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ChemicalBook >> CAS DataBase List >> MZ 1

MZ 1

MZ 1 price.
  • $48 - $4321.4
  • Product name: MZ 1
  • CAS: 1797406-69-9
  • MF: C49H60ClN9O8S2
  • MW: 1002.64
  • EINECS:-0
  • MDL Number:MFCD30742945
  • Synonyms:MZ 1;(2S,4R)-1-((S)-2-(tert-butyl)-17-((S)-4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)-4,16-dioxo-6,9,12-trioxa-3,15-diazaheptadecanoyl)- 4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide;MZ-1;MZ 1;L-Prolinamide, N-[14-[(6S)-4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl]-1,13-dioxo-3,6,9-trioxa-12-azatetradec-1-yl]-3-methyl-L-valyl-4-hydroxy-N-[[4-(4-methyl-5-thiazolyl)phenyl]methyl]-, (4R)-;(2S,4R)-N-((S)-2-(tert-Butyl)-17-((S)-4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)-4,16-dioxo-6,9,12-trioxa-3,15-diazaheptadecan-1-oyl)-4-hydroxy-1-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide;cells,MZ-1,protein,Inhibitor,Degrader,PROTACs,Epigenetic Reader Domain,BRD4,selective,degradation,LS174t,MZ 1,MZ1,inhibit
Price19 Properties Safety Information Description
19 prices
Selected condition：
Brand
  • AK Scientific
  • Ambeed
  • Biorbyt Ltd
  • Cayman Chemical
  • ChemScene
  • DC Chemicals
  • Sigma-Aldrich
  • Tocris
  • TRC
Package
  • 500μg
  • 1mg
  • 2.5mg
  • 5mg
  • 5
  • 10mg
  • 25mg
  • 50mg
  • 100mg
  • 250mg
  • 1000mg
  • ManufacturerAK Scientific
  • Product number1534EH
  • Product descriptionCID122201421
  • Packaging5mg
  • Price$536
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA732871
  • Product description(2S,4R)-N-((S)-2-(tert-Butyl)-17-((S)-4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)-4,16-dioxo-6,9,12-trioxa-3,15-diazaheptadecan-1-oyl)-4-hydroxy-1-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide 98+%
  • Packaging25mg
  • Price$200
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA732871
  • Product description(2S,4R)-N-((S)-2-(tert-Butyl)-17-((S)-4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)-4,16-dioxo-6,9,12-trioxa-3,15-diazaheptadecan-1-oyl)-4-hydroxy-1-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide 98+%
  • Packaging50mg
  • Price$305
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA732871
  • Product description(2S,4R)-N-((S)-2-(tert-Butyl)-17-((S)-4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)-4,16-dioxo-6,9,12-trioxa-3,15-diazaheptadecan-1-oyl)-4-hydroxy-1-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide 98+%
  • Packaging100mg
  • Price$490
  • Updated2021-12-16
  • Buy
  • ManufacturerBiorbyt Ltd
  • Product numberorb573444
  • Product descriptionMZ1
  • Packaging100mg
  • Price$1208.7
  • Updated2021-12-16
  • Buy
  • ManufacturerBiorbyt Ltd
  • Product numberorb573444
  • Product descriptionMZ1
  • Packaging250mg
  • Price$2245.7
  • Updated2021-12-16
  • Buy
  • ManufacturerBiorbyt Ltd
  • Product numberorb573444
  • Product descriptionMZ1
  • Packaging1000mg
  • Price$4321.4
  • Updated2021-12-16
  • Buy
  • ManufacturerCayman Chemical
  • Product number21622
  • Product descriptionMZ1 ≥98%
  • Packaging500μg
  • Price$48
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number21622
  • Product descriptionMZ1 ≥98%
  • Packaging1mg
  • Price$89
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number21622
  • Product descriptionMZ1 ≥98%
  • Packaging5mg
  • Price$393
  • Updated2024-03-01
  • Buy
  • ManufacturerChemScene
  • Product numberCS-0028453
  • Product descriptionMZ1 99.43%
  • Packaging1mg
  • Price$60
  • Updated2021-12-16
  • Buy
  • ManufacturerChemScene
  • Product numberCS-0028453
  • Product descriptionMZ1 99.43%
  • Packaging5mg
  • Price$200
  • Updated2021-12-16
  • Buy
  • ManufacturerChemScene
  • Product numberCS-0028453
  • Product descriptionMZ1 99.43%
  • Packaging10mg
  • Price$380
  • Updated2021-12-16
  • Buy
  • ManufacturerChemScene
  • Product numberCS-0028453
  • Product descriptionMZ1 99.43%
  • Packaging50mg
  • Price$715
  • Updated2021-12-16
  • Buy
  • ManufacturerDC Chemicals
  • Product numberDC21360
  • Product descriptionMZ1 >98%
  • Packaging100mg
  • Price$800
  • Updated2021-12-16
  • Buy
  • ManufacturerSigma-Aldrich
  • Product numberSML3365
  • Product descriptionMZ1 ≥98% (HPLC)
  • Packaging5MG
  • Price$114
  • Updated2024-03-01
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
AK Scientific 1534EH CID122201421 5mg $536 2021-12-16 Buy
Ambeed A732871 (2S,4R)-N-((S)-2-(tert-Butyl)-17-((S)-4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)-4,16-dioxo-6,9,12-trioxa-3,15-diazaheptadecan-1-oyl)-4-hydroxy-1-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide 98+% 25mg $200 2021-12-16 Buy
Ambeed A732871 (2S,4R)-N-((S)-2-(tert-Butyl)-17-((S)-4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)-4,16-dioxo-6,9,12-trioxa-3,15-diazaheptadecan-1-oyl)-4-hydroxy-1-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide 98+% 50mg $305 2021-12-16 Buy
Ambeed A732871 (2S,4R)-N-((S)-2-(tert-Butyl)-17-((S)-4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)-4,16-dioxo-6,9,12-trioxa-3,15-diazaheptadecan-1-oyl)-4-hydroxy-1-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide 98+% 100mg $490 2021-12-16 Buy
Biorbyt Ltd orb573444 MZ1 100mg $1208.7 2021-12-16 Buy
Biorbyt Ltd orb573444 MZ1 250mg $2245.7 2021-12-16 Buy
Biorbyt Ltd orb573444 MZ1 1000mg $4321.4 2021-12-16 Buy
Cayman Chemical 21622 MZ1 ≥98% 500μg $48 2024-03-01 Buy
Cayman Chemical 21622 MZ1 ≥98% 1mg $89 2024-03-01 Buy
Cayman Chemical 21622 MZ1 ≥98% 5mg $393 2024-03-01 Buy
ChemScene CS-0028453 MZ1 99.43% 1mg $60 2021-12-16 Buy
ChemScene CS-0028453 MZ1 99.43% 5mg $200 2021-12-16 Buy
ChemScene CS-0028453 MZ1 99.43% 10mg $380 2021-12-16 Buy
ChemScene CS-0028453 MZ1 99.43% 50mg $715 2021-12-16 Buy
DC Chemicals DC21360 MZ1 >98% 100mg $800 2021-12-16 Buy
Sigma-Aldrich SML3365 MZ1 ≥98% (HPLC) 5MG $114 2024-03-01 Buy
Next Last

