Metolazone
|
- $36 - $1593.9
- Product name: Metolazone
- CAS: 17560-51-9
- MF: C16H16ClN3O3S
- MW: 365.83
- EINECS:241-539-3
- MDL Number:MFCD00069304
- Synonyms:s720-22 ;7-Chloro-1,2,3,4-tetrahydro-2-methyl-3-(2-methylphenyl)-4-oxo-6-quinazolinesulfonamide, SR-720-22, Diulo, Metenix, Mykrox, Oldren,;6-Quinazolinesulfonamide, 7-chloro-1,2,3,4-tetrahydro-2-methyl-3-(2-methylphenyl)-4-oxo- (9CI);6-Quinazolinesulfonamide, 7-chloro-1,2,3,4-tetrahydro-2-methyl-4-oxo-3-o-tolyl- (8CI);Normelan;Xuret;6-Quinazolinesulfonamide, 7-chloro-1,2,3,4-tetrahydro- 2-methyl-3-(2-methylphenyl)-4-oxo-;METAZOLINE
53 prices
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Brand
- AHH
- AK Scientific
- American Custom Chemicals Corporation
- ApexBio Technology
- Arctom
- Axon Medchem
- Biorbyt Ltd
- Biosynth
- Cayman Chemical
- ChemScene
- DC Chemicals
- Sigma-Aldrich
- TCI Chemical
- Thermo Scientific Chemicals
- TRC
- Usbiological
Package
- 200mg
- y0000701
- 10mg
- 250mg
- 500mg
- 1000mg
- y0000702
- 1mg
- 5mg
- 25mg
- 50mg
- 100mg
- 1G
- 10mM*1mLinDMSO(Solid+Solvent)
- 10g
- 80 mg
- 5g
- 10 mg
- 10mM*1mLinDMSO(Solution)
- ManufacturerAHH
- Product numberAPI-1565
- Product descriptionMetolazone 97%
- Packaging10g
- Price$410
- Updated2026-05-26
- Buy
- ManufacturerAK Scientific
- Product numberH024
- Product descriptionMetolazone 98%(HPLC),powder
- Packaging100mg
- Price$429
- Updated2026-06-04
- Buy
- ManufacturerAK Scientific
- Product numberH024
- Product descriptionMetolazone 98%(HPLC),powder
- Packaging5mg
- Price$69
- Updated2026-06-04
- Buy
- ManufacturerAK Scientific
- Product numberH024
- Product descriptionMetolazone
- Packaging50mg
- Price$96
- Updated2021-12-16
- Buy
- ManufacturerAK Scientific
- Product numberH024
- Product descriptionMetolazone 98%(HPLC),powder
- Packaging25mg
- Price$148
- Updated2026-06-04
- Buy
- ManufacturerAmerican Custom Chemicals Corporation
- Product numberAPI0003352
- Product descriptionMETOLAZONE 95.00%
- Packaging100MG
- Price$704.55
- Updated2021-12-16
- Buy
- ManufacturerAmerican Custom Chemicals Corporation
- Product numberAPI0003352
- Product descriptionMETOLAZONE 95.00%
- Packaging1G
- Price$1593.9
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberB1975
- Product descriptionMetolazone
- Packaging50mg
- Price$68
- Updated2026-05-06
- Buy
- ManufacturerArctom
- Product numberHY-B0209
- Product descriptionMetolazone 99.68%
- Packaging100mg
- Price$86
- Updated2026-05-26
- Buy
- ManufacturerArctom
- Product numberHY-B0209
- Product descriptionMetolazone 99.68%
- Packaging50mg
- Price$57
- Updated2026-05-26
- Buy
- ManufacturerArctom
- Product numberHY-B0209
- Product descriptionMetolazone 99.68%
- Packaging10mM*1mLinDMSO(Solid+Solvent)
- Price$60
- Updated2026-05-26
- Buy
- ManufacturerArctom
- Product numberHY-B0209R
- Product descriptionMetolazone (Standard) 97.11%
- Packaging10mg
- Price$62
- Updated2026-05-26
- Buy
- ManufacturerArctom
- Product numberHY-B0209R
- Product descriptionMetolazone (Standard) 97.11%
- Packaging5mg
- Price$39
- Updated2026-05-26
- Buy
- ManufacturerArctom
- Product numberHY-B0209
- Product descriptionMetolazone 99.68%
- Packaging10mM*1mLinDMSO(Solution)
- Price$63
- Updated2026-05-26
- Buy
- ManufacturerArctom
- Product numberHY-B0209R
- Product descriptionMetolazone (Standard) 97.11%
- Packaging25mg
- Price$124
- Updated2026-05-26
- Buy
- ManufacturerArctom
- Product numberHY-B0209R
- Product descriptionMetolazone (Standard) 97.11%
- Packaging50mg
- Price$198
- Updated2026-05-26
