MZ 1
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- $19 - $4350
- Product name: MZ 1
- CAS: 1797406-69-9
- MF: C49H60ClN9O8S2
- MW: 1002.64
- EINECS:-0
- MDL Number:MFCD30742945
- Synonyms:MZ 1;(2S,4R)-1-((S)-2-(tert-butyl)-17-((S)-4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)-4,16-dioxo-6,9,12-trioxa-3,15-diazaheptadecanoyl)- 4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide;MZ-1;MZ 1;L-Prolinamide, N-[14-[(6S)-4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl]-1,13-dioxo-3,6,9-trioxa-12-azatetradec-1-yl]-3-methyl-L-valyl-4-hydroxy-N-[[4-(4-methyl-5-thiazolyl)phenyl]methyl]-, (4R)-;(2S,4R)-N-((S)-2-(tert-Butyl)-17-((S)-4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)-4,16-dioxo-6,9,12-trioxa-3,15-diazaheptadecan-1-oyl)-4-hydroxy-1-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide;cells,MZ-1,protein,Inhibitor,Degrader,PROTACs,Epigenetic Reader Domain,BRD4,selective,degradation,LS174t,MZ 1,MZ1,inhibit;Mz1, selectively degrades BRD4;MZ-1 ，S8889
47 prices
Selected condition：
Brand
- aablocks
- ACHEMBLOCK
- AK Scientific
- Ambeed
- Apolloscientific
- Biorbyt Ltd
- Biosynth
- Cayman Chemical
- ChemScene
- DC Chemicals
- Sigma-Aldrich
- Tocris
- TRC
Package
- 500μg
- 2.5mg
- 10mM*1mLinDMSO
- 1mg
- 5
- 5mg
- 10mg
- 25mg
- 50mg
- 100mg
- 250mg
- 500mg
- 1g
- 1000mg
- Manufactureraablocks
- Product numberAA01ENCD
- Product descriptionMZ1 98%
- Packaging1mg
- Price$19
- Updated2026-05-30
- Buy
- Manufactureraablocks
- Product numberAA01ENCD
- Product descriptionMZ1 98%
- Packaging5mg
- Price$36
- Updated2026-05-30
- Buy
- Manufactureraablocks
- Product numberAA01ENCD
- Product descriptionMZ1 98%
- Packaging25mg
- Price$97
- Updated2026-05-30
- Buy
- Manufactureraablocks
- Product numberAA01ENCD
- Product descriptionMZ1 98%
- Packaging50mg
- Price$189
- Updated2026-05-30
- Buy
- Manufactureraablocks
- Product numberAA01ENCD
- Product descriptionMZ1 98%
- Packaging100mg
- Price$270
- Updated2026-05-30
- Buy
- Manufactureraablocks
- Product numberAA01ENCD
- Product descriptionMZ1 98%
- Packaging250mg
- Price$455
- Updated2026-05-30
- Buy
- Manufactureraablocks
- Product numberAA01ENCD
- Product descriptionMZ1 97%
- Packaging1g
- Price$1298
- Updated2026-05-30
- Buy
- ManufacturerACHEMBLOCK
- Product numberY225629
- Product descriptionMZ 1 97.00%
- Packaging100MG
- Price$420
- Updated2026-05-27
- Buy
- ManufacturerACHEMBLOCK
- Product numberY225629
- Product descriptionMZ 1 97.00%
- Packaging50MG
- Price$210
- Updated2026-05-27
- Buy
- ManufacturerAK Scientific
- Product number1534EH
- Product descriptionCID122201421
- Packaging5mg
- Price$536
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA732871
- Product description(2S,4R)-N-((S)-2-(tert-Butyl)-17-((S)-4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)-4,16-dioxo-6,9,12-trioxa-3,15-diazaheptadecan-1-oyl)-4-hydroxy-1-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide 98+%
- Packaging100mg
- Price$490
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA732871
- Product description(2S,4R)-N-((S)-2-(tert-Butyl)-17-((S)-4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)-4,16-dioxo-6,9,12-trioxa-3,15-diazaheptadecan-1-oyl)-4-hydroxy-1-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide 98+%
- Packaging50mg
- Price$305
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA732871
- Product description(2S,4R)-N-((S)-2-(tert-Butyl)-17-((S)-4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)-4,16-dioxo-6,9,12-trioxa-3,15-diazaheptadecan-1-oyl)-4-hydroxy-1-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide 98+%
- Packaging25mg
- Price$200
- Updated2021-12-16
- Buy
- ManufacturerApolloscientific
- Product numberBIPC1044
- Product descriptionMZ1 98%
- Packaging50mg
- Price$293
- Updated2026-06-04
- Buy
- ManufacturerApolloscientific
- Product numberBIPC1044
