PRT-060318
|
- $27 - $3051
- Product name: PRT-060318
- CAS: 1194961-19-7
- MF: C18H24N6O
- MW: 340.42
- EINECS:
- MDL Number:MFCD28155088
- Synonyms:PRT-060318;PRT-060318(PRT318);2-[[(1R,2S)-2-Aminocyclohexyl]amino]-4-[(3-methylphenyl)amino]-5-pyrimidinecarboxamide;P 142-76;PRT 318;2-(((1R,2S)-2-aminocyclohexyl)amino)-4-(m-tolylamino)pyrimidine-5-carboxamide;CS-1688;PRT-060318 ≥95%
63 prices
Selected condition：
Brand
- A2B
- aablocks
- ACHEMBLOCK
- Adipogen Life Sciences
- Ambeed
- American Custom Chemicals Corporation
- ApexBio Technology
- Arctom
- Biosynth
- Cayman Chemical
- Chemenu
- ChemScene
- Crysdot
- DC Chemicals
- Sigma-Aldrich
- TRC
- Usbiological
Package
- 10mM*1mLinWater(Solution)
- 1mg
- 2mg
- 10mM*1mLinWater(Solid+Solvent)
- 5mg
- 10mg
- 25mg
- 50mg
- 100MG
- 250mg
- 1g
- ManufacturerA2B
- Product numberAA24259
- Product descriptionPRT-060318 99%
- Packaging1mg
- Price$27
- Updated2026-05-25
- Buy
- ManufacturerA2B
- Product numberAA24259
- Product descriptionPRT-060318 99%
- Packaging2mg
- Price$37
- Updated2026-05-25
- Buy
- ManufacturerA2B
- Product numberAA24259
- Product descriptionPRT-060318 99%
- Packaging5mg
- Price$67
- Updated2026-05-25
- Buy
- ManufacturerA2B
- Product numberAA24259
- Product descriptionPRT-060318 99%
- Packaging10mg
- Price$75
- Updated2026-05-25
- Buy
- ManufacturerA2B
- Product numberAA24259
- Product descriptionPRT-060318 99%
- Packaging25mg
- Price$126
- Updated2026-05-25
- Buy
- ManufacturerA2B
- Product numberAA24259
- Product descriptionPRT-060318 99%
- Packaging50mg
- Price$215
- Updated2026-05-25
- Buy
- Manufactureraablocks
- Product numberAA000ISN
- Product descriptionPRT-060318 99%
- Packaging50mg
- Price$239
- Updated2026-05-25
- Buy
- Manufactureraablocks
- Product numberAA000ISN
- Product descriptionPRT-060318 99%
- Packaging25mg
- Price$140
- Updated2026-05-25
- Buy
- Manufactureraablocks
- Product numberAA000ISN
- Product descriptionPRT-060318 99%
- Packaging10mg
- Price$83
- Updated2026-05-25
- Buy
- Manufactureraablocks
- Product numberAA000ISN
- Product descriptionPRT-060318 99
- Packaging1mg
- Price$48
- Updated2026-05-25
- Buy
- Manufactureraablocks
- Product numberAA000ISN
- Product descriptionPRT-060318 99
- Packaging2mg
- Price$59
- Updated2026-05-25
- Buy
- ManufacturerACHEMBLOCK
- Product numberZ238795
- Product descriptionPRT-060318 98%
- Packaging25MG
- Price$200
- Updated2026-05-27
- Buy
- ManufacturerACHEMBLOCK
- Product numberZ238795
- Product descriptionPRT-060318 98%
- Packaging100MG
- Price$570
- Updated2026-05-27
- Buy
- ManufacturerAdipogen Life Sciences
- Product numberSYN-1204-M010
- Product descriptionPRT-060318 ≥95%
- Packaging10mg
- Price$594
- Updated2026-05-06
- Buy
- ManufacturerAdipogen Life Sciences
- Product numberSYN-1204-M050
- Product descriptionPRT-060318 ≥95%
- Packaging50mg
- Price$1782
- Updated2021-12-16
- Buy
- ManufacturerAdipogen Life Sciences
- Product numberSYN-1204-M001