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| AHH | API-1565 | Metolazone 97% | 10g | $410 | 2026-05-26 | Buy |
| AK Scientific | H024 | Metolazone 98%(HPLC),powder | 100mg | $429 | 2026-06-04 | Buy |
| AK Scientific | H024 | Metolazone 98%(HPLC),powder | 5mg | $69 | 2026-06-04 | Buy |
| AK Scientific | H024 | Metolazone | 50mg | $96 | 2021-12-16 | Buy |
| AK Scientific | H024 | Metolazone 98%(HPLC),powder | 25mg | $148 | 2026-06-04 | Buy |
| American Custom Chemicals Corporation | API0003352 | METOLAZONE 95.00% | 100MG | $704.55 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | API0003352 | METOLAZONE 95.00% | 1G | $1593.9 | 2021-12-16 | Buy |
| ApexBio Technology | B1975 | Metolazone | 50mg | $68 | 2026-05-06 | Buy |
| Arctom | HY-B0209 | Metolazone 99.68% | 100mg | $86 | 2026-05-26 | Buy |
| Arctom | HY-B0209 | Metolazone 99.68% | 50mg | $57 | 2026-05-26 | Buy |
| Arctom | HY-B0209 | Metolazone 99.68% | 10mM*1mLinDMSO(Solid+Solvent) | $60 | 2026-05-26 | Buy |
| Arctom | HY-B0209R | Metolazone (Standard) 97.11% | 10mg | $62 | 2026-05-26 | Buy |
| Arctom | HY-B0209R | Metolazone (Standard) 97.11% | 5mg | $39 | 2026-05-26 | Buy |
| Arctom | HY-B0209 | Metolazone 99.68% | 10mM*1mLinDMSO(Solution) | $63 | 2026-05-26 | Buy |
| Arctom | HY-B0209R | Metolazone (Standard) 97.11% | 25mg | $124 | 2026-05-26 | Buy |
| Arctom | HY-B0209R | Metolazone (Standard) 97.11% | 50mg | $198 | 2026-05-26 | Buy |
Properties
Melting point :252-254°C
Boiling point :613.6±65.0 °C(Predicted)
Density :1.2895 (rough estimate)
refractive index :1.6100 (estimate)
storage temp. :2-8°C
solubility :DMSO: >5mg/mL
pka :pKa 9.7 (Uncertain)
form :solid
color :white
Water Solubility :60.3mg/L(25 ºC)
Stability :Stable for 2 years as supplied. Solutions in DMSO may be stored desiccated at -20°C for up to 2 months.
Major Application :pharmaceutical (small molecule)
InChI :1S/C16H16ClN3O3S/c1-9-5-3-4-6-14(9)20-10(2)19-13-8-12(17)15(24(18,22)23)7-11(13)16(20)21/h3-8,10,19H,1-2H3,(H2,18,22,23)
InChIKey :AQCHWTWZEMGIFD-UHFFFAOYSA-N
SMILES :CC1Nc2cc(Cl)c(cc2C(=O)N1c3ccccc3C)S(N)(=O)=O
CAS DataBase Reference :17560-51-9(CAS DataBase Reference)
NIST Chemistry Reference :Metolazone(17560-51-9)
Boiling point :613.6±65.0 °C(Predicted)
Density :1.2895 (rough estimate)
refractive index :1.6100 (estimate)
storage temp. :2-8°C
solubility :DMSO: >5mg/mL
pka :pKa 9.7 (Uncertain)
form :solid
color :white
Water Solubility :60.3mg/L(25 ºC)
Stability :Stable for 2 years as supplied. Solutions in DMSO may be stored desiccated at -20°C for up to 2 months.
Major Application :pharmaceutical (small molecule)
InChI :1S/C16H16ClN3O3S/c1-9-5-3-4-6-14(9)20-10(2)19-13-8-12(17)15(24(18,22)23)7-11(13)16(20)21/h3-8,10,19H,1-2H3,(H2,18,22,23)
InChIKey :AQCHWTWZEMGIFD-UHFFFAOYSA-N
SMILES :CC1Nc2cc(Cl)c(cc2C(=O)N1c3ccccc3C)S(N)(=O)=O
CAS DataBase Reference :17560-51-9(CAS DataBase Reference)
NIST Chemistry Reference :Metolazone(17560-51-9)
Safety Information
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Description
Metolazone is a thiazide-like diuretic that targets the Na+-Cl- cotransporter responsible for salt reabsorption in the distal convoluted tubule of the kidney (IC50 = 0.3 μM in rat). It is also a potent inhibitor of human carbonic anhydrase isoforms VII, XII, and XIII (Kis = 2.1, 5.4, and 15 nM, respectively), which have crucial functions in renal physiology. Metolazone has been predominantly used in the treatment of congestive heart failure and high blood pressure.Related product price
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