- Product descriptionMZ1 98%
- Packaging25mg
- Price$150
- Updated2026-06-04
- Buy
- ManufacturerApolloscientific
- Product numberBIPC1044
- Product descriptionMZ1 98%
- Packaging5mg
- Price$56
- Updated2026-06-04
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| aablocks | AA01ENCD | MZ1 98% | 1mg | $19 | 2026-05-30 | Buy |
| aablocks | AA01ENCD | MZ1 98% | 5mg | $36 | 2026-05-30 | Buy |
| aablocks | AA01ENCD | MZ1 98% | 25mg | $97 | 2026-05-30 | Buy |
| aablocks | AA01ENCD | MZ1 98% | 50mg | $189 | 2026-05-30 | Buy |
| aablocks | AA01ENCD | MZ1 98% | 100mg | $270 | 2026-05-30 | Buy |
| aablocks | AA01ENCD | MZ1 98% | 250mg | $455 | 2026-05-30 | Buy |
| aablocks | AA01ENCD | MZ1 97% | 1g | $1298 | 2026-05-30 | Buy |
| ACHEMBLOCK | Y225629 | MZ 1 97.00% | 100MG | $420 | 2026-05-27 | Buy |
| ACHEMBLOCK | Y225629 | MZ 1 97.00% | 50MG | $210 | 2026-05-27 | Buy |
| AK Scientific | 1534EH | CID122201421 | 5mg | $536 | 2021-12-16 | Buy |
| Ambeed | A732871 | (2S,4R)-N-((S)-2-(tert-Butyl)-17-((S)-4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)-4,16-dioxo-6,9,12-trioxa-3,15-diazaheptadecan-1-oyl)-4-hydroxy-1-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide 98+% | 100mg | $490 | 2021-12-16 | Buy |
| Ambeed | A732871 | (2S,4R)-N-((S)-2-(tert-Butyl)-17-((S)-4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)-4,16-dioxo-6,9,12-trioxa-3,15-diazaheptadecan-1-oyl)-4-hydroxy-1-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide 98+% | 50mg | $305 | 2021-12-16 | Buy |
| Ambeed | A732871 | (2S,4R)-N-((S)-2-(tert-Butyl)-17-((S)-4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)-4,16-dioxo-6,9,12-trioxa-3,15-diazaheptadecan-1-oyl)-4-hydroxy-1-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide 98+% | 25mg | $200 | 2021-12-16 | Buy |
| Apolloscientific | BIPC1044 | MZ1 98% | 50mg | $293 | 2026-06-04 | Buy |
| Apolloscientific | BIPC1044 | MZ1 98% | 25mg | $150 | 2026-06-04 | Buy |
| Apolloscientific | BIPC1044 | MZ1 98% | 5mg | $56 | 2026-06-04 | Buy |
Properties
Density :1.39±0.1 g/cm3(Predicted)
storage temp. :Store at -20°C
solubility :Soluble in DMSO:30.0(Max Conc. mg/mL);29.9(Max Conc. mM)
form :A crystalline solid
pka :13.54±0.46(Predicted)
color :White to light yellow
InChIKey :PTAMRJLIOCHJMQ-PYNGZGNASA-N
SMILES :O=C([C@H]1N(C[C@@H](C1)O)C([C@H](C(C)(C)C)NC(COCCOCCOCCNC(C[C@H]2C3=NN=C(N3C4=C(C(C5=CC=C(C=C5)Cl)=N2)C(C)=C(S4)C)C)=O)=O)=O)NCC6=CC=C(C=C6)C7=C(N=CS7)C
storage temp. :Store at -20°C
solubility :Soluble in DMSO:30.0(Max Conc. mg/mL);29.9(Max Conc. mM)
form :A crystalline solid
pka :13.54±0.46(Predicted)
color :White to light yellow
InChIKey :PTAMRJLIOCHJMQ-PYNGZGNASA-N
SMILES :O=C([C@H]1N(C[C@@H](C1)O)C([C@H](C(C)(C)C)NC(COCCOCCOCCNC(C[C@H]2C3=NN=C(N3C4=C(C(C5=CC=C(C=C5)Cl)=N2)C(C)=C(S4)C)C)=O)=O)=O)NCC6=CC=C(C=C6)C7=C(N=CS7)C
Safety Information
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Description
MZ1 is a hybrid compound that drives the selective proteasomal degradation of bromodomain-containing protein 4 (BRD4). It is characterized as a proteolysis-targeting chimera (PROTAC) and contains JQ-1, which binds bromo- and extra-terminal (BET) proteins, linked to a ligand for the E3 ubiquitin ligase VHL. MZ1 induces the selective degradation of BRD4 in HeLa cells when used at 0.1-0.5 μM. At concentrations of 2-10 μM, MZ1 causes the removal of BRD2, BRD3, and BRD4. BRD protein removal is evident within four hours of adding MZ1 and persists for at least 48 hours, unless MZ1 is removed.Suppliers and manufacturers
Bide Pharmatech Ltd.
Shanghai Lollane Biological Technology Co.,Ltd.
Shanghai YuanYe Biotechnology Co., Ltd.
ShangHai Biochempartner Co.,Ltd
Shanghai Chaolan Chemical Technology Center
Jiaxing Deyi Chemical Co., Ltd.
Fan De(Beijing) Biotechnology Co., Ltd.
Jilin Province Woda Biotechnology Co., Ltd.
InvivoChem
