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ChemicalBook >> CAS DataBase List >> Pomalidomide-d5

Pomalidomide-d5

Pomalidomide-d5 price.
  • $200 - $1585
  • Product name: Pomalidomide-d5
  • CAS: 1377838-49-7
  • MF: C13H11N3O4
  • MW: 273.25
  • EINECS:
  • MDL Number:MFCD34564597
  • Synonyms:4-Amino-2-(2,6-dioxopiperidin-3-yl-3,4,4,5,5-d5)isoindoline-1,3-dione;Pomalidomide-d5
5 prices
Selected condition:
Brand
  • AK Scientific
  • Cayman Chemical
  • TRC
Package
  • 500μg
  • 1mg
  • 10mg
  • ManufacturerAK Scientific
  • Product number5113EG
  • Product description4-Amino-2-(3,4,4,5,5-pentadeuterio-2,6-dioxopiperidin-3-yl)isoindole-1,3-dione
  • Packaging1mg
  • Price$866
  • Updated2021-12-16
  • Buy
  • ManufacturerCayman Chemical
  • Product number25358
  • Product descriptionPomalidomide-d5 ≥99% deuterated forms (d1-d5)
  • Packaging500μg
  • Price$364
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number25358
  • Product descriptionPomalidomide-d5 ≥99% deuterated forms (d1-d5)
  • Packaging1mg
  • Price$691
  • Updated2024-03-01
  • Buy
  • ManufacturerTRC
  • Product numberP688203
  • Product descriptionPomalidomide-d5
  • Packaging10mg
  • Price$1585
  • Updated2021-12-16
  • Buy
  • ManufacturerTRC
  • Product numberP688203
  • Product descriptionPomalidomide-d5
  • Packaging1mg
  • Price$200
  • Updated2021-12-16
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
AK Scientific 5113EG 4-Amino-2-(3,4,4,5,5-pentadeuterio-2,6-dioxopiperidin-3-yl)isoindole-1,3-dione 1mg $866 2021-12-16 Buy
Cayman Chemical 25358 Pomalidomide-d5 ≥99% deuterated forms (d1-d5) 500μg $364 2024-03-01 Buy
Cayman Chemical 25358 Pomalidomide-d5 ≥99% deuterated forms (d1-d5) 1mg $691 2024-03-01 Buy
TRC P688203 Pomalidomide-d5 10mg $1585 2021-12-16 Buy
TRC P688203 Pomalidomide-d5 1mg $200 2021-12-16 Buy

Properties

storage temp. :Store at -20°C
solubility :DMF: 10 mg/ml,DMSO: 15 mg/ml
form :A solid

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H361 Suspected of damaging fertility or the unborn child Reproductive toxicity Category 2 Warning P201, P202, P281, P308+P313, P405,P501
Precautionary statements:
P201 Obtain special instructions before use.
P202 Do not handle until all safety precautions have been read and understood.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P308+P313 IF exposed or concerned: Get medical advice/attention.
P405 Store locked up.
P501 Dispose of contents/container to..…

Description

Pomalidomide-d5 is intended for use as an internal standard for the quantification of pomalidomide by GC- or LC-MS. Pomalidomide is an analog of thalidomide that inhibits the E3 ligase protein cereblon (CRBN) with an IC50 value of approximately 3 μM for the human recombinant CRBN-DNA damage binding protein-1 (CRBN-DDB1) complex. It inhibits autoubiquitination of CRBN in HEK293T cells expressing CRBN but not those expressing a thalidomide-binding defective CRBN mutation. It inhibits proliferation of U266 myeloma cells when used at concentrations ranging from 0.1 to 10 μM. Pomalidomide also has antiangiogenic and immunomodulatory effects against myeloma cells, modulating cell adhesion, decreasing production of key pro-survival cytokines, including TNF-α, and triggering the activation of caspase-8. Pomalidomide (3 mg/kg per day), in combination with dexamethasone, reduces tumor growth in a H929 R10-1 lenalidomide-resistant mouse xenograft model. Formulations containing pomalidomide have been used in the treatment of multiple myeloma.

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