Naltrexone methylbromide
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- $32 - $1871.1
- Product name: Naltrexone methylbromide
- CAS: 73232-52-7
- MF: C21H26BrNO4
- MW: 436.35
- EINECS:
- MDL Number:MFCD06407831
- Synonyms:Naltrexone methobromide;Naltrexone methylbromide;Moa-728;Morphinanium, 17-(cyclopropylmethyl)-4,5-epoxy-3,14-dihydroxy-17-methyl-6-oxo-, bromide, (5alpha)-;Relistor;Unii-rfo6il3D3m;Methylnaltrexone bromide;(5alpha)-17-(Cyclopropylmethyl)-4,5-epoxy-3,14-dihydroxy-17-methyl-6-oxomorphinanium bromide
16 prices
Selected condition：
Brand
- American Custom Chemicals Corporation
- Cayman Chemical
- Chemtos
- DC Chemicals
- Sigma-Aldrich
- TCI Chemical
- Tocris
- TRC
Package
- 1mg
- 5
- 5mg
- 25
- 10MG
- 25mg
- 100MG
- 1g
- ManufacturerAmerican Custom Chemicals Corporation
- Product numberCHM0079522
- Product description17-(CYCLOPROPYLMETHYL)-4,5A-EPOXY-3,14-DIHYDROXY-17-METHYL-6-OXOMORPHINANIUM BROMIDE 95.00%
- Packaging10MG
- Price$739.2
- Updated2021-12-16
- Buy
- ManufacturerAmerican Custom Chemicals Corporation
- Product numberCHM0079522
- Product description17-(CYCLOPROPYLMETHYL)-4,5A-EPOXY-3,14-DIHYDROXY-17-METHYL-6-OXOMORPHINANIUM BROMIDE 95.00%
- Packaging100MG
- Price$1871.1
- Updated2021-12-16
- Buy
- ManufacturerCayman Chemical
- Product number24072
- Product descriptionMethylnaltrexone (bromide) ≥95%
- Packaging1mg
- Price$32
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number24072
- Product descriptionMethylnaltrexone (bromide) ≥95%
- Packaging5mg
- Price$100
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number24072
- Product descriptionMethylnaltrexone (bromide) ≥95%
- Packaging10mg
- Price$184
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number24072
- Product descriptionMethylnaltrexone (bromide) ≥95%
- Packaging25mg
- Price$420
- Updated2024-03-01
- Buy
- ManufacturerChemtos
- Product numberM-5824
- Product descriptionMethylnaltrexoneLabeledd3Bromide
- Packaging10mg
- Price$1190
- Updated2021-12-16
- Buy
- ManufacturerDC Chemicals
- Product numberDC9527
- Product descriptionMethylnaltrexone bromide >98%
- Packaging1g
- Price$1200
- Updated2021-12-16
- Buy
- ManufacturerSigma-Aldrich
- Product numberSML0277
- Product descriptionMethylnaltrexone bromide ≥97% (HPLC)
- Packaging5mg
- Price$113
- Updated2025-07-31
- Buy
- ManufacturerSigma-Aldrich
- Product numberSML0277
- Product descriptionMethylnaltrexone bromide ≥97% (HPLC)
- Packaging25mg
- Price$617
- Updated2025-07-31
- Buy
- ManufacturerSigma-Aldrich
- Product number1430724
- Product descriptionMethylnaltrexone Peak Identification Mixture Cll United States Pharmacopeia (USP) Reference Standard
- Packaging10mg
- Price$1260
- Updated2025-07-31
- Buy
- ManufacturerSigma-Aldrich
- Product number1430735
- Product descriptionMethylnaltrexone bromide United States Pharmacopeia (USP) Reference Standard
- Packaging100mg
- Price$1680
- Updated2025-07-31
- Buy
- ManufacturerTCI Chemical
- Product numberM3504
- Product descriptionMethylnaltrexone Bromide
- Packaging10MG
- Price$208
- Updated2025-07-31
- Buy
- ManufacturerTocris
- Product number6109
- Product descriptionMethylnaltrexone bromide ≥98%(HPLC)
- Packaging5
- Price$79
- Updated2021-12-16
- Buy
- ManufacturerTocris
- Product number6109
- Product descriptionMethylnaltrexone bromide ≥98%(HPLC)
- Packaging25
- Price$309
- Updated2021-12-16
- Buy
- ManufacturerTRC
- Product numberM320350
- Product descriptionN-MethylNaltrexoneBromide
- Packaging5mg
- Price$70
- Updated2021-12-16
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| American Custom Chemicals Corporation | CHM0079522 | 17-(CYCLOPROPYLMETHYL)-4,5A-EPOXY-3,14-DIHYDROXY-17-METHYL-6-OXOMORPHINANIUM BROMIDE 95.00% | 10MG | $739.2 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | CHM0079522 | 17-(CYCLOPROPYLMETHYL)-4,5A-EPOXY-3,14-DIHYDROXY-17-METHYL-6-OXOMORPHINANIUM BROMIDE 95.00% | 100MG | $1871.1 | 2021-12-16 | Buy |
