Nelarabine
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- $37 - $1814
- Product name: Nelarabine
- CAS: 121032-29-9
- MF: C11H15N5O5
- MW: 297.27
- EINECS:642-916-9
- MDL Number:MFCD00871078
- Synonyms:(2R,3S,4S,5R)-2-(2-AMino-6-Methoxy-9H-purin-9-yl)-5-(hydroxyMethyl)tetrahydrofuran-3,4-diol;506U78;(2R,3S,4R,5R)-2-(2-amino-6-methoxy-purin-9-yl)-5-(hydroxymethyl)oxolane-3,4-diol;2-amino-9-β-D-arabinofuranosyl-6-methoxy-9H-purine;NELARABINE;Nelzarabine [USAN];9beta-D-Arabinofuranosyl-6-methoxy-9H-purin-2-amine;Nelarabine (Arranon)
44 prices
Selected condition：
Brand
- AK Scientific
- Ambeed
- ApexBio Technology
- Arctom
- Biorbyt Ltd
- Biosynth Carbosynth
- Cayman Chemical
- Chem-Impex
- ChemScene
- Crysdot
- DC Chemicals
- Matrix Scientific
- TCI Chemical
- Tocris
- TRC
- Usbiological
Package
- 10
- 1mg
- 5mg
- 10mg
- 50
- 25mg
- 10mM(in 1mL DMSO)
- 50mg
- 100mg
- 250mg
- 500mg
- 1g
- ManufacturerAK Scientific
- Product numberJ10096
- Product descriptionNelarabine
- Packaging5mg
- Price$98.6
- Updated2021-12-16
- Buy
- ManufacturerAK Scientific
- Product numberR077
- Product descriptionNelarabine
- Packaging250mg
- Price$380
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA161306
- Product description(2R,3S,4S,5R)-2-(2-Amino-6-methoxy-9H-purin-9-yl)-5-(hydroxymethyl)tetrahydrofuran-3,4-diol 98+%
- Packaging5mg
- Price$62
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA161306
- Product description(2R,3S,4S,5R)-2-(2-Amino-6-methoxy-9H-purin-9-yl)-5-(hydroxymethyl)tetrahydrofuran-3,4-diol 98+%
- Packaging10mg
- Price$104
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA161306
- Product description(2R,3S,4S,5R)-2-(2-Amino-6-methoxy-9H-purin-9-yl)-5-(hydroxymethyl)tetrahydrofuran-3,4-diol 98+%
- Packaging50mg
- Price$265
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA1379
- Product descriptionNelarabine
- Packaging5mg
- Price$80
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA1379
- Product descriptionNelarabine
- Packaging10mM(in 1mL DMSO)
- Price$90
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA1379
- Product descriptionNelarabine
- Packaging25mg
- Price$280
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA1379
- Product descriptionNelarabine
- Packaging100mg
- Price$880
- Updated2021-12-16
- Buy
- ManufacturerArctom
- Product numberAS025480
- Product description(2R,3S,4S,5R)-2-(2-Amino-6-methoxy-9H-purin-9-yl)-5-(hydroxymethyl)tetrahydrofuran-3,4-diol
- Packaging50mg
- Price$262
- Updated2021-12-16
- Buy
- ManufacturerBiorbyt Ltd
- Product numberorb180790
- Product descriptionNelarabine >99%
- Packaging100mg
- Price$606.9
- Updated2021-12-16
- Buy
- ManufacturerBiorbyt Ltd
- Product numberorb180790
- Product descriptionNelarabine >99%
- Packaging250mg
- Price$912.9
- Updated2021-12-16
- Buy
- ManufacturerBiorbyt Ltd
- Product numberorb180790
- Product descriptionNelarabine >99%
- Packaging1g
- Price$1802
- Updated2021-12-16
- Buy
- ManufacturerBiosynth Carbosynth
- Product numberNN26176
- Product descriptionNelarabine
- Packaging50mg
- Price$125
- Updated2021-12-16
- Buy
- ManufacturerBiosynth Carbosynth
- Product numberNN26176
- Product descriptionNelarabine
- Packaging100mg
- Price$190
- Updated2021-12-16
- Buy
- ManufacturerBiosynth Carbosynth
- Product numberNN26176
- Product descriptionNelarabine
- Packaging250mg
- Price$325
- Updated2021-12-16
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| AK Scientific | J10096 | Nelarabine | 5mg | $98.6 | 2021-12-16 | Buy |
