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ChemicalBook >> PF 543

PF 543

PF 543 price.
  • $25 - $313
  • Product name: PF 543
  • CAS: 1415562-82-1
  • MF: C27H31NO4S
  • MW: 465.60434
  • EINECS:
  • MDL Number:
  • Synonyms:Sphingosine Kinase 1 Inhibitor II, PF-543 - CAS 1415562-82-1 - Calbiochem;PF 543;PF543;PF-543;PF543/PF-543;(2R)-1-[[4-[[3-Methyl-5-[(phenylsulfonyl)Methyl]phenoxy]Methyl]phenyl]Methyl]-2-pyrrolidineMethanol;2-PyrrolidineMethanol, 1-[[4-[[3-Methyl-5-[(phenylsulfonyl)Methyl]phenoxy]Methyl]phenyl]Methyl]-, (2R)-;[(2R)-1-[[4-[[3-(benzenesulfonylmethyl)-5-methylphenoxy]methyl]phenyl]methyl]pyrrolidin-2-yl]methanol
5 prices
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Brand

  • Cayman Chemical
  • Sigma-Aldrich

Package

  • 1mg
  • 5mg
  • 10mg
  • 25mg
  • ManufacturerCayman Chemical
  • Product number17034
  • Product descriptionPF-543 ≥98%
  • Packaging1mg
  • Price$25
  • Updated2018-11-13
  • Buy
  • ManufacturerCayman Chemical
  • Product number17034
  • Product descriptionPF-543 ≥98%
  • Packaging5mg
  • Price$81
  • Updated2018-11-13
  • Buy
  • ManufacturerCayman Chemical
  • Product number17034
  • Product descriptionPF-543 ≥98%
  • Packaging10mg
  • Price$150
  • Updated2018-11-13
  • Buy
  • ManufacturerCayman Chemical
  • Product number17034
  • Product descriptionPF-543 ≥98%
  • Packaging25mg
  • Price$313
  • Updated2018-11-13
  • Buy
  • ManufacturerSigma-Aldrich
  • Product number567741
  • Product descriptionSphingosine Kinase 1 Inhibitor II, PF-543 - CAS 1415562-82-1 - Calbiochem
  • Packaging5mg
  • Price$141
  • Updated2018-11-23
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
Cayman Chemical 17034 PF-543 ≥98% 1mg $25 2018-11-13 Buy
Cayman Chemical 17034 PF-543 ≥98% 5mg $81 2018-11-13 Buy
Cayman Chemical 17034 PF-543 ≥98% 10mg $150 2018-11-13 Buy
Cayman Chemical 17034 PF-543 ≥98% 25mg $313 2018-11-13 Buy
Sigma-Aldrich 567741 Sphingosine Kinase 1 Inhibitor II, PF-543 - CAS 1415562-82-1 - Calbiochem 5mg $141 2018-11-23 Buy

Properties

storage temp.  :-20°C
form  :powder
color  :white to light brown

Safety Information

Symbol(GHS):
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Description

PF-543 is a potent inhibitor of sphingosine kinase 1 (SK1; IC50 = 2-3.6 nM) that less effectively inhibits SK2 (IC50 = 356 nM). It does not significantly block the activity of other protein and lipid kinases, or bind sphingosine-1-phosphate receptors, when tested at a concentration of 10 μM. PF-543 prevents the phosphorylation of sphingosine in cancer cells and in whole blood (EC50s = 8.4 and 27 nM, respectively). Through its effects on SK1, PF-543 prevents sickling, hemolysis, and inflammation in sickling cell disease transgenic mice. Unlike inhibitors that are selective for SK2, PF-543 does not impair DNA synthesis in human pulmonary arterial smooth muscle cells.

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