PIERICIDIN A
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- $135 - $1050
- Product name: PIERICIDIN A
- CAS: 2738-64-9
- MF: C25H37NO4
- MW: 415.57
- EINECS:
- MDL Number:MFCD16661265
- Synonyms:,5,7,11-tetramethyl-,(all-e)-(4s,5s)- ;2,6,9,11-tridecatetraen-4-ol,13-(4-hydroxy-5,6-dimethoxy-3-methyl-2-pyridyl)-3 ;piericidin ;piericidin(sub1) ;piericidinea ;SN 198E;SHAOGUAMYCIN B;SHAOGUANMYCIN B
8 prices
Selected condition：
Brand
- AK Scientific
- ApexBio Technology
- Biorbyt Ltd
- Cayman Chemical
- TRC
- Usbiological
Package
- 200ug
- 1mg
- 2.5mg
- 5mg
- ManufacturerAK Scientific
- Product number3261BB
- Product descriptionPiericidinA
- Packaging5mg
- Price$775
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberC3535
- Product descriptionPiericidinA
- Packaging1mg
- Price$173
- Updated2021-12-16
- Buy
- ManufacturerBiorbyt Ltd
- Product numberorb546184
- Product descriptionPiericidin A >98%
- Packaging200ug
- Price$136
- Updated2021-12-16
- Buy
- ManufacturerBiorbyt Ltd
- Product numberorb546184
- Product descriptionPiericidin A >98%
- Packaging1mg
- Price$307.7
- Updated2021-12-16
- Buy
- ManufacturerCayman Chemical
- Product number15379
- Product descriptionPiericidin A ≥95%
- Packaging1mg
- Price$135
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number15379
- Product descriptionPiericidin A ≥95%
- Packaging5mg
- Price$641
- Updated2024-03-01
- Buy
- ManufacturerTRC
- Product numberP991778
- Product descriptionPiericidinA
- Packaging2.5mg
- Price$1050
- Updated2021-12-16
- Buy
- ManufacturerUsbiological
- Product numberP4155
- Product descriptionPiericidin A
- Packaging1mg
- Price$408
- Updated2021-12-16
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| AK Scientific | 3261BB | PiericidinA | 5mg | $775 | 2021-12-16 | Buy |
| ApexBio Technology | C3535 | PiericidinA | 1mg | $173 | 2021-12-16 | Buy |
| Biorbyt Ltd | orb546184 | Piericidin A >98% | 200ug | $136 | 2021-12-16 | Buy |
| Biorbyt Ltd | orb546184 | Piericidin A >98% | 1mg | $307.7 | 2021-12-16 | Buy |
| Cayman Chemical | 15379 | Piericidin A ≥95% | 1mg | $135 | 2024-03-01 | Buy |
| Cayman Chemical | 15379 | Piericidin A ≥95% | 5mg | $641 | 2024-03-01 | Buy |
| TRC | P991778 | PiericidinA | 2.5mg | $1050 | 2021-12-16 | Buy |
| Usbiological | P4155 | Piericidin A | 1mg | $408 | 2021-12-16 | Buy |
Properties
Boiling point :614.9±55.0 °C(Predicted)
Density :1.044±0.06 g/cm3(Predicted)
Flash point :85 °C
storage temp. :2-8°C
solubility :Soluble in DMSO (up to 25 mg/ml) or in Ethanol (up to 20 mg/ml).
pka :5.21±0.33(Predicted)
form :liquid
color :green-yellow
Stability :Stable for 2 years from date of purchase as supplied. Solutions in DMSO or Ethanol may be stored at -20°C for up to 1 month.
Density :1.044±0.06 g/cm3(Predicted)
Flash point :85 °C
storage temp. :2-8°C
solubility :Soluble in DMSO (up to 25 mg/ml) or in Ethanol (up to 20 mg/ml).
pka :5.21±0.33(Predicted)
form :liquid
color :green-yellow
Stability :Stable for 2 years from date of purchase as supplied. Solutions in DMSO or Ethanol may be stored at -20°C for up to 1 month.
Safety Information
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| Signal word: | Warning | ||||||||||||||||||||||||||||
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Description
Complex I, also known as NADH:ubiquinone oxidoreductase or NADH dehydrogenase (ubiquinone), catalyzes the transfer of electrons from NADH to ubiquinone (also known as coenzyme Q10) as part of the respiratory chain leading to ATP generation. Piericidin A is an irreversible inhibitor of mitochondrial complex I that strongly associates with ubiquinone binding sites in both mitochondrial and bacterial forms of the enzyme. First identified as an insecticidal metabolite produced by Streptomyces, piericidin A was soon found to bind and inhibit complex I at nanomolar concentrations. The inhibition of complex I by piericidin A in the presence of NADH results in the generation of reactive oxygen species. In plants, pieridicin A inhibits photosystem II, a water-plastoquinone oxidoreductase involved in light-dependent electron transfer. Piericidin A also suppresses the up-regulation of the glucose-regulated protein GRP78 in glucose-deprived, etoposide-resistant HT-29 cells, resulting in cell death (IC50 = 7.7 nM).More related product prices
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