Properties

Density :1.39±0.1 g/cm3(Predicted)
storage temp. :Store at -20°C
solubility :Soluble in DMSO:30.0(Max Conc. mg/mL);29.9(Max Conc. mM)
form :A crystalline solid
pka :13.54±0.46(Predicted)
color :White to light yellow

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H302 Harmful if swallowed Acute toxicity,oral Category 4 Warning GHS hazard pictograms P264, P270, P301+P312, P330, P501
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning GHS hazard pictograms P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning GHS hazard pictograms P264, P280, P305+P351+P338,P337+P313P
H335 May cause respiratory irritation Specific target organ toxicity, single exposure;Respiratory tract irritation Category 3 Warning GHS hazard pictograms
Precautionary statements:
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Description

MZ1 is a hybrid compound that drives the selective proteasomal degradation of bromodomain-containing protein 4 (BRD4). It is characterized as a proteolysis-targeting chimera (PROTAC) and contains JQ-1, which binds bromo- and extra-terminal (BET) proteins, linked to a ligand for the E3 ubiquitin ligase VHL. MZ1 induces the selective degradation of BRD4 in HeLa cells when used at 0.1-0.5 μM. At concentrations of 2-10 μM, MZ1 causes the removal of BRD2, BRD3, and BRD4. BRD protein removal is evident within four hours of adding MZ1 and persists for at least 48 hours, unless MZ1 is removed.

Suppliers and manufacturers

Wuhan Fortuna Chemical Co., Ltd
MZ 1
$0.00 /1mg
MZ 1 CAS:1797406-69-9
Shanghai finete Pharmaceutical Co., Ltd.
ATK CHEMICAL COMPANY LIMITED
BOC Sciences
Career Henan Chemica Co
HANGZHOU CLAP TECHNOLOGY CO.,LTD
InvivoChem
TargetMol Chemicals Inc.
Wuhan Topule Biopharmaceutical Co., Ltd
LEAPCHEM CO., LTD.