- Product descriptionPRT-060318 ≥95%
- Packaging1mg
- Price$162
- Updated2026-05-06
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| A2B | AA24259 | PRT-060318 99% | 1mg | $27 | 2026-05-25 | Buy |
| A2B | AA24259 | PRT-060318 99% | 2mg | $37 | 2026-05-25 | Buy |
| A2B | AA24259 | PRT-060318 99% | 5mg | $67 | 2026-05-25 | Buy |
| A2B | AA24259 | PRT-060318 99% | 10mg | $75 | 2026-05-25 | Buy |
| A2B | AA24259 | PRT-060318 99% | 25mg | $126 | 2026-05-25 | Buy |
| A2B | AA24259 | PRT-060318 99% | 50mg | $215 | 2026-05-25 | Buy |
| aablocks | AA000ISN | PRT-060318 99% | 50mg | $239 | 2026-05-25 | Buy |
| aablocks | AA000ISN | PRT-060318 99% | 25mg | $140 | 2026-05-25 | Buy |
| aablocks | AA000ISN | PRT-060318 99% | 10mg | $83 | 2026-05-25 | Buy |
| aablocks | AA000ISN | PRT-060318 99 | 1mg | $48 | 2026-05-25 | Buy |
| aablocks | AA000ISN | PRT-060318 99 | 2mg | $59 | 2026-05-25 | Buy |
| ACHEMBLOCK | Z238795 | PRT-060318 98% | 25MG | $200 | 2026-05-27 | Buy |
| ACHEMBLOCK | Z238795 | PRT-060318 98% | 100MG | $570 | 2026-05-27 | Buy |
| Adipogen Life Sciences | SYN-1204-M010 | PRT-060318 ≥95% | 10mg | $594 | 2026-05-06 | Buy |
| Adipogen Life Sciences | SYN-1204-M050 | PRT-060318 ≥95% | 50mg | $1782 | 2021-12-16 | Buy |
| Adipogen Life Sciences | SYN-1204-M001 | PRT-060318 ≥95% | 1mg | $162 | 2026-05-06 | Buy |
Properties
Melting point :152 - 155°C
Boiling point :602.1±65.0 °C(Predicted)
Density :1.277±0.06 g/cm3(Predicted)
storage temp. :Refrigerator, under inert atmosphere
solubility :DMSO (Slightly), Methanol (Slightly)
form :Solid
pka :14.10±0.50(Predicted)
color :Pale Brown
InChIKey :NZNTWOVDIXCHHS-LSDHHAIUSA-N
SMILES :N[C@H]1CCCC[C@H]1NC2=NC(NC3=CC=CC(C)=C3)=C(C=N2)C(N)=O
Boiling point :602.1±65.0 °C(Predicted)
Density :1.277±0.06 g/cm3(Predicted)
storage temp. :Refrigerator, under inert atmosphere
solubility :DMSO (Slightly), Methanol (Slightly)
form :Solid
pka :14.10±0.50(Predicted)
color :Pale Brown
InChIKey :NZNTWOVDIXCHHS-LSDHHAIUSA-N
SMILES :N[C@H]1CCCC[C@H]1NC2=NC(NC3=CC=CC(C)=C3)=C(C=N2)C(N)=O
Safety Information
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| Signal word: | Danger | ||||||||||||||
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Description
PRT060318 is a potent and selective inhibitor of spleen tyrosine kinase (Syk; IC50 = 4 nM). It is selective, inhibiting 92% of Syk activity, while other kinases retain >70% activity, at a concentration of 50 nM in a panel of 270 kinases. PRT060318 inhibits convulxin-induced aggregation of human platelet-rich plasma (IC50 = 2.5 μM) in vitro and prevents thrombosis in a transgenic mouse model of heparin-induced thrombocytopenia. It induces chronic lymphocytic leukemia (CLL) B cell apoptosis and inhibits the secretion of chemokines CCL3, CCL4, and CXCL13. PRT060318 also inhibits CLL B cell chemotaxis and pseudoemperipolesis.Related product price
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