| Cayman Chemical | 24072 | Methylnaltrexone (bromide) ≥95% | 1mg | $32 | 2024-03-01 | Buy |
| Cayman Chemical | 24072 | Methylnaltrexone (bromide) ≥95% | 5mg | $100 | 2024-03-01 | Buy |
| Cayman Chemical | 24072 | Methylnaltrexone (bromide) ≥95% | 10mg | $184 | 2024-03-01 | Buy |
| Cayman Chemical | 24072 | Methylnaltrexone (bromide) ≥95% | 25mg | $420 | 2024-03-01 | Buy |
| Chemtos | M-5824 | MethylnaltrexoneLabeledd3Bromide | 10mg | $1190 | 2021-12-16 | Buy |
| DC Chemicals | DC9527 | Methylnaltrexone bromide >98% | 1g | $1200 | 2021-12-16 | Buy |
| Sigma-Aldrich | SML0277 | Methylnaltrexone bromide ≥97% (HPLC) | 5mg | $113 | 2025-07-31 | Buy |
| Sigma-Aldrich | SML0277 | Methylnaltrexone bromide ≥97% (HPLC) | 25mg | $617 | 2025-07-31 | Buy |
| Sigma-Aldrich | 1430724 | Methylnaltrexone Peak Identification Mixture Cll United States Pharmacopeia (USP) Reference Standard | 10mg | $1260 | 2025-07-31 | Buy |
| Sigma-Aldrich | 1430735 | Methylnaltrexone bromide United States Pharmacopeia (USP) Reference Standard | 100mg | $1680 | 2025-07-31 | Buy |
| TCI Chemical | M3504 | Methylnaltrexone Bromide | 10MG | $208 | 2025-07-31 | Buy |
| Tocris | 6109 | Methylnaltrexone bromide ≥98%(HPLC) | 5 | $79 | 2021-12-16 | Buy |
| Tocris | 6109 | Methylnaltrexone bromide ≥98%(HPLC) | 25 | $309 | 2021-12-16 | Buy |
| TRC | M320350 | N-MethylNaltrexoneBromide | 5mg | $70 | 2021-12-16 | Buy |
Properties
Melting point :237-239°C
storage temp. :-20°C
solubility :H2O: ≥5mg/mL
form :powder
color :white to beige
Water Solubility :H2O: ≥5mg/mL
Stability :Hygroscopic
InChIKey :IFGIYSGOEZJNBE-NIWJRJBUNA-N
SMILES :O[C@]12CCC(=O)[C@]3([H])OC4=C(C=CC5C[C@@]1([H])[N+](C)(CC1CC1)CC[C@@]23C4=5)O.[Br-] |&1:1,6,15,25,r|
storage temp. :-20°C
solubility :H2O: ≥5mg/mL
form :powder
color :white to beige
Water Solubility :H2O: ≥5mg/mL
Stability :Hygroscopic
InChIKey :IFGIYSGOEZJNBE-NIWJRJBUNA-N
SMILES :O[C@]12CCC(=O)[C@]3([H])OC4=C(C=CC5C[C@@]1([H])[N+](C)(CC1CC1)CC[C@@]23C4=5)O.[Br-] |&1:1,6,15,25,r|
Safety Information
| Symbol(GHS): |
 
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| Signal word: | Danger | |||||||||||||||||||||
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Description
The widespread efficacy of opioids in treating patients with moderate to severe acute and chronic pain is often accompanied by untoward side effects. In particular, opioid-induced bowel dysfunction is one of the more common and debilitating consequences afflicting up to 50% of patients. To counteract the peripherally-mediated adverse effects, opioid antagonists such as naloxone, naltrexone, and nalmephene are sometimes prescribed. The latest market entry exploits a strategic modification of naltrexone to lower its lipid solubility and increase its polarity: quaternization of the amine of naltrexone by methylation (methyl bromide) prevents crossing of the blood–brain barrier thereby creating an effective peripheral antagonist. Despite a loss of potency upon methylation, methylnaltrexone antagonizes opioid binding at m-opioid receptors with an IC50 of 70 nM. Its affinity for k-opioid receptors is approximately eightfold less (IC50＝ 575 nM) with no significant binding to d-opioid, orphanin, or non-opioid receptors. Methylnaltrexone bromide has been approved for the treatment of opioid-induced constipation in patients with advanced illness receiving palliative care.Regarding metabolism, methylnaltrexone bromide is eliminated primarily as intact drug (85% based on administered radioactivity) by slightly more renal than hepatic clearance.The most common adverse events were abdominal pain and flatulence followed by nausea, dizziness, and diarrhea.
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