Pomalidomide-d5
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- $200 - $1585
- Product name: Pomalidomide-d5
- CAS: 1377838-49-7
- MF: C13H11N3O4
- MW: 273.25
- EINECS:
- MDL Number:MFCD34564597
- Synonyms:4-Amino-2-(2,6-dioxopiperidin-3-yl-3,4,4,5,5-d5)isoindoline-1,3-dione;Pomalidomide-d5
5 prices
Selected condition:
Brand
- AK Scientific
- Cayman Chemical
- TRC
Package
- 500μg
- 1mg
- 10mg
- ManufacturerAK Scientific
- Product number5113EG
- Product description4-Amino-2-(3,4,4,5,5-pentadeuterio-2,6-dioxopiperidin-3-yl)isoindole-1,3-dione
- Packaging1mg
- Price$866
- Updated2021-12-16
- Buy
- ManufacturerCayman Chemical
- Product number25358
- Product descriptionPomalidomide-d5 ≥99% deuterated forms (d1-d5)
- Packaging500μg
- Price$364
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number25358
- Product descriptionPomalidomide-d5 ≥99% deuterated forms (d1-d5)
- Packaging1mg
- Price$691
- Updated2024-03-01
- Buy
- ManufacturerTRC
- Product numberP688203
- Product descriptionPomalidomide-d5
- Packaging10mg
- Price$1585
- Updated2021-12-16
- Buy
- ManufacturerTRC
- Product numberP688203
- Product descriptionPomalidomide-d5
- Packaging1mg
- Price$200
- Updated2021-12-16
- Buy
Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|
AK Scientific | 5113EG | 4-Amino-2-(3,4,4,5,5-pentadeuterio-2,6-dioxopiperidin-3-yl)isoindole-1,3-dione | 1mg | $866 | 2021-12-16 | Buy |
Cayman Chemical | 25358 | Pomalidomide-d5 ≥99% deuterated forms (d1-d5) | 500μg | $364 | 2024-03-01 | Buy |
Cayman Chemical | 25358 | Pomalidomide-d5 ≥99% deuterated forms (d1-d5) | 1mg | $691 | 2024-03-01 | Buy |
TRC | P688203 | Pomalidomide-d5 | 10mg | $1585 | 2021-12-16 | Buy |
TRC | P688203 | Pomalidomide-d5 | 1mg | $200 | 2021-12-16 | Buy |
Properties
storage temp. :Store at -20°C
solubility :DMF: 10 mg/ml,DMSO: 15 mg/ml
form :A solid
solubility :DMF: 10 mg/ml,DMSO: 15 mg/ml
form :A solid
Safety Information
Symbol(GHS): |
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Signal word: | Warning | ||||||||||||||
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Description
Pomalidomide-d5 is intended for use as an internal standard for the quantification of pomalidomide by GC- or LC-MS. Pomalidomide is an analog of thalidomide that inhibits the E3 ligase protein cereblon (CRBN) with an IC50 value of approximately 3 μM for the human recombinant CRBN-DNA damage binding protein-1 (CRBN-DDB1) complex. It inhibits autoubiquitination of CRBN in HEK293T cells expressing CRBN but not those expressing a thalidomide-binding defective CRBN mutation. It inhibits proliferation of U266 myeloma cells when used at concentrations ranging from 0.1 to 10 μM. Pomalidomide also has antiangiogenic and immunomodulatory effects against myeloma cells, modulating cell adhesion, decreasing production of key pro-survival cytokines, including TNF-α, and triggering the activation of caspase-8. Pomalidomide (3 mg/kg per day), in combination with dexamethasone, reduces tumor growth in a H929 R10-1 lenalidomide-resistant mouse xenograft model. Formulations containing pomalidomide have been used in the treatment of multiple myeloma.More related product prices
3-Nitrophthalic acid 3-AMINOPHTHALIC ACID Pomalidomide 5-amino-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dioneRelated product price
- 3-Nitrophthalic acid
$15-6320.27 - 3-AMINOPHTHALIC ACID
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$5-2245.7