[C@H]4N(C[C@@H](C=C4c3ccc2)C(=O)N[C@H](CO)CC)C)C.OC(=O)\C=C/C(=O)O
solubility :DMSO: >10 mg/mL
form :solid
color :white to off-white
Water Solubility :Soluble to 10 mM in water with gentle warming
Stability :Hygroscopic
InChIKey :LWYXFDXUMVEZKS-ZVFOLQIPSA-N
SMILES :[n]1(c2c3c(c1)C[C@H]4N(C[C@@H](C=C4c3ccc2)C(=O)N[C@H](CO)CC)C)C.OC(=O)\C=C/C(=O)O
Safety Information
| Symbol(GHS): |
|
||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Signal word: | Danger | ||||||||||||||
| Hazard statements: |
|
||||||||||||||
| Precautionary statements: |
|
Description
Methysergide is an agonist of the serotonin (5-HT) receptor subtype 5-HT1 and an antagonist of 5-HT2 receptors. It binds to recombinant human 5-HT1A (KD = 23.44 nM), 5-HT1E (Ki = 229.09 nM), 5-HT1F (Ki = 33.88 nM), and rodent 5-HT1B receptors (KD = 1,513.56 nM). It also binds to recombinant human 5-HT2A (Ki = 2.69 nM) and 5-HT2C receptors (KD = 1.26 nM) and is an insurmountable antagonist at 5-HT2B receptors. It inhibits vasoconstriction induced by 5-HT in isolated postmortem human basilar arterial spiral strips (pA2 = 8.07). Methysergide decreases external carotid blood flow in a dose-dependent manner in vagosympathectomized dogs, an effect that is inhibited by the 5-HT1B/1D receptor antagonist GR127935 . It has antinociceptive activity in mouse models of pain induced by intrathecal injection of substance P , glutamate, NMDA , AMPA , or kainic acid. Methysergide reduces zymosan-induced paw edema in rats when administered at a dose of 10 mg/kg. Formulations containing methysergide were previously used in the prevention and treatment of vascular headaches.Related product price
- Cabergoline
$44-3870 - Nicergoline
$5-1288 - 63737-71-3
$55-1155