| AK Scientific | R077 | Nelarabine | 250mg | $380 | 2021-12-16 | Buy |
| Ambeed | A161306 | (2R,3S,4S,5R)-2-(2-Amino-6-methoxy-9H-purin-9-yl)-5-(hydroxymethyl)tetrahydrofuran-3,4-diol 98+% | 5mg | $62 | 2021-12-16 | Buy |
| Ambeed | A161306 | (2R,3S,4S,5R)-2-(2-Amino-6-methoxy-9H-purin-9-yl)-5-(hydroxymethyl)tetrahydrofuran-3,4-diol 98+% | 10mg | $104 | 2021-12-16 | Buy |
| Ambeed | A161306 | (2R,3S,4S,5R)-2-(2-Amino-6-methoxy-9H-purin-9-yl)-5-(hydroxymethyl)tetrahydrofuran-3,4-diol 98+% | 50mg | $265 | 2021-12-16 | Buy |
| ApexBio Technology | A1379 | Nelarabine | 5mg | $80 | 2021-12-16 | Buy |
| ApexBio Technology | A1379 | Nelarabine | 10mM(in 1mL DMSO) | $90 | 2021-12-16 | Buy |
| ApexBio Technology | A1379 | Nelarabine | 25mg | $280 | 2021-12-16 | Buy |
| ApexBio Technology | A1379 | Nelarabine | 100mg | $880 | 2021-12-16 | Buy |
| Arctom | AS025480 | (2R,3S,4S,5R)-2-(2-Amino-6-methoxy-9H-purin-9-yl)-5-(hydroxymethyl)tetrahydrofuran-3,4-diol | 50mg | $262 | 2021-12-16 | Buy |
| Biorbyt Ltd | orb180790 | Nelarabine >99% | 100mg | $606.9 | 2021-12-16 | Buy |
| Biorbyt Ltd | orb180790 | Nelarabine >99% | 250mg | $912.9 | 2021-12-16 | Buy |
| Biorbyt Ltd | orb180790 | Nelarabine >99% | 1g | $1802 | 2021-12-16 | Buy |
| Biosynth Carbosynth | NN26176 | Nelarabine | 50mg | $125 | 2021-12-16 | Buy |
| Biosynth Carbosynth | NN26176 | Nelarabine | 100mg | $190 | 2021-12-16 | Buy |
| Biosynth Carbosynth | NN26176 | Nelarabine | 250mg | $325 | 2021-12-16 | Buy |
Properties
Melting point :209-217°
alpha :D20 +55.9° (c = 0.27 in DMF)
Boiling point :721.0±70.0 °C(Predicted)
Density :1.98±0.1 g/cm3(Predicted)
storage temp. :2-8°C(protect from light)
solubility :DMSO (Slightly), Methanol (Slightly, Heated), Water (Slightly, Sonicated)
form :Solid
pka :13.07±0.70(Predicted)
color :White
CAS DataBase Reference :121032-29-9(CAS DataBase Reference)
alpha :D20 +55.9° (c = 0.27 in DMF)
Boiling point :721.0±70.0 °C(Predicted)
Density :1.98±0.1 g/cm3(Predicted)
storage temp. :2-8°C(protect from light)
solubility :DMSO (Slightly), Methanol (Slightly, Heated), Water (Slightly, Sonicated)
form :Solid
pka :13.07±0.70(Predicted)
color :White
CAS DataBase Reference :121032-29-9(CAS DataBase Reference)
Safety Information
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Description
Nelarabine is a new member of the purine nucleoside antimetabolite class of drugs. It was launched as an intravenous infusion for treating relapsed or refractory T-cell acute lymphoblastic leukemia (T-ALL) and T-cell lymphoblastic lymphoma (T-LBL) after at least two prior chemotherapy regimens. Nelarabine is a pro-drug of 9-b-D-arabinofuranosylguanine (ara-G), a deoxyguanosine derivative with a high level of T-cell selective cytotoxicity. Although Ara-G has been known since the 1960s, it has not been used in clinical studies due to its poor solubility. Nelarabine is the O-methyl derivative of ara-G with approximately 10 times greater aqueous solubility. It is demethylated in vivo by adenosine deaminase to produce ara-G, which is subsequently converted to the active 5’-triphosphate, ara-GTP. Accumulation of ara-GTP in leukemic blasts allows for incorporation into DNA, leading to inhibition of DNA synthesis and cell death.Related product price
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$16-1292.72 - Bis(2-ethylhexyl)amine
$6-1166.55 - Triethanolamine
$18-4666
